Ca2+-calmodulin antagonist chlorpromazine and poly(ADP-ribose) polymerase modulators 4-aminobenzamide and nicotinamide influence hepatic expression of bcl-XL and p53 and protect against acetaminophen-induced programmed and unprogrammed cell death in mice

Free Radical Biology and Medicine

Volumn 31, Issue 3, 2001, Pages 277-291

  Ray, Sidhartha D ^a   Balasubramanian, Ganesh ^b   Bagchi, Debasis ^a   Reddy, Chadda S ^b  

^a LONG ISLAND UNIVERSITY   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

4 Aminobenzamide; Acetaminophen; Apoptosis; bcl XL; Chlorpromazine; DNA repair; Free radicals; Nicotinamide; p53; Poly(ADP ribose)polymerase

Indexed keywords

4 AMINOBENZAMIDINE; ALANINE AMINOTRANSFERASE; CALMODULIN INHIBITOR; CASPASE; CHLORPROMAZINE; DEOXYRIBONUCLEASE; DNA FRAGMENT; ENDONUCLEASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE MODULATOR; NICOTINAMIDE DERIVATIVE; PARACETAMOL; PROTEIN BCL X; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA REPAIR; DRUG INTOXICATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME REGULATION; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER CELL DAMAGE; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; WESTERN BLOTTING;

4-AMINOBENZOIC ACID; ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CALMODULIN; CELL DEATH; CHLORPROMAZINE; DNA DAMAGE; DNA FRAGMENTATION; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; LIVER; MALE; MICE; MICE, INBRED ICR; NIACINAMIDE; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION-SENSITIZING AGENTS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0035426195     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00562-7     Document Type: Article

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