-
1
-
-
0002136462
-
Malignant bone tumors
-
Ries L, Smith M, Gurney J, et al., editors National Cancer Institute, SEER Program. NIH Pub. No. 99-4649. Bethesda, MD
-
Gurney J, Swensen A, Bulterys M. Malignant bone tumors. In: Ries L, Smith M, Gurney J, et al., editors. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. NIH Pub. No. 99-4649. Bethesda, MD; 1999.
-
(1999)
Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995
-
-
Gurney, J.1
Swensen, A.2
Bulterys, M.3
-
2
-
-
70149098414
-
Malignant Bone Tumors
-
A. Bleyer M. O'Leary R. Barr L.A.G. Ries (eds) National Cancer Institute Bethesda, MD NIH Pub. 06-5767
-
Mascarenhas L, Siegel S, Spector L, et al. Malignant Bone Tumors. In: Bleyer A, O'Leary M, Barr R, Ries LAG, editors. Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000. National Cancer Institute, NIH Pub. No. 06-5767. Bethesda, MD 2006.
-
(2006)
Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000
-
-
Mascarenhas, L.1
Siegel, S.2
Spector, L.3
-
3
-
-
0035934019
-
Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patients
-
DOI 10.1002/1096-8628(20010722)102:1<11::AID-AJMG1413>3.0.CO;2-A
-
Wang LL, Levy ML, Lewis RA, Chintagumpala MM, Lev D, Rogers M, et al. Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patients. Am J Med Genet. 2001;102(1):11-7. doi: 10.1002/1096-8628(20010722)102:1. (Pubitemid 32623258)
-
(2001)
American Journal of Medical Genetics
, vol.102
, Issue.1
, pp. 11-17
-
-
Wang, L.L.1
Levy, M.L.2
Lewis, R.A.3
Chintagumpala, M.M.4
Lev, D.5
Rogers, M.6
Plon, S.E.7
-
4
-
-
84862281808
-
The genetics of osteosarcoma
-
doi: 10.1155/2012/627254
-
Martin JW, Squire JA, Zielenska M. The genetics of osteosarcoma. Sarcoma. 2012:627254. doi: 10.1155/2012/627254.
-
(2012)
Sarcoma.
, pp. 627254
-
-
Martin, J.W.1
Squire, J.A.2
Zielenska, M.3
-
5
-
-
77953433833
-
Osteosarcoma
-
10.1002/jbmr.77 20205169 10.1002/jbmr.77
-
Gorlick R, Khanna C. Osteosarcoma. J Bone Miner Res. 2010;25(4):683-91. doi: 10.1002/jbmr.77.
-
(2010)
J Bone Miner Res
, vol.25
, Issue.4
, pp. 683-691
-
-
Gorlick, R.1
Khanna, C.2
-
6
-
-
84873850148
-
FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo
-
10.1371/journal.pone.0055034 23383046 10.1371/journal.pone.0055034 1:CAS:528:DC%2BC3sXisVeltLk%3D
-
Brun J, Dieudonne FX, Marty C, Muller J, Schule R, Patino-Garcia A, et al. FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. PLoS One. 2013;8(1):e55034. doi: 10.1371/journal.pone.0055034.
-
(2013)
PLoS One
, vol.8
, Issue.1
, pp. 55034
-
-
Brun, J.1
Dieudonne, F.X.2
Marty, C.3
Muller, J.4
Schule, R.5
Patino-Garcia, A.6
-
7
-
-
77949667984
-
Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma
-
10.1158/1535-7163.MCT-09-0147 20197388 10.1158/1535-7163.MCT-09-0147 1:CAS:528:DC%2BC3cXivFensLg%3D
-
Rubin EM, Guo Y, Tu K, Xie J, Zi X, Hoang BH. Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther. 2010;9(3):731-41. doi: 10.1158/1535-7163.MCT-09-0147.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.3
, pp. 731-741
-
-
Rubin, E.M.1
Guo, Y.2
Tu, K.3
Xie, J.4
Zi, X.5
Hoang, B.H.6
-
8
-
-
64549149292
-
Notch signaling contributes to the pathogenesis of human osteosarcomas
-
19228774 10.1093/hmg/ddp057 1:CAS:528:DC%2BD1MXktV2hurY%3D
-
Engin F, Bertin T, Ma O, Jiang MM, Wang L, Sutton RE, et al. Notch signaling contributes to the pathogenesis of human osteosarcomas. Hum Mol Genet. 2009;18(8):1464-70.
-
(2009)
Hum Mol Genet
, vol.18
, Issue.8
, pp. 1464-1470
-
-
Engin, F.1
Bertin, T.2
Ma, O.3
Jiang, M.M.4
Wang, L.5
Sutton, R.E.6
-
9
-
-
49649103793
-
Critical role of notch signaling in osteosarcoma invasion and metastasis
-
18483362 10.1158/1078-0432.CCR-07-1992 1:CAS:528:DC%2BD1cXmtVCmtLw%3D
-
Zhang P, Yang Y, Zweidler-McKay PA, Hughes DP. Critical role of notch signaling in osteosarcoma invasion and metastasis. Clin Cancer Res. 2008;14(10):2962-9.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.10
, pp. 2962-2969
-
-
Zhang, P.1
Yang, Y.2
Zweidler-Mckay, P.A.3
Hughes, D.P.4
-
10
-
-
80052924427
-
Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma
-
10.1002/cncr.26037 21448934 10.1002/cncr.26037
-
Ciernik IF, Niemierko A, Harmon DC, Kobayashi W, Chen YL, Yock TI, et al. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer. 2011;117(19):4522-30. doi: 10.1002/cncr.26037.
-
(2011)
Cancer
, vol.117
, Issue.19
, pp. 4522-4530
-
-
Ciernik, I.F.1
Niemierko, A.2
Harmon, D.C.3
Kobayashi, W.4
Chen, Y.L.5
Yock, T.I.6
-
11
-
-
84872821519
-
The role of fluorine-18-fluorodeoxyglucose positron emission tomography in assessing the response to neoadjuvant treatment in patients with osteosarcoma
-
10.1155/2012/870301 23008768
-
Caldarella C, Salsano M, Isgro MA, Treglia G. The role of fluorine-18-fluorodeoxyglucose positron emission tomography in assessing the response to neoadjuvant treatment in patients with osteosarcoma. Int J Mol Imaging. 2012;2012:870301. doi: 10.1155/2012/870301.
-
(2012)
Int J Mol Imaging
, vol.2012
, pp. 870301
-
-
Caldarella, C.1
Salsano, M.2
Isgro, M.A.3
Treglia, G.4
-
12
-
-
3543035771
-
Biology and therapeutic advances for pediatric osteosarcoma
-
DOI 10.1634/theoncologist.9-4-422
-
Marina N, Gebhardt M, Teot L, Gorlick R. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist. 2004;9(4):422-41. (Pubitemid 39014554)
-
(2004)
Oncologist
, vol.9
, Issue.4
, pp. 422-441
-
-
Marina, N.1
Gebhardt, M.2
Teot, L.3
Gorlick, R.4
-
13
-
-
63449118087
-
Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program
-
10.1002/cncr.24121 19197972 10.1002/cncr.24121
-
Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer. 2009;115(7):1531-43. doi: 10.1002/cncr.24121.
-
(2009)
Cancer
, vol.115
, Issue.7
, pp. 1531-1543
-
-
Mirabello, L.1
Troisi, R.J.2
Savage, S.A.3
-
14
-
-
7344229308
-
Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs
-
DOI 10.1023/A:1008391103132
-
Fuchs N, Bielack SS, Epler D, Bieling P, Delling G, Korholz D, et al. Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs. Ann Oncol. 1998;9(8):893-9. (Pubitemid 28440449)
-
(1998)
Annals of Oncology
, vol.9
, Issue.8
, pp. 893-899
-
-
Fuchs, N.1
Bielack, S.S.2
Epler, D.3
Bieling, P.4
Delling, G.5
Korholz, D.6
Graf, N.7
Heise, U.8
Jurgens, H.9
Kotz, R.10
Salzer-Kuntschik, M.11
Weinel, P.12
Werner, M.13
Winkler, K.14
-
15
-
-
0026503028
-
Chemotherapy for nonmetastatic osteogenic sarcoma: The Memorial Sloan-Kettering experience
-
1370176 1:STN:280:DyaK38%2Fpt1Sluw%3D%3D
-
Meyers PA, Heller G, Healey J, Huvos A, Lane J, Marcove R, et al. Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience. J Clin Oncol. 1992;10(1):5-15.
