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Volumn 5, Issue 9, 2015, Pages

An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis

Author keywords

Demyelination; Diagnosis; Etiology; Immunomodulator; Multiple sclerosis; Pathogenesis; Treatment

Indexed keywords

BETA INTERFERON; FINGOLIMOD; GLATIRAMER; MITOXANTRONE; NATALIZUMAB;

EID: 84941942611     PISSN: None     EISSN: 21623279     Source Type: Journal    
DOI: 10.1002/brb3.362     Document Type: Article
Times cited : (226)

References (115)
  • 1
    • 0029658198 scopus 로고    scopus 로고
    • Immunopathology or organ-specific autoimmunity as a consequence of virus infection
    • Aichele, P., M. F. Bachmann, H. Hengartner, and R. M. Zinkernagel 1996. Immunopathology or organ-specific autoimmunity as a consequence of virus infection. Immunol. Rev. 152:21-45.
    • (1996) Immunol. Rev. , vol.152 , pp. 21-45
    • Aichele, P.1    Bachmann, M.F.2    Hengartner, H.3    Zinkernagel, R.M.4
  • 2
    • 84890084194 scopus 로고    scopus 로고
    • Environmental factors in multiple sclerosis
    • Ascherio, A. 2013. Environmental factors in multiple sclerosis. Expert Rev. Neurother. 13:3-9.
    • (2013) Expert Rev. Neurother. , vol.13 , pp. 3-9
    • Ascherio, A.1
  • 3
    • 34247590137 scopus 로고    scopus 로고
    • Environmental risk factors for multiple sclerosis. Part I: the role of infection
    • Ascherio, A., and K. L. Munger 2007a. Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann. Neurol. 61:288-299.
    • (2007) Ann. Neurol. , vol.61 , pp. 288-299
    • Ascherio, A.1    Munger, K.L.2
  • 4
    • 34447508481 scopus 로고    scopus 로고
    • Environmental risk factors for multiple sclerosis. Part II: noninfectious factors
    • Ascherio, A., and K. L. Munger 2007b. Environmental risk factors for multiple sclerosis. Part II: noninfectious factors. Ann. Neurol. 61:504-513.
    • (2007) Ann. Neurol. , vol.61 , pp. 504-513
    • Ascherio, A.1    Munger, K.L.2
  • 6
    • 85119304125 scopus 로고    scopus 로고
    • (teriflunomide) Prescibing information. Genzyme Corp. (Accessed July 23, 2014).
    • ® (teriflunomide) Prescibing information. 2014. Genzyme Corp. (Accessed July 23, 2014).
    • (2014)
  • 7
    • 77249098682 scopus 로고    scopus 로고
    • Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis
    • Awad, A., B. Hemmer, H. P. Hartung, B. Kieseier, J. L. Bennett, and O. Stuve 2010. Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis. J. Neuroimmunol. 219:1-7.
    • (2010) J. Neuroimmunol. , vol.219 , pp. 1-7
    • Awad, A.1    Hemmer, B.2    Hartung, H.P.3    Kieseier, B.4    Bennett, J.L.5    Stuve, O.6
  • 9
    • 0041522756 scopus 로고    scopus 로고
    • Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance
    • Barkhof, F., W. Bruck, C. J. De Groot, E. Bergers, S. Hulshof, J. Geurts, et al. 2003. Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance. Arch. Neurol. 60:1073-1081.
    • (2003) Arch. Neurol. , vol.60 , pp. 1073-1081
    • Barkhof, F.1    Bruck, W.2    De Groot, C.J.3    Bergers, E.4    Hulshof, S.5    Geurts, J.6
  • 10
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion
    • Barnett, M. H., and J. W. Prineas 2004. Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann. Neurol. 55:458-468.
    • (2004) Ann. Neurol. , vol.55 , pp. 458-468
    • Barnett, M.H.1    Prineas, J.W.2
  • 11
    • 77955844059 scopus 로고    scopus 로고
    • Emerging concepts in autoimmune encephalomyelitis beyond the CD4/T(H)1 paradigm
    • Batoulis, H., K. Addicks, and S. Kuerten 2010. Emerging concepts in autoimmune encephalomyelitis beyond the CD4/T(H)1 paradigm. Annals Anat. 192:179-193.
