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Volumn 12, Issue 4, 2015, Pages 363-374

Curcumin, hesperidin, and rutin selectively interfere with apoptosis signaling and attenuate streptozotocin-induced oxidative stress-mediated hyperglycemia

Author keywords

ALT; Antioxidant; Apoptosis; Bad; Bax; Bcl 2; Bcl XL; Cell signaling pathways; Curcumin; Cytochrome c; Diabetes; DNA fragmentations; Genomic injury; Hepatotoxicity; Hesperidin; Lipid peroxidation; Liver; Mice; Mitochondria; Necrosis; Oxidative stress; Rutin; Streptozotocin, Hyperglycemia

Indexed keywords

CURCUMIN; CYTOCHROME C; GLUCOSE; GLUTATHIONE; HESPERIDIN; NITRATE; NITRITE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; RUTOSIDE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; FLAVONOID; GLUCOSE BLOOD LEVEL; NITRIC ACID DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 84942080370     PISSN: 15672026     EISSN: 18755739     Source Type: Journal    
DOI: 10.2174/1567202612666150812150249     Document Type: Article
Times cited : (27)

References (92)
  • 1
    • 84880898409 scopus 로고    scopus 로고
    • The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver
    • Dey A, Lakshmanan J. The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver. Food Funct 2013; 4(8): 1148-84.
    • (2013) Food Funct , vol.4 , Issue.8 , pp. 1148-1184
    • Dey, A.1    Lakshmanan, J.2
  • 2
    • 0035208918 scopus 로고    scopus 로고
    • Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet -cells
    • Lakey JR, Suarez-Pinzon WL, Strynadka K, et al. Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet -cells. Lab Invest 2001; 81(12): 1683-92.
    • (2001) Lab Invest , vol.81 , Issue.12 , pp. 1683-1692
    • Lakey, J.R.1    Suarez-Pinzon, W.L.2    Strynadka, K.3
  • 3
    • 0029989197 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: Identification of iNOS- expressing cells and relationships to cytokines expressed in the islets
    • Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC. Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS- expressing cells and relationships to cytokines expressed in the islets. Endocrinology 1996;137(5): 2093-9.
    • (1996) Endocrinology , vol.137 , Issue.5 , pp. 2093-2099
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3    Bleackley, R.C.4
  • 4
    • 0029795599 scopus 로고    scopus 로고
    • Human pancreatic islet -cell destruction by cytokines involves oxygen free radicals and aldehyde production
    • Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Lakey JR, Rajotte RV. Human pancreatic islet -cell destruction by cytokines involves oxygen free radicals and aldehyde production. J Clin Endocrinol Metab 1996; 81(9): 3197-202.
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.9 , pp. 3197-3202
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Strynadka, K.3    Lakey, J.R.4    Rajotte, R.V.5
  • 5
    • 0033911688 scopus 로고    scopus 로고
    • Impact of diabetes on coronary artery disease in women and men: A meta-analysis of prospective studies
    • Lee WL, Cheung AM, Cape D, Zinman B. Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies. Diabetes Care 2000; 23(7): 962-8.
    • (2000) Diabetes Care , vol.23 , Issue.7 , pp. 962-968
    • Lee, W.L.1    Cheung, A.M.2    Cape, D.3    Zinman, B.4
  • 6
    • 0036052019 scopus 로고    scopus 로고
    • Chronic liver disease in diabetes mellitus
    • Amarapurkar D, Das HS. Chronic liver disease in diabetes mellitus. Trop Gastroenterol 2002; 23(1): 3-5.
    • (2002) Trop Gastroenterol , vol.23 , Issue.1 , pp. 3-5
    • Amarapurkar, D.1    Das, H.S.2
  • 7
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005; 54(6): 1615-25.
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1615-1625
    • Brownlee, M.1
  • 8
    • 33847146814 scopus 로고    scopus 로고
    • Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus
    • Maiese K, Morhan SD, Chong ZZ. Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res 2007; 4(1): 63-71.
    • (2007) Curr Neurovasc Res , vol.4 , Issue.1 , pp. 63-71
    • Maiese, K.1    Morhan, S.D.2    Chong, Z.Z.3
  • 9
    • 78149440943 scopus 로고    scopus 로고
    • Diabetes and chronic liver disease: Etiology and pitfalls in monitoring
    • Blendea MC, Thompson MJ, Malkani S. Diabetes and chronic liver disease: Etiology and pitfalls in monitoring. Clinical Diabetes. 2010; 28(4): 139-44.
    • (2010) Clinical Diabetes , vol.28 , Issue.4 , pp. 139-144
    • Blendea, M.C.1    Thompson, M.J.2    Malkani, S.3
  • 10
    • 80051520178 scopus 로고    scopus 로고
    • Microvascular and macrovascular complications of diabetes
    • Fowler MJ. Microvascular and macrovascular complications of diabetes. Clinical Diabetes 2011; 29(3): 116-22.