-
(1992)
J Clin Oncol
, vol.10
, Issue.1
, pp. 5-15
-
-
Meyers, P.A.1
Heller, G.2
Healey, J.3
Huvos, A.4
Lane, J.5
Marcove, R.6
-
16
-
-
0031022801
-
Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: A report from the Children's Cancer Group
-
Provisor AJ, Ettinger LJ, Nachman JB, Krailo MD, Makley JT, Yunis EJ, et al. Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group. J Clin Oncol. 1997;15(1):76-84. (Pubitemid 27020560)
-
(1997)
Journal of Clinical Oncology
, vol.15
, Issue.1
, pp. 76-84
-
-
Provisor, A.J.1
Ettinger, L.J.2
Nachman, J.B.3
Krailo, M.D.4
Makley, J.T.5
Yunis, E.J.6
Huvos, A.G.7
Betcher, D.L.8
Baum, E.S.9
Kisker, C.T.10
Miser, J.S.11
-
17
-
-
80054914908
-
Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand?
-
10.1016/j.ejca.2011.05.030 21703851 10.1016/j.ejca.2011.05.030 1:CAS:528:DC%2BC3MXhtlKrs7%2FM
-
Anninga JK, Gelderblom H, Fiocco M, Kroep JR, Taminiau AH, Hogendoorn PC, et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer. 2011;47(16):2431-45. doi: 10.1016/j.ejca.2011.05.030.
-
(2011)
Eur J Cancer
, vol.47
, Issue.16
, pp. 2431-2445
-
-
Anninga, J.K.1
Gelderblom, H.2
Fiocco, M.3
Kroep, J.R.4
Taminiau, A.H.5
Hogendoorn, P.C.6
-
18
-
-
0038518570
-
Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651
-
DOI 10.1200/JCO.2003.08.165
-
• Goorin AM, Schwartzentruber DJ, Devidas M, Gebhardt MC, Ayala AG, Harris MB, et al. Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol. 2003;21(8):1574-80. doi: 10.1200/JCO.2003.08.165. This is a prospective randomized study that demonstrated no advantage in EFS for patients given presurgical chemotherapy compared with immediate surgery. (Pubitemid 46594112)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.8
, pp. 1574-1580
-
-
Goorin, A.M.1
Schwartzentruber, D.J.2
Devidas, M.3
Gebhardt, M.C.4
Ayala, A.G.5
Harris, M.B.6
Helman, L.J.7
Grier, H.E.8
Link, M.P.9
-
19
-
-
0017655886
-
Primary osteogenic sarcoma. Pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement
-
Huvos AG, Rosen G, Marcove RC. Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement. Arch Pathol Lab Med. 1977;101(1):14-8. (Pubitemid 8190735)
-
(1977)
Archives of Pathology and Laboratory Medicine
, vol.101
, Issue.1
, pp. 14-18
-
-
Huvos, A.G.1
Rosen, G.2
Marcove, R.C.3
-
20
-
-
0036467661
-
Prognostic factors in high-grade osteosarcoma of the extremities or trunk: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols
-
DOI 10.1200/JCO.20.3.776
-
Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 2002;20(3):776-90. (Pubitemid 34111386)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.3
, pp. 776-790
-
-
Bielack, S.S.1
Kempf-Bielack, B.2
Delling, G.3
Exner, G.U.4
Flege, S.5
Helmke, K.6
Kotz, R.7
Salzer-Kuntschik, M.8
Wemer, M.9
Winkelmann, W.10
Zoubek, A.11
Jurgens, H.12
Winkler, K.13
-
21
-
-
20144380941
-
Osteosarcoma: A randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate
-
DOI 10.1200/JCO.2005.06.031
-
Meyers PA, Schwartz CL, Krailo M, Kleinerman ES, Betcher D, Bernstein ML, et al. Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. J Clin Oncol. 2005;23(9):2004-11. doi: 10.1200/JCO.2005.06.031. (Pubitemid 46211380)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.9
, pp. 2004-2011
-
-
Meyers, P.A.1
Schwartz, C.L.2
Krailo, M.3
Kleinerman, E.S.4
Betcher, D.5
Bernstein, M.L.6
Conrad, E.7
Ferguson, W.8
Gebhardt, M.9
Goorin, A.M.10
Harris, M.B.11
Healey, J.12
Huvos, A.13
Link, M.14
Montebello, J.15
Nadel, H.16
Nieder, M.17
Sato, J.18
Siegal, G.19
Weiner, M.20
Wells, R.21
Wold, L.22
Womer, R.23
Grier, H.24
more..
-
22
-
-
84863928403
-
Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: An Italian sarcoma group trial ISG/OS-1
-
doi: JCO.2011.38.4420
-
Ferrari S, Ruggieri P, Cefalo G, Tamburini A, Capanna R, Fagioli F, et al. Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1. J Clin Oncol. 2012;30(17):2112-8. doi: JCO.2011.38.4420.
-
(2012)
J Clin Oncol.
, vol.30
, Issue.17
, pp. 2112-2118
-
-
Ferrari, S.1
Ruggieri, P.2
Cefalo, G.3
Tamburini, A.4
Capanna, R.5
Fagioli, F.6
-
23
-
-
33846981552
-
Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: A randomized phase III trial of the European Osteosarcoma Intergroup
-
10.1093/jnci/djk015 17227995 10.1093/jnci/djk015 1:CAS:528: DC%2BD2sXhvVOhtbg%3D
-
Lewis IJ, Nooij MA, Whelan J, Sydes MR, Grimer R, Hogendoorn PC, et al. Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. J Natl Cancer Inst. 2007;99(2):112-28. doi: 10.1093/jnci/djk015.
-
(2007)
J Natl Cancer Inst
, vol.99
, Issue.2
, pp. 112-128
-
-
Lewis, I.J.1
Nooij, M.A.2
Whelan, J.3
Sydes, M.R.4
Grimer, R.5
Hogendoorn, P.C.6
-
24
-
-
0034671416
-
Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the Istituto Ortopedico Rizzoli according to the Istituto Ortopedico Rizzoli/osteosarcoma-2 protocol: An updated report
-
Bacci G, Ferrari S, Bertoni F, Ruggieri P, Picci P, Longhi A, et al. Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report. J Clin Oncol. 2000;18(24):4016-27. (Pubitemid 32038393)
-
(2000)
Journal of Clinical Oncology
, vol.18
, Issue.24
, pp. 4016-4027
-
-
Bacci, G.1
Ferrari, S.2
Bertoni, F.3
Ruggieri, P.4
Picci, P.5
Longhi, A.6
Casadei, R.7
Fabbri, N.8
Forni, C.9
Versari, M.10
Campanacci, M.11
-
25
-
-
79953806901
-
Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years
-
10.3109/17453674.2011.566141 21434784 10.3109/17453674.2011.566141
-
Smeland S, Bruland OS, Hjorth L, Brosjo O, Bjerkehagen B, Osterlundh G, et al. Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years. Acta Orthop. 2011;82(2):211-6. doi: 10.3109/17453674.2011.566141.
-
(2011)
Acta Orthop
, vol.82
, Issue.2
, pp. 211-216
-
-
Smeland, S.1
Bruland, O.S.2
Hjorth, L.3
Brosjo, O.4
Bjerkehagen, B.5
Osterlundh, G.6
-
26
-
-
77953658617
-
International collaboration is feasible in trials for rare conditions: The EURAMOS experience
-
10.1007/978-1-4419-0284-9-18 20213400 10.1007/978-1-4419-0284-9-18 1:STN:280:DC%2BC3c7mslGkug%3D%3D This paper describes the international efforts to conduct a randomized study to improve treatments for good and poor responders in osteosarcoma
-
•• Marina N, Bielack S, Whelan J, Smeland S, Krailo M, Sydes MR, et al. International collaboration is feasible in trials for rare conditions: the EURAMOS experience. Cancer Treat Res. 2009;152:339-53. doi: 10.1007/978-1-4419-0284-9-18. This paper describes the international efforts to conduct a randomized study to improve treatments for good and poor responders in osteosarcoma.