    • (2010) Annals Anat. , vol.192 , pp. 179-193
    • Batoulis, H.1    Addicks, K.2    Kuerten, S.3
  • 12
    • 84873138150 scopus 로고    scopus 로고
    • Treatment of acute relapses in multiple sclerosis
    • Berkovich, R. 2013. Treatment of acute relapses in multiple sclerosis. Neurotherapeutics 10:97-105.
    • (2013) Neurotherapeutics , vol.10 , pp. 97-105
    • Berkovich, R.1
  • 15
    • 20444489863 scopus 로고    scopus 로고
    • The spectrum of multiple sclerosis: new lessons from pathology
    • Bruck, W., and C. Stadelmann 2005. The spectrum of multiple sclerosis: new lessons from pathology. Curr. Opin. Neurol. 18:221-224.
    • (2005) Curr. Opin. Neurol. , vol.18 , pp. 221-224
    • Bruck, W.1    Stadelmann, C.2
  • 17
    • 84923096927 scopus 로고    scopus 로고
    • Treatment of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome with intravenous immunoglobulin in a patient with multiple sclerosis treated with fingolimod after discontinuation of natalizumab
    • Calic, Z., C. Cappelen-Smith, S. J. Hodgkinson, A. McDougall, R. Cuganesan, and B. J. Brew 2015. Treatment of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome with intravenous immunoglobulin in a patient with multiple sclerosis treated with fingolimod after discontinuation of natalizumab. J. Clin. Neurosci. 22:598-600.
    • (2015) J. Clin. Neurosci. , vol.22 , pp. 598-600
    • Calic, Z.1    Cappelen-Smith, C.2    Hodgkinson, S.J.3    McDougall, A.4    Cuganesan, R.5    Brew, B.J.6
  • 18
    • 84941934799 scopus 로고    scopus 로고
    • Case of PML reported in patient treated with Gilenya®.
    • Case of PML reported in patient treated with Gilenya®. https://beta.mssociety.ca/research-news/article/case-of-pml-reported-in-patient-treated-with-gilenya, 2015.
    • (2015)
  • 19
    • 0032525049 scopus 로고    scopus 로고
    • FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
    • Chiba, K., Y. Yanagawa, Y. Masubuchi, H. Kataoka, T. Kawaguchi, M. Ohtsuki, et al. 1998. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J. Immunol. 160:5037-5044.
    • (1998) J. Immunol. , vol.160 , pp. 5037-5044
    • Chiba, K.1    Yanagawa, Y.2    Masubuchi, Y.3    Kataoka, H.4    Kawaguchi, T.5    Ohtsuki, M.6
  • 22
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston, A., and A. Coles 2008. Multiple sclerosis. Lancet 372:1502-1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 23
    • 84894271594 scopus 로고    scopus 로고
    • Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial
    • Confavreux, C., P. O'Connor, G. Comi, M. S. Freedman, A. E. Miller, T. P. Olsson, et al. 2014. Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 13:247-256.
    • (2014) Lancet Neurol. , vol.13 , pp. 247-256
    • Confavreux, C.1    O'Connor, P.2    Comi, G.3    Freedman, M.S.4    Miller, A.E.5    Olsson, T.P.6
  • 24
    • 80053559948 scopus 로고    scopus 로고
    • Environmental factors in early childhood are associated with multiple sclerosis: a case-control study
    • Conradi, S., U. Malzahn, F. Schroter, F. Paul, S. Quill, E. Spruth, et al. 2011. Environmental factors in early childhood are associated with multiple sclerosis: a case-control study. BMC Neurol. 11:123.
