메뉴 건너뛰기




Volumn 46, Issue 4, 2015, Pages 587-608

Targeted Chemotherapy in Bone and Soft-Tissue Sarcoma

Author keywords

Bone; Chemotherapy; Sarcoma; Targeted; Tumor

Indexed keywords

BEVACIZUMAB; CIXUTUMUMAB; CRIZOTINIB; EVEROLIMUS; EZRIN; GANITUMAB; IMATINIB; INTERLEUKIN 11 RECEPTOR ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; NOTCH RECEPTOR; PALBOCICLIB; PAZOPANIB; PROTEIN BCL 2; PROTEIN P53; PROTEIN TYROSINE KINASE; RETINOBLASTOMA PROTEIN; RIDAFOROLIMUS; SCATTER FACTOR RECEPTOR; SOMATOMEDIN; SONIC HEDGEHOG PROTEIN; SORAFENIB; STAT3 PROTEIN; TEMSIROLIMUS; TRABECTEDIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX; TRASTUZUMAB; VASCULOTROPIN; WNT PROTEIN; ANTINEOPLASTIC AGENT;

EID: 84942196627     PISSN: 00305898     EISSN: 15581373     Source Type: Journal    
DOI: 10.1016/j.ocl.2015.06.011     Document Type: Review
Times cited : (24)

References (199)
  • 1
    • 0022656434 scopus 로고
    • The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity
    • Link M.P., Goorin A.M., Miser A.W., et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med 1986, 314:1600-1606.
    • (1986) N Engl J Med , vol.314 , pp. 1600-1606
    • Link, M.P.1    Goorin, A.M.2    Miser, A.W.3
  • 2
    • 0023125939 scopus 로고
    • Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial
    • Eilber F., Giuliano A., Eckardt J., et al. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol 1987, 5:21-26.
    • (1987) J Clin Oncol , vol.5 , pp. 21-26
    • Eilber, F.1    Giuliano, A.2    Eckardt, J.3
  • 3
    • 84869491872 scopus 로고    scopus 로고
    • Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma
    • Bernthal N.M., Federman N., Eilber F.R., et al. Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma. Cancer 2012, 118:5888-5893.
    • (2012) Cancer , vol.118 , pp. 5888-5893
    • Bernthal, N.M.1    Federman, N.2    Eilber, F.R.3
  • 4
    • 0027082303 scopus 로고
    • A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup
    • Bramwell V.H., Burgers M., Sneath R., et al. A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup. J Clin Oncol 1992, 10:1579-1591.
    • (1992) J Clin Oncol , vol.10 , pp. 1579-1591
    • Bramwell, V.H.1    Burgers, M.2    Sneath, R.3
  • 5
    • 0031588180 scopus 로고    scopus 로고
    • Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup
    • Souhami R.L., Craft A.W., Van der Eijken J.W., et al. Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup. Lancet 1997, 350:911-917.
    • (1997) Lancet , vol.350 , pp. 911-917
    • Souhami, R.L.1    Craft, A.W.2    Van der Eijken, J.W.3
  • 6
    • 33846981552 scopus 로고    scopus 로고
    • Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup
    • Lewis I.J., Nooij M.A., Whelan J., et al. Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. J Natl Cancer Inst 2007, 99:112-128.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 112-128
    • Lewis, I.J.1    Nooij, M.A.2    Whelan, J.3
  • 7
    • 33947710840 scopus 로고    scopus 로고
    • SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients
    • Le Deley M.C., Guinebretière J.M., Gentet J.C., et al. SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients. Eur J Cancer 2007, 43:752-761.
    • (2007) Eur J Cancer , vol.43 , pp. 752-761
    • Le Deley, M.C.1    Guinebretière, J.M.2    Gentet, J.C.3
  • 8
    • 84882932037 scopus 로고    scopus 로고
    • Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis
    • Collins M., Wilhelm M., Conyers R., et al. Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis. J Clin Oncol 2013, 31:2303-2312.
    • (2013) J Clin Oncol , vol.31 , pp. 2303-2312
    • Collins, M.1    Wilhelm, M.2    Conyers, R.3
  • 9
    • 0025346003 scopus 로고
    • Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. The Istituto Rizzoli experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial cisplatin
    • Bacci G., Picci P., Ruggieri P., et al. Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. The Istituto Rizzoli experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial cisplatin. Cancer 1990, 65:2539-2553.
    • (1990) Cancer , vol.65 , pp. 2539-2553
    • Bacci, G.1    Picci, P.2    Ruggieri, P.3
  • 10
    • 84863928403 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1
    • Ferrari S., Ruggieri P., Cefalo G., et al. Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1. J Clin Oncol 2012, 30:2112-2118.
    • (2012) J Clin Oncol , vol.30 , pp. 2112-2118
    • Ferrari, S.1    Ruggieri, P.2    Cefalo, G.3
  • 11
    • 84966416069 scopus 로고    scopus 로고
    • Version 1. 2015. Accessed 28 July
    • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Bone Cancer. Version 1. 2015. Available online at: Accessed 28 July, 2015. http://www.nccn.org/professionals/physician_gls/pdf/bone.pdf.
    • (2015) NCCN Clinical Practice Guidelines in Oncology: Bone Cancer
  • 12
    • 0041700123 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide
    • Bacci G., Briccoli A., Rocca M., et al. Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide. Ann Oncol 2003, 14:1126-1134.
    • (2003) Ann Oncol , vol.14 , pp. 1126-1134
    • Bacci, G.1    Briccoli, A.2    Rocca, M.3
  • 13
    • 48249154929 scopus 로고    scopus 로고
    • Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma
    • Navid F., Willert J.R., McCarville M.B., et al. Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. Cancer 2008, 113:419-425.
    • (2008) Cancer , vol.113 , pp. 419-425
    • Navid, F.1    Willert, J.R.2    McCarville, M.B.3
  • 14
    • 0037080289 scopus 로고    scopus 로고
    • Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial
    • Goorin A.M., Harris M.B., Bernstein M., et al. Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial. J Clin Oncol 2002, 20:426-433.
    • (2002) J Clin Oncol , vol.20 , pp. 426-433
    • Goorin, A.M.1    Harris, M.B.2    Bernstein, M.3
  • 15
    • 67649591810 scopus 로고    scopus 로고
    • Phase 2 trial of two courses of cyclophosphamide and etoposide for relapsed high-risk osteosarcoma patients
    • Berger M., Grignani G., Ferrari S., et al. Phase 2 trial of two courses of cyclophosphamide and etoposide for relapsed high-risk osteosarcoma patients. Cancer 2009, 115:2980-2987.
    • (2009) Cancer , vol.115 , pp. 2980-2987
    • Berger, M.1    Grignani, G.2    Ferrari, S.3
  • 16
    • 47549083691 scopus 로고    scopus 로고
    • Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance Epidemiology and End Results data
    • Esiashvili N., Goodman M., Marcus R.B.J. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance Epidemiology and End Results data. J Pediatr Hematol Oncol 2008, 30:425-430.
    • (2008) J Pediatr Hematol Oncol , vol.30 , pp. 425-430
    • Esiashvili, N.1    Goodman, M.2    Marcus, R.B.J.3
  • 17
    • 18044364798 scopus 로고    scopus 로고
    • Overview of sarcomas in the adolescent and young adult population
    • Herzog C.E. Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol 2005, 27:215-218.
    • (2005) J Pediatr Hematol Oncol , vol.27 , pp. 215-218
    • Herzog, C.E.1
  • 18
    • 0033864605 scopus 로고    scopus 로고
    • Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group
    • Cotterill S.J., Ahrens S., Paulussen M., et al. Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol 2000, 18:3108-3114.
    • (2000) J Clin Oncol , vol.18 , pp. 3108-3114
    • Cotterill, S.J.1    Ahrens, S.2    Paulussen, M.3
  • 19
    • 0025008189 scopus 로고
    • Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study
    • Nesbit M.E.J., Gehan E.A., Burgert E.O., et al. Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study. J Clin Oncol 1990, 8:1664-1674.
    • (1990) J Clin Oncol , vol.8 , pp. 1664-1674
    • Nesbit, M.E.J.1    Gehan, E.A.2    Burgert, E.O.3
  • 20
    • 0025126798 scopus 로고
    • Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II
    • Burgert E.O.J., Nesbit M.E., Garnsey L.A., et al. Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II. J Clin Oncol 1990, 8:1514-1524.
    • (1990) J Clin Oncol , vol.8 , pp. 1514-1524
    • Burgert, E.O.J.1    Nesbit, M.E.2    Garnsey, L.A.3
  • 21
    • 0025764101 scopus 로고
    • Multimodal therapy for the management of localized Ewing's sarcoma of pelvic and sacral bones: a report from the second intergroup study
    • Evans R.G., Nesbit M.E., Gehan E.A., et al. Multimodal therapy for the management of localized Ewing's sarcoma of pelvic and sacral bones: a report from the second intergroup study. J Clin Oncol 1991, 9:1173-1180.
    • (1991) J Clin Oncol , vol.9 , pp. 1173-1180
    • Evans, R.G.1    Nesbit, M.E.2    Gehan, E.A.3
  • 22
    • 0035868651 scopus 로고    scopus 로고
    • Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86
    • Paulussen M., Ahrens S., Dunst J., et al. Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86. J Clin Oncol 2001, 19:1818-1829.
    • (2001) J Clin Oncol , vol.19 , pp. 1818-1829
    • Paulussen, M.1    Ahrens, S.2    Dunst, J.3
  • 23
    • 0037456435 scopus 로고    scopus 로고
    • Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone
    • Grier H.E., Krailo M.D., Tarbell N.J., et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003, 348:694-701.
    • (2003) N Engl J Med , vol.348 , pp. 694-701
    • Grier, H.E.1    Krailo, M.D.2    Tarbell, N.J.3
  • 25
    • 66349087641 scopus 로고    scopus 로고
    • Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study
    • Granowetter L., Womer R., Devidas M., et al. Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study. J Clin Oncol 2009, 27:2536-2541.
