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Volumn 55, Issue 5, 1997, Pages 235-243

Metabolism of the tricyclic antidepressant amitriptyline by cdna-expressed human cytochrome p450 enzymes

Author keywords

Amitriptyline; Cytochrome P450; Metabolism, amitriptyline

Indexed keywords

AMITRIPTYLINE; COMPLEMENTARY DNA; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; DRUG METABOLIZING ENZYME; TRICYCLIC ANTIDEPRESSANT AGENT;

EID: 0030735733     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139533     Document Type: Article
Times cited : (71)

References (25)
  • 1
    • 0029979414 scopus 로고    scopus 로고
    • Polymorphic drug oxidation. Relevance to the treatment of psychiatric disorders
    • Bertilsson L, Dahl M-L: Polymorphic drug oxidation. Relevance to the treatment of psychiatric disorders. CNS Drugs 1996:5:200-223.
    • (1996) CNS Drugs , vol.5 , pp. 200-223
    • Bertilsson, L.1    Dahl, M.-L.2
  • 2
    • 0025964524 scopus 로고
    • The mephenytoin oxidation polymorphism is partially responsible for the N-demcthylation of imipramine
    • Skjelbo E. Brosen K. Hallas J. Grant LF: The mephenytoin oxidation polymorphism is partially responsible for the N-demcthylation of imipramine. Clin Pharmacol Ther 1991: 49:18-23.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 18-23
    • Skjelbo, E.1    Brosen, K.2    Hallas, J.3    Grant, L.F.4
  • 3
    • 0030055999 scopus 로고    scopus 로고
    • Steady-state plasma concentrations of imipramine and desi-prantine in relation to S-mephcny-toin 4'-hydroxvlation status in Japanese depressive patients
    • Koyama E, Tanaka T. Chiba K. Ka-wakatsu S. Morinobu S, Totsuka S. Ishizaki T: Steady-state plasma concentrations of imipramine and desi-prantine in relation to S-mephcny-toin 4'-hydroxvlation status in Japanese depressive patients. J Clin Psy-chopharmacol 1996:16:286-293.
    • (1996) J Clin Psy-Chopharmacol , vol.16 , pp. 286-293
    • Koyama, E.1    Tanaka, T.2    Chiba, K.3    Ka-Wakatsu, S.4    Morinobu, S.5    Totsuka, S.6    Ishizaki, T.7
  • 4
    • 0028214359 scopus 로고
    • The role of S-mephenvtoin 4'-hydroxvlase in imipramine metabolism by human liver microsomes: A two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation
    • Chiba K, Saitoh A, Koyama E, Tani M. Hayashi M. Ishizaki T: The role of S-mephenvtoin 4'-hydroxvlase in imipramine metabolism by human liver microsomes: A two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation. BrJ Clin Pharmacol 1994:37:237-242.
    • (1994) Brj Clin Pharmacol , vol.37 , pp. 237-242
    • Chiba, K.1    Saitoh, A.2    Koyama, E.3    Tani, M.4    Hayashi, M.5    Ishizaki, T.6
  • 5
    • 0025733250 scopus 로고
    • Role of P45011D6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine
    • Brosen K. Zeugin T. Meyer UA: Role of P45011D6. the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clin Pharmacol Ther 1991:49:609-617.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 609-617
    • Brosen, K.1    Zeugin, T.2    Meyer, U.A.3
  • 7
    • 0028059720 scopus 로고
    • Involvement of CYP2D6. CYP3A4, and other cytochrome P450 enzymes in N-dcalkylation reaction
    • Coutts RT, Su P. Baker GB: Involvement of CYP2D6. CYP3A4. and other cytochrome P450 enzymes in N-dcalkylation reaction. J Pharmacol Toxicol Methods 1994; 31:177-186.
    • (1994) J Pharmacol Toxicol Methods , vol.31 , pp. 177-186
    • Coutts, R.T.1    Su, P.2    Baker, G.B.3
  • 10
    • 0029558898 scopus 로고
    • Shader Rl: N-Demethylation of amitriptyline in vitro: Role of cytochrome P450 3A (CYP3A) isoforms and effect of metabolic inhibitors
    • Schmider J. Greenblatt DJ. von Moltke LL. Harmatz JS, Shader Rl: N-Demethylation of amitriptyline in vitro: Role of cytochrome P450 3A (CYP3A) isoforms and effect of metabolic inhibitors. J Pharmacol ExpTher 1995:275:592-597.
    • (1995) J Pharmacol Expther , vol.275 , pp. 592-597
    • Schmider, J.1    Greenblatt, D.J.2    Von Moltke, L.L.3    Harmatz, J.S.4
  • 12
    • 0026537062 scopus 로고
    • Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms
    • Fuhr U, Doehmer J. Battula N, Wolfcr C. Kudla C, Keila Y. Staib AH: Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. Biochem Pharmacol 1992: 43:225-235.
    • (1992) Biochem Pharmacol , vol.43 , pp. 225-235
    • Fuhr, U.1    Doehmer, J.2    Battula, N.3    Wolfcr, C.4    Kudla, C.5    Keila, Y.6    Staib, A.H.7
  • 13
    • 0027264432 scopus 로고
    • Cytochrome P450TB (CYP2C): A major monooxvgenase catalyzing diclofenac 4'-hydroxylalion in human liver
    • Leemann T. Transon C. Dayer P; Cytochrome P450TB (CYP2C): A major monooxvgenase catalyzing diclofenac 4'-hydroxylalion in human liver. LifeSci 1993;52:29-34.
