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Volumn 650, Issue 2-3, 2011, Pages 694-702

The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model

Author keywords

Cytokines; Diabetes; Genistein; Nerve growth factor; Neuropathy; Oxidative stress

Indexed keywords

CATALASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GENISTEIN; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPID PEROXIDE; MALONALDEHYDE; NERVE GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 78651064824     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.060     Document Type: Article
Times cited : (157)

References (59)
  • 1
    • 0036895683 scopus 로고    scopus 로고
    • Beneficial role of dietary phytoestrogens in obesity and diabetes
    • S.J. Bhathena, and M.T. Velasquez Beneficial role of dietary phytoestrogens in obesity and diabetes Am. J. Clin. Nutr. 76 2002 1191 1201
    • (2002) Am. J. Clin. Nutr. , vol.76 , pp. 1191-1201
    • Bhathena, S.J.1    Velasquez, M.T.2
  • 2
    • 0035195970 scopus 로고    scopus 로고
    • Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy
    • N.E. Cameron, S.E. Eaton, M.A. Cotter, and S. Tesfaye Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy Diabetologia 44 2001 1973 1988
    • (2001) Diabetologia , vol.44 , pp. 1973-1988
    • Cameron, N.E.1    Eaton, S.E.2    Cotter, M.A.3    Tesfaye, S.4
  • 4
    • 0026476265 scopus 로고
    • Sequential changes in activities of superoxide dismutase and catalase in brain regions and liver during (-)deprenyl infusion in male rats
    • M.C. Carrillo, S. Kanai, G.O. Ivy, and K. Kitani Sequential changes in activities of superoxide dismutase and catalase in brain regions and liver during (-)deprenyl infusion in male rats Biochem. Pharmacol. 44 1992 2185 2189
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 2185-2189
    • Carrillo, M.C.1    Kanai, S.2    Ivy, G.O.3    Kitani, K.4
  • 5
    • 42149124840 scopus 로고    scopus 로고
    • Caffeic acid phenethyl ester (CAPE) protects brain against oxidative stress and inflammation induced by diabetes in rats
    • S. Celik, and S. Erdogan Caffeic acid phenethyl ester (CAPE) protects brain against oxidative stress and inflammation induced by diabetes in rats Mol. Cell. Biochem. 312 2008 39 46
    • (2008) Mol. Cell. Biochem. , vol.312 , pp. 39-46
    • Celik, S.1    Erdogan, S.2
  • 6
    • 77956060239 scopus 로고    scopus 로고
    • Murine models of human neuropathic pain
    • M. Colleoni, and P. Sacerdote Murine models of human neuropathic pain Biochim. Biophys. Acta 1802 2010 924 933
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 924-933
    • Colleoni, M.1    Sacerdote, P.2
  • 7
    • 73449084110 scopus 로고    scopus 로고
    • Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress
    • F. Comelli, I. Bettoni, M. Colleoni, G. Giagnoni, and B. Costa Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress Phytother. Res. 23 2009 1678 1684
    • (2009) Phytother. Res. , vol.23 , pp. 1678-1684
    • Comelli, F.1    Bettoni, I.2    Colleoni, M.3    Giagnoni, G.4    Costa, B.5
  • 8
    • 0037086889 scopus 로고    scopus 로고
    • Macrophage infiltration and death in the nerve during the early phases of experimental diabetic neuropathy: A process concomitant with endoneurial induction of IL-1β and p75NTR
    • G. Conti, E. Scarpini, P. Baron, S. Livraghi, M. Tiriticchio, R. Bianchi, C. Vedeler, and G. Scarlato Macrophage infiltration and death in the nerve during the early phases of experimental diabetic neuropathy: a process concomitant with endoneurial induction of IL-1β and p75NTR J. Neurol. Sci. 195 2002 35 40
    • (2002) J. Neurol. Sci. , vol.195 , pp. 35-40
    • Conti, G.1    Scarpini, E.2    Baron, P.3    Livraghi, S.4    Tiriticchio, M.5    Bianchi, R.6    Vedeler, C.7    Scarlato, G.8
  • 9
    • 33846070616 scopus 로고    scopus 로고
