The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells

Diabetes Research and Clinical Practice

Volumn 93, Issue SUPPL. 1, 2011, Pages

  Henquin, Jean Claude ^a  

^a UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

Author keywords

Arginine; Beta cell; Biphasic insulin secretion; Insulin release; Sulfonylureas; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ARGININE; CALCIUM ION; GLUCOSE; INSULIN; TOLBUTAMIDE; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL GRANULE; CELL INTERACTION; CELL MEMBRANE DEPOLARIZATION; CELL METABOLISM; CELL STIMULATION; CYTOSOL; EXOCYTOSIS; GLUCOSE METABOLISM; HORMONAL REGULATION; HUMAN; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION;

ANIMALS; DIABETES MELLITUS; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; SIGNAL TRANSDUCTION;

EID: 84860400102     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/S0168-8227(11)70010-9     Document Type: Article

References (23)

1. Henquin JC, Nenquin M, Ravier MA, Szollosi A Shortcomings of current models of glucose-induced insulin secretion. Diabetes Obes Metab 2009, ll(Suppl 4):168-179.
2. Tarasov A, Dusonchet J, Ashcroft FM Metabolic regulation of the pancreatic β-cell ATP-sensitive K+ channel: a pas de deux. Diabetes 2004, 53(Suppl 3):S113-S122.
3. Miki T, Nagashima K, Seino S The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic β-cells. J Mol Endocrinol 1999, 22:113-123.
4. Bryan J, Vila-Carriles WH, Zhao G, Babenko AP, Aguilar-Bryan L Toward linking structure with function in ATP-sensitive K+ channels. Diabetes 2004, 53(Suppl 3):S104-S112.
5. Gribble FM, Reimann F Sulphonylurea action revisited: the post-cloning era. Diabetologia 2003, 48:875-891.
6. Henquin JC Pathways in β-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues. Diabetes 2004, 53(Suppl 3):S48-S58.
7. Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic β-cells. J Biol Chem 2004, 279:32316-32324.
8. Ravier MA, Nenquin M, Miki T, Seino S, Henquin JC Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2. Endocrinology 2009, 150:33-45.
9. Ahrén B Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov 2009, 8:369-385.
10. Henquin JC (2009) Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia 2009, 52:739-751.
11. Henquin JC, Nenquin M, Stiernet P, Ahren B In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse: pattern and role of cytoplasmic Ca2+ and amplification signals in β-cells. Diabetes 2006, 55:441-451.
12. Henquin JC, Ishiyama N, Nenquin M, Ravier MA, Jonas JC Signals and pools underlying biphasic insulin secretion. Diabetes 2002, 51(Suppl l):S60-S67.
13. Cerasi E Mechanisms of glucose stimulated insulin secretion in health and in diabetes: some re-evaluations and proposals. Diabetologia 1975, 11:1-13.
14. Straub SG, Sharp GW Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev 2002, 18:451-463.
15. Rorsman P, Renström E Insulin granule dynamics in pancreatic β-cells. Diabetologia 2003, 46:1029-1045.
16. Ohara-Imaizumi M, Fujiwara T, Nakamichi Y, Okamura T, Akimoto Y, Kawai J, et al. Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis. J Cell Biol 2007, 177:695-705.
17. Gilon P, Ravier MA, Jonas JC, Henquin JC Control mechanisms of the oscillations of insulin secretion in vitro and in vivo. Diabetes 2002, 51(Suppl 1):S144-S151.
18. Tengholm A, Gylfe E Oscillatory control of insulin secretion. Mol Cell Endocrinol 2009, 297:58-72.
19. Ravier MA, Güldenagel M, Charollais A, Gjinovci A, Caille D, Sohl G, et al. Loss of connexin36 channels alters β-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes 2005, 54:1798-1807.
20. Gerich JE, Charles MA, Grodsky GM Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas. J Clin Invest 1974, 54:833-841.
21. Pfeifer MA, Halter JB, Graf R, Porte D Potentiation of insulin secretion to nonglucose stimuli in normal man by tolbutamide. Diabetes 1980, 29:335-340.
22. Ishiyama N, Ravier MA, Henquin JC Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets. Am J Physiol Endocrinol Metab 2006, 290:E540-E549.
23. Hermans MP, Schmeer W, Henquin JC The permissive effect of glucose, tolbutamide and high K+ on arginine stimulation of insulin release in isolated mouse islets. Diabetologia 1987, 30:659-665.