Ewing sarcoma family of tumors

Journal of the American Academy of Orthopaedic Surgeons

Volumn 18, Issue 2, 2010, Pages 97-107

  Maheshwari, Aditya V ^a   Cheng, Edward Y ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; BONE TUMOR; CANCER STAGING; EWING SARCOMA; GENE TRANSLOCATION; GENETICS; HUMAN; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PROGNOSIS; REVIEW; SECOND CANCER; TUMOR RECURRENCE;

ALGORITHMS; BONE NEOPLASMS; COMBINED MODALITY THERAPY; HUMANS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASMS, SECOND PRIMARY; PROGNOSIS; SARCOMA, EWING'S; TRANSLOCATION, GENETIC;

EID: 77149130490     PISSN: 1067151X     EISSN: None     Source Type: Journal    
DOI: 10.5435/00124635-201002000-00004     Document Type: Review

References (74)

1. Stout AP: A tumor of the ulnar nerve. Proc NY Pathol Soc 1918;18:2-13.
2. Ewing J: Diffuse endothelioma of bone. Proc NY Pathol Soc 1921;21:17-24.
3. Angervall L, Enzinger FM: Extraskeletal neoplasm resembling Ewing's sarcoma. Cancer 1975;36:240-251.
4. Askin FB, Rosai J, Sibley RK, Dehner LP, McAlister WH: Malignant small cell tumor of the thoracopulmonary region in childhood: A distinctive clinico-pathologic entity of uncertain histogenesis. Cancer 1979;43:2438-2451.
5. Jaffe R, Santamaria M, Yunis EJ, et al: The neuroectodermal tumor of bone. Am J Surg Pathol 1984;8:885-898.
6. Ludwig JA: Ewing sarcoma: Historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol 2008;20:412-418.
7. Delattre O, Zucman J, Melot T, et al: The Ewing family of tumors: A subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994;331:294-299.
8. Grier HE: The Ewing family of tumors: Ewing's sarcoma and primitive neuroectodermal tumors. Pediatr Clin North Am 1997;44:991-1004.
9. Tucker MA, D'Angio GJ, Boice JD Jr, et al: Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 1987;317:588-593.
10. Gibbs CP Jr, Weber K, Scarborough MT: Malignant bone tumors. Instr Course Lect 2002;51:413-428.
11. Herzog CE: Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol 2005;27:215-218. Medline
12. Rodríguez-Galindo C, Navid F, Liu T, Billups CA, Rao BN, Krasin MJ: Prognostic factors for local and distant control in Ewing sarcoma family of tumors. Ann Oncol 2008;19:814-820.
13. Rodriguez-Galindo C, Billups CA, Kun LE, et al: Survival after recurrence of Ewing tumors: The St. Jude Children's Research Hospital experience, 1979-1999. Cancer 2002;94:561-569.
14. Rodríguez-Galindo C, Liu T, Krasin MJ, et al: Analysis of prognostic factors in ewing sarcoma family of tumors: Review of St. Jude Children's Research Hospital studies. Cancer 2007;110:375-384.
15. Cotterill SJ, Ahrens S, Paulussen M, et al: Prognostic factors in Ewing's tumor of bone: Analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol 2000;18:3108-3114.
16. Gurney JG, Swensen AR, Bulterys M: Malignant bone tumors, in Ries LA, Smith MA, GurneyJG, et al, eds: Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975-1995. Bethesda, MD, National Institutes of Health, 1999, pp 99-110.
17. Esiashvili N, Goodman M, Marcus RB Jr: Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance epidemiology and end results data. J Pediatr Hematol Oncol 2008;30:425-430.
18. Dunst J, Jürgens H, Sauer R, et al: Radiation therapy in Ewing's sarcoma: An update of the CESS 86 trial. Int J Radiat Oncol Biol Phys 1995;32:919-930.
19. Dunst J, Schuck A: Role of radiotherapy in Ewing tumors. Pediatr Blood Cancer 2004;42:465-470.