    • (2011) Clinical Diabetes , vol.29 , Issue.3 , pp. 116-122
    • Fowler, M.J.1
  • 11
    • 80155194979 scopus 로고    scopus 로고
    • Curcumin attenuates diabetic nephropathy by inhibiting PKC-alpha and PKC-beta1 activity in streptozotocin-induced type i diabetic rats
    • Soetikno V, Watanabe K, Sari FR, et al. Curcumin attenuates diabetic nephropathy by inhibiting PKC-alpha and PKC-beta1 activity in streptozotocin-induced type I diabetic rats. Mol Nutr Food Res 2011; 55(11): 1655-65.
    • (2011) Mol Nutr Food Res , vol.55 , Issue.11 , pp. 1655-1665
    • Soetikno, V.1    Watanabe, K.2    Sari, F.R.3
  • 12
    • 84860220629 scopus 로고    scopus 로고
    • Duration of diabetes and risk of ischemic stroke: The Northern Manhattan Study
    • Banerjee C, Moon YP, Paik MC, et al. Duration of diabetes and risk of ischemic stroke: the Northern Manhattan Study. Stroke 2012; 43(5): 1212-7.
    • (2012) Stroke , vol.43 , Issue.5 , pp. 1212-1217
    • Banerjee, C.1    Moon, Y.P.2    Paik, M.C.3
  • 13
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414(6865): 813-20.
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 15
    • 80755184724 scopus 로고    scopus 로고
    • Increased phagocytelike NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: Role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet
    • Syed I, Kyathanahalli CN, Jayaram B, et al. Increased phagocytelike NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes 2011; 60(11): 2843-52.
    • (2011) Diabetes , vol.60 , Issue.11 , pp. 2843-2852
    • Syed, I.1    Kyathanahalli, C.N.2    Jayaram, B.3
  • 17
    • 77952551952 scopus 로고    scopus 로고
    • Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS PARP IkappaBalpha/NF-kappaB MAPKs and mitochondriadependent pathways: Prophylactic role of arjunolic acid
    • Manna P, Das J, Ghosh J, Sil PC. Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondriadependent pathways: Prophylactic role of arjunolic acid. Free Radic Biol Med 2010; 48(11): 1465-84.
    • (2010) Free Radic Biol Med , vol.48 , Issue.11 , pp. 1465-1484
    • Manna, P.1    Das, J.2    Ghosh, J.3    Sil, P.C.4
  • 18
    • 77950671984 scopus 로고    scopus 로고
    • Hyperglycemia induces apoptosis in rat liver through the increase of hydroxyl radical: New insights into the insulin effect
    • May
    • Frances DE, Ronco MT, Monti JA, Ingaramo PI, Pisani GB, Parody JP, et al. Hyperglycemia induces apoptosis in rat liver through the increase of hydroxyl radical: new insights into the insulin effect. J Endocrinol. 2010 May;205(2):187-200.
    • (2010) J Endocrinol , vol.205 , Issue.2 , pp. 187-200
    • Frances, D.E.1    Ronco, M.T.2    Monti, J.A.3    Ingaramo, P.I.4    Pisani, G.B.5    Parody, J.P.6
  • 19
    • 84860254902 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 -10 and -12 MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury
    • Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD. Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury. Mol Cell Biochem 2012; 365(1-2): 351-61.
    • (2012) Mol Cell Biochem , vol.365 , Issue.1-2 , pp. 351-361
    • Syed, I.1    Rathod, J.2    Parmar, M.3    Corcoran, G.B.4    Ray, S.D.5
  • 20
    • 84858218929 scopus 로고    scopus 로고
    • Curcumin exposure modulates multiple pro-apoptotic and antiapoptotic signaling pathways to antagonize acetaminophen-induced toxicity
    • Bulku E, Stohs SJ, Cicero L, Brooks T, Halley H, Ray SD. Curcumin exposure modulates multiple pro-apoptotic and antiapoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Curr Neurovasc Res 2012; 9(1): 58-71.
    • (2012) Curr Neurovasc Res , vol.9 , Issue.1 , pp. 58-71
    • Bulku, E.1    Stohs, S.J.2    Cicero, L.3    Brooks, T.4    Halley, H.5    Ray, S.D.6
  • 21
    • 79952817657 scopus 로고    scopus 로고
    • Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: Effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines
    • El-Azab MF, Attia FM, El-Mowafy AM. Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: Effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines. Eur J Pharmacol 2011; 658(1): 41-8.
    • (2011) Eur J Pharmacol , vol.658 , Issue.1 , pp. 41-48
    • El-Azab, M.F.1    Attia, F.M.2    El-Mowafy, A.M.3
  • 22
    • 33748527750 scopus 로고    scopus 로고
    • Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats
    • Murugan P, Pari L. Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats. Life Sci 2006; 79(18): 1720-8.
