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Volumn 18, Issue 12, 2012, Pages 3582-3588

Identification of mutant Asp251Gly/Gln307His of cytochrome P450 BM3 for the generation of metabolites of diclofenac, ibuprofen and tolbutamide

(5) Tsotsou, Georgia E a Sideri, Anastasia a Goyal, Abhineet a Di Nardo, Giovanna a Gilardi, Gianfranco a

a UNIVERSITY OF TURIN (Italy)

Author keywords

diclofenac; directed evolution; drug discovery; ibuprofen; tolbutamide

Indexed keywords

DICLOFENAC; DIRECTED EVOLUTION; DRUG DISCOVERY; IBUPROFEN; TOLBUTAMIDE;

BACTERIOLOGY; DIAGNOSIS; DISSOCIATION; ESCHERICHIA COLI; METABOLISM; METABOLITES; POLYMERASE CHAIN REACTION;

SUBSTRATES;

4' HYDROXYDICLOFENAC; 4'-HYDROXYDICLOFENAC; ASPARAGINE; CYTOCHROME P450; DICLOFENAC; DRUG DERIVATIVE; GLUTAMINE; GLYCINE; HISTIDINE; HYDROXYIBUPROFEN; IBUPROFEN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; TOLBUTAMIDE;

ARTICLE; BACILLUS MEGATERIUM; CATALYSIS; CHEMISTRY; DRUG DEVELOPMENT; ESCHERICHIA COLI; GENETICS; HUMAN; HYDROXYLATION; METABOLISM; OXIDATION REDUCTION REACTION;

ASPARAGINE; BACILLUS MEGATERIUM; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; DRUG DISCOVERY; ESCHERICHIA COLI; GLUTAMINE; GLYCINE; HISTIDINE; HUMANS; HYDROXYLATION; IBUPROFEN; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; TOLBUTAMIDE;

EID: 84859054604 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201102470 Document Type: Article

Times cited : (33)

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