-
1
-
-
0029003427
-
Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas
-
De Leeuw B, Balemans M, Weghuis DO, van Kessel AG. Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. Hum Mol Gene 1995; 4: 1097-9.
-
(1995)
Hum Mol Gene
, vol.4
, pp. 1097-1099
-
-
De Leeuw, B.1
Balemans, M.2
Weghuis, D.O.3
van Kessel, A.G.4
-
2
-
-
0029066330
-
Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma
-
Crew AJ, Clark J, Fisher C et al. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J 1995; 14: 2333-40.
-
(1995)
EMBO J
, vol.14
, pp. 2333-2340
-
-
Crew, A.J.1
Clark, J.2
Fisher, C.3
-
3
-
-
0031740499
-
Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues
-
Tsuji S, Hisaoka M, Morimitsu Y et al. Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues. Am J Pathol 1998; 153: 1807-12.
-
(1998)
Am J Pathol
, vol.153
, pp. 1807-1812
-
-
Tsuji, S.1
Hisaoka, M.2
Morimitsu, Y.3
-
4
-
-
38749096959
-
Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan
-
Takenaka S, Ueda T, Naka N et al. Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan. Oncol Rep 2008; 19: 467-76.
-
(2008)
Oncol Rep
, vol.19
, pp. 467-476
-
-
Takenaka, S.1
Ueda, T.2
Naka, N.3
-
6
-
-
77954823179
-
Synovial sarcoma is a stem cell malignancy
-
Naka N, Takenaka S, Araki N et al. Synovial sarcoma is a stem cell malignancy. Stem Cells 2010; 28: 1119-31.
-
(2010)
Stem Cells
, vol.28
, pp. 1119-1131
-
-
Naka, N.1
Takenaka, S.2
Araki, N.3
-
7
-
-
84861414679
-
Reprogramming of mesenchymal stem cells by synovial sarcoma-associated oncogene SYT-SSX2
-
Garcia CB, Shaffer CM, Alfaro MP et al. Reprogramming of mesenchymal stem cells by synovial sarcoma-associated oncogene SYT-SSX2. Oncogene 2012; 31: 2323-34.
-
(2012)
Oncogene
, vol.31
, pp. 2323-2334
-
-
Garcia, C.B.1
Shaffer, C.M.2
Alfaro, M.P.3
-
8
-
-
84863337645
-
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics
-
Su L, Sampaio AV, Jones KB et al. Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell 2012; 21: 333-47.
-
(2012)
Cancer Cell
, vol.21
, pp. 333-347
-
-
Su, L.1
Sampaio, A.V.2
Jones, K.B.3
-
9
-
-
84875727068
-
Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma
-
Kadoch C, Crabtree GR. Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell 2013; 153: 71-85.
-
(2013)
Cell
, vol.153
, pp. 71-85
-
-
Kadoch, C.1
Crabtree, G.R.2
-
10
-
-
25444443688
-
Modelling glandular epithelial cancer in three-dimensional cultures
-
Debnath J, Brugge SJ. Modelling glandular epithelial cancer in three-dimensional cultures. Nat Rev Cancer 2005; 5: 675-88.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 675-688
-
-
Debnath, J.1
Brugge, S.J.2
-
11
-
-
34248650697
-
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
-
Kenny AP, Lee GY, Myers CA et al. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 2007; 1: 84-96.
-
(2007)
Mol Oncol
, vol.1
, pp. 84-96
-
-
Kenny, A.P.1
Lee, G.Y.2
Myers, C.A.3
-
12
-
-
84855723930
-
The effect of vironectin on the differentiation of embryonic stem cells in a 3D culture system
-
Heydarkhan-Hagvall S, Gluck JM, Delman C et al. The effect of vironectin on the differentiation of embryonic stem cells in a 3D culture system. Biomaterials 2012; 33: 2032-40.
