Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid

Free Radical Biology and Medicine

Volumn 48, Issue 11, 2010, Pages 1465-1484

  Manna, Prasenjit ^a   Das, Joydeep ^a   Ghosh, Jyotirmoy ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Antidiabetic; Antioxidant; Apoptosis; Arjunolic acid; Free radicals; Hyperglycemia; Liver dysfunction; Reactive intermediates

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; 8 HYDROXYDEOXYGUANOSINE; ADENOSINE TRIPHOSPHATE; ADVANCED GLYCATION END PRODUCT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; ARJUNOLIC ACID; CASPASE; ENZYME ANTIBODY; GLUTATHIONE; HEMOGLOBIN A1C; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DIABETIC PATIENT; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; EXPERIMENTAL RAT; FLUORESCENCE ACTIVATED CELL SORTING; HYPERGLYCEMIA; IMMUNOFLUORESCENCE; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; LIPID PEROXIDATION; LIVER DYSFUNCTION; LIVER HISTOLOGY; LIVER PROTECTION; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STAINING; STREPTOZOCIN DIABETES; WEIGHT REDUCTION;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DNA FRAGMENTATION; FREE RADICAL SCAVENGERS; GLUTATHIONE; I-KAPPA B PROTEINS; LIPID PEROXIDATION; LIVER; LIVER DISEASES; MALE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN CARBONYLATION; RATS; REACTIVE OXYGEN SPECIES; TRITERPENES;

ANIMALIA; RATTUS;

EID: 77952551952     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.02.025     Document Type: Article

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