    • The non-psychoactive cannabis constituent cannabidiol is an orally active therapeutic agent in rat chronic inflammatory and neuropathic pain
    • B. Costa, A.E. Trovato, F. Comelli, G. Giagnoni, and M. Colleoni The non-psychoactive cannabis constituent cannabidiol is an orally active therapeutic agent in rat chronic inflammatory and neuropathic pain Eur. J. Pharmacol. 556 2007 75 83
    • (2007) Eur. J. Pharmacol. , vol.556 , pp. 75-83
    • Costa, B.1    Trovato, A.E.2    Comelli, F.3    Giagnoni, G.4    Colleoni, M.5
  • 10
    • 0027286569 scopus 로고
    • Streptozotocin-induced diabetic rats: Behavioural evidence for a model of chronic pain
    • C. Courteix, A. Eschalier, and J. Lavarenne Streptozotocin-induced diabetic rats: behavioural evidence for a model of chronic pain Pain 53 1993 81 88
    • (1993) Pain , vol.53 , pp. 81-88
    • Courteix, C.1    Eschalier, A.2    Lavarenne, J.3
  • 12
    • 0343293802 scopus 로고    scopus 로고
    • Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: Structure-activity relationships
    • A.J. Dugas, J. Castaeda-Acosta, G.C. Bonin, K.L. Price, N.H. Fisher, and G.W. Winston Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: structure-activity relationships J. Nat. Prod. 63 2000 327 331
    • (2000) J. Nat. Prod. , vol.63 , pp. 327-331
    • Dugas, A.J.1    Castaeda-Acosta, J.2    Bonin, G.C.3    Price, K.L.4    Fisher, N.H.5    Winston, G.W.6
  • 13
    • 0025306760 scopus 로고
    • Low serum levels of nerve growth factor in diabetic neuropathy
    • V. Faradji, and J. Sotelo Low serum levels of nerve growth factor in diabetic neuropathy Acta Neurol. Scand. 1 1990 402 406
    • (1990) Acta Neurol. Scand. , vol.1 , pp. 402-406
    • Faradji, V.1    Sotelo, J.2
  • 15
    • 0024595407 scopus 로고
    • Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes
    • G.F. Gaetani, S. Galiano, L. Canepa, A.M. Ferraris, and H.N. Kirkman Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes Blood 73 1989 334 339
    • (1989) Blood , vol.73 , pp. 334-339
    • Gaetani, G.F.1    Galiano, S.2    Canepa, L.3    Ferraris, A.M.4    Kirkman, H.N.5
  • 18
    • 48249129214 scopus 로고    scopus 로고
    • Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: A novel circulating marker for diabetic neuropathy
    • EURODIAB Prospective Complication Study Group
    • G. Gruden, G. Bruno, N. Chaturvedi EURODIAB Prospective Complication Study Group Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: a novel circulating marker for diabetic neuropathy Diabetes 57 2008 1966 1970
    • (2008) Diabetes , vol.57 , pp. 1966-1970
    • Gruden, G.1    Bruno, G.2    Chaturvedi, N.3
  • 20
    • 0017064979 scopus 로고
    • A fluorimetric method for determination of oxidized and reduced glutathione in tissues
    • P.J. Hissin, and R. Hilf A fluorimetric method for determination of oxidized and reduced glutathione in tissues Anal. Biochem. 74 1976 214 226
    • (1976) Anal. Biochem. , vol.74 , pp. 214-226
    • Hissin, P.J.1    Hilf, R.2
  • 21
    • 34047262030 scopus 로고    scopus 로고
    • The effect of low-dose insulin on mechanical sensitivity and allodynia in type i diabetes neuropathy
    • Y.M.J.J. Hoybergs, and T.F. Meert The effect of low-dose insulin on mechanical sensitivity and allodynia in type I diabetes neuropathy Neurosci. Lett. 417 2007 149 154
    • (2007) Neurosci. Lett. , vol.417 , pp. 149-154
    • Hoybergs, Y.M.J.J.1    Meert, T.F.2
  • 22
    • 33845455480 scopus 로고    scopus 로고
    • Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy
    • I. Idris, and R. Donnelly Protein kinase C beta inhibition: a novel therapeutic strategy for diabetic microangiopathy Diab. Vasc. Dis. Res. 3 2006 172 178
    • (2006) Diab. Vasc. Dis. Res. , vol.3 , pp. 172-178
    • Idris, I.1    Donnelly, R.2
  • 23
    • 57649225736 scopus 로고    scopus 로고
    • Effects of intrathecal administration of newer antidepressant on mechanical allodynia in rat models of neuropathic pain