-
(2012)
Biomaterials
, vol.33
, pp. 2032-2040
-
-
Heydarkhan-Hagvall, S.1
Gluck, J.M.2
Delman, C.3
-
13
-
-
79955009779
-
Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer
-
Kondo J, Endo H, Okuyama H et al. Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer. PNAS 2011; 108: 6235-40.
-
(2011)
PNAS
, vol.108
, pp. 6235-6240
-
-
Kondo, J.1
Endo, H.2
Okuyama, H.3
-
14
-
-
84856989746
-
Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells
-
Muranen T, Selfors LM, Worster DT et al. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell 2012; 21: 227-39.
-
(2012)
Cancer Cell
, vol.21
, pp. 227-239
-
-
Muranen, T.1
Selfors, L.M.2
Worster, D.T.3
-
15
-
-
83355163224
-
The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs
-
Chen L, Xiao Z, Meng Y et al. The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials 2012; 33: 1437-44.
-
(2012)
Biomaterials
, vol.33
, pp. 1437-1444
-
-
Chen, L.1
Xiao, Z.2
Meng, Y.3
-
18
-
-
34548443831
-
Vascular endothelial growth factor receptor-2: structure, function, intracellular signaling and therapeutic inhibition
-
Holmes K, Roberts OL, Thomas AM, Cross MJ. Vascular endothelial growth factor receptor-2: structure, function, intracellular signaling and therapeutic inhibition. Cell Signal 2007; 19: 2003-12.
-
(2007)
Cell Signal
, vol.19
, pp. 2003-2012
-
-
Holmes, K.1
Roberts, O.L.2
Thomas, A.M.3
Cross, M.J.4
-
19
-
-
43249095919
-
Tumor angiogenesis
-
Kerbel RS. Tumor angiogenesis. N Engl J Med 2008; 358: 2039-49.
-
(2008)
N Engl J Med
, vol.358
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
20
-
-
34547941252
-
Autocrine VEGF signaling is required for vascular homeostasis
-
Lee S, Chen TT, Barber CL et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell 2007; 130: 691-703.
-
(2007)
Cell
, vol.130
, pp. 691-703
-
-
Lee, S.1
Chen, T.T.2
Barber, C.L.3
-
21
-
-
80055003796
-
A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumors
-
Beck B, Driessens G, Goossens S et al. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumors. Nature 2011; 478: 399-403.
-
(2011)
Nature
, vol.478
, pp. 399-403
-
-
Beck, B.1
Driessens, G.2
Goossens, S.3
-
22
-
-
74549133965
-
Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development
-
Lichtenberger BM, Tan PK, Niederleithner H et al. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell 2010; 140: 268-79.
-
(2010)
Cell
, vol.140
, pp. 268-279
-
-
Lichtenberger, B.M.1
Tan, P.K.2
Niederleithner, H.3
-
23
-
-
47949089077
-
VEGF-targeted therapy: mechanisms of anti-tumor activity
-
Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumor activity. Nat Rev Cancer 2008; 8: 579-91.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
24
-
-
80052933197
-
Basic and therapeutic aspects of angiogenesis
-
Potent M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell 2011; 146: 873-87.
-
(2011)
Cell
, vol.146
, pp. 873-887
-
-
Potent, M.1
Gerhardt, H.2
Carmeliet, P.3
-
25
-
-
0031008750
-
The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts
-
Takahashi T, Shibuya M. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 1997; 14: 2079-89.
-
(1997)
Oncogene
, vol.14
, pp. 2079-2089
-
-
Takahashi, T.1
Shibuya, M.2
-
26
-
-
0036359548
-
Hypoxia-a key regulatory factor in tumor growth
-
Harris AL. Hypoxia-a key regulatory factor in tumor growth. Nat Rev Cancer 2002; 2: 38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
27
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3: 391-400.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
28
-
-
49449117755
-
Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor
-
Harris PA, Boloor A, Cheung M et al. Discovery of 5-[[4-[(2, 3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor. J Med Chem 2008; 51: 4632-40.
