Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

Journal of Clinical Investigation

Volumn 125, Issue 10, 2015, Pages 3847-3860

  Ferdaoussi, Mourad ^a,b   Dai, Xiaoqing ^a,b   Jensen, Mette V ^c   Wang, Runsheng ^d   Peterson, Brett S ^c   Huang, Chao ^d   Ilkayeva, Olga ^c   Smith, Nancy ^a,b   Miller, Nathanael ^e   Hajmrle, Catherine ^a,b   Spigelman, Aliya F ^a,b   Wright, Robert C ^a,b   Plummer, Gregory ^a,b   Suzuki, Kunimasa ^a   Mackay, James P ^b   Van De Bunt, Martijn ^f   Gloyn, Anna L ^f,g   Ryan, Terence E ^h   Norquay, Lisa D ^i,j   Brosnan, M Julia ^j   Trimmer, Jeff K ^k   Rolph, Timothy P ^j   Kibbey, Richard G ^l   Manning Fox, Jocelyn E ^l   Colmers, William F ^b   Shirihai, Orian S ^e,m   Neufer, P Darrell ^h   Yeh, Edward T H ^d   Newgard, Christopher B ^c   MacDonald, Patrick E ^a,b   more..

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h EAST CAROLINA UNIVERSITY   (United States)

ⁱ JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^j PFIZER INC   (United States)

^k BioElectron Technology Corporation   (United States)

^l YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CRE RECOMBINASE; CYCLIC AMP; GLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; INSULIN; ISOCITRATE DEHYDROGENASE; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUMO PROTEIN; SUMO SPECIFIC PROTEASE 1; UNCLASSIFIED DRUG; HYBRID PROTEIN; ISOCITRIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROTEINASE; SENP1 PROTEIN, HUMAN; SENP1 PROTEIN, MOUSE;

ARTICLE; EXOCYTOSIS; GENE AMPLIFICATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; INSULIN RELEASE; INSULINOMA CELL LINE; MEMBRANE DEPOLARIZATION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUMOYLATION; WHOLE CELL PATCH CLAMP; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; C57BL MOUSE; CELL MEMBRANE; DEFICIENCY; DRUG EFFECTS; ENZYME ACTIVE SITE; GENE INACTIVATION; GENETICS; HEK293 CELL LINE; HOMEOSTASIS; MALE; MEMBRANE POTENTIAL; METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RNA INTERFERENCE; SECRETION (PROCESS); SECRETORY VESICLE;

ANIMALS; CATALYTIC DOMAIN; CELL MEMBRANE; DIABETES MELLITUS, TYPE 2; ENDOPEPTIDASES; EXOCYTOSIS; GENE KNOCKOUT TECHNIQUES; GLUCOSE; GLUTATHIONE; HEK293 CELLS; HOMEOSTASIS; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISOCITRATE DEHYDROGENASE; ISOCITRATES; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; NADP; ORGAN SPECIFICITY; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SECRETORY VESICLES; SIGNAL TRANSDUCTION; SUMOYLATION;

EID: 84943311794     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI82498     Document Type: Article

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