Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor

Chemico-Biological Interactions

Volumn 219, Issue , 2014, Pages 211-220

  Agrawal, Yogeeta O ^a,b,c   Sharma, Pankaj Kumar ^a   Shrivastava, Birendra ^a   Arya, Dharamvir Singh ^b   Goyal, Sameer N ^c  

^a JAIPUR NATIONAL UNIVERSITY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Apoptosis; Bioflavonoid; Cardiotoxicity; Isoproterenol; Myocardial infarction; PPAR

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CATALASE; CREATINE KINASE MB; GLUTATHIONE; HESPERIDIN; ISOPRENALINE; LACTATE DEHYDROGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BAX; PROTEIN BCL 2; STREPTOZOCIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TROPONIN I; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DOWN REGULATION; DRUG POTENTIATION; DRUG TARGETING; FEMALE; HEART EDEMA; HEART HEMODYNAMICS; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE NECROSIS; HEART PROTECTION; INFLAMMATION; ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; RAT MODEL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CHEMICALLY INDUCED; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; RANDOMIZATION; TRANSMISSION ELECTRON MICROSCOPY; WISTAR RAT;

ANILIDES; ANIMALS; CATALASE; CREATINE KINASE, MB FORM; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GLUTATHIONE; HESPERIDIN; ISOPROTERENOL; L-LACTATE DEHYDROGENASE; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MYOCARDIAL INFARCTION; PPAR GAMMA; RANDOM ALLOCATION; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TROPONIN I;

EID: 84904023122     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.06.010     Document Type: Article

References (48)

