Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity

Toxicology

Volumn 226, Issue 2-3, 2006, Pages 152-160

  Kaur, Gaganjit ^a   Tirkey, Naveen ^a   Chopra, Kanwaljit ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Citrus; Free radicals; Hepatotoxicity; Hesperidin; Lipopolysaccharide; Nitrosative stress; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; ENDOTOXIN; GLUTATHIONE; HESPERIDIN; LIPOPOLYSACCHARIDE; LIVER ENZYME; NITRATE; NITRIC OXIDE; OXYGEN RADICAL; PEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; LIVER DYSFUNCTION; LIVER HOMOGENATE; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TISSUE LEVEL;

ANIMALS; GLUTATHIONE; HEPATITIS, TOXIC; HESPERIDIN; LIPOPOLYSACCHARIDES; LIVER; LIVER FUNCTION TESTS; MALE; MITOCHONDRIA, LIVER; NITRITES; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE NITROGEN SPECIES; SUPEROXIDE DISMUTASE;

CITRUS;

EID: 33748660469     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.06.018     Document Type: Article

References (58)

1. Aniya Y., Koyama T., Miyagi C., Miyahira M., Inomata C., Kinoshita S., and Ichiba T. Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Biol. Pharm. Bull. 28 (2005) 19-23
2. Ansorge S., Reinhold D., and Lendeckel U. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta1 production of human immune cells. Z. Naturforsch. [C] 58 (2003) 580-589
3. Arthur M.J., Kowalski-Saunders P., and Wright R. Effect of endotoxin on release of reactive oxygen intermediates by rat hepatic macrophages. Gastroenterology 95 (1988) 1588-1594
4. Bautista A.P., Meszaros K., Bojta J., and Spitzer J.J. Superoxide anion generation in the liver during the early stage of endotoxemia in rats. J. Leukocyte Biol. 48 (1990) 123-128
5. Beutler B., and Cerami A. Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu. Rev. Biochem. 57 (1988) 505-518
6. Billiar T.R., Curran R.D., West M.A., Hofmann K., and Simmons R.L. Kupffer cell cytotoxicity to hepatocytes in coculture requires l-arginine. Arch. Surg. 124 (1989) 1416-1420 discussion 1420-1411
7. Brandi M.L. Flavonoids: biochemical effects and therapeutic applications. Bone Miner. 19 Suppl. 1 (1992) S3-S14
8. Butterfield D.A., and Kanski J. Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech. Ageing Dev. 122 (2001) 945-962
9. Cesquini M., Torsoni M.A., Stoppa G.R., and Ogo S.H. t-BOOH-induced oxidative damage in sickle red blood cells and the role of flavonoids. Biomed. Pharmacother. 57 (2003) 124-129
10. Chiao C.W., Lee S.S., Wu C.C., and Su M.J. Thaliporphine increases survival rate and attenuates multiple organ injury in LPS-induced endotoxaemia. N. S. Arch. Pharmacol. 371 (2005) 34-43
11. Cotelle N., Bernier J.L., Catteau J.P., Pommery J., Wallet J.C., and Gaydou E.M. Antioxidant properties of hydroxy-flavones. Free Radic. Biol. Med. 20 (1996) 35-43
12. Duval D.L., Miller D.R., Collier J., and Billings R.E. Characterization of hepatic nitric oxide synthase: Identification as the cytokine-inducible form primarily regulated by oxidants. Mol. Pharmacol. 50 (1996) 277-284
13. Finkel T. Oxygen radicals and signaling. Curr. Opin. Cell Biol. 10 (1998) 248-253
14. Fraga C.G., Martino V.S., Ferraro G.E., Coussio J.D., and Boveris A. Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence. Biochem. Pharmacol. 36 (1987) 717-720
15. Galati E.M., Monforte M.T., Kirjavainen S., Forestieri A.M., Trovato A., and Tripodo M.M. Biological effects of hesperidin, a citrus flavonoid (Note I): antiinflammatory and analgesic activity. Farmaco 40 (1994) 709-712
16. Garg A., Garg S., Zaneveld L.J., and Singla A.K. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother. Res. 15 (2001) 655-669
17. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126 (1982) 131-138
18. Haller C., and Hizoh I. The cytotoxicity of iodinated radiocontrast agents on renal cells in vitro. Invest. Radiol. 39 (2004) 149-154
19. Hartung T., Tiegs G., and Wendel A. The role of leukotriene D4 in septic shock models. Eicosanoids 5 Suppl. (1992) S42-S44
20. Hartung T., and Wendel A. Endotoxin-inducible cytotoxicity in liver cell cultures-I. Biochem. Pharmacol. 42 (1991) 1129-1135
21. Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharmacol. 32 (1983) 1141-1148
22. Hayashi Y., Abe M., Murai A., Shimizu N., Okamoto I., Katsuragi T., and Tanaka K. Comparison of effects of nitric oxide synthase (NOS) inhibitors on plasma nitrite/nitrate levels and tissue NOS activity in septic organs. Microbiol. Immunol. 49 (2005) 139-147
23. Hines I.N., and Wheeler M.D. Recent advances in alcoholic liver disease. III. Role of the innate immune response in alcoholic hepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 287 (2004) G310-G314
24. Hirata A., Murakami Y., Shoji M., Kadoma Y., and Fujisawa S. Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression. Anticancer Res. 25 (2005) 3367-3374
25. IFCC methods for the measurement of catalytic concentrations of enzymes. Part 3, IFCC. Method for alanine aminotransferase (l-alanine 2-oxoglutarate aminotransferase, ec 2.6.1.2). Clin. Chim. Acta 105 (1980) 145F-172F