-
(2009)
Cancer Treat Res
, vol.152
, pp. 339-353
-
-
Marina, N.1
Bielack, S.2
Whelan, J.3
Smeland, S.4
Krailo, M.5
Sydes, M.R.6
-
27
-
-
0037080289
-
Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: A pediatric oncology group trial
-
DOI 10.1200/JCO.20.2.426
-
Goorin AM, Harris MB, Bernstein M, Ferguson W, Devidas M, Siegal GP, et al. Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial. J Clin Oncol. 2002;20(2):426-33. (Pubitemid 34072525)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.2
, pp. 426-433
-
-
Goorin, A.M.1
Harris, M.B.2
Bernstein, M.3
Ferguson, W.4
Devidas, M.5
Siegal, G.P.6
Gebhardt, M.C.7
Schwartz, C.L.8
Link, M.9
Grier, H.E.10
-
28
-
-
84857914348
-
Gemcitabine with or without docetaxel and resection for recurrent osteosarcoma: The experience at Children's Memorial Hospital
-
10.1097/MPH.0b013e3182331ee8 22217487 10.1097/MPH.0b013e3182331ee8 1:CAS:528:DC%2BC38XivVymsbg%3D
-
Gosiengfiao Y, Reichek J, Woodman J, Ben-Ami T, Walterhouse D. Gemcitabine with or without docetaxel and resection for recurrent osteosarcoma: the experience at Children's Memorial Hospital. J Pediatr Hematol Oncol. 2012;34(2):e63-5. doi: 10.1097/MPH.0b013e3182331ee8.
-
(2012)
J Pediatr Hematol Oncol
, vol.34
, Issue.2
-
-
Gosiengfiao, Y.1
Reichek, J.2
Woodman, J.3
Ben-Ami, T.4
Walterhouse, D.5
-
29
-
-
48249154929
-
Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma
-
18484657 10.1002/cncr.23586 1:CAS:528:DC%2BD1cXpt1Orsbg%3D
-
Navid F, Willert JR, McCarville MB, Furman W, Watkins A, Roberts W, et al. Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. Cancer. 2008;113(2):419-25.
-
(2008)
Cancer
, vol.113
, Issue.2
, pp. 419-425
-
-
Navid, F.1
Willert, J.R.2
McCarville, M.B.3
Furman, W.4
Watkins, A.5
Roberts, W.6
-
30
-
-
84859381932
-
Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: Results of sarcoma alliance for research through collaboration study 003
-
22363068 10.1634/theoncologist.2010-0265
-
Fox E, Patel S, Wathen JK, Schuetze S, Chawla S, Harmon D, et al. Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of sarcoma alliance for research through collaboration study 003. Oncologist. 2012;17(3):321-e9.
-
(2012)
Oncologist
, vol.17
, Issue.3
-
-
Fox, E.1
Patel, S.2
Wathen, J.K.3
Schuetze, S.4
Chawla, S.5
Harmon, D.6
-
31
-
-
79953783840
-
Addition of pamidronate to chemotherapy for the treatment of osteosarcoma
-
10.1002/cncr.25744 21472721 10.1002/cncr.25744 1:CAS:528: DC%2BC3MXlvFWktrw%3D
-
Meyers PA, Healey JH, Chou AJ, Wexler LH, Merola PR, Morris CD, et al. Addition of pamidronate to chemotherapy for the treatment of osteosarcoma. Cancer. 2011;117(8):1736-44. doi: 10.1002/cncr.25744.
-
(2011)
Cancer
, vol.117
, Issue.8
, pp. 1736-1744
-
-
Meyers, P.A.1
Healey, J.H.2
Chou, A.J.3
Wexler, L.H.4
Merola, P.R.5
Morris, C.D.6
-
32
-
-
71049179078
-
Irinotecan and temozolomide for Ewing sarcoma: The Memorial Sloan-Kettering experience
-
19637327 10.1002/pbc.22206
-
Casey DA, Wexler LH, Merchant MS, Chou AJ, Merola PR, Price AP, et al. Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience. Pediatr Blood Cancer. 2009;53(6):1029-34.
-
(2009)
Pediatr Blood Cancer
, vol.53
, Issue.6
, pp. 1029-1034
-
-
Casey, D.A.1
Wexler, L.H.2
Merchant, M.S.3
Chou, A.J.4
Merola, P.R.5
Price, A.P.6
-
33
-
-
84855932427
-
Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells
-
21706056 10.1038/onc.2011.245 1:CAS:528:DC%2BC3MXotV2iurk%3D
-
Bulut G, Hong SH, Chen K, Beauchamp EM, Rahim S, Kosturko GW, et al. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012;31(3):269-81.
-
(2012)
Oncogene
, vol.31
, Issue.3
, pp. 269-281
-
-
Bulut, G.1
Hong, S.H.2
Chen, K.3
Beauchamp, E.M.4
Rahim, S.5
Kosturko, G.W.6
-
34
-
-
11144357298
-
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
-
DOI 10.1038/nm982
-
Khanna C, Wan X, Bose S, Cassaday R, Olomu O, Mendoza A, et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med. 2004;10(2):182-6. doi: 10.1038/nm982 nm982. (Pubitemid 38524889)
-
(2004)
Nature Medicine
, vol.10
, Issue.2
, pp. 182-186
-
-
Khanna, C.1
Wan, X.2
Bose, S.3
Cassaday, R.4
Olomu, O.5
Mendoza, A.6
Yeung, C.7
Gorlick, R.8
Hewitt, S.M.9
Helman, L.J.10
-
35
-
-
84864044404
-
Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: A report from the children's oncology group
-
10.1200/JCO.2011.37.4546 22665540 10.1200/JCO.2011.37.4546 1:CAS:528:DC%2BC38XhtlWgsL3J
-
Ebb D, Meyers P, Grier H, Bernstein M, Gorlick R, Lipshultz SE, et al. Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. J Clin Oncol. 2012;30(20):2545-51. doi: 10.1200/JCO.2011.37.4546.
-
(2012)
J Clin Oncol
, vol.30
, Issue.20
, pp. 2545-2551
-
-
Ebb, D.1
Meyers, P.2
Grier, H.3
Bernstein, M.4
Gorlick, R.5
Lipshultz, S.E.6
-
36
-
-
70349852616
-
Immunotherapy for osteosarcoma: Genetic modification of T cells overcomes low levels of tumor antigen expression
-
10.1038/mt.2009.133 19532139 10.1038/mt.2009.133 1:CAS:528: DC%2BD1MXntlGnsbw%3D This preclinical study showed that immunotherapy may be an effective approach to treat metastatic disease in osteosarcoma. The same group also demonstrated that immunotherapy effectively eliminates osteosarcoma cancer stem cells
-
• Ahmed N, Salsman VS, Yvon E, Louis CU, Perlaky L, Wels WS, et al. Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression. Mol Ther. 2009;17(10):1779-87. doi: 10.1038/mt.2009.133. This preclinical study showed that immunotherapy may be an effective approach to treat metastatic disease in osteosarcoma. The same group also demonstrated that immunotherapy effectively eliminates osteosarcoma cancer stem cells.
-
(2009)
Mol Ther
, vol.17
, Issue.10
, pp. 1779-1787
-
-
Ahmed, N.1
Salsman, V.S.2
Yvon, E.3
Louis, C.U.4
Perlaky, L.5
Wels, W.S.6
-
37
-
-
67649939163
-
The increasing complexity of the cancer stem cell paradigm
-
10.1126/science.1171837 19556499 10.1126/science.1171837 1:CAS:528:DC%2BD1MXnsFOmtb8%3D
-
Rosen JM, Jordan CT. The increasing complexity of the cancer stem cell paradigm. Science. 2009;324(5935):1670-3. doi: 10.1126/science.1171837.