    • (2009) J Clin Oncol , vol.27 , pp. 2536-2541
    • Granowetter, L.1    Womer, R.2    Devidas, M.3
  • 26
    • 84869447819 scopus 로고    scopus 로고
    • Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group
    • Womer R.B., West D.C., Krailo M.D., et al. Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol 2012, 30:4148-4154.
    • (2012) J Clin Oncol , vol.30 , pp. 4148-4154
    • Womer, R.B.1    West, D.C.2    Krailo, M.D.3
  • 27
    • 0021876637 scopus 로고
    • The response to initial chemotherapy as a prognostic factor in localized Ewing's sarcoma
    • Oberlin O., Patte C., Demeocq F., et al. The response to initial chemotherapy as a prognostic factor in localized Ewing's sarcoma. Eur J Cancer Clin Oncol 1985, 21:463-467.
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 463-467
    • Oberlin, O.1    Patte, C.2    Demeocq, F.3
  • 28
    • 17444447915 scopus 로고    scopus 로고
    • Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli
    • Bacci G., Ferrari S., Bertoni F., et al. Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. J Clin Oncol 2000, 18:4-11.
    • (2000) J Clin Oncol , vol.18 , pp. 4-11
    • Bacci, G.1    Ferrari, S.2    Bertoni, F.3
  • 29
    • 33846662246 scopus 로고    scopus 로고
    • Chemotherapy response is an important predictor of local recurrence in Ewing sarcoma
    • Lin P.P., Jaffe N., Herzog C.E., et al. Chemotherapy response is an important predictor of local recurrence in Ewing sarcoma. Cancer 2007, 109:603-611.
    • (2007) Cancer , vol.109 , pp. 603-611
    • Lin, P.P.1    Jaffe, N.2    Herzog, C.E.3
  • 30
    • 0031846401 scopus 로고    scopus 로고
    • The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing sarcoma
    • Wunder J.S., Paulian G., Huvos A.G., et al. The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing sarcoma. J Bone Joint Surg Am 1998, 80:1020-1033.
    • (1998) J Bone Joint Surg Am , vol.80 , pp. 1020-1033
    • Wunder, J.S.1    Paulian, G.2    Huvos, A.G.3
  • 31
    • 7144261049 scopus 로고    scopus 로고
    • Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. European Intergroup Cooperative Ewing Sarcoma Studies
    • Paulussen M., Ahrens S., Burdach S., et al. Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. European Intergroup Cooperative Ewing Sarcoma Studies. Ann Oncol 1998, 9:275-281.
    • (1998) Ann Oncol , vol.9 , pp. 275-281
    • Paulussen, M.1    Ahrens, S.2    Burdach, S.3
  • 32
    • 4344571848 scopus 로고    scopus 로고
    • Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide-a Children's Cancer Group and Pediatric Oncology Group study
    • Miser J.S., Krailo M.D., Tarbell N.J., et al. Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide-a Children's Cancer Group and Pediatric Oncology Group study. J Clin Oncol 2004, 22:2873-2876.
    • (2004) J Clin Oncol , vol.22 , pp. 2873-2876
    • Miser, J.S.1    Krailo, M.D.2    Tarbell, N.J.3
  • 33
    • 84923222093 scopus 로고    scopus 로고
    • Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma
    • Magnan H., Goodbody C.M., Riedel E., et al. Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma. Pediatr Blood Cancer 2015, 62(4):594-597.
    • (2015) Pediatr Blood Cancer , vol.62 , Issue.4 , pp. 594-597
    • Magnan, H.1    Goodbody, C.M.2    Riedel, E.3
  • 34
    • 84942204326 scopus 로고    scopus 로고
    • Long-term outcomes and complications in pediatric Ewing sarcoma
    • [Epub ahead of print]
    • Hamilton S.N., Carlson R., Hasan H., et al. Long-term outcomes and complications in pediatric Ewing sarcoma. Am J Clin Oncol 2015, [Epub ahead of print].
    • (2015) Am J Clin Oncol
    • Hamilton, S.N.1    Carlson, R.2    Hasan, H.3
  • 35
  • 36
    • 79957989586 scopus 로고    scopus 로고
    • Treating soft tissue sarcomas with adjuvant chemotherapy
    • Patrikidou A., Domont J., Cioffi A., et al. Treating soft tissue sarcomas with adjuvant chemotherapy. Curr Treat Options Oncol 2011, 12:21-31.
    • (2011) Curr Treat Options Oncol , vol.12 , pp. 21-31
    • Patrikidou, A.1    Domont, J.2    Cioffi, A.3
  • 38
    • 0029918660 scopus 로고    scopus 로고
    • Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma
    • Pisters P.W., Harrison L.B., Leung D.H., et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol 1996, 14:859-868.
    • (1996) J Clin Oncol , vol.14 , pp. 859-868
    • Pisters, P.W.1    Harrison, L.B.2    Leung, D.H.3
  • 39
    • 0031962230 scopus 로고    scopus 로고
    • Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity
    • Yang J.C., Chang A.E., Baker A.R., et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 1998, 16:197-203.
    • (1998) J Clin Oncol , vol.16 , pp. 197-203
    • Yang, J.C.1    Chang, A.E.2    Baker, A.R.3
  • 40
    • 0037315695 scopus 로고    scopus 로고
    • High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality
    • Eilber F.C., Rosen G., Nelson S.D., et al. High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality. Ann Surg 2003, 237:218-226.
    • (2003) Ann Surg , vol.237 , pp. 218-226
    • Eilber, F.C.1    Rosen, G.2    Nelson, S.D.3
  • 41
    • 84901240696 scopus 로고    scopus 로고
    • Post-metastasis survival in extremity soft tissue sarcoma: a recursive partitioning analysis of prognostic factors
    • Kang S., Kim H.S., Kim S., et al. Post-metastasis survival in extremity soft tissue sarcoma: a recursive partitioning analysis of prognostic factors. Eur J Cancer 2014, 50:1649-1656.
    • (2014) Eur J Cancer , vol.50 , pp. 1649-1656
    • Kang, S.1    Kim, H.S.2    Kim, S.3
  • 42
    • 0031566814 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-analysis Collaboration
    • Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-analysis Collaboration. Lancet 1997, 350:1647-1654.
    • (1997) Lancet , vol.350 , pp. 1647-1654
  • 43
    • 7344222584 scopus 로고    scopus 로고
    • Phase II trial of first-line high-dose ifosfamide in advanced soft tissue sarcomas of the adult: a study of the Spanish Group for Research on Sarcomas (GEIS)
    • Buesa J.M., López-Pousa A., Martín J., et al. Phase II trial of first-line high-dose ifosfamide in advanced soft tissue sarcomas of the adult: a study of the Spanish Group for Research on Sarcomas (GEIS). Ann Oncol 1998, 9:871-876.
    • (1998) Ann Oncol , vol.9 , pp. 871-876
    • Buesa, J.M.1    López-Pousa, A.2    Martín, J.3
  • 44
    • 77954337682 scopus 로고    scopus 로고
    • Soft tissue sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Casali P.G., Blay J.Y. Soft tissue sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010, 21(Suppl 5):v198-v203.
    • (2010) Ann Oncol , vol.21 , pp. v198-v203
    • Casali, P.G.1    Blay, J.Y.2
  • 45
    • 49049089340 scopus 로고    scopus 로고
    • A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma
    • Pervaiz N., Colterjohn N., Farrokhyar F., et al. A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer 2008, 113:573-581.
    • (2008) Cancer , vol.113 , pp. 573-581
    • Pervaiz, N.1    Colterjohn, N.2    Farrokhyar, F.3
  • 46
    • 55949086834 scopus 로고    scopus 로고
    • Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study
    • Penel N., Bui B.N., Bay J.O., et al. Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol 2008, 26:5269-5274.
    • (2008) J Clin Oncol , vol.26 , pp. 5269-5274
    • Penel, N.1    Bui, B.N.2    Bay, J.O.3
  • 47
    • 84896727097 scopus 로고    scopus 로고
    • Current management options for liposarcoma and challenges for the future
    • Kollar A., Benson C. Current management options for liposarcoma and challenges for the future. Expert Rev Anticancer Ther 2014, 14:297-306.
    • (2014) Expert Rev Anticancer Ther , vol.14 , pp. 297-306
    • Kollar, A.1    Benson, C.2
  • 48
    • 0028284326 scopus 로고
    • Synovial sarcoma. Uniform response of metastases to high dose ifosfamide
    • Rosen G., Forscher C., Lowenbraun S., et al. Synovial sarcoma. Uniform response of metastases to high dose ifosfamide. Cancer 1994, 73:2506-2511.
    • (1994) Cancer , vol.73 , pp. 2506-2511
    • Rosen, G.1    Forscher, C.2    Lowenbraun, S.3
  • 49
    • 71049122368 scopus 로고    scopus 로고
    • Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG)
    • Sleijfer S., Ouali M., van Glabbeke M., et al. Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG). Eur J Cancer 2010, 46:72-83.
    • (2010) Eur J Cancer , vol.46 , pp. 72-83
    • Sleijfer, S.1    Ouali, M.2    van Glabbeke, M.3
  • 50
    • 84867128772 scopus 로고    scopus 로고
    • Chemotherapy treatment patterns and clinical outcomes in patients with metastatic soft tissue sarcoma. The SArcoma treatment and Burden of Illness in North America and Europe (SABINE) study
    • Leahy M., Garcia Del Muro X., Reichardt P., et al. Chemotherapy treatment patterns and clinical outcomes in patients with metastatic soft tissue sarcoma. The SArcoma treatment and Burden of Illness in North America and Europe (SABINE) study. Ann Oncol 2012, 23:2763-2770.