1. S.W. Yang, Y.J. Zhou, X.F. Tian, G.Z. Pan, Y.Y. Liu, J. Zhang, Z.F. Guo, S.Y. Chen, S.T. Gao, J. Du, D.A. Jia, Z. Fang, B. Hu, H.Y. Han, F. Gao, D.Y. Hu, Y.Y. Xu, and Beijing Heart and Metabolism Survey Study Group Association of dysglycemia and all-cause mortality across the spectrum of coronary artery disease Mayo Clin. Proc. 88 2013 930 941
2. A. Menotti, P.E. Puddu, M. Lanti, D. Kromhout, H. Tolonen, B. Parapid, B. Kircanski, A. Kafatos, and H. Adachi Epidemiology of typical coronary heart disease versus heart disease of uncertain etiology (atypical) fatalities and their relationships with classic coronary risk factors Int. J. Cardiol. 168 2013 3963 3967
3. M. Connolly, and I.B. Menown Key advances in clinical cardiology Adv. Ther. 33 2013 369 386
4. J. Narula, F.D. Kolodgie, and R. Virmani Apoptosis and cardiomyopathy Curr. Opin. Cardiol. 15 2000 183 188 (Pubitemid 30326641)
5. L. Cai, W. Li, G. Wang, L. Guo, Y. Jiang, and Y.J. Kang Hyperglycemia induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway Diabetes 51 2002 1938 1948 (Pubitemid 34564309)
6. J. Wang, H. Bo, X. Meng, Y. Wu, Y. Bao, and Y. Li A simple and fast experimental model of myocardial infarction in the mouse Tex. Heart Inst. J. 33 2006 290 293 (Pubitemid 44683420)
7. S. Bhimji, and J.H. McNeill Isoproterenol-induced ultrastructural alterations in hearts of alloxan-diabetic rabbits Gen. Pharmacol. 20 1989 479 485 (Pubitemid 19161429)
8. J.S. Kumar, and V.P. Menon Changes in levels of lipid peroxides and activity of superoxide dismutase and catalase in diabetes associated with myocardial infarction Indian J. Exp. Biol. 30 1992 122 127
9. H.K. Loh, K.C. Sahoo, K. Kishore, R. Ray, T.C. Nag, S. Kumari, and D.S. Arya Effects of thalidomide on isoprenaline-induced acute myocardial injury: a haemodynamic, histopathological and ultrastructural study Basic Clin. Pharmacol. Toxicol. 100 2007 233 239 (Pubitemid 46435082)
10. D. Bishop-Bailey Peroxisome proliferator-activated receptors in the cardiovascular system Br. J. Pharmacol. 129 2000 823 834
11. G. Chinetti, J.C. Fruchart, and B. Staels Peroxisome proliferator- activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation Inflamm. Res. 49 2000 497 505
12. C. Thiemermann, and N.S. Wayman Menarini Academy Cardiovascular Research Awards in Basic Science 2001: ligands of the orphan receptor peroxisome-proliferator activator-gamma reduce myocardial infarct size Med. Sci. Monit. 7 2001 2001 787 789 (Pubitemid 32691764)
13. A. Sivarajah, M.C. McDonald, and C. Thiemermann The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a peroxisome proliferator-activated receptor-gamma antagonist J. Pharmacol. Exp. Ther. 313 2005 896 901 (Pubitemid 40604193)
14. M. Collin, N.S. Patel, L. Dugo, and C. Thiemermann Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12, 14 prostaglandin J2 against the multiple organ failure caused by endotoxin Crit. Care Med. 32 2004 826 831 (Pubitemid 38340084)
15. A. Ghorbani, M. Nazari, M. Jeddi-Tehrani, and H. Zand The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism Eur. J. Nutr. 51 2012 39 46
16. S.K. Banerjee, and S.K. Maulik Effect of garlic on cardiovascular disorders: a review Nutr. J. 19 2002 1 4
17. J. Kakadiya, M. Shah, and N. Shah Effect of hesperidin on serum heart marker, myocardial tissues parameter and histopathological of heart in isoproterenol induced myocardial infarction in diabetic rats Int. J. Biol. Technol. 1 2010 57 62
18. R.P. Constantin, A. Bracht, N.S. Yamamoto, E.L. Ishii-Iwamoto, and J. Constantin Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis Fitoterapia 15 2013 148 162
19. X. Shi, S. Liao, H. Mi, C. Guo, D. Qi, F. Li, C. Zhang, and Z. Yang Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats Molecules 17 2012 12868 12881
20. S. Kumar, N. Dhankhar, V. Kar, M. Shrivastava, and S. Shrivastava Myocardial injury provoked by cyclophosphamide, protective aspect of hesperidin in rats Int. J. Res. Pharm. Biomed Sci. 2 2001 1288 1296
21. B. Zarebczan, S.N. Pinchot, M. Kunnimalaiyaan, and H. Chen Hesperetin, a potential therapy for carcinoid cancer Am. J. Surg. 201 2011 329 332
22. S.Y. Lee, B. Munerol, S. Pollard, K.A. Youdim, A.S. Pannala, G.G. Kuhnle, E.S. Debnam, C. Rice-Evans, and J.P. Spencer The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth Free Radic. Biol. Med. 40 2006 323 334 (Pubitemid 43069356)
23. L. Liu, S. Shan, K. Zhang, Z.Q. Ning, X.P. Lu, and Y.Y. Cheng Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin Phytother. Res. 22 2008 1400 1403
24. C. Gandhi, A. Upaganalawar, and R. Balaraman Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin Free Radic. Res. 43 2009 817 827
