ERM proteins: From cellular architecture to cell signaling

Biology of the Cell

Volumn 92, Issue 5, 2000, Pages 305-316

  Louvet Vallée, Sophie ^a  

^a Université René Descartes   (France)

Author keywords

Cell signalling; Cytoskeleton; ERM proteins; Membrane dynamics

Indexed keywords

ACTIN; CELL PROTEIN; CELL SURFACE PROTEIN; CYTOSKELETON PROTEIN; EZRIN; MOESIN; RADIXIN; RHO FACTOR;

ACTIN FILAMENT; AMINO TERMINAL SEQUENCE; ANIMAL CELL; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL ADHESION; CELL MEMBRANE; CELL MOTILITY; CELL SHAPE; CELL SURFACE; CONTROLLED STUDY; CYTOARCHITECTURE; CYTOSKELETON; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; MICROVILLUS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW;

ANIMALIA;

EID: 0033777011     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0248-4900(00)01078-9     Document Type: Review

References (90)

1. Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker
2. Radixin is a component of hepatocyte microvilli in situ
3. Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts
4. Characterization of moesin in the sea urchin Lytechinus variegatus: Redistribution to the plasma membrane following fertilization is inhibited by cytochalasin
5. The spectrin-actin junction of erythrocyte membrane skeletons
6. Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells
7. Mapping of ezrin dimerization using yeast two-hybrid screening
8. Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium
9. Purification of an 80,000-daltion protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells
10. Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor
11. Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains
12. Ezrin: A protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures
13. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor
14. Cytoskeletal dissociation of ezrin during renal anoxia: Role in microvillar injury
15. Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury
16. The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane
17. Identification of the functional site of erythrocyte protein 4.1 involved in spectrinactin associations
18. Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells
19. Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes
20. Normal development of mice and unimpaired cell adhesion / cell motility / actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout
21. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein
22. Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast
23. Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable
24. Association of the myosin-binding subunit of myosin phosphatase and moesin: Dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase
25. Radixin is a novel member of the band 4.1 family
26. Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase / Akt pathway
27. CDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1
28. Ezrin links syndecan-2 to the cytoskeleton
29. Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1
30. Immunological localization of an 80-kDa phosphoprotein to the apical membrane of gastric parietal cells
31. The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli
32. ICAM-2 redistributed by ezrin as a target for killer cells
33. Regulation mechanism of ERM., ezrin/radixin/moesin) protein/plasma membrane association: Possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
34. Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/(and bgr;)-catenin
35. Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells
36. A highly expressed 81 kDa protein in immortalized mouse fibroblast: Its proliferative function and identity with ezrin
37. ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis
38. Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells
39. Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin
40. Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts
41. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
42. A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation
43. Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44
44. Ezrin becomes restricted to outer cells following asymmetrical division in the preimplantation mouse embryo
45. Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: An essential role for ezrin/radixin/moesin proteins
46. Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein
47. Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain
48. Three determinants in ezrin are responsible for cell extension activity
49. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin,(ERM) proteins and regulates their head-to-tail association
50. Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases
51. Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin
52. Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets
53. Identification of a phosphatidylinositol-4,5-bisphosphate-binding domain in the N-terminal region of ezrin
54. Immunofluorescent and immunochemical evidence for the expression of cytovillin in the microvilli of a wide range of cultured human cells
55. Microvillus-specific Mr 75,000 plasma membrane protein of human choriocarcinoma cells
56. Redistribution of Mr 75,000 plasma membrane protein, cytovillin, into newly formed microvilli in herpes simplex and Semliki Forest virus infected human embryonal fibroblasts
57. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
58. Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes
59. Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence
60. Calpain regulates actin remodeling during cell spreading
61. The carboxyl-terminal region of EBP50 binds to a site in the amino- terminal domain of ezrin that is masked in the dormant molecule
62. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
63. Sequence and domain structure of talin
64. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2
65. A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding
66. Radixin, a barbed end-capping actin-modulating protein, is concentrated at the cleavage furrow during cytokinesis
67. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites
68. Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes
69. The many faces of Src: Multiple functions of a prototypical tyrosine kinase
70. Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization
71. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts
72. Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain
73. Indirect association of ezrin with F-actin: Isoform specificity and calcium sensitivity
74. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
75. Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl
76. Brachyury downstream notochord differentiation in the ascidian embryo
77. Structural diversity of band 4.1 superfamily members
78. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members
79. Identification and characterisation of Xenopus moesin, a Src substrate in Xenopus laevis oocytes
80. Ligation of CD4 surface antigen induces rapid tyrosine phosphorylation of the cytoskeletal protein ezrin
81. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
82. A new 82-kD barbed end-capping protein (radixin) localized in the cell- to-cell adherens junction: Purification and characterization
83. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
84. Cytovillin, a microvillar Mr 75,000 protein. cDNA sequence, prokaryotic expression, and chromosomal localization
85. Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family
86. Ezrin-calpain I interactions in gastric parietal cells
87. Biochemical characterization of ezrin-actin interaction
88. Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins
89. Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons
90. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2