Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

Journal of Biological Chemistry

Volumn 284, Issue 39, 2009, Pages 26578-26590

  Stark, Romana ^a   Pasquel, Francisco ^a   Turcu, Adina ^a   Pongratz, Rebecca L ^a   Roden, Michael ^b   Cline, Gary W ^a   Shulman, Gerald I ^a   Kibbey, Richard G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLEROTIC PATHWAY; CYTOSOLIC; CYTOSOLIC CALCIUM; ENZYMATIC ACTIVITIES; GLUCOSE-STIMULATED INSULIN SECRETIONS; INSULIN RELEASE; INSULIN SECRETION; ISOFORMS; LABELING STRATEGY; MITOCHONDRIAL MATRIX; MITOCHONDRIAL METABOLISM; PHOSPHOENOLPYRUVATE CARBOXYKINASE; PHOSPHOENOLPYRUVATES; PRIMARY HEPATOCYTES; RAT ISLETS; SYNTHETASES;

CALCIUM; CELL MEMBRANES; GLUCOSE; PHYSIOLOGY; SYNTHESIS (CHEMICAL);

INSULIN;

CARBON 13; GLUCOSE; GUANOSINE TRIPHOSPHATE; INSULIN; MESSENGER RNA; PHOSPHOENOLPYRUVATE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SUCCINYL COENZYME A SYNTHETASE;

ANAPLEROSIS; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; GENETIC TRANSFECTION; HYDROLYSIS; INSULIN RELEASE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; CITRIC ACID CYCLE; GUANOSINE TRIPHOSPHATE; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; PHOSPHOENOLPYRUVATE; PHOSPHOENOLPYRUVATE CARBOXYLASE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SUCCINATE-COA LIGASES;

RATTUS;

EID: 70350374347     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.011775     Document Type: Article

References (76)

