Quantifying metabolic heterogeneity in head and neck tumors in real time: 2-DG uptake is highest in hypoxic tumor regions

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Nakajima, Erica C ^a,b,c   Laymon, Charles ^c   Oborski, Matthew ^c   Hou, Weizhou ^c   Wang, Lin ^c   Grandis, Jennifer R ^c   Ferris, Robert L ^c   Mountz, James M ^c   Van Houten, Bennett ^c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE IX; DEOXYGLUCOSE; FLUORODEOXYGLUCOSE F 18; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE M; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE SUBUNIT 5BETA; UNCLASSIFIED DRUG; FLUORESCENT DYE; FLUORINE; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAL33 CELL LINE; CANCER CELL LINE; CANCER PROGNOSIS; CASE REPORT; CELL METABOLISM; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FLUORESCENCE IMAGING; FLUORESCENT MOLECULAR TOMOGRAPHY; GLUCOSE TRANSPORT; GLYCOLYSIS; HEAD AND NECK TUMOR; HUMAN; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; ONCOLOGICAL PARAMETERS; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TOMOGRAPHY; TUMOR METABOLIC HETEROGENEITY; ANIMAL; CELL HYPOXIA; IMMUNOBLOTTING; METABOLISM; MOUSE; NUDE MOUSE; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; SQUAMOUS CELL CARCINOMA; XENOGRAFT;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; FLUORESCENT DYES; FLUORINE RADIOISOTOPES; GLUCOSE; GLYCOLYSIS; HEAD AND NECK NEOPLASMS; HETEROGRAFTS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; OXIDATIVE PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY;

EID: 84929055221     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102452     Document Type: Article

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