Human pancreatic islet β-cell destruction by cytokines involves oxygen free radicals and aldehyde production

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 9, 1996, Pages 3197-3202

  Rabinovitch, Alex ^a   Suarez Pinzon, Wilma L ^a   Strynadka, Ken ^a   Lakey, Jonathan R T ^a   Rajotte, Ray V ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; ANTIOXIDANT; CYTOKINE; DNA; INSULIN; LAZAROID; MALONALDEHYDE; NITRIC OXIDE; NITRITE; OXYGEN RADICAL;

ARTICLE; CELL DESTRUCTION; CLINICAL ARTICLE; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN DEPENDENT DIABETES MELLITUS; LIPID PEROXIDATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ALDEHYDES; ANTIOXIDANTS; ARGININE; AUTOIMMUNE DISEASES; CYTOKINES; DIABETES MELLITUS, TYPE 1; DNA; ENZYME INHIBITORS; ETHYLAMINES; FREE RADICALS; HUMANS; INSULIN; INTERFERON TYPE II; INTERLEUKIN-1; ISLETS OF LANGERHANS; MALONDIALDEHYDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PIPERAZINES; PYRIDINES; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029795599     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.9.3197     Document Type: Article

References (5)

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3. Mandrup-Poulsen T, Helqvist S, Wogensen LD, et al. 1990 Cytokines and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr Top Microbiol Immunol. 164:169-193.
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5. Rabinovitch A. 1993 Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev. 1:215-240.