1. Newgard, C. B., Lu, D., Jensen, M. V., Schissler, J., Boucher, A., Burgess, S., and Sherry, A. D. (2002) Diabetes 51, S389-393
2. Lu, D., Mulder, H., Zhao, P., Burgess, S. C., Jensen, M. V., Kamzolova, S., Newgard, C. B., and Sherry, A. D. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 2708-2713
3. Pongratz, R. L., Kibbey, R. G., Shulman, G. I., and Cline, G. W. (2007) J. Biol. Chem. 282, 200-207
4. Cline, G. W., Lepine, R. L., Papas, K. K., Kibbey, R. G., and Shulman, G. I. (2004) J. Biol. Chem. 279, 44370-44375
5. Kibbey, R. G., Pongratz, R. L., Romanelli, A. J., Wollheim, C. B., Cline, G. W., and Shulman, G. I. (2007) Cell Metab. 5, 253-264
6. Wiese, T. J., Lambeth, D. O., and Ray, P. D. (1991) Comp. Biochem. Physiol. B 100, 297-302
7. Petrescu, I., Bojan, O., Saied, M., Bârzu, O., Schmidt, F., and Kühnle, H. F. (1979) Anal. Biochem. 96, 279-281
8. Ishihara, H., Wang, H., Drewes, L. R., and Wollheim, C. B. (1999) J. Clin. Invest. 104, 1621-1629
9. Garber, A. J., and Ballard, F. J. (1969) J. Biol. Chem. 244, 4696-4703
10. Wood, H. G., Lifson, N., and Lorber, V. (1945) J. Biol. Chem. 159, 475-489
11. Shreeve, W. W., and De Meutter, R. C. (1964) J. Biol. Chem. 239, 729-734
12. MacDonald, M. J., McKenzie, D. I., Walker, T. M., and Kaysen, J. H. (1992) Horm. Metab. Res. 24, 158-160
13. MacDonald, M. J., and Chang, C. M. (1985) Diabetes 34, 246-250
14. Hedeskov, C. J., Capito, K., and Thams, P. (1984) Biochim. Biophys. Acta 791, 37-44
15. Hedeskov, C. J., and Capito, K. (1980) Horm. Metab. Res. Suppl. 10, 8-13
16. Bârzu, O., Abrudan, I., Proinov, I., Kiss, L., Ty, N. G., Jebeleanu, G., Goia, I., Kezdi, M., and Mantsch, H. H. (1976) Biochim. Biophys. Acta 452, 406-412
17. Hohnadel, D. C., and Cooper, C. (1973) FEBS Lett. 30, 18-20
18. Plowman, K. M., and Krall, A. R. (1965) Biochemistry 4, 2809-2814
19. Holyoak, T., and Nowak, T. (2004) Biochemistry 43, 7054-7065
20. Ballard, F. J., Hanson, R. W., and Reshef, L. (1970) Biochem. J. 119, 735-742
21. Goto, Y., Shimizu, J., Okazaki, T., and Shukuya, R. (1979) J. Biochem. 86, 71-78
22. Holten, D. D., and Nordlie, R. C. (1965) Biochemistry 4, 723-731
23. Ishihara, N., and Kikuchi, G. (1968) Biochim. Biophys. Acta 153, 733-748
24. Sato, A., Suzuki, T., and Kochi, H. (1986) J. Biochem. 100, 671-678
25. MacDonald, M. J., and Chang, C. M. (1985) Mol. Cell Biochem. 68, 115-120
26. Szollosi, A., Nenquin, M., Aguilar-Bryan, L., Bryan, J., and Henquin, J. C. (2007) J. Biol. Chem. 282, 1747-1756
27. Szollosi, A., Nenquin, M., and Henquin, J. C. (2007) J. Biol. Chem. 282, 14768-14776
28. Söling, H. D., Willms, B., Kleineke, J., and Gehlhoff, M. (1970) Eur. J. Biochem. 16, 289-302
29. Cornell, N. W., Schramm, V. L., Kerich, M. J., and Emig, F. A. (1986) J. Nutr. 116, 1101-1108
30. Nordlie, R. C., and Lardy, H. A. (1963) J. Biol. Chem. 238, 2259-2263
31. Ballard, F. J., and Hanson, R. W. (1967) Biochem. J. 104, 866-871
32. Usatenko, M. S. (1970) Biochem. Med. 3, 298-310
33. Heitzman, R. J., Herriman, I. D., and Mallinson, C. B. (1972) FEBS Lett. 20, 19-21
34. Saggerson, D., and Evans, C. J. (1975) Biochem. J. 146, 329-332
35. Horn, D. B., Podolin, D. A., Friedman, J. E., Scholnick, D. A., and Mazzeo, R. S. (1997) Metab. Clin. Exp. 46, 414-419
36. Söling, H. D., Kleineke, J., Willms, B., Janson, G., and Kuhn, A. (1973) Eur. J. Biochem. 37, 233-243
37. Ghanaat-Pour, H., Huang, Z., Lehtihet, M., and Sjöholm, A. (2007) J. Mol. Endocrinol. 39, 135-150
38. Boquist, L. (1987) Biochem. Int. 14, 531-538
39. Punekar, N. S., and Lardy, H. A. (1987) J. Biol. Chem. 262, 6714-6719
40. Modaressi, S., Brechtel, K., Christ, B., and Jungermann, K. (1998) Biochem. J. 333, 359-366