26. Jaeschke H., Farhood A., Bautista A.P., Spolarics Z., and Spitzer J.J. Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. Am. J. Physiol. 264 (1993) G801-G809
27. James P.E., Madhani M., Roebuck W., Jackson S.K., and Swartz H.M. Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption. Nitric Oxide 6 (2002) 18-28
28. Jean T., and Bodinier M.C. Mediators involved in inflammation: effects of daflon 500 mg on their release. Angiology 45 (1994) 554-559
29. Jollow D., Mitchell L., Zampaglione N., and Gillete J. Bromobenze induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacology 11 (1974) 151-169
30. Kao E.S., Wang C.J., Lin W.L., Yin Y.F., Wang C.P., and Tseng T.H. Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo. J. Agric. Food Chem. 53 (2005) 430-436
31. Kono H., Asakawa M., Fujii H., Maki A., Amemiya H., Yamamoto M., Matsuda M., and Matsumoto Y. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J. Pharmacol. Exp. Ther. 307 (2003) 74-82
32. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch. Biochem. Biophys. 186 (1978) 189-195
33. Levy E., and Ruebner B.H. Hepatic changes produced by a single dose of endotoxin in the mouse. Light microscopy and histochemistry. Am. J. Pathol. 51 (1967) 269-285
34. Luster M.I., Germolec D.R., Yoshida T., Kayama F., and Thompson M. Endotoxin-induced cytokine gene expression and excretion in the liver. Hepatology 19 (1994) 480-488
35. Machlin L.J., and Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J. 1 (1987) 441-445
36. Malterud K.E., and Rydland K.M. Inhibitors of 15-lipoxygenase from orange peel. J. Agric. Food Chem. 48 (2000) 5576-5580
37. Matsuda H., Ishikado A., Nishida N., Ninomiya K., Fujiwara H., Kobayashi Y., and Yoshikawa M. Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica. Bioorg. Med. Chem. Lett. 8 (1998) 2939-2944
38. Miyake Y., Yamamoto K., Tsujihara N., and Osawa T. Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids 33 (1998) 689-695
39. Morel I., Lescoat G., Cillard P., and Cillard J. Role of flavonoids and iron chelation in antioxidant action. Methods Enzymol. 234 (1994) 437-443
40. Morel I., Lescoat G., Cogrel P., Sergent O., Pasdeloup N., Brissot P., Cillard P., and Cillard J. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochem. Pharmacol. 45 (1993) 13-19
41. Nagai H., Matsumaru K., Feng G., and Kaplowitz N. Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology 36 (2002) 55-64
42. Pearlman F.C., and Lee R.T. Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents. Clin. Chem. 20 (1974) 447-453
43. Radi R., Beckman J.S., Bush K.M., and Freeman B.A. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266 (1991) 4244-4250
44. Ratty A.K., and Das N.P. Effects of flavonoids on non-enzymatic lipid peroxidation: structure-activity relationship. Biochem. Med. Metab. Biol. 39 (1988) 69-79
45. Recommendations of the German Society for Clinical Chemistry. Standardisation of methods for the estimation of enzyme activities in biological fluids. Experimental basis for the optimized standard conditions. Z. Klin. Chem. Klin. Biochem. 10 (1972) 281-291
46. Roland C.R., Naziruddin B., Mohanakumar T., and Flye M.W. Gadolinium chloride inhibits Kupffer cell nitric oxide synthase (iNOS) induction. J. Leukocyte Biol. 60 (1996) 487-492
47. Sewerynek E., Melchiorri D., Reiter R.J., Ortiz G.G., and Lewinski A. Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin. Eur. J. Pharmacol. 293 (1995) 327-334
48. Shoji Y., Uedono Y., Ishikura H., Takeyama N., and Tanaka T. DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation. Immunology 84 (1995) 543-548
49. Singal A., Tirkey N., Pilkhwal S., and Chopra K. Green tea (Camellia sinensis) extract ameliorates endotoxin induced sickness behavior and liver damage in rats. Phytother. Res. 20 (2006) 125-129
50. Su G.L. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2002) G256-G265
51. Sugino K., Dohi K., Yamada K., and Kawasaki T. The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants. Surgery 101 (1987) 746-752
52. Tirkey N., Pilkhwal S., Kuhad A., and Chopra K. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol. 5 (2005) 2
53. Tsuji K., Kwon A.H., Yoshida H., Qiu Z., Kaibori M., Okumura T., and Kamiyama Y. Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats. J. Hepatol. 42 (2005) 94-101
54. Wacker A., and Eilmes H.G. Virus inhibition using hesperidin. Naturwissenschaften 62 (1975) 301
55. Wills E.D. Mechanisms of lipid peroxide formation in animal tissues. Biochem. J. 99 (1966) 667-676
56. Wilmsen P.K., Spada D.S., and Salvador M. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J. Agric. Food Chem. 53 (2005) 4757-4761
57. Yoshikawa T., Takano H., Takahashi S., Ichikawa H., and Kondo M. Changes in tissue antioxidant enzyme activities and lipid peroxides in endotoxin-induced multiple organ failure. Circ. Shock 42 (1994) 53-58
58. Zhang C., Walker L.M., Hinson J.A., and Mayeux P.R. Oxidant stress in rat liver after lipopolysaccharide administration: effect of inducible nitric-oxide synthase inhibition. J. Pharmacol. Exp. Ther. 293 (2000) 968-972