    • T. Ikeda, Y. Ishida, R. Naono, R. Takeda, H. Abe, T. Nakamura, and T. Nishimori Effects of intrathecal administration of newer antidepressant on mechanical allodynia in rat models of neuropathic pain Neurosci. Res. 63 2009 42 46
    • (2009) Neurosci. Res. , vol.63 , pp. 42-46
    • Ikeda, T.1    Ishida, Y.2    Naono, R.3    Takeda, R.4    Abe, H.5    Nakamura, T.6    Nishimori, T.7
  • 25
    • 9644264237 scopus 로고    scopus 로고
    • C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes
    • H. Kamiya, W. Zhang, and A.A. Sima C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes Ann. Neurol. 56 2004 827 835
    • (2004) Ann. Neurol. , vol.56 , pp. 827-835
    • Kamiya, H.1    Zhang, W.2    Sima, A.A.3
  • 26
    • 1242337435 scopus 로고    scopus 로고
    • Oxcarbazepine antinociception in animals with inflammatory pain or painful diabetic neuropathy
    • S. Kiguchi, T. Imamura, K. Ichikawa, and M. Kojima Oxcarbazepine antinociception in animals with inflammatory pain or painful diabetic neuropathy Clin. Exp. Pharmacol. Physiol. 31 2004 57 64
    • (2004) Clin. Exp. Pharmacol. Physiol. , vol.31 , pp. 57-64
    • Kiguchi, S.1    Imamura, T.2    Ichikawa, K.3    Kojima, M.4
  • 27
    • 68749098097 scopus 로고    scopus 로고
    • Tocotrienol attenuates oxidative-nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy
    • A. Kuhad, and K. Chopra Tocotrienol attenuates oxidative-nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy Neuropharmacology 57 2009 456 462
    • (2009) Neuropharmacology , vol.57 , pp. 456-462
    • Kuhad, A.1    Chopra, K.2
  • 29
    • 0037861856 scopus 로고    scopus 로고
    • Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle
    • J.M. Lawler, W. Song, and S.R. Demaree Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle Free Radic. Biol. Med. 35 2003 9 16
    • (2003) Free Radic. Biol. Med. , vol.35 , pp. 9-16
    • Lawler, J.M.1    Song, W.2    Demaree, S.R.3
  • 30
    • 0030961020 scopus 로고    scopus 로고
    • The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy
    • P.A. Low, K.K. Nickander, and H.J. Tritschler The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy Diabetes 46 1997 S38 S42
    • (1997) Diabetes , vol.46
    • Low, P.A.1    Nickander, K.K.2    Tritschler, H.J.3
  • 31
    • 77952551952 scopus 로고    scopus 로고
    • Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid
    • P. Manna, J. Das, J. Ghosh, and P.C. Sil Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: prophylactic role of arjunolic acid Free Radic. Biol. Med. 48 2010 1465 1484
    • (2010) Free Radic. Biol. Med. , vol.48 , pp. 1465-1484
    • Manna, P.1    Das, J.2    Ghosh, J.3    Sil, P.C.4
  • 32
    • 33645213907 scopus 로고    scopus 로고
    • Isoflavones made simple-Genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits
    • M.F. McCarty Isoflavones made simple-Genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits Med. Hypotheses 66 2006 1093 1114
    • (2006) Med. Hypotheses , vol.66 , pp. 1093-1114
    • McCarty, M.F.1
  • 33
    • 74049088228 scopus 로고    scopus 로고
    • Mitigating micro- and macro-vascular complications of diabetes beginning in adolescence
    • D.J. Moore, J.M. Gregory, Y.A. Kumah-Crystal, and J.H. Simmons Mitigating micro- and macro-vascular complications of diabetes beginning in adolescence Vasc. Health Risk Manag. 5 2009 1015 1031
    • (2009) Vasc. Health Risk Manag. , vol.5 , pp. 1015-1031
    • Moore, D.J.1    Gregory, J.M.2    Kumah-Crystal, Y.A.3    Simmons, J.H.4
  • 34
    • 0029090976 scopus 로고
    • Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy
    • M. Nagamatsu, K.K. Nickander, J.D. Schmelzer, A. Raya, D.A. Wittrock, H. Tritschler, and P.A. Low Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy Diab. Care 18 1995 1160 1167
    • (1995) Diab. Care , vol.18 , pp. 1160-1167