    • (2011) BMC Neurol. , vol.11 , pp. 123
    • Conradi, S.1    Malzahn, U.2    Schroter, F.3    Paul, F.4    Quill, S.5    Spruth, E.6
  • 25
    • 66549129834 scopus 로고    scopus 로고
    • Immunomodulatory effects of Vitamin D in multiple sclerosis
    • Correale, J., M. C. Ysrraelit, and M. I. Gaitan 2009. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 132:1146-1160.
    • (2009) Brain , vol.132 , pp. 1146-1160
    • Correale, J.1    Ysrraelit, M.C.2    Gaitan, M.I.3
  • 26
    • 84888400062 scopus 로고    scopus 로고
    • Optimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of action
    • Damal, K., E. Stoker, and J. F. Foley 2013. Optimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of action. Biologics 7:247-258.
    • (2013) Biologics , vol.7 , pp. 247-258
    • Damal, K.1    Stoker, E.2    Foley, J.F.3
  • 27
    • 0037161237 scopus 로고    scopus 로고
    • Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis
    • Dhib-Jalbut, S. 2002. Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis. Neurology 58:S3-S9.
    • (2002) Neurology , vol.58 , pp. S3-S9
    • Dhib-Jalbut, S.1
  • 28
    • 84876539679 scopus 로고    scopus 로고
    • PML in a patient treated with fumaric acid
    • Ermis, U., J. Weis, and J. B. Schulz 2013. PML in a patient treated with fumaric acid. N. Engl. J. Med. 368:1657-1658.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1657-1658
    • Ermis, U.1    Weis, J.2    Schulz, J.B.3
  • 30
    • 84941944637 scopus 로고    scopus 로고
    • FDA Drug Safety Communication: FDA warns about case of rare brain infection PML with MS drug Tecfidera (dimethyl fumarate)
    • Accessed January 8, 2015).
    • FDA Drug Safety Communication: FDA warns about case of rare brain infection PML with MS drug Tecfidera (dimethyl fumarate). http://www.fda.gov/Drugs/DrugSafety/ucm424625.htm, 2014. (Accessed January 8, 2015).
    • (2014)
  • 31
    • 0028359265 scopus 로고
    • Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis
    • Filippi, M., M. A. Horsfield, S. P. Morrissey, D. G. MacManus, P. Rudge, W. I. McDonald, et al. 1994. Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis. Neurology 44:635-641.
    • (1994) Neurology , vol.44 , pp. 635-641
    • Filippi, M.1    Horsfield, M.A.2    Morrissey, S.P.3    MacManus, D.G.4    Rudge, P.5    McDonald, W.I.6
  • 33
    • 33745285962 scopus 로고    scopus 로고
    • Management of worsening multiple sclerosis with mitoxantrone: a review
    • Fox, E. J. 2006. Management of worsening multiple sclerosis with mitoxantrone: a review. Clin. Ther. 28:461-474.
    • (2006) Clin. Ther. , vol.28 , pp. 461-474
    • Fox, E.J.1
  • 34
    • 84866355653 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
    • Fox, R. J., D. H. Miller, J. T. Phillips, M. Hutchinson, E. Havrdova, M. Kita, et al. 2012. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N. Engl. J. Med. 367:1087-1097.
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1087-1097
    • Fox, R.J.1    Miller, D.H.2    Phillips, J.T.3    Hutchinson, M.4    Havrdova, E.5    Kita, M.6
  • 36
    • 84911360224 scopus 로고    scopus 로고
    • Modifiable environmental factors in multiple sclerosis
    • Fragoso, Y. D. 2014. Modifiable environmental factors in multiple sclerosis. Arq. Neuropsiquiatr. 72:889-894.
    • (2014) Arq. Neuropsiquiatr. , vol.72 , pp. 889-894
    • Fragoso, Y.D.1
  • 37
  • 38
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis-the plaque and its pathogenesis
    • Frohman, E. M., M. K. Racke, and C. S. Raine 2006. Multiple sclerosis-the plaque and its pathogenesis. N. Engl. J. Med. 354:942-955.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 39
    • 0022375427 scopus 로고
    • Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity
    • Fujinami, R. S., and M. B. Oldstone 1985. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230:1043-1045.