-
(2009)
Science
, vol.324
, Issue.5935
, pp. 1670-1673
-
-
Rosen, J.M.1
Jordan, C.T.2
-
38
-
-
84882904822
-
Perspectives on cancer stem cells in osteosarcoma
-
10.1016/j.canlet.2012.05.028 22659734 This is a review paper that describes the current knowledge regarding osteosarcoma cancer stem cells and the implications for designing future therapies
-
• Basu-Roy U, Basilico C, Mansukhani A. Perspectives on cancer stem cells in osteosarcoma. Cancer Lett. 2012. doi: 10.1016/j.canlet.2012.05.028. This is a review paper that describes the current knowledge regarding osteosarcoma cancer stem cells and the implications for designing future therapies.
-
(2012)
Cancer Lett
-
-
Basu-Roy, U.1
Basilico, C.2
Mansukhani, A.3
-
39
-
-
84857115215
-
Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma
-
10.1038/cgt.2011.83 22173710 10.1038/cgt.2011.83 1:CAS:528: DC%2BC3MXhs1aitrbJ
-
Rainusso N, Brawley VS, Ghazi A, Hicks MJ, Gottschalk S, Rosen JM, et al. Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. Cancer Gene Ther. 2012;19(3):212-7. doi: 10.1038/cgt.2011.83.
-
(2012)
Cancer Gene Ther
, vol.19
, Issue.3
, pp. 212-217
-
-
Rainusso, N.1
Brawley, V.S.2
Ghazi, A.3
Hicks, M.J.4
Gottschalk, S.5
Rosen, J.M.6
-
40
-
-
33746691887
-
Molecular diagnosis of sarcomas: Chromosomal translocations in sarcomas
-
Lazar A, Abruzzo LV, Pollock RE, Lee S, Czerniak B. Molecular diagnosis of sarcomas: chromosomal translocations in sarcomas. Arch Pathol Lab Med. 2006;130(8):1199-207. (Pubitemid 44168792)
-
(2006)
Archives of Pathology and Laboratory Medicine
, vol.130
, Issue.8
, pp. 1199-1207
-
-
Lazar, A.1
Abruzzo, L.V.2
Pollock, R.E.3
Lee, S.4
Czerniak, B.5
-
41
-
-
34447324657
-
The Biology of Ewing sarcoma
-
DOI 10.1016/j.canlet.2006.12.009, PII S0304383506006811
-
Riggi N, Stamenkovic I. The biology of Ewing sarcoma. Cancer Lett. 2007;254(1):1-10. (Pubitemid 47058800)
-
(2007)
Cancer Letters
, vol.254
, Issue.1
, pp. 1-10
-
-
Riggi, N.1
Stamenkovic, I.2
-
42
-
-
0023215290
-
Experimental evidence for a neural origin of Ewing's sarcoma of bone
-
Cavazzana AO, Miser JS, Jefferson J, Triche TJ. Experimental evidence for a neural origin of Ewing's sarcoma of bone. Am J Pathol. 1987;127(3):507-18. (Pubitemid 17089812)
-
(1987)
American Journal of Pathology
, vol.127
, Issue.3
, pp. 507-518
-
-
Cavazzana, A.O.1
Miser, J.S.2
Jefferson, J.3
Triche, T.J.4
-
43
-
-
56649114486
-
Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors
-
10.1038/labinvest.2008.99 1:CAS:528:DC%2BD1cXhtl2qt7jF
-
Potikyan G, France KA, Carlson MR, Dong J, Nelson SF, Denny CT. Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. Lab Invest J Tech Methods Pathol. 2008;88(12):1291-302.
-
(2008)
Lab Invest J Tech Methods Pathol
, vol.88
, Issue.12
, pp. 1291-1302
-
-
Potikyan, G.1
France, K.A.2
Carlson, M.R.3
Dong, J.4
Nelson, S.F.5
Denny, C.T.6
-
44
-
-
34249890232
-
Is Ewing's Sarcoma a Stem Cell Tumor?
-
DOI 10.1016/j.stem.2007.05.011, PII S1934590907000173
-
Meltzer PS. Is Ewing's sarcoma a stem cell tumor? Cell Stem Cell. 2007;1(1):13-5. (Pubitemid 46865810)
-
(2007)
Cell Stem Cell
, vol.1
, Issue.1
, pp. 13-15
-
-
Meltzer, P.S.1
-
45
-
-
42049089299
-
EWS-FLI-1 expression triggers a ewing's sarcoma initiation program in primary human mesenchymal stem cells
-
DOI 10.1158/0008-5472.CAN-07-1761
-
Riggi N, Suva ML, Suva D, Cironi L, Provero P, Tercier S, et al. EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res. 2008;68(7):2176-85. (Pubitemid 351521790)
-
(2008)
Cancer Research
, vol.68
, Issue.7
, pp. 2176-2185
-
-
Riggi, N.1
Suva, M.-L.2
Suva, D.3
Cironi, L.4
Provero, P.5
Tercier, S.6
Joseph, J.-M.7
Stehle, J.-C.8
Baumer, K.9
Kindler, V.10
Stamenkovic, I.11
-
46
-
-
55349094311
-
EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model
-
18974141 10.1158/0008-5472.CAN-08-0573 1:CAS:528:DC%2BD1cXhtlSkurzI This report demonstrates that the mesenchymal-specific activation of EWS-Fli1alone was not sufficient to drive sarcomagenesis, but required additional genetic mutations (p53 alterations) to produce undifferentiated sarcomas
-
• Lin PP, Pandey MK, Jin F, Xiong S, Deavers M, Parant JM, et al. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res. 2008;68(21):8968-75. This report demonstrates that the mesenchymal-specific activation of EWS-Fli1alone was not sufficient to drive sarcomagenesis, but required additional genetic mutations (p53 alterations) to produce undifferentiated sarcomas.
-
(2008)
Cancer Res
, vol.68
, Issue.21
, pp. 8968-8975
-
-
Lin, P.P.1
Pandey, M.K.2
Jin, F.3
Xiong, S.4
Deavers, M.5
Parant, J.M.6
-
47
-
-
84855893656
-
A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis
-
21979944 10.1242/dmm.007401 1:CAS:528:DC%2BC38XhtVKlsbg%3D
-
Leacock SW, Basse AN, Chandler GL, Kirk AM, Rakheja D, Amatruda JF. A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis. Dis Model Mech. 2012;5(1):95-106.
-
(2012)
Dis Model Mech
, vol.5
, Issue.1
, pp. 95-106
-
-
Leacock, S.W.1
Basse, A.N.2
Chandler, G.L.3
Kirk, A.M.4
Rakheja, D.5
Amatruda, J.F.6
-
48
-
-
79959536614
-
Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms
-
21531709 10.1074/jbc.M111.225433 1:CAS:528:DC%2BC3MXnvFektb8%3D
-
France KA, Anderson JL, Park A, Denny CT. Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms. J Biol Chem. 2011;286(26):22750-7.
-
(2011)
J Biol Chem
, vol.286
, Issue.26
, pp. 22750-22757
-
-
France, K.A.1
Anderson, J.L.2
Park, A.3
Denny, C.T.4
-
49
-
-
82955237238
-
A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs
-
21643012 10.1038/onc.2011.197 1:CAS:528:DC%2BC3MXntV2qtLw%3D This report provides evidence for the importance of miRNAs in ES biology by determining a novel post-transcriptional mechanism of derepression of IGF signaling by the EWS/Fli1 suppression of miRNAs
-
• McKinsey EL, Parrish JK, Irwin AE, Niemeyer BF, Kern HB, Birks DK, et al. A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs. Oncogene. 2011;30(49):4910-20. This report provides evidence for the importance of miRNAs in ES biology by determining a novel post-transcriptional mechanism of derepression of IGF signaling by the EWS/Fli1 suppression of miRNAs.