    • Nagamatsu, M.1    Nickander, K.K.2    Schmelzer, J.D.3    Raya, A.4    Wittrock, D.A.5    Tritschler, H.6    Low, P.A.7
  • 35
    • 0035215435 scopus 로고    scopus 로고
    • Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy
    • I.G. Obrosova, L. Fathallah, and M.J. Stevens Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy Exp. Neurol. 172 2001 211 219
    • (2001) Exp. Neurol. , vol.172 , pp. 211-219
    • Obrosova, I.G.1    Fathallah, L.2    Stevens, M.J.3
  • 36
    • 62549115284 scopus 로고    scopus 로고
    • Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats
    • P. Palsamy, and S. Subramanian Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats Chem. Biol. Interact. 179 2009 356 362
    • (2009) Chem. Biol. Interact. , vol.179 , pp. 356-362
    • Palsamy, P.1    Subramanian, S.2
  • 37
    • 70649088771 scopus 로고    scopus 로고
    • Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats
    • L. Pari, and C. Sankaranarayanan Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats Life Sci. 85 2009 830 834
    • (2009) Life Sci. , vol.85 , pp. 830-834
    • Pari, L.1    Sankaranarayanan, C.2
  • 38
    • 33845596741 scopus 로고    scopus 로고
    • Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals
    • J. Park, S.S. Choe, A.H. Choi, K.H. Kim, M.J. Yoon, T. Suganami, Y. Ogawa, and J.B. Kim Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals Diabetes 55 2006 2939 2949
    • (2006) Diabetes , vol.55 , pp. 2939-2949
    • Park, J.1    Choe, S.S.2    Choi, A.H.3    Kim, K.H.4    Yoon, M.J.5    Suganami, T.6    Ogawa, Y.7    Kim, J.B.8
  • 39
    • 77952548706 scopus 로고    scopus 로고
    • The role of vitamin e and oxidative stress in diabetic complications
    • R. Pazdro, and J.R. Burgess The role of vitamin E and oxidative stress in diabetic complications Mech. Ageing Dev. 131 2010 276 286
    • (2010) Mech. Ageing Dev. , vol.131 , pp. 276-286
    • Pazdro, R.1    Burgess, J.R.2
  • 40
    • 17144404203 scopus 로고    scopus 로고
    • Animal models of diabetes mellitus
    • D.A. Rees, and J.C. Alcolado Animal models of diabetes mellitus Diabet. Med. 22 2005 359 370
    • (2005) Diabet. Med. , vol.22 , pp. 359-370
    • Rees, D.A.1    Alcolado, J.C.2
  • 42
    • 34347219785 scopus 로고    scopus 로고
    • Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy
    • A.K. Saini, H.A.S. Kumar, and S.S. Sharma Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy Eur. J. Pharmacol. 568 2007 164 172
    • (2007) Eur. J. Pharmacol. , vol.568 , pp. 164-172
    • Saini, A.K.1    Kumar, H.A.S.2    Sharma, S.S.3
  • 43
    • 35548980921 scopus 로고    scopus 로고
    • Phytochemical genistein in the regulation of vascular function: New insights
    • H. Si, and D. Liu Phytochemical genistein in the regulation of vascular function: new insights Curr. Med. Chem. 14 2007 2581 2589
    • (2007) Curr. Med. Chem. , vol.14 , pp. 2581-2589
    • Si, H.1    Liu, D.2
  • 44
    • 33847634280 scopus 로고    scopus 로고
    • Cardiovascular targets for estrogens and phytoestrogens: Transcriptional regulation of nitric oxide synthase and antioxidant defence genes
    • R.C.M. Siow, F.Y.L. Li, D.J. Rowlands, P. de Winter, and G.E. Mann Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and antioxidant defence genes Free Radic. Biol. Med. 42 2007 909 925
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 909-925
    • Siow, R.C.M.1    Li, F.Y.L.2    Rowlands, D.J.3    De Winter, P.4    Mann, G.E.5
  • 45
    • 0346398463 scopus 로고    scopus 로고
    • Role of neuropoietic cytokines in development and progression of diabetic polineuropathy: From glucose metabolism to neurodegeneration
    • D.S. Skundric, and R.P. Lisak Role of neuropoietic cytokines in development and progression of diabetic polineuropathy: from glucose metabolism to neurodegeneration Exp. Diabesity Res. 4 2003 303 312