    • (1985) Science , vol.230 , pp. 1043-1045
    • Fujinami, R.S.1    Oldstone, M.B.2
  • 40
    • 48849116689 scopus 로고    scopus 로고
    • Grey matter pathology in multiple sclerosis
    • Geurts, J. J., and F. Barkhof 2008. Grey matter pathology in multiple sclerosis. Lancet Neurol. 7:841-851.
    • (2008) Lancet Neurol. , vol.7 , pp. 841-851
    • Geurts, J.J.1    Barkhof, F.2
  • 41
    • 79953016820 scopus 로고    scopus 로고
    • Pathophysiology of multiple sclerosis and the place of teriflunomide
    • Gold, R., and J. S. Wolinsky 2011. Pathophysiology of multiple sclerosis and the place of teriflunomide. Acta Neurol. Scand. 124:75-84.
    • (2011) Acta Neurol. Scand. , vol.124 , pp. 75-84
    • Gold, R.1    Wolinsky, J.S.2
  • 42
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold, R., C. Linington, and H. Lassmann 2006. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129:1953-1971.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 43
    • 84866423965 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
    • Gold, R., L. Kappos, D. L. Arnold, A. Bar-Or, G. Giovannoni, K. Selmaj, et al. 2012. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N. Engl. J. Med. 367:1098-1107.
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1098-1107
    • Gold, R.1    Kappos, L.2    Arnold, D.L.3    Bar-Or, A.4    Giovannoni, G.5    Selmaj, K.6
  • 44
    • 0032915806 scopus 로고    scopus 로고
    • Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity
    • Gran, B., B. Hemmer, M. Vergelli, H. F. McFarland, and R. Martin 1999. Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity. Ann. Neurol. 45:559-567.
    • (1999) Ann. Neurol. , vol.45 , pp. 559-567
    • Gran, B.1    Hemmer, B.2    Vergelli, M.3    McFarland, H.F.4    Martin, R.5
  • 48
    • 0022459287 scopus 로고
    • Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
    • Hauser, S. L., A. K. Bhan, F. Gilles, M. Kemp, C. Kerr, and H. L. Weiner 1986. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann. Neurol. 19:578-587.
    • (1986) Ann. Neurol. , vol.19 , pp. 578-587
    • Hauser, S.L.1    Bhan, A.K.2    Gilles, F.3    Kemp, M.4    Kerr, C.5    Weiner, H.L.6
  • 49
    • 0036546066 scopus 로고    scopus 로고
    • New concepts in the immunopathogenesis of multiple sclerosis
    • Hemmer, B., J. J. Archelos, and H. P. Hartung 2002. New concepts in the immunopathogenesis of multiple sclerosis. Nat. Rev. Neurosci. 3:291-301.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 291-301
    • Hemmer, B.1    Archelos, J.J.2    Hartung, H.P.3
  • 50
    • 80052927697 scopus 로고    scopus 로고
    • Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
    • Howell, O. W., C. A. Reeves, R. Nicholas, D. Carassiti, B. Radotra, S. M. Gentleman, et al. 2011. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain 134:2755-2771.
    • (2011) Brain , vol.134 , pp. 2755-2771
    • Howell, O.W.1    Reeves, C.A.2    Nicholas, R.3    Carassiti, D.4    Radotra, B.5    Gentleman, S.M.6
  • 52
    • 33750579981 scopus 로고    scopus 로고
    • Multiple sclerosis: new insights and trends
    • Inglese, M. 2006. Multiple sclerosis: new insights and trends. AJNR Am. J. Neuroradiol. 27:954-957.
    • (2006) AJNR Am. J. Neuroradiol. , vol.27 , pp. 954-957
    • Inglese, M.1
  • 53
    • 39449090773 scopus 로고    scopus 로고
    • Genetics and natural history of multiple sclerosis
    • Kantarci, O. H. 2008. Genetics and natural history of multiple sclerosis. Semin. Neurol. 28:7-16.