-
(2011)
Oncogene
, vol.30
, Issue.49
, pp. 4910-4920
-
-
McKinsey, E.L.1
Parrish, J.K.2
Irwin, A.E.3
Niemeyer, B.F.4
Kern, H.B.5
Birks, D.K.6
-
50
-
-
79955601706
-
Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma
-
21217773 10.1038/onc.2010.581 1:CAS:528:DC%2BC3MXjtVOnsA%3D%3D
-
Ban J, Jug G, Mestdagh P, Schwentner R, Kauer M, Aryee DN, et al. Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma. Oncogene. 2011;30(18):2173-80.
-
(2011)
Oncogene
, vol.30
, Issue.18
, pp. 2173-2180
-
-
Ban, J.1
Jug, G.2
Mestdagh, P.3
Schwentner, R.4
Kauer, M.5
Aryee, D.N.6
-
51
-
-
84862128379
-
A TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcoma
-
22698405 10.1016/j.ccr.2012.04.023
-
De Vito C, Riggi N, Cornaz S, Suva ML, Baumer K, Provero P, et al. A TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcoma. Cancer Cell. 2012;21(6):807-21.
-
(2012)
Cancer Cell
, vol.21
, Issue.6
, pp. 807-821
-
-
De Vito, C.1
Riggi, N.2
Cornaz, S.3
Suva, M.L.4
Baumer, K.5
Provero, P.6
-
52
-
-
84856732824
-
MiR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy
-
21960059 10.1002/path.3007 1:CAS:528:DC%2BC38XjsVWhtro%3D
-
Nakatani F, Ferracin M, Manara MC, Ventura S, Del Monaco V, Ferrari S, et al. miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy. J Pathol. 2012;226(5):796-805.
-
(2012)
J Pathol
, vol.226
, Issue.5
, pp. 796-805
-
-
Nakatani, F.1
Ferracin, M.2
Manara, M.C.3
Ventura, S.4
Del Monaco, V.5
Ferrari, S.6
-
53
-
-
84861505724
-
Diagnostic accuracy of (1)(8)F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: A systematic review and a meta-analysis
-
22072239 10.1007/s00256-011-1298-9
-
Treglia G, Salsano M, Stefanelli A, Mattoli MV, Giordano A, Bonomo L. Diagnostic accuracy of (1)(8)F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis. Skeletal Radiol. 2012;41(3):249-56.
-
(2012)
Skeletal Radiol
, vol.41
, Issue.3
, pp. 249-256
-
-
Treglia, G.1
Salsano, M.2
Stefanelli, A.3
Mattoli, M.V.4
Giordano, A.5
Bonomo, L.6
-
54
-
-
84864923755
-
Clinical features and outcomes in patients with Ewing sarcoma and regional lymph node involvement
-
22184129 10.1002/pbc.24053
-
Applebaum MA, Goldsby R, Neuhaus J, DuBois SG. Clinical features and outcomes in patients with Ewing sarcoma and regional lymph node involvement. Pediatr Blood Cancer. 2012;59(4):617-20.
-
(2012)
Pediatr Blood Cancer
, vol.59
, Issue.4
, pp. 617-620
-
-
Applebaum, M.A.1
Goldsby, R.2
Neuhaus, J.3
Dubois, S.G.4
-
55
-
-
79955490259
-
Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry
-
21467162 10.1158/1078-0432.CCR-10-3069 1:CAS:528:DC%2BC3MXlsVGgs7s%3D
-
Ash S, Luria D, Cohen IJ, Goshen Y, Toledano H, Issakov J, et al. Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry. Clin Cancer Res. 2011;17(9):2900-7.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.9
, pp. 2900-2907
-
-
Ash, S.1
Luria, D.2
Cohen, I.J.3
Goshen, Y.4
Toledano, H.5
Issakov, J.6
-
56
-
-
0037402107
-
Treatment of ewing sarcoma family of tumors: Current status and outlook for the future
-
DOI 10.1002/mpo.10240
-
Rodriguez-Galindo C, Spunt SL, Pappo AS. Treatment of Ewing sarcoma family of tumors: current status and outlook for the future. Med Pediatr Oncol. 2003;40(5):276-87. (Pubitemid 36397630)
-
(2003)
Medical and Pediatric Oncology
, vol.40
, Issue.5
, pp. 276-287
-
-
Rodriguez-Galindo, C.1
Spunt, S.L.2
Pappo, A.S.3
-
57
-
-
42649145826
-
Second cancers in patients with the Ewing sarcoma family of tumours
-
18353632 10.1016/j.ejca.2008.02.027
-
Navid F, Billups C, Liu T, Krasin MJ, Rodriguez-Galindo C. Second cancers in patients with the Ewing sarcoma family of tumours. Eur J Cancer. 2008;44(7):983-91.
-
(2008)
Eur J Cancer
, vol.44
, Issue.7
, pp. 983-991
-
-
Navid, F.1
Billups, C.2
Liu, T.3
Krasin, M.J.4
Rodriguez-Galindo, C.5
-
58
-
-
34547186749
-
Analysis of prognostic factors in Ewing sarcoma family of tumors: Review of St. Jude Children's Research Hospital studies
-
DOI 10.1002/cncr.22821
-
Rodriguez-Galindo C, Liu T, Krasin MJ, Wu J, Billups CA, Daw NC, et al. Analysis of prognostic factors in ewing sarcoma family of tumors: review of St. Jude Children's Research Hospital studies. Cancer. 2007;110(2):375-84. (Pubitemid 47121899)
-
(2007)
Cancer
, vol.110
, Issue.2
, pp. 375-384
-
-
Rodriguez-Galindo, C.1
Liu, T.2
Krasin, M.J.3
Wu, J.4
Billups, C.A.5
Daw, N.C.6
Spunt, S.L.7
Rao, B.N.8
Santana, V.M.9
Navid, F.10
-
59
-
-
17444447915
-
Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: Analysis of 359 patients at the Istituto Ortopedico Rizzoli
-
Bacci G, Ferrari S, Bertoni F, Rimondini S, Longhi A, Bacchini P, et al. Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. J Clin Oncol. 2000;18(1):4-11. (Pubitemid 30036330)
-
(2000)
Journal of Clinical Oncology
, vol.18
, Issue.1
, pp. 4-11
-
-
Bacci, G.1
Ferrari, S.2
Bertoni, F.3
Rimondini, S.4
Longhi, A.5
Bacchini, P.6
Forni, C.7
Manfrini, M.8
Donati, D.9
Picci, P.10
-
60
-
-
33745097435
-
Prognostic factors in non-metastatic Ewing's sarcoma tumor of bone: An analysis of 579 patients treated at a single institution with adjuvant or neoadjuvant chemotherapy between 1972 and 1998
-
DOI 10.1080/02841860500519760, PII Q0727654639621
-
Bacci G, Longhi A, Ferrari S, Mercuri M, Versari M, Bertoni F. Prognostic factors in non-metastatic Ewing's sarcoma tumor of bone: an analysis of 579 patients treated at a single institution with adjuvant or neoadjuvant chemotherapy between 1972 and 1998. Acta Oncol Stockholm Sweden. 2006;45(4):469-75. (Pubitemid 43884616)
-
(2006)
Acta Oncologica
, vol.45
, Issue.4
, pp. 469-475
-
-
Bacci, G.1
Longhi, A.2
Ferrari, S.3
Mercuri, M.4
Versari, M.5
Bertoni, F.6
-
61
-
-
65349144856
-
Nucleophosmin as a candidate prognostic biomarker of Ewing's sarcoma revealed by proteomics
-
19351769 10.1158/1078-0432.CCR-08-1913 1:CAS:528:DC%2BD1MXksV2nt7w%3D
-
Kikuta K, Tochigi N, Shimoda T, Yabe H, Morioka H, Toyama Y, et al. Nucleophosmin as a candidate prognostic biomarker of Ewing's sarcoma revealed by proteomics. Clin Cancer Res. 2009;15(8):2885-94.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.8
, pp. 2885-2894
-
-
Kikuta, K.1
Tochigi, N.2
Shimoda, T.3
Yabe, H.4
Morioka, H.5
Toyama, Y.6
-
62
-
-
0019816447
-
Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: An intergroup study
-
Nesbit Jr ME, Perez CA, Tefft M, Burgert Jr EO, Vietti TJ, Kissane J, et al. Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: an Intergroup Study. Natl Cancer Inst Monogr. 1981;56:255-62. (Pubitemid 12193869)
-
(1981)
National Cancer Institute Monograph
, vol.56
, pp. 255-262
-
-
Nesbit Jr., M.E.1
Perez, C.A.2
Tefft, M.3
-
63
-
-
0037456435
-
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone
-
DOI 10.1056/NEJMoa020890
-
Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003;348(8):694-701. (Pubitemid 36237038)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.8
, pp. 694-701
-
-
Grier, H.E.1
Krailo, M.D.2
Tarbell, N.J.3
Link, M.P.4
Fryer, C.J.H.5
Pritchard, D.J.6
Gebhardt, M.C.7
Dickman, P.S.8
Perlman, E.J.9
Meyers, P.A.10
Donaldson, S.S.11
Moore, S.12
Rausen, A.R.13
Vietti, T.J.14
Miser, J.S.15
-
64
-
-
84869447819
-
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: A report from the children's oncology group
-
23091096 10.1200/JCO.2011.41.5703 1:CAS:528:DC%2BC3sXosVantA%3D%3D This study determined that interval compression of chemotherapy from every 21 days to every 14 days provided significant prognostic benefit to nonmetastatic ES patients without an increase in toxicities. This has now become the standard of care for nonmetastatic patients in North America
-
•• Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, et al. Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the children's oncology group. J Clin Oncol. 2012;30(33):4148-54. This study determined that interval compression of chemotherapy from every 21 days to every 14 days provided significant prognostic benefit to nonmetastatic ES patients without an increase in toxicities. This has now become the standard of care for nonmetastatic patients in North America.