    • (2003) Exp. Diabesity Res. , vol.4 , pp. 303-312
    • Skundric, D.S.1    Lisak, R.P.2
  • 46
    • 0030930678 scopus 로고    scopus 로고
    • Role of neurotrophins in diabetic neuropathy and treatment with nerve growth factors
    • D.R. Tomlinson, P. Fernyhough, and L.T. Diemel Role of neurotrophins in diabetic neuropathy and treatment with nerve growth factors Diabetes 46 Suppl 2 1997 S43 S49
    • (1997) Diabetes , vol.46 , Issue.SUPPL. 2
    • Tomlinson, D.R.1    Fernyhough, P.2    Diemel, L.T.3
  • 49
    • 70449732132 scopus 로고    scopus 로고
    • Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
    • T. Valente, A. Gella, X. Fernandez-Busquets, M. Unzeta, and N. Durany Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus Neurobiol. Dis. 37 2010 67 76
    • (2010) Neurobiol. Dis. , vol.37 , pp. 67-76
    • Valente, T.1    Gella, A.2    Fernandez-Busquets, X.3    Unzeta, M.4    Durany, N.5
  • 50
    • 51849101592 scopus 로고    scopus 로고
    • Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: Anti-inflammatory and antioxidant activity
    • A.E. Valsecchi, S. Franchi, A.E. Panerai, P. Sacerdote, A.E. Trovato, and M. Collleoni Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity J. Neurochem. 107 2008 230 240
    • (2008) J. Neurochem. , vol.107 , pp. 230-240
    • Valsecchi, A.E.1    Franchi, S.2    Panerai, A.E.3    Sacerdote, P.4    Trovato, A.E.5    Collleoni, M.6
  • 54
    • 8544220372 scopus 로고    scopus 로고
    • Ischemia-reperfusion injury of peripheral nerve in experimental diabetic neuropathy
    • DOI 10.1016/j.jns.2004.09.020, PII S0022510X04002801
    • Y. Wang, J.D. Schmelzer, A. Schmeichel, H. Iida, and P.A. Low Ischemia-reperfusion injury of peripheral nerve in experimental diabetic neuropathy J. Neurol. Sci. 227 2004 101 107 (Pubitemid 39491132)
    • (2004) Journal of the Neurological Sciences , vol.227 , Issue.1 , pp. 101-107
    • Wang, Y.1    Schmelzer, J.D.2    Schmeichel, A.3    Iida, H.4    Low, P.A.5
  • 55
    • 70749131115 scopus 로고    scopus 로고
    • Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats
    • C.F. Wang, D.Q. Li, H.Y. Xue, and B. Hu Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats Brain Res. 2307 2010 158 165
    • (2010) Brain Res. , vol.2307 , pp. 158-165
    • Wang, C.F.1    Li, D.Q.2    Xue, H.Y.3    Hu, B.4
  • 56
    • 30344475859 scopus 로고    scopus 로고
    • Benfotiamine alleviates diabetic-induced cerebral oxidative damage independent of advanced of advanced glycation end-product, tissue factor and TNF-alpha
    • S. Wu, and J. Ren Benfotiamine alleviates diabetic-induced cerebral oxidative damage independent of advanced of advanced glycation end-product, tissue factor and TNF-alpha Neurosci. Lett. 394 2006 158 162
    • (2006) Neurosci. Lett. , vol.394 , pp. 158-162
    • Wu, S.1    Ren, J.2
  • 57
    • 5044245855 scopus 로고    scopus 로고
    • Protective effect of caffeic acid phenenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver
    • H.R. Yilmaz, E. Uz, N. Yucel, I. Altuntas, and N. Ozcelik Protective effect of caffeic acid phenenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver J. Biochem. Mol. Toxicol. 18 2004 234 238
    • (2004) J. Biochem. Mol. Toxicol. , vol.18 , pp. 234-238
    • Yilmaz, H.R.1    Uz, E.2    Yucel, N.3    Altuntas, I.4    Ozcelik, N.5
  • 58
    • 30544453969 scopus 로고    scopus 로고
    • Oral administration of soy-derived genistein suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat
    • J.H. Zhao, Y. Arao, S.J. Sun, A. Kikuchi, and F. Kayama Oral administration of soy-derived genistein suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat Life Sci. 78 2006 812 819
    • (2006) Life Sci. , vol.78 , pp. 812-819
    • Zhao, J.H.1    Arao, Y.2    Sun, S.J.3    Kikuchi, A.4    Kayama, F.5
  • 59
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


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