    • (2008) Semin. Neurol. , vol.28 , pp. 7-16
    • Kantarci, O.H.1
  • 54
    • 8844285856 scopus 로고    scopus 로고
    • Interferon beta-1b in secondary progressive MS: a combined analysis of the two trials
    • Kappos, L., B. Weinshenker, C. Pozzilli, A. J. Thompson, F. Dahlke, K. Beckmann, et al. 2004. Interferon beta-1b in secondary progressive MS: a combined analysis of the two trials. Neurology 63:1779-1787.
    • (2004) Neurology , vol.63 , pp. 1779-1787
    • Kappos, L.1    Weinshenker, B.2    Pozzilli, C.3    Thompson, A.J.4    Dahlke, F.5    Beckmann, K.6
  • 56
    • 84895894740 scopus 로고    scopus 로고
    • The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review
    • Karussis, D. 2014. The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review. J. Autoimmun. 48-49:134-142.
    • (2014) J. Autoimmun. , vol.48-49 , pp. 134-142
    • Karussis, D.1
  • 57
    • 84876246277 scopus 로고    scopus 로고
    • Disability in multiple sclerosis: a reference for patients and clinicians
    • Kister, I., E. Chamot, A. R. Salter, G. R. Cutter, T. E. Bacon, and J. Herbert 2013. Disability in multiple sclerosis: a reference for patients and clinicians. Neurology 80:1018-1024.
    • (2013) Neurology , vol.80 , pp. 1018-1024
    • Kister, I.1    Chamot, E.2    Salter, A.R.3    Cutter, G.R.4    Bacon, T.E.5    Herbert, J.6
  • 58
    • 84876787121 scopus 로고    scopus 로고
    • Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
    • Kleinewietfeld, M., A. Manzel, J. Titze, H. Kvakan, N. Yosef, R. A. Linker, et al. 2013. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 496:518-522.
    • (2013) Nature , vol.496 , pp. 518-522
    • Kleinewietfeld, M.1    Manzel, A.2    Titze, J.3    Kvakan, H.4    Yosef, N.5    Linker, R.A.6
  • 61
    • 33750604563 scopus 로고    scopus 로고
    • Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness
    • Link, H., and Y. M. Huang 2006. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness. J. Neuroimmunol. 180:17-28.
    • (2006) J. Neuroimmunol. , vol.180 , pp. 17-28
    • Link, H.1    Huang, Y.M.2
  • 62
    • 79952136166 scopus 로고    scopus 로고
    • Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
    • Linker, R. A., D. H. Lee, S. Ryan, A. M. van Dam, R. Conrad, P. Bista, et al. 2011. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134:678-692.
    • (2011) Brain , vol.134 , pp. 678-692
    • Linker, R.A.1    Lee, D.H.2    Ryan, S.3    van Dam, A.M.4    Conrad, R.5    Bista, P.6
  • 63
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin, F. D., and S. C. Reingold 1996. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46:907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 65
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
    • Lucchinetti, C., W. Bruck, J. Parisi, B. Scheithauer, M. Rodriguez, and H. Lassmann 2000. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 47:707-717.
    • (2000) Ann. Neurol. , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 66
    • 46849083076 scopus 로고    scopus 로고
    • Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
    • Lucchinetti, C. F., R. H. Gavrilova, I. Metz, J. E. Parisi, B. W. Scheithauer, S. Weigand, et al. 2008. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis. Brain 131:1759-1775.
    • (2008) Brain , vol.131 , pp. 1759-1775
    • Lucchinetti, C.F.1    Gavrilova, R.H.2    Metz, I.3    Parisi, J.E.4    Scheithauer, B.W.5    Weigand, S.6
  • 69
    • 34548633861 scopus 로고    scopus 로고
    • Primary-progressive multiple sclerosis
    • Miller, D. H., and S. M. Leary 2007. Primary-progressive multiple sclerosis. Lancet Neurol. 6:903-912.
    • (2007) Lancet Neurol. , vol.6 , pp. 903-912
    • Miller, D.H.1    Leary, S.M.2
  • 70
    • 0030796646 scopus 로고    scopus 로고
    • Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
    • Miller, S. D., C. L. Vanderlugt, W. S. Begolka, W. Pao, R. L. Yauch, K. L. Neville, et al. 1997. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat. Med. 3:1133-1136.
