Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington's Disease

Cell Reports

Volumn 2, Issue 5, 2012, Pages 1137-1142

  Xun, Zhiyin ^a   Rivera Sánchez, Sulay ^b   Ayala Peña, Sylvette ^b,c   Lim, James ^a   Budworth, Helen ^a   Skoda, Erin M ^d   Robbins, Paul D ^e,f,g   Niedernhofer, Laura J ^e,f,g   Wipf, Peter ^d   McMurray, Cynthia T ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS   (Puerto Rico)

^c UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^g NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; MITOCHONDRIAL DNA; UNCLASSIFIED DRUG; XJB 5 131;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG EFFICACY; DRUG SPECIFICITY; DRUG TARGETING; EMBRYO; GENE DOSAGE; HUNTINGTON CHOREA; IN VIVO STUDY; MITOCHONDRION; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; WEIGHT REDUCTION;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA, MITOCHONDRIAL; GENE DOSAGE; HUNTINGTON DISEASE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MOTOR ACTIVITY; NEURONS; OXIDATIVE STRESS; WEIGHT LOSS;

EID: 84870468673     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.10.001     Document Type: Article

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