Introduction: Human metabolites in safety testing (MIST) issue

Chemical Research in Toxicology

Volumn 22, Issue 2, 2009, Pages 237-238

  Guengerich, F Peter ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE;

EDITORIAL; ELECTROCHEMISTRY; MASS SPECTROMETRY; MEDICAL RESEARCH; NUCLEAR MAGNETIC RESONANCE; PRACTICE GUIDELINE; PREDICTION; RISK ASSESSMENT; SCIENTIST;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; GUIDELINES AS TOPIC; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; PHARMACEUTICAL PREPARATIONS; TOXICITY TESTS;

EID: 62249176950     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx900003k     Document Type: Editorial

References (4)

1. Guengerich, F. P. (2006) Safety assessment of stable drug metabolites. Chem. Res. Toxicol. 19, 1559-1560.
2. Davis-Bruno, K. L., and Atrakchi, A. (2006) A regulatory perspective on issues and approaches in characterizing human metabolites. Chem. Res. Toxicol. 19, 1561-1563.
3. Humphreys, G. H., and Unger, S. E. (2006) Safety assessment of drug metabolites: Characterization of chemically stable metabolites. Chem. Res. Toxicol. 19, 1564-1569.
4. Smith, D. A., and Obach, R. S. (2006) Metabolites and safety: What are the concerns and how should we address them? Chem. Res. Toxicol. 19, 1570-1579.