-
(2012)
J Clin Oncol
, vol.30
, Issue.33
, pp. 4148-4154
-
-
Womer, R.B.1
West, D.C.2
Krailo, M.D.3
Dickman, P.S.4
Pawel, B.R.5
Grier, H.E.6
-
65
-
-
1942422778
-
Role of Radiotherapy in Ewing Tumors
-
DOI 10.1002/pbc.10446
-
Dunst J, Schuck A. Role of radiotherapy in Ewing tumors. Pediatr Blood Cancer. 2004;42(5):465-70. (Pubitemid 38524480)
-
(2004)
Pediatric Blood and Cancer
, vol.42
, Issue.5
, pp. 465-470
-
-
Dunst, J.1
Schuck, A.2
-
66
-
-
41949134602
-
Whole lung irradiation in patients with exclusively pulmonary metastases of Ewing tumors: Toxicity analysis and treatment results of the EICESS-92 trial
-
DOI 10.1007/s00066-008-1810-x
-
Bolling T, Schuck A, Paulussen M, Dirksen U, Ranft A, Konemann S, et al. Whole lung irradiation in patients with exclusively pulmonary metastases of Ewing tumors. Toxicity analysis and treatment results of the EICESS-92 trial. Strahlenther Onkol. 2008;184(4):193-7. (Pubitemid 351508131)
-
(2008)
Strahlentherapie und Onkologie
, vol.184
, Issue.4
, pp. 193-197
-
-
Bolling, T.1
Schuck, A.2
Paulussen, M.3
Dirksen, U.4
Ranft, A.5
Konemann, S.6
Dunst, J.7
Willich, N.8
Jurgens, H.9
-
67
-
-
70149105476
-
Ewing's sarcoma: Standard and experimental treatment options
-
19533369 10.1007/s11864-009-0104-6
-
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA. Ewing's sarcoma: standard and experimental treatment options. Curr Treat Options Oncol. 2009;10(1-2):126-40.
-
(2009)
Curr Treat Options Oncol
, vol.10
, Issue.1-2
, pp. 126-140
-
-
Subbiah, V.1
Anderson, P.2
Lazar, A.J.3
Burdett, E.4
Raymond, K.5
Ludwig, J.A.6
-
68
-
-
0037080272
-
Survival after recurrence of ewing tumors: The St. Jude children's research hospital experience, 1979-1999
-
DOI 10.1002/cncr.10192
-
Rodriguez-Galindo C, Billups CA, Kun LE, Rao BN, Pratt CB, Merchant TE, et al. Survival after recurrence of Ewing tumors: the St Jude Children's Research Hospital experience, 1979-1999. Cancer. 2002;94(2):561-9. (Pubitemid 34081388)
-
(2002)
Cancer
, vol.94
, Issue.2
, pp. 561-569
-
-
Rodriguez-Galindo, C.1
Billups, C.A.2
Kun, L.E.3
Rao, B.N.4
Pratt, C.B.5
Merchant, T.E.6
Santana, V.M.7
Pappo, A.S.8
-
69
-
-
79251565814
-
Current therapeutic approaches in metastatic and recurrent ewing sarcoma
-
Huang M, Lucas K. Current therapeutic approaches in metastatic and recurrent ewing sarcoma. Sarcoma. 2011;863210.
-
(2011)
Sarcoma
, pp. 863210
-
-
Huang, M.1
Lucas, K.2
-
70
-
-
0031670670
-
Ewing's tumors with primary lung metastases: Survival analysis of 114 (European intergroup) cooperative Ewing's sarcoma studies patients
-
Paulussen M, Ahrens S, Craft AW, Dunst J, Frohlich B, Jabar S, et al. Ewing's tumors with primary lung metastases: survival analysis of 114 (European Intergroup) Cooperative Ewing's Sarcoma Studies patients. J Clin Oncol. 1998;16(9):3044-52. (Pubitemid 28417425)
-
(1998)
Journal of Clinical Oncology
, vol.16
, Issue.9
, pp. 3044-3052
-
-
Paulussen, M.1
Ahrens, S.2
Craft, A.W.3
Dunst, J.4
Frohlich, B.5
Jabar, S.6
Rube, C.7
Winkelmann, W.8
Wissing, S.9
Zoubek, A.10
Jurgens, H.11
-
71
-
-
84880264480
-
Cyclophosphamide and topotecan as first-line salvage therapy in patients with relapsed Ewing sarcoma at a single institution
-
Farhat R, Raad R, Khoury NJ, Feghaly J, Eid T, Muwakkit S, et al. Cyclophosphamide and topotecan as first-line salvage therapy in patients with relapsed Ewing sarcoma at a single institution. J Pediatr Hematol Oncol. 2012.
-
(2012)
J Pediatr Hematol Oncol
-
-
Farhat, R.1
Raad, R.2
Khoury, N.J.3
Feghaly, J.4
Eid, T.5
Muwakkit, S.6
-
72
-
-
84874115809
-
Phase II study of cisplatin and oral VP16 in patients with refractory or relapsed Ewing sarcoma
-
doi: 10.1007/S00280-012-2015-7
-
Owens C, Laurence V, Benboubker L, Defachelles AS, Cupissol D, Rubie H, et al. Phase II study of cisplatin and oral VP16 in patients with refractory or relapsed Ewing sarcoma. Cancer Chemother Pharmacol. 2013;71(2):339-404. doi: 10.1007/S00280-012-2015-7.