    • (2012) Ann Oncol , vol.23 , pp. 2763-2770
    • Leahy, M.1    Garcia Del Muro, X.2    Reichardt, P.3
  • 51
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 52
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study
    • van Oosterom A.T., Judson I., Verweij J., et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 2001, 358:1421-1423.
    • (2001) Lancet , vol.358 , pp. 1421-1423
    • van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 54
    • 79958835059 scopus 로고    scopus 로고
    • Comprehensive next-generation cancer genome sequencing in the era of targeted therapy and personalized oncology
    • Cronin M., Ross J.S. Comprehensive next-generation cancer genome sequencing in the era of targeted therapy and personalized oncology. Biomark Med 2011, 5:293-305.
    • (2011) Biomark Med , vol.5 , pp. 293-305
    • Cronin, M.1    Ross, J.S.2
  • 55
    • 84868115867 scopus 로고    scopus 로고
    • Clinical cancer genome and precision medicine
    • Roukos D.H., Ku C.S. Clinical cancer genome and precision medicine. Ann Surg Oncol 2012, 19:3646-3650.
    • (2012) Ann Surg Oncol , vol.19 , pp. 3646-3650
    • Roukos, D.H.1    Ku, C.S.2
  • 56
    • 84885957225 scopus 로고    scopus 로고
    • Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology
    • Workman P., Al-Lazikani B., Clarke P.A. Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology. Curr Opin Pharmacol 2013, 13:486-496.
    • (2013) Curr Opin Pharmacol , vol.13 , pp. 486-496
    • Workman, P.1    Al-Lazikani, B.2    Clarke, P.A.3
  • 57
    • 84908122111 scopus 로고    scopus 로고
    • Systemic treatment of soft-tissue sarcoma-gold standard and novel therapies
    • Linch M., Miah A.B., Thway K., et al. Systemic treatment of soft-tissue sarcoma-gold standard and novel therapies. Nat Rev Clin Oncol 2014, 11:187-202.
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 187-202
    • Linch, M.1    Miah, A.B.2    Thway, K.3
  • 58
    • 84908156415 scopus 로고    scopus 로고
    • Translational biology of osteosarcoma
    • Kansara M., Teng M.W., Smyth M.J., et al. Translational biology of osteosarcoma. Nat Rev Cancer 2014, 14:722-735.
    • (2014) Nat Rev Cancer , vol.14 , pp. 722-735
    • Kansara, M.1    Teng, M.W.2    Smyth, M.J.3
  • 59
    • 84896748416 scopus 로고    scopus 로고
    • WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition
    • Jo V.Y., Fletcher C.D. WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition. Pathology 2014, 46:95-104.
    • (2014) Pathology , vol.46 , pp. 95-104
    • Jo, V.Y.1    Fletcher, C.D.2
  • 61
    • 84857356609 scopus 로고    scopus 로고
    • Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 database
    • Ognjanovic S., Olivier M., Bergemann T.L., et al. Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 database. Cancer 2012, 118:1387-1396.
    • (2012) Cancer , vol.118 , pp. 1387-1396
    • Ognjanovic, S.1    Olivier, M.2    Bergemann, T.L.3
  • 62
    • 84879690229 scopus 로고    scopus 로고
    • Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951-2004
    • MacCarthy A., Bayne A.M., Brownbill P.A., et al. Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951-2004. Br J Cancer 2013, 108:2455-2463.
    • (2013) Br J Cancer , vol.108 , pp. 2455-2463
    • MacCarthy, A.1    Bayne, A.M.2    Brownbill, P.A.3
  • 63
    • 0024544554 scopus 로고
    • Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma
    • Toguchida J., Ishizaki K., Sasaki M.S., et al. Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma. Nature 1989, 338:156-158.
    • (1989) Nature , vol.338 , pp. 156-158
    • Toguchida, J.1    Ishizaki, K.2    Sasaki, M.S.3
  • 64
    • 84898027965 scopus 로고    scopus 로고
    • Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma
    • Chen X., Bahrami A., Pappo A., et al. Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep 2014, 7:104-112.
    • (2014) Cell Rep , vol.7 , pp. 104-112
    • Chen, X.1    Bahrami, A.2    Pappo, A.3
  • 65
    • 20144381477 scopus 로고    scopus 로고
    • TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study
    • Wunder J.S., Gokgoz N., Parkes R., et al. TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. J Clin Oncol 2005, 23:1483-1490.
    • (2005) J Clin Oncol , vol.23 , pp. 1483-1490
    • Wunder, J.S.1    Gokgoz, N.2    Parkes, R.3
  • 66
    • 84884979633 scopus 로고    scopus 로고
    • Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma
    • van Oosterwijk J.G., Anninga J.K., Gelderblom H., et al. Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma. Hematol Oncol Clin North Am 2013, 27:1021-1048.
    • (2013) Hematol Oncol Clin North Am , vol.27 , pp. 1021-1048
    • van Oosterwijk, J.G.1    Anninga, J.K.2    Gelderblom, H.3
  • 67
    • 0029760533 scopus 로고    scopus 로고
    • Mutant p53 expression: a marker of diminished survival in well-differentiated soft tissue sarcoma
    • Hieken T.J., Das Gupta T.K. Mutant p53 expression: a marker of diminished survival in well-differentiated soft tissue sarcoma. Clin Cancer Res 1996, 2:1391-1395.
    • (1996) Clin Cancer Res , vol.2 , pp. 1391-1395
    • Hieken, T.J.1    Das Gupta, T.K.2
  • 68
    • 28344447734 scopus 로고    scopus 로고
    • Osteosarcoma: basic science and clinical implications
    • Hayden J.B., Hoang B.H. Osteosarcoma: basic science and clinical implications. Orthop Clin North Am 2006, 37:1-7.
    • (2006) Orthop Clin North Am , vol.37 , pp. 1-7
    • Hayden, J.B.1    Hoang, B.H.2
  • 69
    • 79551715546 scopus 로고    scopus 로고
    • Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis
    • Ito M., Barys L., O'Reilly T., et al. Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. Clin Cancer Res 2011, 17:416-426.
    • (2011) Clin Cancer Res , vol.17 , pp. 416-426
    • Ito, M.1    Barys, L.2    O'Reilly, T.3
  • 70
    • 84868203735 scopus 로고    scopus 로고
    • Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
    • Ray-Coquard I., Blay J.Y., Italiano A., et al. Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study. Lancet Oncol 2012, 13:1133-1140.
    • (2012) Lancet Oncol , vol.13 , pp. 1133-1140
    • Ray-Coquard, I.1    Blay, J.Y.2    Italiano, A.3
  • 71
    • 41649102468 scopus 로고    scopus 로고
    • Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
    • Shangary S., Qin D., McEachern D., et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A 2008, 105:3933-3938.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 3933-3938
    • Shangary, S.1    Qin, D.2    McEachern, D.3
  • 72
    • 79551713220 scopus 로고    scopus 로고
    • Nutlin-3a is a potential therapeutic for Ewing sarcoma
    • Pishas K.I., Al-Ejeh F., Zinonos I., et al. Nutlin-3a is a potential therapeutic for Ewing sarcoma. Clin Cancer Res 2011, 17:494-504.
    • (2011) Clin Cancer Res , vol.17 , pp. 494-504
    • Pishas, K.I.1    Al-Ejeh, F.2    Zinonos, I.3
  • 73
    • 84880819777 scopus 로고    scopus 로고
    • Novel pathways and molecular targets for the treatment of sarcoma
    • Frith A.E., Hirbe A.C., Van Tine B.A. Novel pathways and molecular targets for the treatment of sarcoma. Curr Oncol Rep 2013, 15:378-385.
    • (2013) Curr Oncol Rep , vol.15 , pp. 378-385
    • Frith, A.E.1    Hirbe, A.C.2    Van Tine, B.A.3
  • 74
    • 84863966819 scopus 로고    scopus 로고
    • Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
    • Graves B., Thompson T., Xia M., et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc Natl Acad Sci U S A 2012, 109:11788-11793.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 11788-11793
    • Graves, B.1    Thompson, T.2    Xia, M.3
  • 75
    • 0033864484 scopus 로고    scopus 로고
    • Dual roles of Wnt signaling during chondrogenesis in the chicken limb
    • Hartmann C., Tabin C.J. Dual roles of Wnt signaling during chondrogenesis in the chicken limb. Development 2000, 127:3141-3159.
    • (2000) Development , vol.127 , pp. 3141-3159
    • Hartmann, C.1    Tabin, C.J.2
  • 76
    • 84859513115 scopus 로고    scopus 로고
    • Wnt, osteosarcoma, and future therapy
    • Hoang B.H. Wnt, osteosarcoma, and future therapy. J Am Acad Orthop Surg 2012, 20:58-59.
    • (2012) J Am Acad Orthop Surg , vol.20 , pp. 58-59
    • Hoang, B.H.1
  • 77
    • 73649132981 scopus 로고    scopus 로고
    • Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma
    • Cai Y., Mohseny A.B., Karperien M., et al. Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. J Pathol 2010, 220:24-33.
    • (2010) J Pathol , vol.220 , pp. 24-33
    • Cai, Y.1    Mohseny, A.B.2    Karperien, M.3
  • 78
    • 65249167488 scopus 로고    scopus 로고
    • Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
    • Kansara M., Tsang M., Kodjabachian L., et al. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest 2009, 119:837-851.
    • (2009) J Clin Invest , vol.119 , pp. 837-851
    • Kansara, M.1    Tsang, M.2    Kodjabachian, L.3
  • 79
    • 33845581657 scopus 로고    scopus 로고
    • Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma
    • Mandal D., Srivastava A., Mahlum E., et al. Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma. Gene 2007, 386:131-138.
    • (2007) Gene , vol.386 , pp. 131-138
    • Mandal, D.1    Srivastava, A.2    Mahlum, E.3
  • 80
    • 79955964176 scopus 로고    scopus 로고
    • High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/beta-catenin target gene, CDC25A
    • Vijayakumar S., Liu G., Rus I.A., et al. High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/beta-catenin target gene, CDC25A. Cancer Cell 2011, 19:601-612.