    • (2006) Life Sci , vol.79 , Issue.18 , pp. 1720-1728
    • Murugan, P.1    Pari, L.2
  • 23
    • 0026291426 scopus 로고
    • Traditional dietary adjuncts for the treatment of diabetes mellitus
    • Swanston-Flatt SK, Flatt PR, Day C, Bailey CJ. Traditional dietary adjuncts for the treatment of diabetes mellitus. Proc Nutr Soc 1991; 50(3): 641-51.
    • (1991) Proc Nutr Soc , vol.50 , Issue.3 , pp. 641-651
    • Swanston-Flatt, S.K.1    Flatt, P.R.2    Day, C.3    Bailey, C.J.4
  • 24
    • 23744510724 scopus 로고    scopus 로고
    • Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia
    • Jun
    • Osawa T, Kato Y. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann N Y Acad Sci. 2005 Jun;1043:440-51.
    • (2005) Ann N y Acad Sci , vol.1043 , pp. 440-451
    • Osawa, T.1    Kato, Y.2
  • 25
    • 78651064824 scopus 로고    scopus 로고
    • The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model
    • Valsecchi AE, Franchi S, Panerai AE, Rossi A, Sacerdote P, Colleoni M. The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model. Eur J Pharmacol. 2011; 650(2-3): 694-702.
    • (2011) Eur J Pharmacol , vol.650 , Issue.2-3 , pp. 694-702
    • Valsecchi, A.E.1    Franchi, S.2    Panerai, A.E.3    Rossi, A.4    Sacerdote, P.5    Colleoni, M.6
  • 27
    • 84918768167 scopus 로고    scopus 로고
    • Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes
    • Wang YB, Ge ZM, Kang WQ, Lian ZX, Yao J, Zhou CY. Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Exp Ther Med 2015; 9(2): 451-5.
    • (2015) Exp Ther Med , vol.9 , Issue.2 , pp. 451-455
    • Wang, Y.B.1    Ge, Z.M.2    Kang, W.Q.3    Lian, Z.X.4    Yao, J.5    Zhou, C.Y.6
  • 28
    • 0033008969 scopus 로고    scopus 로고
    • Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy- 3-methyl-glutaryl-CoA reductase and acyl CoA: Cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids
    • Bok SH, Lee SH, Park YB, Bae KH, Son KH, Jeong TS, et al. Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy- 3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. J Nutr 1999; 129(6): 1182-5.
    • (1999) J Nutr , vol.129 , Issue.6 , pp. 1182-1185
    • Bok, S.H.1    Lee, S.H.2    Park, Y.B.3    Bae, K.H.4    Son, K.H.5    Jeong, T.S.6
  • 29
    • 0029782890 scopus 로고    scopus 로고
    • The effect of dietary treatment on lipid peroxidation and antioxidant status in newly diagnosed noninsulin dependent diabetes
    • Armstrong AM, Chestnutt JE, Gormley MJ, Young IS. The effect of dietary treatment on lipid peroxidation and antioxidant status in newly diagnosed noninsulin dependent diabetes. Free Radic Biol Med 1996; 21(5): 719-26.
    • (1996) Free Radic Biol Med , vol.21 , Issue.5 , pp. 719-726
    • Armstrong, A.M.1    Chestnutt, J.E.2    Gormley, M.J.3    Young, I.S.4
  • 30
    • 42949122588 scopus 로고    scopus 로고
    • Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice
    • Apr
    • Ray SD, Parmar M, Syed I, et al. Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice. Phytother Res. 2008 Apr;22(4):458-71.
    • (2008) Phytother Res , vol.22 , Issue.4 , pp. 458-471
    • Ray, S.D.1    Parmar, M.2    Syed, I.3
  • 31
    • 0025897408 scopus 로고
    • Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, prunin
    • Choi JS, Yokozawa T, Oura H. Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, prunin. Planta Med 1991; 57(3): 208-11.
    • (1991) Planta Med , vol.57 , Issue.3 , pp. 208-211
    • Choi, J.S.1    Yokozawa, T.2    Oura, H.3
  • 32
    • 0030048414 scopus 로고    scopus 로고
    • Insulinomimetic effects of myricetin on lipogenesis and glucose transport in rat adipocytes but not glucose transport translocation
    • Ong KC, Khoo HE. Insulinomimetic effects of myricetin on lipogenesis and glucose transport in rat adipocytes but not glucose transport translocation. Biochem Pharmacol 1996; 51(4): 423-9.
    • (1996) Biochem Pharmacol , vol.51 , Issue.4 , pp. 423-429
    • Ong, K.C.1    Khoo, H.E.2
  • 33
    • 0038204299 scopus 로고    scopus 로고
    • Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats
    • Hsu FL, Liu IM, Kuo DH, Chen WC, Su HC, Cheng JT. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 2003; 66(6): 788-92.