    • (1997) Nat. Med. , vol.3 , pp. 1133-1136
    • Miller, S.D.1    Vanderlugt, C.L.2    Begolka, W.S.3    Pao, W.4    Yauch, R.L.5    Neville, K.L.6
  • 72
    • 17444424938 scopus 로고    scopus 로고
    • Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis
    • Miller, D., F. Barkhof, X. Montalban, A. Thompson, and M. Filippi 2005. Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis. Lancet Neurol. 4:281-288.
    • (2005) Lancet Neurol. , vol.4 , pp. 281-288
    • Miller, D.1    Barkhof, F.2    Montalban, X.3    Thompson, A.4    Filippi, M.5
  • 75
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Munger, K. L., L. I. Levin, B. W. Hollis, N. S. Howard, and A. Ascherio 2006. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296:2832-2838.
    • (2006) JAMA , vol.296 , pp. 2832-2838
    • Munger, K.L.1    Levin, L.I.2    Hollis, B.W.3    Howard, N.S.4    Ascherio, A.5
  • 76
    • 77953335494 scopus 로고    scopus 로고
    • Rituximab add-on therapy for breakthrough relapsing multiple sclerosis: a 52-week phase II trial
    • Naismith, R. T., L. Piccio, J. A. Lyons, J. Lauber, N. T. Tutlam, B. J. Parks, et al. 2010. Rituximab add-on therapy for breakthrough relapsing multiple sclerosis: a 52-week phase II trial. Neurology 74:1860-1867.
    • (2010) Neurology , vol.74 , pp. 1860-1867
    • Naismith, R.T.1    Piccio, L.2    Lyons, J.A.3    Lauber, J.4    Tutlam, N.T.5    Parks, B.J.6
  • 77
    • 0035044638 scopus 로고    scopus 로고
    • The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis
    • O'Connor, K. C., A. Bar-Or, and D. A. Hafler 2001. The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. J. Clin. Immunol. 21:81-92.
    • (2001) J. Clin. Immunol. , vol.21 , pp. 81-92
    • O'Connor, K.C.1    Bar-Or, A.2    Hafler, D.A.3
  • 79
    • 84877888607 scopus 로고    scopus 로고
    • An update of teriflunomide for treatment of multiple sclerosis
    • Oh, J., and P. W. O'Connor 2013. An update of teriflunomide for treatment of multiple sclerosis. Ther. Clin. Risk Manag. 9:177-190.
    • (2013) Ther. Clin. Risk Manag. , vol.9 , pp. 177-190
    • Oh, J.1    O'Connor, P.W.2
  • 82
    • 84856249964 scopus 로고    scopus 로고
    • Fingolimod for multiple sclerosis
    • Pelletier, D., and D. A. Hafler 2012. Fingolimod for multiple sclerosis. N. Engl. J. Med. 366:339-347.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 339-347
    • Pelletier, D.1    Hafler, D.A.2
  • 84
    • 79952501096 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
    • Polman, C. H., S. C. Reingold, B. Banwell, M. Clanet, J. A. Cohen, M. Filippi, et al. 2011. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 69:292-302.
    • (2011) Ann. Neurol. , vol.69 , pp. 292-302
    • Polman, C.H.1    Reingold, S.C.2    Banwell, B.3    Clanet, M.4    Cohen, J.A.5    Filippi, M.6
  • 87
    • 34250779802 scopus 로고    scopus 로고
    • Natalizumab for multiple sclerosis
    • Ransohoff, R. M. 2007. Natalizumab for multiple sclerosis. N. Engl. J. Med. 356:2622-2629.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2622-2629
    • Ransohoff, R.M.1
  • 89
    • 34447299372 scopus 로고    scopus 로고
    • Glatiramer acetate in multiple sclerosis: a review
    • Ruggieri, M., C. Avolio, P. Livrea, and M. Trojano 2007. Glatiramer acetate in multiple sclerosis: a review. CNS Drug Rev. 13:178-191.