    • (2011) Cancer Cell , vol.19 , pp. 601-612
    • Vijayakumar, S.1    Liu, G.2    Rus, I.A.3
  • 81
    • 84907170839 scopus 로고    scopus 로고
    • Wnt signaling in osteosarcoma
    • Lin C.H., Ji T., Chen C.F., et al. Wnt signaling in osteosarcoma. Adv Exp Med Biol 2014, 804:33-45.
    • (2014) Adv Exp Med Biol , vol.804 , pp. 33-45
    • Lin, C.H.1    Ji, T.2    Chen, C.F.3
  • 82
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • Yang Q., Guan K.L. Expanding mTOR signaling. Cell Res 2007, 17:666-681.
    • (2007) Cell Res , vol.17 , pp. 666-681
    • Yang, Q.1    Guan, K.L.2
  • 83
    • 84873850148 scopus 로고    scopus 로고
    • FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo
    • Brun J., Dieudonné F.X., Marty C., et al. FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. PLoS One 2013, 8:e55034.
    • (2013) PLoS One , vol.8 , pp. e55034
    • Brun, J.1    Dieudonné, F.X.2    Marty, C.3
  • 84
    • 84909975477 scopus 로고    scopus 로고
    • Notch activation as a driver of osteogenic sarcoma
    • Tao J., Jiang M.M., Jiang L., et al. Notch activation as a driver of osteogenic sarcoma. Cancer Cell 2014, 26:390-401.
    • (2014) Cancer Cell , vol.26 , pp. 390-401
    • Tao, J.1    Jiang, M.M.2    Jiang, L.3
  • 85
    • 84891613866 scopus 로고    scopus 로고
    • Notch signaling is associated with ALDH activity and an aggressive metastatic phenotype in murine osteosarcoma cells
    • Mu X., Isaac C., Greco N., et al. Notch signaling is associated with ALDH activity and an aggressive metastatic phenotype in murine osteosarcoma cells. Front Oncol 2013, 3:143.
    • (2013) Front Oncol , vol.3 , pp. 143
    • Mu, X.1    Isaac, C.2    Greco, N.3
  • 86
    • 84899618645 scopus 로고    scopus 로고
    • Genetic alterations in chondrosarcomas - keys to targeted therapies?
    • Samuel A.M., Costa J., Lindskog D.M. Genetic alterations in chondrosarcomas - keys to targeted therapies?. Cell Oncol (Dordr) 2014, 37:95-105.
    • (2014) Cell Oncol (Dordr) , vol.37 , pp. 95-105
    • Samuel, A.M.1    Costa, J.2    Lindskog, D.M.3
  • 87
    • 84893747723 scopus 로고    scopus 로고
    • Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma
    • Lo W.W., Wunder J.S., Dickson B.C., et al. Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma. Cancer 2014, 120:537-547.
    • (2014) Cancer , vol.120 , pp. 537-547
    • Lo, W.W.1    Wunder, J.S.2    Dickson, B.C.3
  • 88
    • 84867332609 scopus 로고    scopus 로고
    • Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma
    • Kelleher F.C., Cain J.E., Healy J.M., et al. Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma. Pharmacol Ther 2012, 136:153-168.
    • (2012) Pharmacol Ther , vol.136 , pp. 153-168
    • Kelleher, F.C.1    Cain, J.E.2    Healy, J.M.3
  • 89
    • 79251553733 scopus 로고    scopus 로고
    • The Role of RUNX2 in osteosarcoma oncogenesis
    • Martin J.W., Zielenska M., Stein G.S., et al. The Role of RUNX2 in osteosarcoma oncogenesis. Sarcoma 2011, 2011:282745.
    • (2011) Sarcoma , vol.2011 , pp. 282745
    • Martin, J.W.1    Zielenska, M.2    Stein, G.S.3
  • 90
    • 80053312080 scopus 로고    scopus 로고
    • The expression of c-Met pathway components in unclassified pleomorphic sarcoma/malignant fibrous histiocytoma (UPS/MFH): a tissue microarray study
    • Lahat G., Zhang P., Zhu Q.S., et al. The expression of c-Met pathway components in unclassified pleomorphic sarcoma/malignant fibrous histiocytoma (UPS/MFH): a tissue microarray study. Histopathology 2011, 59:556-561.
    • (2011) Histopathology , vol.59 , pp. 556-561
    • Lahat, G.1    Zhang, P.2    Zhu, Q.S.3
  • 91
    • 0029834568 scopus 로고    scopus 로고
    • Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors
    • Scotlandi K., Baldini N., Oliviero M., et al. Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. Am J Pathol 1996, 149:1209-1219.
    • (1996) Am J Pathol , vol.149 , pp. 1209-1219
    • Scotlandi, K.1    Baldini, N.2    Oliviero, M.3
  • 92
    • 0033901252 scopus 로고    scopus 로고
    • Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors
    • Wallenius V., Hisaoka M., Helou K., et al. Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors. Am J Pathol 2000, 156:821-829.
    • (2000) Am J Pathol , vol.156 , pp. 821-829
    • Wallenius, V.1    Hisaoka, M.2    Helou, K.3
  • 93
    • 33646390939 scopus 로고    scopus 로고
    • MET overexpression turns human primary osteoblasts into osteosarcomas
    • Patane S., Avnet S., Coltella N., et al. MET overexpression turns human primary osteoblasts into osteosarcomas. Cancer Res 2006, 66:4750-4757.
    • (2006) Cancer Res , vol.66 , pp. 4750-4757
    • Patane, S.1    Avnet, S.2    Coltella, N.3
  • 94
    • 84869493002 scopus 로고    scopus 로고
    • Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial
    • Wagner A.J., Goldberg J.M., Dubois S.G., et al. Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial. Cancer 2012, 118:5894-5902.
    • (2012) Cancer , vol.118 , pp. 5894-5902
    • Wagner, A.J.1    Goldberg, J.M.2    Dubois, S.G.3
  • 95
    • 84907972332 scopus 로고    scopus 로고
    • Theranostic profiling for actionable aberrations in advanced high risk osteosarcoma with aggressive biology reveals high molecular diversity: the human fingerprint hypothesis
    • Egas-Bejar D., Anderson P.M., Agarwal R., et al. Theranostic profiling for actionable aberrations in advanced high risk osteosarcoma with aggressive biology reveals high molecular diversity: the human fingerprint hypothesis. Oncoscience 2014, 1:167-179.
    • (2014) Oncoscience , vol.1 , pp. 167-179
    • Egas-Bejar, D.1    Anderson, P.M.2    Agarwal, R.3
  • 96
    • 84860389568 scopus 로고    scopus 로고
    • Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma
    • Wang Y.H., Han X.D., Qiu Y., et al. Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. J Surg Oncol 2012, 105:235-243.
    • (2012) J Surg Oncol , vol.105 , pp. 235-243
    • Wang, Y.H.1    Han, X.D.2    Qiu, Y.3
  • 97
    • 78049510428 scopus 로고    scopus 로고
    • Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
    • Krueger D.A., Care M.M., Holland K., et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 2010, 363:1801-1811.
    • (2010) N Engl J Med , vol.363 , pp. 1801-1811
    • Krueger, D.A.1    Care, M.M.2    Holland, K.3
  • 98
    • 84925231101 scopus 로고    scopus 로고
    • Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex: 2-year open-label extension of the randomised EXIST-1 study
    • Franz D.N., Belousova E., Sparagana S., et al. Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex: 2-year open-label extension of the randomised EXIST-1 study. Lancet Oncol 2014, 15:1513-1520.
    • (2014) Lancet Oncol , vol.15 , pp. 1513-1520
    • Franz, D.N.1    Belousova, E.2    Sparagana, S.3
  • 99
    • 84874746597 scopus 로고    scopus 로고
    • Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
    • Bissler J.J., Kingswood J.C., Radzikowska E., et al. Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2013, 381:817-824.
    • (2013) Lancet , vol.381 , pp. 817-824
    • Bissler, J.J.1    Kingswood, J.C.2    Radzikowska, E.3
  • 100
    • 84942199242 scopus 로고    scopus 로고
    • FDA Approval for everolimus
    • Accessed June 23, 2015.
    • Pazdur R, et al. FDA Approval for everolimus. 2013. Available at: Accessed June 23, 2015. http://www.cancer.gov/about-cancer/treatment/drugs/fda-everolimus.
    • (2013)
    • Pazdur, R.1
  • 101
    • 84883063380 scopus 로고    scopus 로고
    • Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy
    • Demetri G.D., Chawla S.P., Ray-Coquard I., et al. Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy. J Clin Oncol 2013, 31:2485-2492.
    • (2013) J Clin Oncol , vol.31 , pp. 2485-2492
    • Demetri, G.D.1    Chawla, S.P.2    Ray-Coquard, I.3
  • 102
    • 62849105383 scopus 로고    scopus 로고
    • The insulin-like growth factor system and sarcomas
    • Rikhof B., de Jong S., Suurmeijer A.J., et al. The insulin-like growth factor system and sarcomas. J Pathol 2009, 217:469-482.
    • (2009) J Pathol , vol.217 , pp. 469-482
    • Rikhof, B.1    de Jong, S.2    Suurmeijer, A.J.3
  • 103
    • 67650688576 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor 2 in mesenchymal neoplasms
    • Steigen S.E., Schaeffer D.F., West R.B., et al. Expression of insulin-like growth factor 2 in mesenchymal neoplasms. Mod Pathol 2009, 22:914-921.
    • (2009) Mod Pathol , vol.22 , pp. 914-921
    • Steigen, S.E.1    Schaeffer, D.F.2    West, R.B.3
  • 104
    • 49949085240 scopus 로고    scopus 로고
    • IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells
    • Cironi L., Riggi N., Provero P., et al. IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells. PLoS One 2008, 3:e2634.
