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Volumn 15, Issue 43, 2009, Pages 11723-11729

A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds

(6) Sawayama, Andrew M a Chen, Michael M Y a Kulanthaivel, Palaniappan b Kuo, Ming Shang b Hemmerle, Horst b Arnold, Frances H a

a California Institute of Technology (United States)

b ELI LILLY AND COMPANY (United States)

Author keywords

C H activation; Cytochrome P450; Drug development; Drug metabolism; Oxidation

Indexed keywords

BACILLUS MEGATERIUM; C-H ACTIVATION; CYTOCHROME P450; CYTOCHROME P450 BM3; DIRECTED EVOLUTION; DRUG DEVELOPMENT; DRUG LEADS; DRUG METABOLISM; DRUG METABOLITES; ENZYME CATALYSTS; EVOLUTIONARY HISTORY; HYDROXYLATED SPECIES; POTENTIAL UTILITY; VERAPAMIL;

ACTIVATION ANALYSIS; BACTERIOLOGY; BIOCHEMISTRY; BIOMOLECULES; CATALYSTS; ENZYMES; LEAD COMPOUNDS; MAMMALS; METABOLITES; OXIDATION;

METABOLISM;

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ASTEMIZOLE; CHROMONE DERIVATIVE; CYTOCHROME P450; DRUG; HYBRID PROTEIN; MORPHOLINE DERIVATIVE; VERAPAMIL;

ARTICLE; BACILLUS MEGATERIUM; BIOCATALYSIS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOLECULAR EVOLUTION; SITE DIRECTED MUTAGENESIS;

ASTEMIZOLE; BACILLUS MEGATERIUM; BIOCATALYSIS; CATALYTIC DOMAIN; CHROMONES; CYTOCHROME P-450 ENZYME SYSTEM; EVOLUTION, MOLECULAR; HUMANS; MORPHOLINES; MUTAGENESIS, SITE-DIRECTED; PHARMACEUTICAL PREPARATIONS; RECOMBINANT FUSION PROTEINS; VERAPAMIL;

EID: 70350518093 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.200900643 Document Type: Article

Times cited : (129)

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