20. Ozaki T, Hillmann A, Hoffmann C, et al: Significance of surgical margin on the prognosis of patients with Ewing's sarcoma: A report from the Cooperative Ewing's Sarcoma Study. Cancer 1996;78: 892-900.
21. Ginsberg JP, Woo SY, Johnson ME, Hicks MJ, Horowitz ME: Ewing's sarcoma family of tumors: Ewing's sarcoma of bone and soft tissue and the peripheral primitive neuroectodermal tumors, in Pizzo PA, Poplack DG, eds: Principles and Practice of Pediatric Oncology, ed 4. Philadelphia, PA, Lippincott Williams and Wilkins, 2002, pp 973-1016.
22. Grier HE, Krailo MD, Tarbell NJ, et al: Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003;348: 694-701.
23. Kissane JM, Askin FB, Foulkes M, Stratton LB, Shirley SF: Ewing's sarcoma of bone: Clinicopathologic aspects of 303 cases from the Intergroup Ewing's Sarcoma Study. Hum Pathol 1983;14: 773-779.
24. Paulussen M, Ahrens S, Dunst J, et al: Localized Ewing tumor of bone: Final results of the cooperative Ewing's Sarcoma Study CESS 86. J Clin Oncol 2001;19:1818-1829.
25. Reinus WR, Gilula LA, IESS Committee: Radiology of Ewing's sarcoma: Intergroup Ewing's Sarcoma Study. Radiographics 1984;4:929-944.
26. Green DM: Diagnosis and Management of Malignant Solid Tumors in Infants and Children. Boston, MA, Martinus Nijhoff Publishing, 1985.
27. Pritchard DJ, Dahlin DC, Dauphine RT, Taylor WF, Beabout JW: Ewing's sarcoma: A clinicopathological and statistical analysis of patients surviving five years or longer. J Bone Joint Surg Am 1975;57:10-16.
28. Widhe B, Widhe T: Initial symptoms and clinical features in osteosarcoma and Ewing sarcoma. J Bone Joint Surg Am 2000;82:667-674.
29. Bacci G, Balladelli A, Forni C, et al: Ewing's sarcoma family tumours: Differences in clinicopathological characteristics at presentation between localised and metastatic tumours. J Bone Joint Surg Br 2007;89:1229-1233.
30. van der Woude HJ, Bloem JL, Hogendoorn PC: Preoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing's sarcoma: Review of current imaging modalities. Skeletal Radiol 1998;27:57-71.
31. Greene FL: Musculoskeletal sites, in Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, Morrow M, eds: AJCC Cancer Staging Manual, ed 6. New York, NY, Springer, 2002, pp 185-200.
32. Enneking WF, Spanier SS, Goodman MA: A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 1980;153:106-120.
33. Sebire NJ, Gibson S, Rampling D, Williams S, Malone M, Ramsay AD: Immunohistochemical findings in embryonal small round cell tumors with molecular diagnostic confirmation. Appl Immunohistochem Mol Morphol 2005; 13:1-5.
34. Lin PP, Brody RI, Hamelin AC, Bradner JE, Healey JH, Ladanyi M: Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma. Cancer Res 1999;59:1428-1432.
35. Urano F, Umezawa A, Yabe H, et al: Molecular analysis of Ewing's sarcoma: Another fusion gene, EWS-E1AF, available for diagnosis. Jpn J Cancer Res 1998;89:703-711.
36. Bridge RS, Rajaram V, Dehner LP, Pfeifer JD, Perry A: Molecular diagnosis of Ewing sarcoma/primitive neuroectodermal tumor in routinely processed tissue: A comparison of two FISH strategies and RT-PCR in malignant round cell tumors. Mod Pathol 2006;19:1-8.
37. Thorner P, Squire J, Chilton-MacNeil S, et al: Is the EWS/FLI-1 fusion transcript specific for Ewing sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types. Am J Pathol 1996;148:1125-1138.