    • (2008) PLoS One , vol.3 , pp. e2634
    • Cironi, L.1    Riggi, N.2    Provero, P.3
  • 105
    • 84856835709 scopus 로고    scopus 로고
    • Activated growth signaling pathway expression in Ewing sarcoma and clinical outcome
    • Mora J., Rodríguez E., de Torres C., et al. Activated growth signaling pathway expression in Ewing sarcoma and clinical outcome. Pediatr Blood Cancer 2012, 58:532-538.
    • (2012) Pediatr Blood Cancer , vol.58 , pp. 532-538
    • Mora, J.1    Rodríguez, E.2    de Torres, C.3
  • 106
    • 84890566073 scopus 로고    scopus 로고
    • Prognostic and therapeutic relevance of the IGF pathway in Ewing's sarcoma patients
    • van de Luijtgaarden A.C., Versleijen-Jonkers Y.M., Roeffen M.H., et al. Prognostic and therapeutic relevance of the IGF pathway in Ewing's sarcoma patients. Target Oncol 2013, 8:253-260.
    • (2013) Target Oncol , vol.8 , pp. 253-260
    • van de Luijtgaarden, A.C.1    Versleijen-Jonkers, Y.M.2    Roeffen, M.H.3
  • 107
    • 33244494390 scopus 로고    scopus 로고
    • IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1
    • Sun Y., Gao D., Liu Y., et al. IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Oncogene 2006, 25:1042-1052.
    • (2006) Oncogene , vol.25 , pp. 1042-1052
    • Sun, Y.1    Gao, D.2    Liu, Y.3
  • 108
    • 0035728324 scopus 로고    scopus 로고
    • Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein
    • Ayalon D., Glaser T., Werner H. Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein. Growth Horm IGF Res 2001, 11:289-297.
    • (2001) Growth Horm IGF Res , vol.11 , pp. 289-297
    • Ayalon, D.1    Glaser, T.2    Werner, H.3
  • 109
    • 63449142234 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors
    • Makawita S., Ho M., Durbin A.D., et al. Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors. Pediatr Dev Pathol 2009, 12:127-135.
    • (2009) Pediatr Dev Pathol , vol.12 , pp. 127-135
    • Makawita, S.1    Ho, M.2    Durbin, A.D.3
  • 110
    • 84887289838 scopus 로고    scopus 로고
    • IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization
    • van de Luijtgaarden A.C., Roeffen M.H., Leus M.A., et al. IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization. Future Oncol 2013, 9:1733-1740.
    • (2013) Future Oncol , vol.9 , pp. 1733-1740
    • van de Luijtgaarden, A.C.1    Roeffen, M.H.2    Leus, M.A.3
  • 111
    • 77953256426 scopus 로고    scopus 로고
    • Kamara D, Zhang W, R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts
    • Kolb E.A., Kamara D., Zhang W., et al. Kamara D, Zhang W, R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. Pediatr Blood Cancer 2010, 55:67-75.
    • (2010) Pediatr Blood Cancer , vol.55 , pp. 67-75
    • Kolb, E.A.1    Kamara, D.2    Zhang, W.3
  • 112
    • 84880827542 scopus 로고    scopus 로고
    • The adolescent and young adult with cancer: state of the art-bone tumors
    • Rainusso N., Wang L.L., Yustein J.T. The adolescent and young adult with cancer: state of the art-bone tumors. Curr Oncol Rep 2013, 15:296-307.
    • (2013) Curr Oncol Rep , vol.15 , pp. 296-307
    • Rainusso, N.1    Wang, L.L.2    Yustein, J.T.3
  • 113
    • 34247478069 scopus 로고    scopus 로고
    • Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma
    • Stegmaier K., Wong J.S., Ross K.N., et al. Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. PLoS Med 2007, 4:e122.
    • (2007) PLoS Med , vol.4 , pp. e122
    • Stegmaier, K.1    Wong, J.S.2    Ross, K.N.3
  • 114
    • 67650447477 scopus 로고    scopus 로고
    • A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
    • Erkizan H.V., Kong Y., Merchant M., et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med 2009, 15:750-756.
    • (2009) Nat Med , vol.15 , pp. 750-756
    • Erkizan, H.V.1    Kong, Y.2    Merchant, M.3
  • 115
    • 79959714071 scopus 로고    scopus 로고
    • Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening
    • Grohar P.J., Woldemichael G.M., Griffin L.B., et al. Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening. J Natl Cancer Inst 2011, 103:962-978.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 962-978
    • Grohar, P.J.1    Woldemichael, G.M.2    Griffin, L.B.3
  • 116
    • 0033594950 scopus 로고    scopus 로고
    • Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway
    • Gautreau A., Poullet P., Louvard D., et al. Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 1999, 96:7300-7305.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7300-7305
    • Gautreau, A.1    Poullet, P.2    Louvard, D.3
  • 117
    • 0033777011 scopus 로고    scopus 로고
    • ERM proteins: from cellular architecture to cell signaling
    • Louvet-Vallee S. ERM proteins: from cellular architecture to cell signaling. Biol Cell 2000, 92:305-316.
    • (2000) Biol Cell , vol.92 , pp. 305-316
    • Louvet-Vallee, S.1
  • 118
    • 0036346708 scopus 로고    scopus 로고
    • ERM proteins and merlin: integrators at the cell cortex
    • Bretscher A., Edwards K., Fehon R.G. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 2002, 3:586-599.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 586-599
    • Bretscher, A.1    Edwards, K.2    Fehon, R.G.3
  • 119
    • 0037572145 scopus 로고    scopus 로고
    • Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation
    • Pujuguet P., Del Maestro L., Gautreau A., et al. Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation. Mol Biol Cell 2003, 14:2181-2191.
    • (2003) Mol Biol Cell , vol.14 , pp. 2181-2191
    • Pujuguet, P.1    Del Maestro, L.2    Gautreau, A.3
  • 120
    • 84890814264 scopus 로고    scopus 로고
    • Regulation of Son of sevenless by the membrane-actin linker protein ezrin
    • Geissler K.J., Jung M.J., Riecken L.B., et al. Regulation of Son of sevenless by the membrane-actin linker protein ezrin. Proc Natl Acad Sci U S A 2013, 110:20587-20592.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 20587-20592
    • Geissler, K.J.1    Jung, M.J.2    Riecken, L.B.3
  • 121
    • 11144357298 scopus 로고    scopus 로고
    • The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
    • Khanna C., Wan X., Bose S., et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 2004, 10:182-186.
    • (2004) Nat Med , vol.10 , pp. 182-186
    • Khanna, C.1    Wan, X.2    Bose, S.3
  • 122
    • 2342477964 scopus 로고    scopus 로고
    • Ezrin, a key component in tumor metastasis
    • Hunter K.W. Ezrin, a key component in tumor metastasis. Trends Mol Med 2004, 10:201-204.
    • (2004) Trends Mol Med , vol.10 , pp. 201-204
    • Hunter, K.W.1
  • 123
    • 33644550284 scopus 로고    scopus 로고
    • The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis
    • Yu Y., Davicioni E., Triche T.J., et al. The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. Cancer Res 2006, 66:1982-1989.
    • (2006) Cancer Res , vol.66 , pp. 1982-1989
    • Yu, Y.1    Davicioni, E.2    Triche, T.J.3
  • 124
    • 33750573063 scopus 로고    scopus 로고
    • Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway
    • Krishnan K., Bruce B., Hewitt S., et al. Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway. Clin Exp Metastasis 2006, 23:227-236.
    • (2006) Clin Exp Metastasis , vol.23 , pp. 227-236
    • Krishnan, K.1    Bruce, B.2    Hewitt, S.3
  • 125
    • 24344464300 scopus 로고    scopus 로고
    • Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas
    • Weng W.H., Ahlen J., Astrom K., et al. Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas. Clin Cancer Res 2005, 11:6198-6204.
    • (2005) Clin Cancer Res , vol.11 , pp. 6198-6204
    • Weng, W.H.1    Ahlen, J.2    Astrom, K.3
  • 126
    • 79960730612 scopus 로고    scopus 로고
    • Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas
    • Carneiro A., Bendahl P.O., Åkerman M., et al. Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas. J Clin Pathol 2011, 64:689-694.
    • (2011) J Clin Pathol , vol.64 , pp. 689-694
    • Carneiro, A.1    Bendahl, P.O.2    Åkerman, M.3
  • 127
    • 34247126202 scopus 로고    scopus 로고
    • Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma
    • Kim M.S., Cho W.H., Song W.S., et al. Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. Anticancer Res 2007, 27:1171-1178.
    • (2007) Anticancer Res , vol.27 , pp. 1171-1178
    • Kim, M.S.1    Cho, W.H.2    Song, W.S.3
  • 128
    • 78650968656 scopus 로고    scopus 로고
    • Prognostic implication of ezrin overexpression in myxofibrosarcomas
    • Huang H.Y., Li C.F., Fang F.M., et al. Prognostic implication of ezrin overexpression in myxofibrosarcomas. Ann Surg Oncol 2010, 17:3212-3219.
    • (2010) Ann Surg Oncol , vol.17 , pp. 3212-3219
    • Huang, H.Y.1    Li, C.F.2    Fang, F.M.3
  • 129
    • 77956896015 scopus 로고    scopus 로고
    • Expression of ezrin, Bcl-2, and Ki-67 in chondrosarcomas
    • Soderstrom M., Palokangas T., Vahlberg T., et al. Expression of ezrin, Bcl-2, and Ki-67 in chondrosarcomas. APMIS 2010, 118:769-776.
    • (2010) APMIS , vol.118 , pp. 769-776
    • Soderstrom, M.1    Palokangas, T.2    Vahlberg, T.3
  • 130
    • 34347382603 scopus 로고    scopus 로고
    • High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis
    • Ogino W., Takeshima Y., Mori T., et al. High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. J Pediatr Hematol Oncol 2007, 29:435-439.