41. Kebede, M., Favaloro, J., Gunton, J. E., Laybutt, D. R., Shaw, M., Wong, N., Fam, B. C., Aston-Mourney, K., Rantzau, C., Zulli, A., Proietto, J., and Andrikopoulos, S. (2008) Diabetes 57, 1887-1895
42. Suzuki, M., Yamasaki, T., Shinohata, R., Hata, M., Nakajima, H., and Kono, N. (2004) Gene 338, 157-162
43. Baly, D. L., Curry, D. L., Keen, C. L., and Hurley, L. S. (1984) J. Nutr. 114, 1438-1446
44. Schramm, V. L. (1982) Trends Biochem. Sci. 7, 369-371
45. Hanson, R. W., and Patel, Y. M. (1994) Adv. Enzymol. Relat. Areas Mol. Biol. 69, 203-281
46. Holyoak, T., Sullivan, S. M., and Nowak, T. (2006) Biochemistry 45, 8254-8263
47. Hlavaty, J. J., and Nowak, T. (2000) Biochemistry 39, 1373-1388
48. Deaciuc, I. V., D'Souza, N. B., and Miller, H. I. (1992) Int. J. Biochem. 24, 129-132
49. She, P., Burgess, S. C., Shiota, M., Flakoll, P., Donahue, E. P., Malloy, C. R., Sherry, A. D., and Magnuson, M. A. (2003) Diabetes 52, 1649-1654
50. She, P., Shiota, M., Shelton, K. D., Chalkley, R., Postic, C., and Magnuson, M. A. (2000) Mol. Cell. Biol. 20, 6508-6517
51. Davis, B., and Lazarus, N. R. (1977) J. Physiol. 271, 273-288
52. Sugden, M. C., and Ashcroft, S. J. (1978) Diabetologia 15, 173-180
53. Ewart, R. B., Yousufzai, S. Y., Bradford, M. W., and Shrago, E. (1983) Diabetes 32, 793-797
54. Sugden, M. C., and Ashcroft, S. J. (1977) Diabetologia 13, 481-486
55. Cook, D. L., and Hales, C. N. (1984) Nature 311, 271-273
56. Chatterton, T. A., Reynolds, C. H., Lazarus, N. R., and Pogson, C. I. (1984) Experientia 40, 1426-1427
57. German, M. S. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 1781-1785
58. Heart, E., Cline, G. W., Collis, L. P., Pongratz, R. L., Gray, J. P., and Smith, P. J. (2009) Am. J. Physiol. Endocrinol. Metab. 296, E1354-E1362
59. Guay, C., Madiraju, S. R., Aumais, A., Joly, E., and Prentki, M. (2007) J. Biol. Chem. 282, 35657-35665
60. Ronnebaum, S. M., Jensen, M. V., Hohmeier, H. E., Burgess, S. C., Zhou, Y. P., Qian, S., MacNeil, D., Howard, A., Thornberry, N., Ilkayeva, O., Lu, D., Sherry, A. D., and Newgard, C. B. (2008) J. Biol. Chem. 283, 28909-28917
61. Joseph, J. W., Jensen, M. V., Ilkayeva, O., Palmieri, F., Alárcon, C., Rhodes, C. J., and Newgard, C. B. (2006) J. Biol. Chem. 281, 35624-35632
62. Ronnebaum, S. M., Ilkayeva, O., Burgess, S. C., Joseph, J. W., Lu, D., Stevens, R. D., Becker, T. C., Sherry, A. D., Newgard, C. B., and Jensen, M. V. (2006) J. Biol. Chem. 281, 30593-30602
63. Pongratz, R. L., Kibbey, R. G., and Cline, G. W. (2009) Methods Enzymol. 457, 425-450
64. Jensen, M. V., Joseph, J. W., Ronnebaum, S. M., Burgess, S. C., Sherry, A. D., and Newgard, C. B. (2008) Am. J. Physiol. Endocrinol. Metab. 295, E1287-E1297
65. Joseph, J. W., Odegaard, M. L., Ronnebaum, S. M., Burgess, S. C., Muehlbauer, J., Sherry, A. D., and Newgard, C. B. (2007) J. Biol. Chem. 282, 31592-31600
66. Palmieri, F. (2004) Pflugers Arch. 447, 689-709
67. Sies, H., Akerboom, T. P., and Tager, J. M. (1977) Eur. J. Biochem. 72, 301-307
68. Chudapongse, P., and Haugaard, N. (1973) Biochim. Biophys. Acta 307, 599-606
69. Tong, W. H., and Rouault, T. A. (2007) Biometals 20, 549-564
70. Passarella, S., Atlante, A., Valenti, D., and de Bari, L. (2003) Mitochondrion 2, 319-343
71. Satrústegui, J., Pardo, B., and Del Arco, A. (2007) Physiol. Rev. 87, 29-67
72. Shug, A. L., and Shrago, E. (1973) Biochem. Biophys. Res. Commun. 53, 659-665
73. Peng, C. F., Price, D. W., Bhuvaneswaran, C., and Wadkins, C. L. (1974) Biochem. Biophys. Res. Commun. 56, 134-141
74. Chudapongse, P. (1976) Biochim. Biophys. Acta 423, 196-202
75. Sul, H. S., Shrago, E., and Shug, A. L. (1976) Arch. Biochem. Biophys. 172, 230-237
76. Roos, I., Crompton, M., and Carafoli, E. (1978) FEBS Lett. 94, 418-421