38. Ladanyi M, Gerald W: Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res 1994;54:2837-2840.
39. Zucman J, Delattre O, Desmaze C, et al: EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat Genet 1993;4:341-345.
40. Bacci G, Ferrari S, Longhi A, et al: Role of surgery in local treatment of Ewing's sarcoma of the extremities in patients undergoing adjuvant and neoadjuvant chemotherapy. Oncol Rep 2004;11:111-120.
41. Bacci G, Forni C, Longhi A, et al: Longterm outcome for patients with non-metastatic Ewing's sarcoma treated with adjuvant and neoadjuvant chemotherapies: 402 patients treated at Rizzoli between 1972 and 1992. Eur J Cancer 2004;40:73-83.
42. Bacci G, Longhi A, Ferrari S, et al: Pattern of relapse in 290 patients with nonmetastatic Ewing's sarcoma family tumors treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. Eur J Surg Oncol 2006;32:974-979.
43. Bacci G, Longhi A, Ferrari S, Mercuri M, Versari M, Bertoni F: Prognostic factors in non-metastatic Ewing's sarcoma tumor of bone: An analysis of 579 patients treated at a single institution with adjuvant or neoadjuvant chemotherapy between 1972 and 1998. Acta Oncol 2006;45:469-475.
44. Ahrens S, Hoffmann C, Jabar S, et al: Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: The CESS 86 experience. Cooperative Ewing Sarcoma Study. Med Pediatr Oncol 1999;32:186-195.
45. Rodriguez-Galindo C, Spunt SL, Pappo AS: Treatment of Ewing sarcoma family of tumors: current status and outlook for the future. Med Pediatr Oncol 2003;40: 276-287.
46. Oberlin O, Deley MC, Bui BN, et al: Prognostic factors in localized Ewing's tumours and peripheral neuroectodermal tumours: The third study of the French Society of Paediatric Oncology (EW88 study). Br J Cancer 2001;85:1646-1654.
47. Abudu A, Mangham DC, Reynolds GM, et al: Overexpression of p53 protein in primary Ewing's sarcoma of bone: relationship to tumour stage, response and prognosis. Br J Cancer 1999;79: 1185-1189.
48. Amir G, Issakov J, Meiler I, et al: Expression of p53 gene product and cell proliferation marker Ki-67 in Ewing's sarcoma: Correlation with clinical outcome. Hum Pathol 2002;33:170-174.
49. Ohali A, Avigad S, Cohen IJ, et al: Association between telomerase activity and outcome in patients with nonmetastatic Ewing family of tumors. J Clin Oncol 2003;21:3836-3843.
50. Ozaki T, Paulussen M, Poremba C, et al: Genetic imbalances revealed by comparative genomic hybridization in Ewing tumors. Genes Chromosomes Cancer 2001;32:164-171.
51. Honoki K, Stojanovski E, McEvoy M, et al: Prognostic significance of p16 INK4a alteration for Ewing sarcoma: A meta-analysis. Cancer 2007;110:1351-1360.
52. Schleiermacher G, Peter M, Oberlin O, et al: Increased risk of systemic relapses associated with bone marrow micrometastasis and circulating tumor cells in localized ewing tumor. J Clin Oncol 2003;21:85-91.
53. Hawkins DS, Schuetze SM, Butrynski JE, et al: [18F]Fluorodeoxyglucose positron emission tomography predicts outcome for Ewing sarcoma family of tumors. J Clin Oncol 2005;23:8828-8834.
54. Sluga M, Windhager R, Lang S, et al: The role of surgery and resection margins in the treatment of Ewing's sarcoma. Clin Orthop Relat Res 2001; 392:394-399.
55. Renard AJ, Veth RP, Schreuder HW, van Loon CJ, Koops HS, van Horn JR: Function and complications after ablative and limb-salvage therapy in lower extremity sarcoma of bone. J Surg Oncol 2000;73:198-205.