    • (2003) J Nat Prod , vol.66 , Issue.6 , pp. 788-792
    • Hsu, F.L.1    Liu, I.M.2    Kuo, D.H.3    Chen, W.C.4    Su, H.C.5    Cheng, J.T.6
  • 34
    • 30644469766 scopus 로고    scopus 로고
    • Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats
    • Pari L, Murugan P. Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats. J Basic Clin Physiol Pharmacol 2005; 16(4): 257-74.
    • (2005) J Basic Clin Physiol Pharmacol , vol.16 , Issue.4 , pp. 257-274
    • Pari, L.1    Murugan, P.2
  • 35
    • 54949119528 scopus 로고    scopus 로고
    • Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice
    • Seo KI, Choi MS, Jung UJ, et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res 2008; 52(9): 995-1004.
    • (2008) Mol Nutr Food Res , vol.52 , Issue.9 , pp. 995-1004
    • Seo, K.I.1    Choi, M.S.2    Jung, U.J.3
  • 36
    • 84922737144 scopus 로고    scopus 로고
    • Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats
    • Rashid K, Sil PC. Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats. Toxicol Appl Pharmacol 2015; 282(3): 297-310.
    • (2015) Toxicol Appl Pharmacol , vol.282 , Issue.3 , pp. 297-310
    • Rashid, K.1    Sil, P.C.2
  • 37
    • 4744373549 scopus 로고    scopus 로고
    • The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucoseregulating enzymes in C57BL/KsJ-db/db mice
    • Jung UJ, Lee MK, Jeong KS, Choi MS. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucoseregulating enzymes in C57BL/KsJ-db/db mice. J Nutr 2004; 134(10): 2499-503.
    • (2004) J Nutr , vol.134 , Issue.10 , pp. 2499-2503
    • Jung, U.J.1    Lee, M.K.2    Jeong, K.S.3    Choi, M.S.4
  • 38
    • 33645103657 scopus 로고    scopus 로고
    • Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats
    • Kamalakkannan N, Prince PS. Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin Pharmacol Toxicol 2006; 98(1): 97-103.
    • (2006) Basic Clin Pharmacol Toxicol , vol.98 , Issue.1 , pp. 97-103
    • Kamalakkannan, N.1    Prince, P.S.2
  • 39
    • 33750042821 scopus 로고    scopus 로고
    • Stanely Mainzen Prince P. Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues
    • Kamalakkannan N, Stanely Mainzen Prince P. Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Mol Cell Biochem 2006; 293(1-2): 211-9.
    • (2006) Mol Cell Biochem , vol.293 , Issue.1-2 , pp. 211-219
    • Kamalakkannan, N.1
  • 40
    • 37249074345 scopus 로고    scopus 로고
    • Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat
    • Suryanarayana P, Satyanarayana A, Balakrishna N, Kumar PU, Reddy GB. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med Sci Monit 2007; 13(12): BR286-92.
    • (2007) Med Sci Monit , vol.13 , Issue.12 , pp. BR286-BR292
    • Suryanarayana, P.1    Satyanarayana, A.2    Balakrishna, N.3    Kumar, P.U.4    Reddy, G.B.5
  • 41
    • 77249151607 scopus 로고    scopus 로고
    • Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats
    • Akiyama S, Katsumata S, Suzuki K, Ishimi Y, Wu J, Uehara M. Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats. J Clin Biochem Nutr2010; 46(1): 87-92.
    • J Clin Biochem Nutr2010 , vol.46 , Issue.1 , pp. 87-92
    • Akiyama, S.1    Katsumata, S.2    Suzuki, K.3    Ishimi, Y.4    Wu, J.5    Uehara, M.6
  • 42
    • 74349129815 scopus 로고    scopus 로고
    • Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes
    • Akiyama S, Katsumata S, Suzuki K, Nakaya Y, Ishimi Y, Uehara M. Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes. Biosci Biotechnol Biochem 2009; 73(12): 2779-82.
    • (2009) Biosci Biotechnol Biochem , vol.73 , Issue.12 , pp. 2779-2782
    • Akiyama, S.1    Katsumata, S.2    Suzuki, K.3    Nakaya, Y.4    Ishimi, Y.5    Uehara, M.6
  • 43
    • 77649236635 scopus 로고    scopus 로고
    • Influence of rutin treatment on biochemical alterations in experimental diabetes
    • Mar
    • Fernandes AA, Novelli EL, Okoshi K, et al. Influence of rutin treatment on biochemical alterations in experimental diabetes. Biomed Pharmacother. 2010 Mar;64(3):214-9.