-
(2013)
Cancer Chemother Pharmacol
, vol.71
, Issue.2
, pp. 339-404
-
-
Owens, C.1
Laurence, V.2
Benboubker, L.3
Defachelles, A.S.4
Cupissol, D.5
Rubie, H.6
-
73
-
-
0035368059
-
High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis
-
Meyers PA, Krailo MD, Ladanyi M, Chan KW, Sailer SL, Dickman PS, et al. High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis. J Clin Oncol. 2001;19(11):2812-20. (Pubitemid 32538189)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.11
, pp. 2812-2820
-
-
Meyers, P.A.1
Krailo, M.D.2
Ladanyi, M.3
Chan, K.-W.4
Sailer, S.L.5
Dickman, P.S.6
Baker, D.L.7
Davis, J.H.8
Gerbing, R.B.9
Grovas, A.10
Herzog, C.E.11
Lindsley, K.L.12
Liu-Mares, W.13
Nachman, J.B.14
Sieger, L.15
Wadman, J.16
Gorlick, R.G.17
-
74
-
-
84870776913
-
Consolidation of first-line therapy with busulphan and melphalan, and autologous stem cell rescue in children with Ewing's sarcoma
-
22609883 10.1038/bmt.2012.78 1:CAS:528:DC%2BC38XhvVSnu77M
-
Drabko K, Raciborska A, Bilska K, Styczynski J, Ussowicz M, Choma M, et al. Consolidation of first-line therapy with busulphan and melphalan, and autologous stem cell rescue in children with Ewing's sarcoma. Bone Marrow Transplantation. 2012;47(12):1530-4.
-
(2012)
Bone Marrow Transplantation
, vol.47
, Issue.12
, pp. 1530-1534
-
-
Drabko, K.1
Raciborska, A.2
Bilska, K.3
Styczynski, J.4
Ussowicz, M.5
Choma, M.6
-
75
-
-
83255163333
-
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: Results of a phase II Sarcoma Alliance for Research through Collaboration study
-
22025149 10.1200/JCO.2010.34.0000 1:CAS:528:DC%2BC38XhtlKmtbg%3D
-
Pappo AS, Patel SR, Crowley J, Reinke DK, Kuenkele KP, Chawla SP, et al. R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study. J Clin Oncol. 2011;29(34):4541-7.
-
(2011)
J Clin Oncol
, vol.29
, Issue.34
, pp. 4541-4547
-
-
Pappo, A.S.1
Patel, S.R.2
Crowley, J.3
Reinke, D.K.4
Kuenkele, K.P.5
Chawla, S.P.6
-
76
-
-
80053062871
-
Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma
-
Juergens H, Daw NC, Geoerger B, Ferrari S, Villarroel M, Aerts I, et al. Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma. J Clin Oncol. 2011;29(34):4534-40.
-
(2011)
J Clin Oncol.
, vol.29
, Issue.34
, pp. 4534-4540
-
-
Juergens, H.1
Daw, N.C.2
Geoerger, B.3
Ferrari, S.4
Villarroel, M.5
Aerts, I.6
-
77
-
-
84862907964
-
Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: A report from the Children's Oncology Group
-
22184397 10.1200/JCO.2011.37.4355 1:CAS:528:DC%2BC38XjsFCitrY%3D
-
Malempati S, Weigel B, Ingle AM, Ahern CH, Carroll JM, Roberts CT, et al. Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2012;30(3):256-62.
-
(2012)
J Clin Oncol
, vol.30
, Issue.3
, pp. 256-262
-
-
Malempati, S.1
Weigel, B.2
Ingle, A.M.3
Ahern, C.H.4
Carroll, J.M.5
Roberts, C.T.6
-
78
-
-
79956205779
-
Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models
-
21385891 10.1124/jpet.110.178400 1:CAS:528:DC%2BC3MXmvFeitbY%3D
-
Beltran PJ, Chung YA, Moody G, Mitchell P, Cajulis E, Vonderfecht S, et al. Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models. J Pharmacol Exp Ther. 2011;337(3):644-54.
-
(2011)
J Pharmacol Exp Ther
, vol.337
, Issue.3
, pp. 644-654
-
-
Beltran, P.J.1
Chung, Y.A.2
Moody, G.3
Mitchell, P.4
Cajulis, E.5
Vonderfecht, S.6
-
79
-
-
84865585349
-
Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma
-
22798295 10.1210/me.2012-1142 1:CAS:528:DC%2BC38XhtlentLnE
-
Garofalo C, Mancarella C, Grilli A, Manara MC, Astolfi A, Marino MT, et al. Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma. Mol Endocrinol. 2012;26(9):1603-16.
-
(2012)
Mol Endocrinol
, vol.26
, Issue.9
, pp. 1603-1616
-
-
Garofalo, C.1
Mancarella, C.2
Grilli, A.3
Manara, M.C.4
Astolfi, A.5
Marino, M.T.6
-
80
-
-
79958863370
-
Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling
-
21278796 10.1038/onc.2010.640 1:CAS:528:DC%2BC3MXht12mt7o%3D This report elucidates the role of insulin signaling as a possible mechanism towards IGF-1R antibody therapy, thus suggesting that targeting the insulin receptor pathway, or its downstream signaling cascade, could be an avenue of therapeutic potential
-
• Garofalo C, Manara MC, Nicoletti G, Marino MT, Lollini PL, Astolfi A, et al. Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling. Oncogene. 2011;30(24):2730-40. This report elucidates the role of insulin signaling as a possible mechanism towards IGF-1R antibody therapy, thus suggesting that targeting the insulin receptor pathway, or its downstream signaling cascade, could be an avenue of therapeutic potential.
-
(2011)
Oncogene
, vol.30
, Issue.24
, pp. 2730-2740
-
-
Garofalo, C.1
Manara, M.C.2
Nicoletti, G.3
Marino, M.T.4
Lollini, P.L.5
Astolfi, A.6
-
81
-
-
67650447477
-
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
-
19584866 10.1038/nm.1983 1:CAS:528:DC%2BD1MXotlSntrk%3D This report describes the identification of one of the first small molecules specifically designed to target the transcriptional activity of the oncogenic EWS-Fli1 protein. They demonstrate that inhibition of the EWS-Fli1 and RHA interaction leads to altered cell proliferation and xenograft tumor progression
-
• Erkizan HV, Kong Y, Merchant M, Schlottmann S, Barber-Rotenberg JS, Yuan L, et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med. 2009;15(7):750-6. This report describes the identification of one of the first small molecules specifically designed to target the transcriptional activity of the oncogenic EWS-Fli1 protein. They demonstrate that inhibition of the EWS-Fli1 and RHA interaction leads to altered cell proliferation and xenograft tumor progression.
-
(2009)
Nat Med
, vol.15
, Issue.7
, pp. 750-756
-
-
Erkizan, H.V.1
Kong, Y.2
Merchant, M.3
Schlottmann, S.4
Barber-Rotenberg, J.S.5
Yuan, L.6
-
82
-
-
84865561615
-
Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma
-
22323082 10.1002/ijc.27472 1:CAS:528:DC%2BC38Xks12gurk%3D
-
Boro A, Pretre K, Rechfeld F, Thalhammer V, Oesch S, Wachtel M, et al. Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma. Int J Cancer. 2012;131(9):2153-64.
-
(2012)
Int J Cancer
, vol.131
, Issue.9
, pp. 2153-2164
-
-
Boro, A.1
Pretre, K.2
Rechfeld, F.3
Thalhammer, V.4
Oesch, S.5
Wachtel, M.6
-
83
-
-
79951471957
-
Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells
-
21403840 1:CAS:528:DC%2BC3MXivVensrs%3D
-
Grohar PJ, Griffin LB, Yeung C, Chen QR, Pommier Y, Khanna C, et al. Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells. Neoplasia. 2011;13(2):145-53.
-
(2011)
Neoplasia
, vol.13
, Issue.2
, pp. 145-153
-
-
Grohar, P.J.1
Griffin, L.B.2
Yeung, C.3
Chen, Q.R.4
Pommier, Y.5
Khanna, C.6
-
84
-
-
84857053120
-
A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children's Oncology Group
-
22088484 10.1016/j.ejca.2011.09.027 1:CAS:528:DC%2BC38XislSkur0%3D
-
Baruchel S, Pappo A, Krailo M, Baker KS, Wu B, Villaluna D, et al. A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: a report from the Children's Oncology Group. Eur J Cancer. 2012;48(4):579-85.