    • (1993) Lifesci , vol.52 , pp. 29-34
    • Leemann, T.1    Transon, C.2    Dayer, P.3
  • 14
    • 0023136337 scopus 로고
    • Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes
    • Hall SD. Guengerich FP. Branch RA. Wilkinson GR: Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. .J Pharmacol Exp Thcr 1987;240:216-222.
    • (1987) J Pharmacol Exp Thcr , vol.240 , pp. 216-222
    • Hall, S.D.1    Guengerich, F.P.2    Branch, R.A.3    Wilkinson, G.R.4
  • 15
    • 0029035739 scopus 로고
    • Intcrindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic hydroxylation in men and women and its rclat onship to CYP2EI genetic polymorphisms
    • Kim RB, O’Shea D. Wilkinson GR: Intcrindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic hydroxylation in men and women and its rclat onship to CYP2EI genetic polymorphisms. Clin Pharmacol Ther 1995:57:645-655.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 645-655
    • Kim, R.B.1    O’shea, D.2    Wilkinson, G.R.3
  • 16
    • 0026001359 scopus 로고
    • Enantiosclcctivc hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline
    • Dahl M-L. Nordin C. Bertilsson L: Enantiosclcctivc hydroxylation of nortriptyline in human liver microsomes. intestinal homogenate, and patients treated with nortriptyline. Thcr Drug Mon it 1991:13:189-194.
    • (1991) Thcr Drug Mon It , vol.13 , pp. 189-194
    • Dahl, M.-L.1    Nordin, C.2    Bertilsson, L.3
  • 17
    • 0030036673 scopus 로고    scopus 로고
    • Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: Implications for diazepam disposition in humans
    • Schmider J, Greenblatt DJ. von Moltke LL, Shader RI: Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: Implications for diazepam disposition in humans. J Clin Psychopharmacot 1996; 16: 267-272.
    • (1996) J Clin Psychopharmacot , vol.16 , pp. 267-272
    • Schmider, J.1    Greenblatt, D.J.2    Von Moltke, L.L.3    Shader, R.I.4
  • 18
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P 450 isozymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes in 30 Japanese and 30 Caucasians
    • Shimada T. Yamazaki Y. Mimura M. Inui Y. Guengerich FP: Interindividual variations in human liver cytochrome P 450 isozymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes in 30 Japanese and 30 Caucasians. J Pharmacol ExpTher 1994:270:414-423.
    • (1994) J Pharmacol Expther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, Y.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 20
    • 0021923893 scopus 로고
    • Tricyclic antidepressant blood level measurements and clinical outcome: An APA Task Force Report
    • Task Force on the Use of Laboratory Tests in Psychiatry: Tricyclic antidepressant blood level measurements and clinical outcome: An APA Task Force Report. Am.1 Psychiatry 1985;142:155-162.
    • (1985) Am.1 Psychiatry , vol.142 , pp. 155-162
  • 21
    • 0029861060 scopus 로고    scopus 로고
    • Site to site variability of postmortem drug concentrations in liver and lung
    • Pounder DJ. Adams E. Fuke C. Langford AM: Site to site variability of postmortem drug concentrations in liver and lung. J Forensic Sei 1996:41:927-932.
    • (1996) J Forensic Sei , vol.41 , pp. 927-932
    • Pounder, D.J.1    Adams, E.2    Fuke, C.3    Langford, A.M.4
  • 23
    • 0022481136 scopus 로고
    • Amitriptyline metabolism: Association with debrisoquin hydroxylation in nonsmokers
    • Mcllslröm B, Wäwe J. Bertilsson L, Sjöqvist F: Amitriptyline metabolism: Association with debrisoquin hydroxylation in nonsmokers. Clin Pharmacol Ther 1986;39:369-371.
    • (1986) Clin Pharmacol Ther , vol.39 , pp. 369-371
    • Mc Llslröm, B.1    Wäwe, J.2    Bertilsson, L.3    Sjöqvist, F.4
  • 24
    • 0029934305 scopus 로고    scopus 로고
    • Shader Rl: Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: Application to ami-triptylin N-dcmethylation
    • Schmider J, Greenblatt DJ, Harmatz JS. Shader Rl: Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: Application to ami-triptylin N-dcmethylation. Br J Clin Pharmacol 1996;41:593-604.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 593-604
    • Schmider, J.1    Greenblatt, D.J.2    Harmatz, J.S.3
  • 25
    • 0026795695 scopus 로고
    • Inhibition of imipramine metabolism by human liver microsomes
    • Skjelbo E. Brosen K: Inhibition of imipramine metabolism by human liver microsomes. Br J Clin Pharmacol 1992;34:256-261.
    • (1992) Br J Clin Pharmacol , vol.34 , pp. 256-261
    • Skjelbo, E.1    Brosen, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.