Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets

Journal of Biological Chemistry

Volumn 283, Issue 43, 2008, Pages 28909-28917

  Ronnebaum, Sarah M ^a   Jensen, Mette V ^a   Hohmeier, Hans E ^a   Burgess, Shawn C ^b   Zhou, Yun Ping ^c   Qian, Su ^c   MacNeil, Douglas ^c   Howard, Andrew ^c   Thornberry, Nancy ^c   Ilkayeva, Olga ^a   Lu, Danhong ^a   Sherry, A Dean ^b   Newgard, Christopher B ^a  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ENZYMES; GLUCOSE; GROWTH KINETICS; HORMONES; INSULIN; NUCLEIC ACIDS; POLARIZATION; POTASSIUM; RNA; SEMICONDUCTOR SWITCHES;

CELL LINES; CYTOSOLIC; EFFECTIVE SUPPRESSIONS; INSULIN SECRETIONS; ISOFORMS; MALIC ENZYMES; PYRUVATE; RAT ISLETS;

CELL GROWTH;

CELL ENZYME; GLUCOSE; INCRETIN; INSULIN; MALATE DEHYDROGENASE (DECARBOXYLATING); MITOCHONDRIAL ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; SMALL INTERFERING RNA;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL ISOLATION; CELL LINE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME REPRESSION; INSULIN RELEASE; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RODENT;

ANIMALS; CYTOSOL; GENE SILENCING; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MALATE DEHYDROGENASE; MALE; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING;

ADENOVIRIDAE; MUS; RATTUS; RODENTIA;

EID: 57349189962     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804665200     Document Type: Article

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