-
(2012)
Eur J Cancer
, vol.48
, Issue.4
, pp. 579-585
-
-
Baruchel, S.1
Pappo, A.2
Krailo, M.3
Baker, K.S.4
Wu, B.5
Villaluna, D.6
-
85
-
-
84873710768
-
Initial testing of the MDM2 inhibitor RG7112 by the pediatric preclinical testing program
-
10.1002/pbc.24235 22753001 10.1002/pbc.24235
-
Carol H, Reynolds CP, Kang MH, Keir ST, Maris JM, Gorlick R, et al. Initial testing of the MDM2 inhibitor RG7112 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60(4):633-41. doi: 10.1002/pbc.24235.
-
(2013)
Pediatr Blood Cancer
, vol.60
, Issue.4
, pp. 633-641
-
-
Carol, H.1
Reynolds, C.P.2
Kang, M.H.3
Keir, S.T.4
Maris, J.M.5
Gorlick, R.6
-
87
-
-
79551713220
-
Nutlin-3a is a potential therapeutic for ewing sarcoma
-
21098696 10.1158/1078-0432.CCR-10-1587 1:CAS:528:DC%2BC3MXhsVersbo%3D This study demonstrates that activating the endogenous, unmutated p53 pathway, through the inhibition of MDM2 via Nutlin-3a, can lead to significant antitumor activity and synergism with standard chemotherapy. This is a potentially exciting new therapeutic target for ES
-
• Pishas KI, Al-Ejeh F, Zinonos I, Kumar R, Evdokiou A, Brown MP, et al. Nutlin-3a is a potential therapeutic for ewing sarcoma. Clin Cancer Res. 2011;17(3):494-504. This study demonstrates that activating the endogenous, unmutated p53 pathway, through the inhibition of MDM2 via Nutlin-3a, can lead to significant antitumor activity and synergism with standard chemotherapy. This is a potentially exciting new therapeutic target for ES.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.3
, pp. 494-504
-
-
Pishas, K.I.1
Al-Ejeh, F.2
Zinonos, I.3
Kumar, R.4
Evdokiou, A.5
Brown, M.P.6
-
88
-
-
84858290569
-
The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting
-
22374462 10.1038/bjc.2012.57 1:CAS:528:DC%2BC38XktVaitrY%3D
-
Kailayangiri S, Altvater B, Meltzer J, Pscherer S, Luecke A, Dierkes C, et al. The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting. Br J Cancer. 2012;106(6):1123-33.
-
(2012)
Br J Cancer
, vol.106
, Issue.6
, pp. 1123-1133
-
-
Kailayangiri, S.1
Altvater, B.2
Meltzer, J.3
Pscherer, S.4
Luecke, A.5
Dierkes, C.6
-
89
-
-
84857081656
-
Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection
-
22355347 10.1371/journal.pone.0031210 1:CAS:528:DC%2BC38XjtVelu7k%3D
-
Lehner M, Gotz G, Proff J, Schaft N, Dorrie J, Full F, et al. Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection. PLoS One. 2012;7(2):e31210.
-
(2012)
PLoS One
, vol.7
, Issue.2
, pp. 31210
-
-
Lehner, M.1
Gotz, G.2
Proff, J.3
Schaft, N.4
Dorrie, J.5
Full, F.6
-
90
-
-
79953773922
-
Systemic administration of reovirus (Reolysin) inhibits growth of human sarcoma xenografts
-
21472724 10.1002/cncr.25741 1:CAS:528:DC%2BC3MXlvFWktr0%3D
-
Hingorani P, Zhang W, Lin J, Liu L, Guha C, Kolb EA. Systemic administration of reovirus (Reolysin) inhibits growth of human sarcoma xenografts. Cancer. 2011;117(8):1764-74.
-
(2011)
Cancer
, vol.117
, Issue.8
, pp. 1764-1774
-
-
Hingorani, P.1
Zhang, W.2
Lin, J.3
Liu, L.4
Guha, C.5
Kolb, E.A.6
-
91
-
-
74549164751
-
NVP-BEZ235 as a new therapeutic option for sarcomas
-
20068094 10.1158/1078-0432.CCR-09-0816 1:CAS:528:DC%2BC3cXktF2qtrg%3D
-
Manara MC, Nicoletti G, Zambelli D, Ventura S, Guerzoni C, Landuzzi L, et al. NVP-BEZ235 as a new therapeutic option for sarcomas. Clin Cancer Res. 2010;16(2):530-40.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.2
, pp. 530-540
-
-
Manara, M.C.1
Nicoletti, G.2
Zambelli, D.3
Ventura, S.4
Guerzoni, C.5
Landuzzi, L.6
-
92
-
-
79957545097
-
Anticancer effects of the p53 activator nutlin-3 in Ewing's sarcoma cells
-
21334198 10.1016/j.ejca.2011.01.015 1:CAS:528:DC%2BC3MXmvVejsLw%3D
-
Sonnemann J, Palani CD, Wittig S, Becker S, Eichhorn F, Voigt A, et al. Anticancer effects of the p53 activator nutlin-3 in Ewing's sarcoma cells. Eur J Cancer. 2011;47(9):1432-41.
-
(2011)
Eur J Cancer
, vol.47
, Issue.9
, pp. 1432-1441
-
-
Sonnemann, J.1
Palani, C.D.2
Wittig, S.3
Becker, S.4
Eichhorn, F.5
Voigt, A.6
-
93
-
-
77957337429
-
Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients
-
20841471 10.1158/0008-5472.CAN-09-4272 1:CAS:528:DC%2BC3cXht1akt7bL
-
Odri GA, Dumoucel S, Picarda G, Battaglia S, Lamoureux F, Corradini N, et al. Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients. Cancer Res. 2010;70(19):7610-9.
-
(2010)
Cancer Res
, vol.70
, Issue.19
, pp. 7610-7619
-
-
Odri, G.A.1
Dumoucel, S.2
Picarda, G.3
Battaglia, S.4
Lamoureux, F.5
Corradini, N.6
-
94
-
-
77950980364
-
Preclinical evidence that use of TRAIL in Ewing's sarcoma and osteosarcoma therapy inhibits tumor growth, prevents osteolysis, and increases animal survival
-
20371692 10.1158/1078-0432.CCR-09-1779 1:CAS:528:DC%2BC3cXkslSlsro%3D
-
Picarda G, Lamoureux F, Geffroy L, Delepine P, Montier T, Laud K, et al. Preclinical evidence that use of TRAIL in Ewing's sarcoma and osteosarcoma therapy inhibits tumor growth, prevents osteolysis, and increases animal survival. Clin Cancer Res. 2010;16(8):2363-74.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.8
, pp. 2363-2374
-
-
Picarda, G.1
Lamoureux, F.2
Geffroy, L.3
Delepine, P.4
Montier, T.5
Laud, K.6
-
95
-
-
84863338259
-
Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program
-
21584937 10.1002/pbc.23176
-
Lock RB, Carol H, Morton CL, Keir ST, Reynolds CP, Kang MH, et al. Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012;58(6):916-23.
-
(2012)
Pediatr Blood Cancer
, vol.58
, Issue.6
, pp. 916-923
-
-
Lock, R.B.1
Carol, H.2
Morton, C.L.3
Keir, S.T.4
Reynolds, C.P.5
Kang, M.H.6
-
96
-
-
84859391984
-
PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma
-
22287547 10.1158/0008-5472.CAN-11-3648 1:CAS:528:DC%2BC38XkvVels7Y%3D This study demonstrated that targeting the interaction between EWS-Fli1 and the DNA damaging response protein, PARP-1, led to significant decrease in tumor growth and metastasis. Addition of Temozolomide resulted in complete responses in xenograft models
-
• Brenner JC, Feng FY, Han S, Patel S, Goyal SV, Bou-Maroun LM, et al. PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma. Cancer Res. 2012;72(7):1608-13. This study demonstrated that targeting the interaction between EWS-Fli1 and the DNA damaging response protein, PARP-1, led to significant decrease in tumor growth and metastasis. Addition of Temozolomide resulted in complete responses in xenograft models.
-
(2012)
Cancer Res
, vol.72
, Issue.7
, pp. 1608-1613
-
-
Brenner, J.C.1
Feng, F.Y.2
Han, S.3
Patel, S.4
Goyal, S.V.5
Bou-Maroun, L.M.6
|