    • (2010) Biomed Pharmacother , vol.64 , Issue.3 , pp. 214-219
    • Fernandes, A.A.1    Novelli, E.L.2    Okoshi, K.3
  • 44
    • 84903792466 scopus 로고    scopus 로고
    • Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines, antioxidants and lipid biomarkers
    • Jul
    • Niture NT, Ansari AA, Naik SR. Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: an effect mediated through cytokines, antioxidants and lipid biomarkers. Indian J Exp Biol. 2014 Jul;52(7):720-7.
    • (2014) Indian J Exp Biol , vol.52 , Issue.7 , pp. 720-727
    • Niture, N.T.1    Ansari, A.A.2    Naik, S.R.3
  • 45
    • 84865248403 scopus 로고    scopus 로고
    • Curcumin-supplemented yoghurt improves physiological and biochemical markers of experimental diabetes
    • Gutierres VO, Pinheiro CM, Assis RP, Vendramini RC, Pepato MT, Brunetti IL. Curcumin-supplemented yoghurt improves physiological and biochemical markers of experimental diabetes. Br J Nutr 2012; 108(3): 440-8.
    • (2012) Br J Nutr , vol.108 , Issue.3 , pp. 440-448
    • Gutierres, V.O.1    Pinheiro, C.M.2    Assis, R.P.3    Vendramini, R.C.4    Pepato, M.T.5    Brunetti, I.L.6
  • 46
    • 34247542013 scopus 로고    scopus 로고
    • Effects of curcumin on retinal oxidative stress and inflammation in diabetes
    • Kowluru RA, Kanwar M. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr Metab (Lond) 2007; 4: 8.
    • (2007) Nutr Metab (Lond) , vol.4 , pp. 8
    • Kowluru, R.A.1    Kanwar, M.2
  • 47
    • 79957910169 scopus 로고    scopus 로고
    • Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat
    • Lakshmanan AP, Watanabe K, Thandavarayan RA, et al. Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat. Free Radic Res 2011; 45(7): 788-95.
    • (2011) Free Radic Res , vol.45 , Issue.7 , pp. 788-795
    • Lakshmanan, A.P.1    Watanabe, K.2    Thandavarayan, R.A.3
  • 48
    • 84904023122 scopus 로고    scopus 로고
    • Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-gamma receptor
    • Agrawal YO, Sharma PK, Shrivastava B, Arya DS, Goyal SN. Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-gamma receptor. Chem Biol Interact 2014; 219: 211-20.
    • (2014) Chem Biol Interact , vol.219 , pp. 211-220
    • Agrawal, Y.O.1    Sharma, P.K.2    Shrivastava, B.3    Arya, D.S.4    Goyal, S.N.5
  • 49
    • 33748660469 scopus 로고    scopus 로고
    • Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity
    • Kaur G, Tirkey N, Chopra K. Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity. Toxicology 2006; 226(2-3): 152-60.
    • (2006) Toxicology , vol.226 , Issue.2-3 , pp. 152-160
    • Kaur, G.1    Tirkey, N.2    Chopra, K.3
  • 51
    • 85039816205 scopus 로고    scopus 로고
    • Antiapoptotic and antinecrotic properties of bioflavonoids curcumin and rutin
    • Bulku E, Rathod J, Ismail S, Parmar M, Ray S. Antiapoptotic and antinecrotic properties of bioflavonoids curcumin and rutin. Am J Pharma Edu 2007; 71: 3.
    • (2007) Am J Pharma Edu , vol.71 , pp. 3
    • Bulku, E.1    Rathod, J.2    Ismail, S.3    Parmar, M.4    Ray, S.5
  • 52
    • 65349181500 scopus 로고    scopus 로고
    • Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury
    • Acquaviva R, Lanteri R, Li Destri G, et al. Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2009; 296(3): G664-70.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , Issue.3 , pp. G664-G670
    • Acquaviva, R.1    Lanteri, R.2    Li Destri, G.3
  • 53
    • 84925804765 scopus 로고    scopus 로고
    • Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats
    • Afrin R, Arumugam S, Soetikno V, et al. Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats. Free Radic Res 2015; 49(3): 279-89.
    • (2015) Free Radic Res , vol.49 , Issue.3 , pp. 279-289
    • Afrin, R.1    Arumugam, S.2    Soetikno, V.3
  • 54
    • 8644267972 scopus 로고    scopus 로고
    • Hyperglycemia-induced oxidative stress in diabetic complications
    • King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol 2004; 122(4): 333-8.
    • (2004) Histochem Cell Biol , vol.122 , Issue.4 , pp. 333-338
    • King, G.L.1    Loeken, M.R.2
  • 55
    • 0033942156 scopus 로고    scopus 로고
    • Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis
    • Gottlieb E, Vander Heiden MG, Thompson CB. Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 2000; 20(15): 5680-9.