    • (2007) CNS Drug Rev. , vol.13 , pp. 178-191
    • Ruggieri, M.1    Avolio, C.2    Livrea, P.3    Trojano, M.4
  • 90
    • 84941941553 scopus 로고    scopus 로고
    • PML in suspected MS patient taking Fingolimod Raises FDA concerns
    • Samson, K. 2013. PML in suspected MS patient taking Fingolimod Raises FDA concerns. Neurology Today 13:37.
    • (2013) Neurology Today , vol.13 , pp. 37
    • Samson, K.1
  • 91
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer, S., G. Hellenthal, M. Pirinen, C. C. Spencer, N. A. Patsopoulos, L. Moutsianas, et al. 2011. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476:214-219.
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3    Spencer, C.C.4    Patsopoulos, N.A.5    Moutsianas, L.6
  • 92
    • 84929082229 scopus 로고    scopus 로고
    • Update on immunopathogenesis and immunotherapy in multiple sclerosis
    • Selter, C. R., and B. Hemmer 2013. Update on immunopathogenesis and immunotherapy in multiple sclerosis. Immuno. Targets Therapy 2:21-30.
    • (2013) Immuno. Targets Therapy , vol.2 , pp. 21-30
    • Selter, C.R.1    Hemmer, B.2
  • 94
    • 68549109071 scopus 로고    scopus 로고
    • Demyelinating diseases. Greenfield's neuropathology, London, UK: Oxford Univ. Press
    • Sobel, R., and W. Moore 2008. Demyelinating diseases. Greenfield's neuropathology, London, UK: Oxford Univ. Press 2:1513-1608.
    • (2008) , vol.2 , pp. 1513-1608
    • Sobel, R.1    Moore, W.2
  • 95
    • 0043065368 scopus 로고    scopus 로고
    • Does the "hygiene hypothesis" provide an explanation for the high prevalence of multiple sclerosis in Sardinia?
    • Sotgiu, S., M. Pugliatti, A. Sotgiu, A. Sanna, and G. Rosati 2003. Does the "hygiene hypothesis" provide an explanation for the high prevalence of multiple sclerosis in Sardinia? Autoimmunity 36:257-260.
    • (2003) Autoimmunity , vol.36 , pp. 257-260
    • Sotgiu, S.1    Pugliatti, M.2    Sotgiu, A.3    Sanna, A.4    Rosati, G.5
  • 96
    • 18744394057 scopus 로고    scopus 로고
    • Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis
    • Stadelmann, C., S. Ludwin, T. Tabira, A. Guseo, C. F. Lucchinetti, L. Leel-Ossy, et al. 2005. Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis. Brain 128:979-987.
    • (2005) Brain , vol.128 , pp. 979-987
    • Stadelmann, C.1    Ludwin, S.2    Tabira, T.3    Guseo, A.4    Lucchinetti, C.F.5    Leel-Ossy, L.6
  • 98
    • 34447506320 scopus 로고    scopus 로고
    • MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study
    • Swanton, J. K., A. Rovira, M. Tintore, D. R. Altman, F. Barkhof, M. Filippi, et al. 2007. MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study. Lancet Neurol. 6:677-686.
    • (2007) Lancet Neurol. , vol.6 , pp. 677-686
    • Swanton, J.K.1    Rovira, A.2    Tintore, M.3    Altman, D.R.4    Barkhof, F.5    Filippi, M.6
  • 99
    • 84884303937 scopus 로고    scopus 로고
    • Case reports of PML in patients treated for psoriasis
    • Sweetser, M. T., K. T. Dawson, and C. Bozic 2013. Case reports of PML in patients treated for psoriasis. N. Engl. J. Med. 369:1082.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1082
    • Sweetser, M.T.1    Dawson, K.T.2    Bozic, C.3
  • 101
    • 85119304002 scopus 로고    scopus 로고
    • ® (natalizumab): PML Incidence in Patients Receiving TYSABRI (December). Medical Information, medinfo@biogenidec.com
    • ® (natalizumab): PML Incidence in Patients Receiving TYSABRI (December 2014). Medical Information, medinfo@biogenidec.com, http://medinfo.biogenidec.com.