-
(2008)
J Med Chem
, vol.51
, pp. 4632-4640
-
-
Harris, P.A.1
Boloor, A.2
Cheung, M.3
-
29
-
-
34447322566
-
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
-
Kumar R, Knick VB, Rudolph SK et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2011; 6: 2012-21.
-
(2011)
Mol Cancer Ther
, vol.6
, pp. 2012-2021
-
-
Kumar, R.1
Knick, V.B.2
Rudolph, S.K.3
-
30
-
-
77749261678
-
Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo
-
Takenaka S, Naka N, Araki N et al. Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo. Int J Oncol 2010; 36: 823-31.
-
(2010)
Int J Oncol
, vol.36
, pp. 823-831
-
-
Takenaka, S.1
Naka, N.2
Araki, N.3
-
32
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III Trial
-
Sternberg CN, Davis ID, Mardiak J et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III Trial. J Clin Oncol 2010; 28: 1061-8.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
-
33
-
-
73349120007
-
Independent review of E2100: a phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer
-
Gray R, Bhattacharya S, Bowden C, Miller K, Comis RL. Independent review of E2100: a phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer. J Clin Oncol 2009; 27: 4966-72.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4966-4972
-
-
Gray, R.1
Bhattacharya, S.2
Bowden, C.3
Miller, K.4
Comis, R.L.5
-
34
-
-
62449204461
-
Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma
-
Oda Y, Tateishi N, Matono H et al. Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma. Int J Cancer 2009; 124: 1852-9.
-
(2009)
Int J Cancer
, vol.124
, pp. 1852-1859
-
-
Oda, Y.1
Tateishi, N.2
Matono, H.3
-
35
-
-
77953090345
-
CXCL12 (SDF-1)/CXCR4 pathway in cancer
-
Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010; 16: 2927-31.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2927-2931
-
-
Teicher, B.A.1
Fricker, S.P.2
-
36
-
-
84871412842
-
A review on CXCR4/CXCL12 axis in oncology: no place to hide
-
Domanska UM. A review on CXCR4/CXCL12 axis in oncology: no place to hide. Eur J Cancer 2013; 49: 219-30.
-
(2013)
Eur J Cancer
, vol.49
, pp. 219-230
-
-
Domanska, U.M.1
-
37
-
-
77951667987
-
Mechanism of resistance to antiangiogenesis therapy
-
Azam F, Mehta S, Harris AL. Mechanism of resistance to antiangiogenesis therapy. Eur J Cancer 2010; 46: 1323-32.
-
(2010)
Eur J Cancer
, vol.46
, pp. 1323-1332
-
-
Azam, F.1
Mehta, S.2
Harris, A.L.3
-
38
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Pàez-Ribes M, Allen E, Hudock J et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15: 220-31.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Pàez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
39
-
-
55249126800
-
The role of endothelial-to-mesenchymal transition in cancer progression
-
Potenta S, Zeisberg E, Kalluri R. The role of endothelial-to-mesenchymal transition in cancer progression. Br J Cancer 2008; 99: 1375-9.
-
(2008)
Br J Cancer
, vol.99
, pp. 1375-1379
-
-
Potenta, S.1
Zeisberg, E.2
Kalluri, R.3
-
40
-
-
78650153633
-
Tumor vascularization via endothelial differentiation of glioblastoma stem-like cells
-
Ricci-Vitiani L, Pallini R, Biffoni M et al. Tumor vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 2010; 468: 824-8.
-
(2010)
Nature
, vol.468
, pp. 824-828
-
-
Ricci-Vitiani, L.1
Pallini, R.2
Biffoni, M.3
-
41
-
-
84883482019
-
SOX2 expression associates with stem cell state in human ovarian carcinoma
-
Bareiss PM, Paczulla A, Wang H et al. SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Res 2013; 73: 5544-55.
-
(2013)
Cancer Res
, vol.73
, pp. 5544-5555
-
-
Bareiss, P.M.1
Paczulla, A.2
Wang, H.3
-
42
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Bianco I, Sawyers CL. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Bianco, I.1
Sawyers, C.L.2
|