    • (2000) Mol Cell Biol , vol.20 , Issue.15 , pp. 5680-5689
    • Gottlieb, E.1    Vander Heiden, M.G.2    Thompson, C.B.3
  • 56
    • 84876273640 scopus 로고    scopus 로고
    • Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases
    • Fiorentino TV, Prioletta A, Zuo P, Folli F. Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr Pharm Des 2013; 19(32): 5695-703.
    • (2013) Curr Pharm des , vol.19 , Issue.32 , pp. 5695-5703
    • Fiorentino, T.V.1    Prioletta, A.2    Zuo, P.3    Folli, F.4
  • 57
    • 3242659967 scopus 로고    scopus 로고
    • Liver disease and diabetes mellitus
    • Levinthal GN, Tavill AS. Liver disease and diabetes mellitus. Clin Diabetes 1999; 17(2): 478-535.
    • (1999) Clin Diabetes , vol.17 , Issue.2 , pp. 478-535
    • Levinthal, G.N.1    Tavill, A.S.2
  • 58
    • 79958211266 scopus 로고    scopus 로고
    • Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats
    • Panchal SK, Poudyal H, Arumugam TV, Brown L. Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats. J Nutr 2011; 141(6): 1062-9.
    • (2011) J Nutr , vol.141 , Issue.6 , pp. 1062-1069
    • Panchal, S.K.1    Poudyal, H.2    Arumugam, T.V.3    Brown, L.4
  • 60
    • 84888427840 scopus 로고    scopus 로고
    • Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet
    • Oner-Iyidogan Y, Kocak H, Seyidhanoglu M, et al. Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet. J Physiol Biochem 2013; 69(4): 677-86.
    • (2013) J Physiol Biochem , vol.69 , Issue.4 , pp. 677-686
    • Oner-Iyidogan, Y.1    Kocak, H.2    Seyidhanoglu, M.3
  • 61
    • 33748891024 scopus 로고    scopus 로고
    • Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats
    • Sharma S, Kulkarni SK, Chopra K. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol 2006; 33(10): 940-5.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , Issue.10 , pp. 940-945
    • Sharma, S.1    Kulkarni, S.K.2    Chopra, K.3
  • 62
    • 77955434498 scopus 로고    scopus 로고
    • Protective effect of hesperidin, a citrus bioflavonoid, on diabetes-induced brain damage in rats
    • Ibrahim SS. Protective effect of hesperidin, a citrus bioflavonoid, on diabetes-induced brain damage in rats. J Appl Sci Res 2008; 4(1): 84.
    • (2008) J Appl Sci Res , vol.4 , Issue.1 , pp. 84
    • Ibrahim, S.S.1
  • 63
    • 77957765255 scopus 로고    scopus 로고
    • Curcumin supplementation could improve diabetesinduced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition
    • Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P, Patumraj S. Curcumin supplementation could improve diabetesinduced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med 2010; 10: 57.
    • (2010) BMC Complement Altern Med , vol.10 , pp. 57
    • Rungseesantivanon, S.1    Thenchaisri, N.2    Ruangvejvorachai, P.3    Patumraj, S.4
  • 64
    • 84863074195 scopus 로고    scopus 로고
    • Icariin ameliorates streptozotocininduced diabetic retinopathy in vitro and in vivo
    • Xin H, Zhou F, Liu T, et al. Icariin ameliorates streptozotocininduced diabetic retinopathy in vitro and in vivo. Int J Mol Sci 2012; 13(1): 866-78.
    • (2012) Int J Mol Sci , vol.13 , Issue.1 , pp. 866-878
    • Xin, H.1    Zhou, F.2    Liu, T.3
  • 65
    • 26844460741 scopus 로고    scopus 로고
    • Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney
    • Tirkey N, Pilkhwal S, Kuhad A, Chopra K. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol 2005; 5: 2.
    • (2005) BMC Pharmacol , vol.5 , pp. 2
    • Tirkey, N.1    Pilkhwal, S.2    Kuhad, A.3    Chopra, K.4
  • 66
    • 82055165424 scopus 로고    scopus 로고
    • Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress apoptosis and inflammation
    • Ahmad ST, Arjumand W, Nafees S, et al. Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicol Lett 2012; 208(2): 149-61.
    • (2012) Toxicol Lett , vol.208 , Issue.2 , pp. 149-161
    • Ahmad, S.T.1    Arjumand, W.2    Nafees, S.3
  • 67
    • 84866452339 scopus 로고    scopus 로고
    • Study of curcumin on microvasculature characteristic in diabetic rat's liver as revealed by vascular corrosion cast/scanning electron microscope (SEM) technique
    • Khimmaktong W, Petpiboolthai H, Panyarachun B, Anupunpisit V. Study of curcumin on microvasculature characteristic in diabetic rat's liver as revealed by vascular corrosion cast/scanning electron microscope (SEM) technique. J Med Assoc Thai 2012; 95 Suppl 5: S133-41.