25. I. Mohanty, D.S. Arya, A. Dinda, K.K. Talwar, S. Joshi, and S.K. Gupta Mechanisms of cardioprotective effect of Withania somnifera in experimentally induced myocardial infarction Basic Clin. Pharmacol. Toxicol. 94 2004 184 190 (Pubitemid 38525315)
26. S. Goyal, S. Arora, R. Mittal, S. Joshi, T.C. Nag, R. Ray, S. Kumari, and D.S. Arya Myocardial salvaging effect of telmisartan in experimental model of myocardial infarction Eur. J. Pharmacol. 619 2009 75 84
27. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358 (Pubitemid 9194347)
28. M.S. Moron, J.W. Depierre, and B. Mannervik Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver Biochem. Biophys. Acta 582 1979 67 78 (Pubitemid 9065588)
29. P. Cabaud, and F. Wroblewski Colorimetric measurement of lactic dehydrogenase activity of body fluid Am. J. Clin. Pathol. 30 1958 234 236
30. H. Aebi Catalase H.U. Bergmeyer, Methods of Enzymatic Analysis 1974 Academic Press Inc New York 673 685
31. S. Marklund, and G. Marklund Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase Eur. J. Biochem. 47 1974 469 474
32. M.M. Bradford A rapid and sensitive method for quantization of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
33. S. Goyal, S. Arora, T.K. Bhatt, P. Das, A. Sharma, S. Kumari, and D.S. Arya Modulation of PPAR-gamma by telmisartan protects the heart against myocardial infarction in experimental diabetes Chem. Biol. Interact. 185 2010 271 280
34. S.K. Gupta, D.S. Arya, U. Singh, and K.K. Talwar Effect of diabetes mellitus on hemodynamic and cardiometabolic correlates in experimental myocardial infarction Adv. Exp. Med. Biol. 498 2001 229 240 (Pubitemid 34113545)
35. P.S. Bora, L.M. Srivastava, and S.D. Bhatt Myocardial dysfunction in diabetic rats: influence of beta-adrenoceptor blockade (propranolol) Indian J. Exp. Biol. 27 1989 615 620 (Pubitemid 19177474)
36. C. Gandhi, A. Upaganalawar, and R. Balaraman Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin Free Radic. Res. 43 2009 817 827
37. D.F. Geng, W. Wu, D.M. Jin, J.F. Wang, and Y.M. Wu Effect of peroxisome proliferator-activated receptor gamma ligand rosiglitazone on left ventricular remodeling in rats with myocardial infarction Int. J. Cardiol. 113 2006 86 91 (Pubitemid 44648366)
38. N. Kobayashi, T. Ohno, K. Yoshida, H. Fukushima, Y. Mamada, M. Nomura, H. Hirata, Y. Machida, M. Shinoda, N. Suzuki, and H. Matsuoka Cardioprotective mechanism of telmisartan via PPAR-gamma-eNOS pathway in dahl salt-sensitive hypertensive rats Am. J. Hypertens. 21 2008 576 581 (Pubitemid 351589680)
39. O. Silva-Junior Gde, S. Tda Torres, S. Lde Mendonca, and C.A. Mandarim-de-Lacerda Rosiglitazone (peroxisome proliferator-activated receptor-gamma) counters hypertension and adverse cardiac and vascular remodeling in 2K1C hypertensive rats Exp. Toxicol. Pathol. 63 2011 1 7
40. T. Shiomi, H. Tsutsui, S. Hayashidani, N. Suematsu, M. Ikeuchi, J. Wen, M. Ishibashi, T. Kubota, K. Egashira, and A. Takeshita Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction Circulation 106 2002 3126 3132 (Pubitemid 35440299)
41. N.S. Dhalla, A.B. Elmoselhi, T. Hata, and N. Makino Status of myocardial antioxidants in ischemia-reperfusion injury Cardiovasc. Res. 47 2000 446 456 (Pubitemid 30646067)
42. P. Selvaraj, and K.V. Pugalendi Hesperidin, a flavanone glycoside, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats Redox Rep. 15 2010 217 223
43. P.K. Singal, N. Kapur, K.S. Dhillon, R.E. Beamish, and N.S. Dhalla Role of free radicals in catecholamine-induced cardiomyopathy Can. J. Physiol. Pharmacol. 60 1982 1390 1397 (Pubitemid 13209544)
44. P. Stanely Mainzen Prince, and A.J. Roy p-Coumaric acid attenuates apoptosis in isoproterenol-induced myocardial infarcted rats by inhibiting oxidative stress Int. J. Cardiol. 168 2013 3259 3266
45. E.J. Huang, W.W. Kuo, Y.J. Chen, T.H. Chen, M.H. Chang, M.C. Lu, B.S. Tzang, H.H. Hsu, C.Y. Huang, and S.D. Lee Homocysteine and other biochemical parameters in Type 2 diabetes mellitus with different diabetic duration or diabetic retinopathy Clin. Chim. Acta 366 2006 293 298
46. M.T. Crow, K. Mani, Y.J. Nam, and R.N. Kitsis The mitochondrial death pathway and cardiac myocyte apoptosis Circ. Res. 95 2004 957 970 (Pubitemid 39532326)
47. A. Saraste, K. Pulkki, M. Kallajoki, K. Henriksen, M. Parvinen, and L.M. Voipio-Pulkki Apoptosis in human acute myocardial infarction Circulation 95 1997 320 323 (Pubitemid 27056193)
48. H.R. Liu, L. Tao, E. Gao, B.L. Lopez, T.A. Christopher, R.N. Willette, E.H. Ohlstein, T.L. Yue, and X.L. Ma Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion Cardiovasc. Res. 62 2004 135 144 (Pubitemid 38326819)