    • (2007) J Pediatr Hematol Oncol , vol.29 , pp. 435-439
    • Ogino, W.1    Takeshima, Y.2    Mori, T.3
  • 131
    • 40449110894 scopus 로고    scopus 로고
    • Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma
    • Ferrari S., Zanella L., Alberghini M., et al. Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. Pediatr Blood Cancer 2008, 50:752-756.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 752-756
    • Ferrari, S.1    Zanella, L.2    Alberghini, M.3
  • 132
    • 84880347584 scopus 로고    scopus 로고
    • Meta-analysis of associations of the ezrin gene with human osteosarcoma response to chemotherapy and prognosis
    • Wang Z., He M.L., Zhao J.M., et al. Meta-analysis of associations of the ezrin gene with human osteosarcoma response to chemotherapy and prognosis. Asian Pac J Cancer Prev 2013, 14:2753-2758.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 2753-2758
    • Wang, Z.1    He, M.L.2    Zhao, J.M.3
  • 133
    • 84891770814 scopus 로고    scopus 로고
    • Clinical significance of microRNA-183/Ezrin axis in judging the prognosis of patients with osteosarcoma
    • Mu Y., Zhang H., Che L., et al. Clinical significance of microRNA-183/Ezrin axis in judging the prognosis of patients with osteosarcoma. Med Oncol 2014, 31:821.
    • (2014) Med Oncol , vol.31 , pp. 821
    • Mu, Y.1    Zhang, H.2    Che, L.3
  • 134
    • 84907167494 scopus 로고    scopus 로고
    • Role of ezrin in osteosarcoma metastasis
    • Ren L., Khanna C. Role of ezrin in osteosarcoma metastasis. Adv Exp Med Biol 2014, 804:181-201.
    • (2014) Adv Exp Med Biol , vol.804 , pp. 181-201
    • Ren, L.1    Khanna, C.2
  • 135
    • 84855932427 scopus 로고    scopus 로고
    • Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells
    • Bulut G., Hong S.H., Chen K., et al. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene 2012, 31:269-281.
    • (2012) Oncogene , vol.31 , pp. 269-281
    • Bulut, G.1    Hong, S.H.2    Chen, K.3
  • 136
    • 0032823806 scopus 로고    scopus 로고
    • Hematopoietic, immunomodulatory and epithelial effects of interleukin-11
    • Schwertschlag U.S., Trepicchio W.L., Dykstra K.H., et al. Hematopoietic, immunomodulatory and epithelial effects of interleukin-11. Leukemia 1999, 13:1307-1315.
    • (1999) Leukemia , vol.13 , pp. 1307-1315
    • Schwertschlag, U.S.1    Trepicchio, W.L.2    Dykstra, K.H.3
  • 137
    • 84866517658 scopus 로고    scopus 로고
    • Interleukin-11 increases cell motility and up-regulates intercellular adhesion molecule-1 expression in human chondrosarcoma cells
    • Li T.M., Wu C.M., Huang H.C., et al. Interleukin-11 increases cell motility and up-regulates intercellular adhesion molecule-1 expression in human chondrosarcoma cells. J Cell Biochem 2012, 113:3353-3362.
    • (2012) J Cell Biochem , vol.113 , pp. 3353-3362
    • Li, T.M.1    Wu, C.M.2    Huang, H.C.3
  • 138
    • 62449095801 scopus 로고    scopus 로고
    • The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples
    • Lewis V.O., Ozawa M.G., Deavers M.T., et al. The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples. Cancer Res 2009, 69:1995-1999.
    • (2009) Cancer Res , vol.69 , pp. 1995-1999
    • Lewis, V.O.1    Ozawa, M.G.2    Deavers, M.T.3
  • 139
    • 69149098253 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?
    • Aggarwal B.B., Kunnumakkara A.B., Harikumar K.B., et al. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?. Ann N Y Acad Sci 2009, 1171:59-76.
    • (2009) Ann N Y Acad Sci , vol.1171 , pp. 59-76
    • Aggarwal, B.B.1    Kunnumakkara, A.B.2    Harikumar, K.B.3
  • 140
    • 34548526140 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
    • Chen C.L., Loy A., Cen L., et al. Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. BMC Cancer 2007, 7:111.
    • (2007) BMC Cancer , vol.7 , pp. 111
    • Chen, C.L.1    Loy, A.2    Cen, L.3
  • 141
    • 79955907216 scopus 로고    scopus 로고
    • Prognostic significance of STAT3 and phosphorylated STAT3 in human soft tissue tumors - a clinicopathological analysis
    • David D., Rajappan L.M., Balachandran K., et al. Prognostic significance of STAT3 and phosphorylated STAT3 in human soft tissue tumors - a clinicopathological analysis. J Exp Clin Cancer Res 2011, 30:56.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 56
    • David, D.1    Rajappan, L.M.2    Balachandran, K.3
  • 142
    • 84916217259 scopus 로고    scopus 로고
    • Impact of STAT3 inhibition on survival of osteosarcoma cell lines
    • Wang X., Goldstein D., Crowe P.J., et al. Impact of STAT3 inhibition on survival of osteosarcoma cell lines. Anticancer Res 2014, 34:6537-6545.
    • (2014) Anticancer Res , vol.34 , pp. 6537-6545
    • Wang, X.1    Goldstein, D.2    Crowe, P.J.3
  • 143
    • 84903816370 scopus 로고    scopus 로고
    • Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors
    • Bendell J.C., Hong D.S., Burris H.A., et al. Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors. Cancer Chemother Pharmacol 2014, 74:125-130.
    • (2014) Cancer Chemother Pharmacol , vol.74 , pp. 125-130
    • Bendell, J.C.1    Hong, D.S.2    Burris, H.A.3
  • 144
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim K.J., Li B., Winer J., et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993, 362:841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 145
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
    • Takahashi H., Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond) 2005, 109:227-241.
    • (2005) Clin Sci (Lond) , vol.109 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 146
    • 84921635171 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor increases vascular endothelial growth factor expression and enhances angiogenesis in human chondrosarcoma cells
    • Lin C.Y., Hung S.Y., Chen H.T., et al. Brain-derived neurotrophic factor increases vascular endothelial growth factor expression and enhances angiogenesis in human chondrosarcoma cells. Biochem Pharmacol 2014, 91:522-533.
    • (2014) Biochem Pharmacol , vol.91 , pp. 522-533
    • Lin, C.Y.1    Hung, S.Y.2    Chen, H.T.3
  • 147
    • 84910022151 scopus 로고    scopus 로고
    • Deflection of vascular endothelial growth factor action by SS18-SSX and composite vascular endothelial growth factor- and chemokine (C-X-C motif) receptor 4-targeted therapy in synovial sarcoma
    • Wakamatsu T., Naka N., Sasagawa S., et al. Deflection of vascular endothelial growth factor action by SS18-SSX and composite vascular endothelial growth factor- and chemokine (C-X-C motif) receptor 4-targeted therapy in synovial sarcoma. Cancer Sci 2014, 105:1124-1134.
    • (2014) Cancer Sci , vol.105 , pp. 1124-1134
    • Wakamatsu, T.1    Naka, N.2    Sasagawa, S.3
  • 148
    • 84901227839 scopus 로고    scopus 로고
    • WT1 regulates angiogenesis in Ewing Sarcoma
    • Katuri V., Gerber S., Qiu X., et al. WT1 regulates angiogenesis in Ewing Sarcoma. Oncotarget 2014, 5:2436-2449.
    • (2014) Oncotarget , vol.5 , pp. 2436-2449
    • Katuri, V.1    Gerber, S.2    Qiu, X.3
  • 149
    • 84908880202 scopus 로고    scopus 로고
    • Close correlation between CXCR4 and VEGF expression and frequent CXCR7 expression in rhabdomyosarcoma
    • Miyoshi K., Kohashi K., Fushiujmi F., et al. Close correlation between CXCR4 and VEGF expression and frequent CXCR7 expression in rhabdomyosarcoma. Hum Pathol 2014, 45:1900-1909.
    • (2014) Hum Pathol , vol.45 , pp. 1900-1909
    • Miyoshi, K.1    Kohashi, K.2    Fushiujmi, F.3
  • 150
    • 84889982620 scopus 로고    scopus 로고
    • Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma
    • Yang J., Zhao L., Tian W., et al. Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma. BMC Med Genomics 2013, 6:56.
    • (2013) BMC Med Genomics , vol.6 , pp. 56
    • Yang, J.1    Zhao, L.2    Tian, W.3
  • 151
    • 38149060090 scopus 로고    scopus 로고
    • Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas
    • Itakura E., Yamamoto H., Oda Y., et al. Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas. J Surg Oncol 2008, 97:74-81.
    • (2008) J Surg Oncol , vol.97 , pp. 74-81
    • Itakura, E.1    Yamamoto, H.2    Oda, Y.3
  • 152
    • 84903790497 scopus 로고    scopus 로고
    • Angiogenic growth factor expression in benign and malignant vascular tumours
    • Young R.J., Fernando M., Hughes D., et al. Angiogenic growth factor expression in benign and malignant vascular tumours. Exp Mol Pathol 2014, 97:148-153.
    • (2014) Exp Mol Pathol , vol.97 , pp. 148-153
    • Young, R.J.1    Fernando, M.2    Hughes, D.3
  • 153
    • 84882955940 scopus 로고    scopus 로고
    • Cediranib for metastatic alveolar soft part sarcoma
    • Kummar S., Allen D., Monks A., et al. Cediranib for metastatic alveolar soft part sarcoma. J Clin Oncol 2013, 31:2296-2302.
