[O-methyl 14c]naproxen O-demethylase activity in human liver microsomes: Evidence for the involvement of cytochrome P4501A2 and P4502C9/10

Drug Metabolism and Disposition

Volumn 24, Issue 1, 1996, Pages 126-136

  David Rodrigues, A ^a,c   Kukulka, Michael J ^a   Roberts, Ellen M ^a   Ouellet, Daniele ^a   Rodgers, Thomas R ^b  

^a Gilead Sciences   (United States)

^b DUPONT COMPANY   (United States)

^c ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; COMPLEMENTARY DNA; CYTOCHROME P450; ISOENZYME; NAPROXEN; O DEMETHYLASE; RECOMBINANT PROTEIN; 4 METHYLPYRAZOLE; CARBON 14; DIETHYLDITHIOCARBAMIC ACID; ETHOXYRESORUFIN DEETHYLASE; FURAFYLLINE; IBUPROFEN; KETOCONAZOLE; MEPHENYTOIN; NAPROXEN DERIVATIVE; OXYGENASE; PHENYTOIN; QUINIDINE; SULFAPHENAZOLE; TIENILIC ACID; TOLBUTAMIDE; TROLEANDOMYCIN;

ARTICLE; B LYMPHOCYTE; CELL LINE; ENZYMOLOGY; GENETICS; HUMAN; KINETICS; LIVER MICROSOME; METABOLISM; B LYMPHOBLAST; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME METABOLISM; MICHAELIS CONSTANT; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL;

B-LYMPHOCYTES; CARBON RADIOISOTOPES; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMANS; ISOENZYMES; KINETICS; MICROSOMES, LIVER; NAPROXEN; OXIDOREDUCTASES, O-DEMETHYLATING; RECOMBINANT PROTEINS;

EID: 0029662234     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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