56. Thacker MM, Temple HT, Scully SP: Current treatment for Ewing's sarcoma. Expert Rev Anticancer Ther 2005;5:319-331.
57. Donaldson SS: Ewing sarcoma: Radiation dose and target volume. Pediatr Blood Cancer 2004;42:471-476.
58. Bolek TW, Marcus RB Jr, Mendenhall NP, Scarborough MT, Graham-Pole J: Local control and functional results after twice-daily radiotherapy for Ewing's sarcoma of the extremities. Int J Radiat Oncol Biol Phys 1996;35:687-692.
59. Paulino AC: Late effects of radiotherapy for pediatric extremity sarcomas. Int J Radiat Oncol Biol Phys 2004;60:265-274.
60. Pritchard DJ: Indications for surgical treatment of localized Ewing's sarcoma of bone. Clin Orthop Relat Res 1980; 153:39-43.
61. DuBois SG, Krailo MD, Cook EF, et al: Abstract: Evaluation of local control in patients with non-metastatic Ewing sarcoma of bone: A report from the Children's Oncology Group. J Clin Oncol 2007;25(Jun 20 suppl):10013. Available at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst-detail- view&confID=47&abstractID=31798. Accessed September 16, 2009.
62. Dunst J, Hoffmann C, Ahrens S, Jürgens H: Surgery versus radiotherapy in Ewing's sarcoma with good prognosis: Analysis of the CESS-86 data [German]. Strahlenther Onkol 1996;172:244-249.
63. Ullmann C, Beck JD, Holter W, et al: Long-term results following multidisciplinary treatment of localized Ewing's sarcoma in children and adolescents [German]. Strahlenther Onkol 2008;184:137-144.
64. McTiernan A, Driver D, Michelagnoli MP, Kilby AM, Whelan JS: High dose chemotherapy with bone marrow or peripheral stem cell rescue is an effective treatment option for patients with relapsed or progressive Ewing's sarcoma family of tumours. Ann Oncol 2006;17: 1301-1305.
65. Meyers PA, Krailo MD, Ladanyi M, et al: High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis. J Clin Oncol 2001;19:2812-2820.
66. Riggi N, Stamenkovic I: The biology of Ewing sarcoma. Cancer Lett 2007;254: 1-10.
67. Miser JS, Krailo MD, Tarbell NJ, et al: Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: Evaluation of combination ifosfamide and etoposide. A Children's Cancer Group and Pediatric Oncology Group study. J Clin Oncol 2004;22: 2873-2876.
68. Burdach S, van Kaick B, Laws HJ, et al: Allogeneic and autologous stem-cell transplantation in advanced Ewing tumors: An update after long-term follow-up from two centers of the European Intergroup study EICESS. Stem-Cell Transplant Programs at Düsseldorf University Medical Center, Germany and St. Anna Kinderspital, Vienna, Austria. Ann Oncol 2000;11: 1451-1462.
69. Wagner LM, McAllister N, Goldsby RE, et al: Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma. Pediatr Blood Cancer 2007;48:132-139.
70. Kuttesch JF Jr , Wexler LH, Marcus RB, et al: Second malignancies after Ewing's sarcoma: Radiation dose-dependency of secondary sarcomas. J Clin Oncol 1996; 14:2818-2825.
71. Dunst J, Ahrens S, Paulussen M, et al: Second malignancies after treatment for Ewing's sarcoma: A report of the CESS-studies. Int J Radiat Oncol Biol Phys 1998;42:379-384.
72. Fuchs B, Valenzuela RG, Petersen IA, Arndt CA, Sim FH: Ewing's sarcoma and the development of secondary malignancies. Clin Orthop Relat Res 2003;415:82-89.
73. Bhatia S, Krailo MD, Chen Z, et al: Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group. Blood 2007;109:46-51.
74. Kontny U: Regulation of apoptosis and proliferation in Ewing's sarcoma: Opportunities for targeted therapy. Hematol Oncol 2006;24:14-21.