Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options

Chemical Communications

Volumn , Issue 8, 2008, Pages 966-968

  Whitehouse, Christopher J C ^a   Bell, Stephen G ^a   Tufton, Henry G ^a   Kenny, Richard J P ^a   Ogilvie, Lydia C I ^a   Wong, Luet Lok ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 BM3; ENZYME VARIANT;

ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; IN VITRO STUDY; NONHUMAN;

EID: 39549111087     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b718124h     Document Type: Article

References (26)

1. Cytochrome P450: Structure, Mechanism and Biochemistry, ed., P. R. Ortiz de Montellano,, Kluwer Academic/Plenum Publishers, New York, 3rd edn, 2005
2. The Ubiquitous Roles of Cytochrome P450 Proteins, ed., A. Sigel,,, H. Sigel, and, R. K. O. Sigel,, John Wiley & Sons, Chichester, Metal Ions in Life Sciences, 2007, vol. 3
3. M. J. Cryle R. D. Espinoza S. J. Smith N. J. Matovic J. J. De Voss Chem. Commun. 2006 2353 2355
4. S. G. Bell, N. Hoskins, C. J. C. Whitehouse and L. L. Wong, in The Ubiquitous Roles of Cytochrome P450 Proteins, ed., A. Sigel,,, H. Sigel, and, R. K. O. Sigel,, John Wiley & Sons, Chichester, Metal Ions in Life Sciences, 2007, vol. 3, ch. 14, pp. 437-476
5. A. B. Carmichael L. L. Wong Eur. J. Biochem. 2001 268 3117 3125
6. Q. S. Li J. Ogawa R. D. Schmid S. Shimizu Appl. Environ. Microbiol. 2001 67 5735 5739
7. M. W. Peters P. Meinhold A. Glieder F. H. Arnold J. Am. Chem. Soc. 2003 125 13442 13450
8. R. Fasan M. M. Chen N. C. Crook F. H. Arnold Angew. Chem., Int. Ed. 2007 46 8414 8418
9. B. M. Vugt-Lussenburg E. Stjernschantz J. Lastdrager C. Oostenbrink N. P. Vermeulen J. N. Commandeur J. Med. Chem. 2007 50 455 461
10. G. Di Nardo A. Fantuzzi A. Sideri P. Panicco C. Sassone C. Giunta G. Gilardi J. Biol. Inorg. Chem. 2007 12 313 323
11. V. B. Urlacher, S. G. Bell and L. L. Wong, in Modern Biooxidation, ed., R. D. Schmid, and, V. B. Urlacher,, Wiley-VCH, Weinheim, 2007, ch. 4, pp. 99-122
12. K. L. Tee U. Schwaneberg Comb. Chem. High Throughput Screening 2007 10 197 217
13. E. M. Gillam A. M. Aguinaldo L. M. Notley D. Kim R. G. Mundkowski A. A. Volkov F. H. Arnold P. Soucek J. J. DeVoss F. P. Guengerich Biochem. Biophys. Res. Commun. 1999 265 469 472
14. Q. S. Li U. Schwaneberg P. Fischer R. D. Schmid Chemistry 2000 6 1531 1536
15. Q. S. Li J. Ogawa R. D. Schmid S. Shimizu FEBS Lett. 2001 508 249 252
16. V. B. Urlacher A. Makhsumkhanov R. D. Schmid Appl. Microbiol. Biotechnol. 2006 70 53 59
17. J. H. Capdevila S. Wei C. Helvig J. R. Falck Y. Belosludtsev G. Truan S. E. Graham-Lorence J. A. Peterson J. Biol. Chem. 1996 271 22663 22671
18. A. Glieder E. T. Farinas F. H. Arnold Nat. Biotechnol. 2002 20 1135 1139
19. P. Meinhold M. W. Peters M. M. Chen K. Takahashi F. H. Arnold ChemBioChem 2005 6 1765 1768
20. H. Li T. L. Poulos Nat. Struct. Biol. 1997 4 140 146
21. M. D. Paulsen R. L. Ornstein Proteins: Struct. Funct. Genet. 1995 21 237 243
22. P. C. Cirino F. H. Arnold Angew. Chem., Int. Ed. 2003 42 3299 3301
23. US Pat., 2003100744, 2003. World Pat., 2003008563, 2003
24. R. J. Sowden S. Yasmin N. H. Rees S. G. Bell L. L. Wong Org. Biomol. Chem. 2005 3 57 64
25. T. S. Wong N. Wu D. Roccatano M. Zacharias U. Schwaneberg J. Biomol. Screening 2005 10 246 252
26. O. Lentz A. Feenstra T. Habicher B. Hauer R. D. Schmid V. B. Urlacher ChemBioChem 2005 7 345 350