    • (2012) J Med Assoc Thai , vol.95 , pp. S133-S141
    • Khimmaktong, W.1    Petpiboolthai, H.2    Panyarachun, B.3    Anupunpisit, V.4
  • 68
    • 84868655005 scopus 로고    scopus 로고
    • Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats
    • Mahmoud AM, Ashour MB, Abdel-Moneim A, Ahmed OM. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complications 2012; 26(6): 483-90.
    • (2012) J Diabetes Complications , vol.26 , Issue.6 , pp. 483-490
    • Mahmoud, A.M.1    Ashour, M.B.2    Abdel-Moneim, A.3    Ahmed, O.M.4
  • 69
    • 33645892889 scopus 로고    scopus 로고
    • Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice
    • Jung UJ, Lee MK, Park YB, Kang MA, Choi MS. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 2006; 38(7): 1134-45.
    • (2006) Int J Biochem Cell Biol , vol.38 , Issue.7 , pp. 1134-1145
    • Jung, U.J.1    Lee, M.K.2    Park, Y.B.3    Kang, M.A.4    Choi, M.S.5
  • 70
    • 33645817531 scopus 로고    scopus 로고
    • Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes
    • Stanley Mainzen Prince P, Kamalakkannan N. Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes. J Biochem Mol Toxicol 2006; 20(2): 96-102.
    • (2006) J Biochem Mol Toxicol , vol.20 , Issue.2 , pp. 96-102
    • Stanley Mainzen Prince, P.1    Kamalakkannan, N.2
  • 71
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120(5): 1183-92.
    • (2001) Gastroenterology , vol.120 , Issue.5 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 72
    • 34548804940 scopus 로고    scopus 로고
    • Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: Possible role of Vitamin A intake
    • Musso G, Gambino R, De Michieli F, et al. Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake. Am J Clin Nutr 2007; 86(3): 661-71.
    • (2007) Am J Clin Nutr , vol.86 , Issue.3 , pp. 661-671
    • Musso, G.1    Gambino, R.2    De Michieli, F.3
  • 73
    • 84855589344 scopus 로고    scopus 로고
    • Strategies for reducing or preventing the generation of oxidative stress
    • Poljsak B. Strategies for reducing or preventing the generation of oxidative stress. Oxid Med Cell Longev 2011; 2011: 194586.
    • (2011) Oxid Med Cell Longev , vol.2011 , pp. 194586
    • Poljsak, B.1
  • 74
    • 54449084867 scopus 로고    scopus 로고
    • Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice
    • Yoh K, Hirayama A, Ishizaki K, et al. Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. Genes Cells 2008; 13(11): 1159-70.
    • (2008) Genes Cells , vol.13 , Issue.11 , pp. 1159-1170
    • Yoh, K.1    Hirayama, A.2    Ishizaki, K.3
  • 75
    • 12144251636 scopus 로고    scopus 로고
    • Postprandial hyperglycemia and diabetes complications: Is it time to treat?
    • Ceriello A. Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 2005; 54(1): 1-7.
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 1-7
    • Ceriello, A.1
  • 76
    • 4143110556 scopus 로고    scopus 로고
    • Oxidative stress in the pathogenesis of diabetic neuropathy
    • Vincent AM, Russell JW, Low P, Feldman EL. Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev 2004; 25(4): 612-28.
    • (2004) Endocr Rev , vol.25 , Issue.4 , pp. 612-628
    • Vincent, A.M.1    Russell, J.W.2    Low, P.3    Feldman, E.L.4
  • 77
    • 75149164344 scopus 로고    scopus 로고
    • Measurement of superoxide dismutase catalase and glutathione peroxidase in cultured cells and tissue
    • Weydert CJ, Cullen JJ. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc 2010; 5(1): 51-66.
    • (2010) Nat Protoc , vol.5 , Issue.1 , pp. 51-66
    • Weydert, C.J.1    Cullen, J.J.2
  • 78
    • 84869110746 scopus 로고    scopus 로고
    • Glutathione homeostasis and functions: Potential targets for medical interventions
    • Lushchak VI. Glutathione homeostasis and functions: potential targets for medical interventions. J Amino Acids 2012; 2012: 736837.
    • (2012) J Amino Acids , vol.2012 , pp. 736837
    • Lushchak, V.I.1
  • 79
    • 13244289773 scopus 로고    scopus 로고
    • Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity
    • Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid Redox Signal 2005; 7(1-2): 32-41.
    • (2005) Antioxid Redox Signal , vol.7 , Issue.1-2 , pp. 32-41
    • Biswas, S.K.1    McClure, D.2    Jimenez, L.A.3    Megson, I.L.4    Rahman, I.5
  • 80
    • 84871664426 scopus 로고    scopus 로고
    • Effect of hesperidin and rutin on doxorubicin induced testicular toxicity in male rats
    • Hozayen WG. Effect of hesperidin and rutin on doxorubicin induced testicular toxicity in male rats. Int J Food Nutr Sci. 2012;1(1):31-42.
