Production and NMR analysis of the human ibuprofen metabolite 3-hydroxyibuprofen

Journal of Biotechnology

Volumn 157, Issue 3, 2012, Pages 417-420

  Neunzig, Ina ^a   Göhring, Anke ^a   Drǎgan, Cǎlin Aurel ^a   Zapp, Josef ^b   Peters, Frank T ^c   Maurer, Hans H ^d   Bureik, Matthias ^a  

^a PomBioTech GmbH   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

3 Hydroxyibuprofen; Biocatalysis; Cytochrome P450 2C9; Recombinant fission yeast; Whole cell biotransformation

Indexed keywords

3-HYDROXYIBUPROFEN; BIOCATALYSIS; CYTOCHROME P450; FISSION YEAST; WHOLE-CELL BIOTRANSFORMATIONS;

BATCH CELL CULTURE; BIOCONVERSION; BIOMOLECULES; DRUG PRODUCTS; METABOLISM; YEAST;

METABOLITES;

1 HYDROXYIBUPROFEN; 2 HYDROXYIBUPROFEN; 3 HYDROXYIBUPROFEN; CYTOCHROME P450 2C9; DRUG METABOLITE; IBUPROFEN; UNCLASSIFIED DRUG;

ARTICLE; BIOMASS; BIOTRANSFORMATION; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG MANUFACTURE; DRUG SYNTHESIS; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IBUPROFEN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; SCHIZOSACCHAROMYCES;

SCHIZOSACCHAROMYCETACEAE;

EID: 84856708060     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2011.12.016     Document Type: Article

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