    • (2013) J Clin Oncol , vol.31 , pp. 2296-2302
    • Kummar, S.1    Allen, D.2    Monks, A.3
  • 154
    • 84876506864 scopus 로고    scopus 로고
    • An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas
    • Agulnik M., Yarber J.L., Okuno S.H., et al. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol 2013, 24:257-263.
    • (2013) Ann Oncol , vol.24 , pp. 257-263
    • Agulnik, M.1    Yarber, J.L.2    Okuno, S.H.3
  • 155
    • 0032884917 scopus 로고    scopus 로고
    • Serum levels of vascular endothelial growth factor and basic fibroblast growth factor in patients with soft-tissue sarcoma
    • Graeven U., Andre N., Achilles E., et al. Serum levels of vascular endothelial growth factor and basic fibroblast growth factor in patients with soft-tissue sarcoma. J Cancer Res Clin Oncol 1999, 125:577-581.
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 577-581
    • Graeven, U.1    Andre, N.2    Achilles, E.3
  • 156
    • 4444286921 scopus 로고    scopus 로고
    • Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma
    • Yoon S.S., Segal N.H., Olshen A.B., et al. Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma. Ann Oncol 2004, 15:1261-1266.
    • (2004) Ann Oncol , vol.15 , pp. 1261-1266
    • Yoon, S.S.1    Segal, N.H.2    Olshen, A.B.3
  • 157
    • 84875163071 scopus 로고    scopus 로고
    • Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFbeta as potential targets
    • van Oosterwijk J.G., Meijer D., van Ruler M.A., et al. Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFbeta as potential targets. Am J Pathol 2013, 182:1347-1356.
    • (2013) Am J Pathol , vol.182 , pp. 1347-1356
    • van Oosterwijk, J.G.1    Meijer, D.2    van Ruler, M.A.3
  • 158
    • 84877586101 scopus 로고    scopus 로고
    • Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations
    • Hoffman A., Ghadimi M.P., Demicco E.G., et al. Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations. Cancer 2013, 119:1868-1877.
    • (2013) Cancer , vol.119 , pp. 1868-1877
    • Hoffman, A.1    Ghadimi, M.P.2    Demicco, E.G.3
  • 159
    • 84865722534 scopus 로고    scopus 로고
    • PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma
    • Ho A.L., Vasudeva S.D., Laé M., et al. PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma. Cancer Res 2012, 72:4515-4525.
    • (2012) Cancer Res , vol.72 , pp. 4515-4525
    • Ho, A.L.1    Vasudeva, S.D.2    Laé, M.3
  • 160
    • 80051802494 scopus 로고    scopus 로고
    • Dermatofibrosarcoma protuberans: a clinicopathological, immunohistochemical, genetic (COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade (fibrosarcomatous) tumors
    • Llombart B., Monteagudo C., Sanmartín O., et al. Dermatofibrosarcoma protuberans: a clinicopathological, immunohistochemical, genetic (COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade (fibrosarcomatous) tumors. J Am Acad Dermatol 2011, 65:564-575.
    • (2011) J Am Acad Dermatol , vol.65 , pp. 564-575
    • Llombart, B.1    Monteagudo, C.2    Sanmartín, O.3
  • 161
    • 84872425841 scopus 로고    scopus 로고
    • Molecular and clinicopathological analysis of dermatofibrosarcoma protuberans
    • Walluks K., Chen Y., Woelfel C., et al. Molecular and clinicopathological analysis of dermatofibrosarcoma protuberans. Pathol Res Pract 2013, 209:30-35.
    • (2013) Pathol Res Pract , vol.209 , pp. 30-35
    • Walluks, K.1    Chen, Y.2    Woelfel, C.3
  • 162
    • 0031661840 scopus 로고    scopus 로고
    • Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas
    • O'Brien K.P., Seroussi E., Dal Cin P., et al. Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes Chromosomes Cancer 1998, 23:187-193.
    • (1998) Genes Chromosomes Cancer , vol.23 , pp. 187-193
    • O'Brien, K.P.1    Seroussi, E.2    Dal Cin, P.3
  • 163
    • 84906935033 scopus 로고    scopus 로고
    • Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis
    • Takagi S., Takemoto A., Takami M., et al. Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis. Cancer Sci 2014, 105:983-988.
    • (2014) Cancer Sci , vol.105 , pp. 983-988
    • Takagi, S.1    Takemoto, A.2    Takami, M.3
  • 164
    • 77950469922 scopus 로고    scopus 로고
    • Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials
    • Rutkowski P., Van Glabbeke M., Rankin C.J., et al. Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials. J Clin Oncol 2010, 28:1772-1779.
    • (2010) J Clin Oncol , vol.28 , pp. 1772-1779
    • Rutkowski, P.1    Van Glabbeke, M.2    Rankin, C.J.3
  • 165
    • 84896877553 scopus 로고    scopus 로고
    • Long-term responders and survivors on pazopanib for advanced soft tissue sarcomas: subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072
    • Kasper B., Sleijfer S., Litière S., et al. Long-term responders and survivors on pazopanib for advanced soft tissue sarcomas: subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072. Ann Oncol 2014, 25:719-724.
    • (2014) Ann Oncol , vol.25 , pp. 719-724
    • Kasper, B.1    Sleijfer, S.2    Litière, S.3
  • 166
    • 84861098484 scopus 로고    scopus 로고
    • Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial
    • van der Graaf W.T., Blay J.Y., Chawla S.P., et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012, 379:1879-1886.
    • (2012) Lancet , vol.379 , pp. 1879-1886
    • van der Graaf, W.T.1    Blay, J.Y.2    Chawla, S.P.3
  • 167
    • 84903693640 scopus 로고    scopus 로고
    • Investigation of IGF2, Hedgehog and fusion gene expression profiles in pediatric sarcomas
    • de Souza R.R., Oliveira I.D., del Giúdice Paniago M., et al. Investigation of IGF2, Hedgehog and fusion gene expression profiles in pediatric sarcomas. Growth Horm IGF Res 2014, 24:130-136.
    • (2014) Growth Horm IGF Res , vol.24 , pp. 130-136
    • de Souza, R.R.1    Oliveira, I.D.2    del Giúdice Paniago, M.3
  • 168
    • 0027227651 scopus 로고
    • Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    • Crozat A., Aman P., Mandahl N., et al. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 1993, 363:640-644.
    • (1993) Nature , vol.363 , pp. 640-644
    • Crozat, A.1    Aman, P.2    Mandahl, N.3
  • 169
    • 84887925395 scopus 로고    scopus 로고
    • Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation
    • Rodriguez R., Tornin J., Suarez C., et al. Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation. Stem Cells 2013, 31:2061-2072.
    • (2013) Stem Cells , vol.31 , pp. 2061-2072
    • Rodriguez, R.1    Tornin, J.2    Suarez, C.3
  • 170
    • 84875054627 scopus 로고    scopus 로고
    • Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein
    • Kobos R., Nagai M., Tsuda M., et al. Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein. J Pathol 2013, 229:743-754.
    • (2013) J Pathol , vol.229 , pp. 743-754
    • Kobos, R.1    Nagai, M.2    Tsuda, M.3
  • 171
    • 84884419328 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway activity in alveolar soft part sarcoma
    • Reis H., Hager T., Wohlschlaeger J., et al. Mammalian target of rapamycin pathway activity in alveolar soft part sarcoma. Hum Pathol 2013, 44:2266-2274.
    • (2013) Hum Pathol , vol.44 , pp. 2266-2274
    • Reis, H.1    Hager, T.2    Wohlschlaeger, J.3
  • 172
    • 84860739005 scopus 로고    scopus 로고
    • PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation
    • Charytonowicz E., Matushansky I., Doménech J.D., et al. PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation. Clin Transl Oncol 2012, 14:197-206.
    • (2012) Clin Transl Oncol , vol.14 , pp. 197-206
    • Charytonowicz, E.1    Matushansky, I.2    Doménech, J.D.3
  • 173
    • 0034537352 scopus 로고    scopus 로고
    • Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
    • Bovee J.V., van den Broek L.J., Cleton-Jansen A.M., et al. Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. Lab Invest 2000, 80:1925-1934.
    • (2000) Lab Invest , vol.80 , pp. 1925-1934
    • Bovee, J.V.1    van den Broek, L.J.2    Cleton-Jansen, A.M.3
  • 174
    • 84861723964 scopus 로고    scopus 로고
    • Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance
    • van Oosterwijk J.G., Herpers B., Meijer D., et al. Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance. Ann Oncol 2012, 23:1617-1626.
    • (2012) Ann Oncol , vol.23 , pp. 1617-1626
    • van Oosterwijk, J.G.1    Herpers, B.2    Meijer, D.3
  • 175
    • 84916203286 scopus 로고    scopus 로고
    • BH3 mimetics inhibit growth of chondrosarcoma-a novel targeted-therapy for candidate models
    • Morii T., Ohtsuka K., Ohnishi H., et al. BH3 mimetics inhibit growth of chondrosarcoma-a novel targeted-therapy for candidate models. Anticancer Res 2014, 34:6423-6430.
    • (2014) Anticancer Res , vol.34 , pp. 6423-6430
    • Morii, T.1    Ohtsuka, K.2    Ohnishi, H.3
  • 177
    • 84942204328 scopus 로고    scopus 로고
    • Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1). ClinicalTrials.gov Identifier NCT00093080. Available at: Accessed July 28
    • Chawla SP, Staddon AP, Baker LH, et al. Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1). ClinicalTrials.gov Identifier NCT00093080. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00093080?term=NCT00093080%26rank=1.
    • (2015)
    • Chawla, S.P.1    Staddon, A.P.2    Baker, L.H.3
  • 178
    • 84888642081 scopus 로고    scopus 로고
    • Multicenter phase II study of everolimus in patients with metastatic or recurrent bone and soft-tissue sarcomas after failure of anthracycline and ifosfamide
    • Yoo C., Lee J., Rha S.Y., et al. Multicenter phase II study of everolimus in patients with metastatic or recurrent bone and soft-tissue sarcomas after failure of anthracycline and ifosfamide. Invest New Drugs 2013, 31(6):1602-1608.