    • (2012) Int J Food Nutr Sci , vol.1 , Issue.1 , pp. 31-42
    • Hozayen, W.G.1
  • 81
    • 79951696287 scopus 로고    scopus 로고
    • Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine
    • Sekhar RV, McKay SV, Patel SG, et al. Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care 2011; 34(1): 162-7.
    • (2011) Diabetes Care , vol.34 , Issue.1 , pp. 162-167
    • Sekhar, R.V.1    McKay, S.V.2    Patel, S.G.3
  • 82
    • 0030434801 scopus 로고    scopus 로고
    • Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment
    • Ray SD, Mumaw VR, Raje RR, Fariss MW. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther 1996; 279(3): 1470-83.
    • (1996) J Pharmacol Exp Ther , vol.279 , Issue.3 , pp. 1470-1483
    • Ray, S.D.1    Mumaw, V.R.2    Raje, R.R.3    Fariss, M.W.4
  • 83
    • 0033380284 scopus 로고    scopus 로고
    • A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo
    • Ray SD, Jena N. A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo. Arch Toxicol 2000; 73(10-11): 594-606.
    • (2000) Arch Toxicol , vol.73 , Issue.10-11 , pp. 594-606
    • Ray, S.D.1    Jena, N.2
  • 84
    • 0035426195 scopus 로고    scopus 로고
    • Ca(2+)- calmodulin antagonist chlorpromazine and poly(ADP-ribose) polymerase modulators 4-aminobenzamide and nicotinamide influence hepatic expression of BCL-XL and P53 and protect against acetaminophen-induced programmed and unprogrammed cell death in mice
    • Ray SD, Balasubramanian G, Bagchi D, Reddy CS. Ca(2+)- calmodulin antagonist chlorpromazine and poly(ADP-ribose) polymerase modulators 4-aminobenzamide and nicotinamide influence hepatic expression of BCL-XL and P53 and protect against acetaminophen-induced programmed and unprogrammed cell death in mice. Free Radic Biol Med 2001; 31(3): 277-91.
    • (2001) Free Radic Biol Med , vol.31 , Issue.3 , pp. 277-291
    • Ray, S.D.1    Balasubramanian, G.2    Bagchi, D.3    Reddy, C.S.4
  • 85
    • 77952891323 scopus 로고    scopus 로고
    • Silymarin modulates doxorubicin-induced oxidative stress Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver
    • Patel N, Joseph C, Corcoran GB, Ray SD. Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver. Toxicol Appl Pharmacol 2010; 245(2): 143-52.
    • (2010) Toxicol Appl Pharmacol , vol.245 , Issue.2 , pp. 143-152
    • Patel, N.1    Joseph, C.2    Corcoran, G.B.3    Ray, S.D.4
  • 86
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl- 2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis. Science 1997; 275(5303): 1132-6.
    • (1997) Science , vol.275 , Issue.5303 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 87
    • 0029845983 scopus 로고    scopus 로고
    • Bcl- 2 potentiates the maximal calcium uptake capacity of neural cell mitochondria
    • Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G. Bcl- 2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci USA 1996; 93(18): 9893-8.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.18 , pp. 9893-9898
    • Murphy, A.N.1    Bredesen, D.E.2    Cortopassi, G.3    Wang, E.4    Fiskum, G.5
  • 88
    • 0032587982 scopus 로고    scopus 로고
    • Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange
    • Vander Heiden MG, Chandel NS, Schumacker PT, Thompson CB. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol Cell 1999; 3(2): 159-67.
    • (1999) Mol Cell , vol.3 , Issue.2 , pp. 159-167
    • Vander Heiden, M.G.1    Chandel, N.S.2    Schumacker, P.T.3    Thompson, C.B.4
  • 90
    • 0642345209 scopus 로고    scopus 로고
    • Potentiation of cellular antioxidant capacity by Bcl-2: Implications for its antiapoptotic function
    • Jang JH, Surh YJ. Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function. Biochem Pharmacol 2003; 66(8): 1371-9.
    • (2003) Biochem Pharmacol , vol.66 , Issue.8 , pp. 1371-1379
    • Jang, J.H.1    Surh, Y.J.2
  • 91
    • 66449104640 scopus 로고    scopus 로고
    • Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model
    • Sung B, Kunnumakkara AB, Sethi G, Anand P, Guha S, Aggarwal BB. Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther 2009; 8(4): 959-70.
    • (2009) Mol Cancer Ther , vol.8 , Issue.4 , pp. 959-970
    • Sung, B.1    Kunnumakkara, A.B.2    Sethi, G.3    Anand, P.4    Guha, S.5    Aggarwal, B.B.6


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