    • (2013) Invest New Drugs , vol.31 , Issue.6 , pp. 1602-1608
    • Yoo, C.1    Lee, J.2    Rha, S.Y.3
  • 179
    • 84942204329 scopus 로고    scopus 로고
    • Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma
    • Accessed July 28
    • Wagner L. Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma. ClinicalTrials.gov Identifier NCT01614795. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT01614795?term=nct01614795%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT01614795
    • Wagner, L.1
  • 180
    • 84942204330 scopus 로고    scopus 로고
    • Temsirolimus and Cixutumumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent Soft Tissue Sarcoma or Bone Sarcoma
    • Accessed July 28
    • Schwartz GK, Tap WD, Qin LX, et al. Temsirolimus and Cixutumumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent Soft Tissue Sarcoma or Bone Sarcoma. ClinicalTrials.gov Identifier NCT01016015. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT01016015?term=NCT01016015%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT01016015
    • Schwartz, G.K.1    Tap, W.D.2    Qin, L.X.3
  • 181
    • 84942204331 scopus 로고    scopus 로고
    • Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors
    • Accessed July 28
    • Weigel B. Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors. ClinicalTrials.gov Identifier NCT00831844. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00831844?term=NCT00831844%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT00831844
    • Weigel, B.1
  • 182
    • 84942204332 scopus 로고    scopus 로고
    • A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors
    • Accessed July 28
    • Tap WD, Demetri G, Barnette P, et al. A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors. ClinicalTrials.gov Identifier NCT00563680. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00563680?term=00563680%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT00563680
    • Tap, W.D.1    Demetri, G.2    Barnette, P.3
  • 183
    • 84942204333 scopus 로고    scopus 로고
    • A Study of R1507 in Patients With Recurrent or Refractory Sarcoma
    • Accessed July 28
    • Pappo AS, Patel SR, Crowley J, et al. A Study of R1507 in Patients With Recurrent or Refractory Sarcoma. ClinicalTrials.gov Identifier NCT00642941. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00642941?term=00642941%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT00642941
    • Pappo, A.S.1    Patel, S.R.2    Crowley, J.3
  • 184
    • 84942204334 scopus 로고    scopus 로고
    • The Biological Activity of Cediranib (AZD2171) in Gastro-Intestinal Stromal Tumours(GIST)
    • Accessed July 28
    • Judson I, Scurr M, Gardner K, et al. The Biological Activity of Cediranib (AZD2171) in Gastro-Intestinal Stromal Tumours(GIST). ClinicalTrials.gov Identifier NCT00385203. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00385203?term=00385203%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT00385203
    • Judson, I.1    Scurr, M.2    Gardner, K.3
  • 185
    • 84942204335 scopus 로고    scopus 로고
    • Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part Sarcoma
    • Accessed July 28
    • Kummar S, Allen D, Monks A, et al. Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part Sarcoma. ClinicalTrials.gov Identifier NCT00942877. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00942877?term=00942877%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT00942877
    • Kummar, S.1    Allen, D.2    Monks, A.3
  • 186
    • 84942204336 scopus 로고    scopus 로고
    • Bevacizumab in Treating Patients With Angiosarcoma
    • Accessed July 28
    • Agulnik M. Bevacizumab in Treating Patients With Angiosarcoma. ClinicalTrials.gov Identifier NCT00288015. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00288015?term=00288015%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT00288015
    • Agulnik, M.1
  • 187
    • 84942204337 scopus 로고    scopus 로고
    • Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors
    • Accessed July 28
    • Baruchel S, Pappo A, Krailo M, et al. Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors. ClinicalTrials.gov Identifier: NCT00070109. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00070109?term=00070109%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT00070109
    • Baruchel, S.1    Pappo, A.2    Krailo, M.3
  • 188
    • 84942204338 scopus 로고    scopus 로고
    • Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma
    • Accessed July 28
    • Butrynski JE. Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma. ClinicalTrials.gov Identifier NCT01189253. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT01189253?term=NCT01189253%26rank=1.
    • (2015) ClinicalTrials.gov Identifier NCT01189253
    • Butrynski, J.E.1
  • 189
    • 84885175708 scopus 로고    scopus 로고
    • Trabectedin is a feasible treatment for soft tissue sarcoma patients regardless of patient age: a retrospective pooled analysis of five phase II trials
    • Cesne A.L., Judson I., Maki R., et al. Trabectedin is a feasible treatment for soft tissue sarcoma patients regardless of patient age: a retrospective pooled analysis of five phase II trials. Br J Cancer 2013, 109(7):1717-1724.
    • (2013) Br J Cancer , vol.109 , Issue.7 , pp. 1717-1724
    • Cesne, A.L.1    Judson, I.2    Maki, R.3
  • 190
    • 84942204339 scopus 로고    scopus 로고
    • Continuing vs Intermittent Trabectedin-regimen in Patients With Advanced Soft Tissue Sarcoma Experiencing Response or Stable Disease After the 6th Cycle (T-DIS)
    • Accessed July 28
    • Le Cesne A, Blay JY, Domont J, et al. Continuing vs Intermittent Trabectedin-regimen in Patients With Advanced Soft Tissue Sarcoma Experiencing Response or Stable Disease After the 6th Cycle (T-DIS). ClinicalTrials.gov Identifier: NCT01303094. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT01303094?term=01303094%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT01303094
    • Le Cesne, A.1    Blay, J.Y.2    Domont, J.3
  • 191
    • 84942204340 scopus 로고    scopus 로고
    • Imatinib in Patients With Desmoid Tumor and Chondrosarcoma (Basket 1)
    • Accessed July 28
    • Grignani G. Imatinib in Patients With Desmoid Tumor and Chondrosarcoma (Basket 1). ClinicalTrials.gov Identifier: NCT00928525. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00928525?term=grignani+imatinib%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT00928525
    • Grignani, G.1
  • 192
    • 84892742296 scopus 로고    scopus 로고
    • Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up
    • Ugurel S., Mentzel T., Utikal J., et al. Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up. Clin Cancer Res 2014, 20(2):499-510.
    • (2014) Clin Cancer Res , vol.20 , Issue.2 , pp. 499-510
    • Ugurel, S.1    Mentzel, T.2    Utikal, J.3
  • 193
    • 78149452583 scopus 로고    scopus 로고
    • Multicenter phase II trial assessing effectiveness of imatinib mesylate on relapsed or refractory KIT-positive or PDGFR-positive sarcoma
    • Sugiura H., Fujiwara Y., Ando M., et al. Multicenter phase II trial assessing effectiveness of imatinib mesylate on relapsed or refractory KIT-positive or PDGFR-positive sarcoma. J Orthop Sci 2010, 15(5):654-660.
    • (2010) J Orthop Sci , vol.15 , Issue.5 , pp. 654-660
    • Sugiura, H.1    Fujiwara, Y.2    Ando, M.3
  • 194
    • 84942204341 scopus 로고    scopus 로고
    • PD0332991 in Patients With Advanced or Metastatic Liposarcoma
    • Accessed July 28
    • Dickson M. PD0332991 in Patients With Advanced or Metastatic Liposarcoma. ClinicalTrials.gov Identifier: NCT01209598. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT01209598?term=NCT01209598%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT01209598
    • Dickson, M.1
  • 195
    • 84942204342 scopus 로고    scopus 로고
    • Chemotherapy With or Without Trastuzumab in Treating Patients With Metastatic Osteosarcoma
    • Accessed July 28
    • Ebb D. Chemotherapy With or Without Trastuzumab in Treating Patients With Metastatic Osteosarcoma. ClinicalTrials.gov Identifier: NCT00023998. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00023998?term=NCT00023998%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT00023998
    • Ebb, D.1
  • 196
    • 84942204343 scopus 로고    scopus 로고
    • S0505 Sorafenib in Treating Patients With Advanced Soft Tissue Sarcomas
    • Accessed July 28
    • Von Mehren M, Demetri GD. S0505 Sorafenib in Treating Patients With Advanced Soft Tissue Sarcomas. ClinicalTrials.gov Identifier: NCT00217620. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00217620?term=00217620%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT00217620
    • Von Mehren, M.1    Demetri, G.D.2
  • 197
    • 84942204344 scopus 로고    scopus 로고
    • Sorafenib in Relapsed High Grade Osteosarcoma
    • Accessed July 28
    • Grignani G. Sorafenib in Relapsed High Grade Osteosarcoma. ClinicalTrials.gov Identifier: NCT00889057. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00889057?term=NCT00889057%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT00889057
    • Grignani, G.1
  • 198
    • 84942204345 scopus 로고    scopus 로고
    • Phase II Open Label, Non-randomized Study of Sorafenib and Everolimus in Relapsed and Non-resectable Osteosarcoma (SERIO)
    • Accessed July 28
    • Aglietta M. Phase II Open Label, Non-randomized Study of Sorafenib and Everolimus in Relapsed and Non-resectable Osteosarcoma (SERIO). ClinicalTrials.gov Identifier: NCT01804374. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT01804374?term=NCT01804374%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT01804374
    • Aglietta, M.1
  • 199
    • 84942204346 scopus 로고    scopus 로고
    • Pazopanib In Patients With Relapsed Or Refractory Soft Tissue Sarcoma
    • Accessed July 28
    • Sleijfer S, Ray-Coquard I, Papai Z, et al. Pazopanib In Patients With Relapsed Or Refractory Soft Tissue Sarcoma. ClinicalTrials.gov Identifier: NCT00297258. Available at: Accessed July 28, 2015. https://clinicaltrials.gov/ct2/show/NCT00297258?term=NCT00297258%26rank=1.
    • (2015) ClinicalTrials.gov Identifier: NCT00297258
    • Sleijfer, S.1    Ray-Coquard, I.2    Papai, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.