    • (2014)
  • 102
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos, J. S., M. A. Friese, M. J. Craner, J. Palace, J. Newcombe, M. M. Esiri, et al. 2008. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 172:146-155.
    • (2008) Am. J. Pathol. , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6
  • 103
    • 0033596842 scopus 로고    scopus 로고
    • Effect of interferon beta on human myelin basic protein-specific T-cell lines: comparison of IFNbeta-1a and IFNbeta-1b
    • Weber, F., J. Janovskaja, T. Polak, S. Poser, and P. Rieckmann 1999. Effect of interferon beta on human myelin basic protein-specific T-cell lines: comparison of IFNbeta-1a and IFNbeta-1b. Neurology 52:1069-1071.
    • (1999) Neurology , vol.52 , pp. 1069-1071
    • Weber, F.1    Janovskaja, J.2    Polak, T.3    Poser, S.4    Rieckmann, P.5
  • 104
    • 0029979038 scopus 로고    scopus 로고
    • Epidemiology of multiple sclerosis
    • Weinshenker, B. G. 1996. Epidemiology of multiple sclerosis. Neurol. Clin. 14:291-308.
    • (1996) Neurol. Clin. , vol.14 , pp. 291-308
    • Weinshenker, B.G.1
  • 105
    • 0024504359 scopus 로고
    • The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability
    • Weinshenker, B. G., B. Bass, G. P. Rice, J. Noseworthy, W. Carriere, J. Baskerville, et al. 1989. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 112(Pt 1):133-146.
    • (1989) Brain , vol.112 , Issue.Pt 1 , pp. 133-146
    • Weinshenker, B.G.1    Bass, B.2    Rice, G.P.3    Noseworthy, J.4    Carriere, W.5    Baskerville, J.6
  • 106
    • 0028936221 scopus 로고
    • The interferons: biological effects, mechanisms of action, and use in multiple sclerosis
    • Weinstock-Guttman, B., R. M. Ransohoff, R. P. Kinkel, and R. A. Rudick 1995. The interferons: biological effects, mechanisms of action, and use in multiple sclerosis. Ann. Neurol. 37:7-15.
    • (1995) Ann. Neurol. , vol.37 , pp. 7-15
    • Weinstock-Guttman, B.1    Ransohoff, R.M.2    Kinkel, R.P.3    Rudick, R.A.4
  • 108
    • 84858216423 scopus 로고    scopus 로고
    • Smoking: effects on multiple sclerosis susceptibility and disease progression
    • Wingerchuk, D. M. 2012. Smoking: effects on multiple sclerosis susceptibility and disease progression. Therapeut. Advan. Neurol. Dis. 5:13-22.
    • (2012) Therapeut. Advan. Neurol. Dis. , vol.5 , pp. 13-22
    • Wingerchuk, D.M.1
  • 109
    • 0029114427 scopus 로고
    • Copolymer 1: a most reasonable alternative therapy for early relapsing-remitting multiple sclerosis with mild disability
    • Wolinsky, J. S. 1995. Copolymer 1: a most reasonable alternative therapy for early relapsing-remitting multiple sclerosis with mild disability. Neurology 45:1245-1247.
    • (1995) Neurology , vol.45 , pp. 1245-1247
    • Wolinsky, J.S.1
  • 110
    • 84876798411 scopus 로고    scopus 로고
    • Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
    • Wu, C., N. Yosef, T. Thalhamer, C. Zhu, S. Xiao, Y. Kishi, et al. 2013. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496:513-517.
    • (2013) Nature , vol.496 , pp. 513-517
    • Wu, C.1    Yosef, N.2    Thalhamer, T.3    Zhu, C.4    Xiao, S.5    Kishi, Y.6
  • 111
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig, K. W., and J. L. Strominger 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695-705.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 112
    • 21044445742 scopus 로고    scopus 로고
    • Immunopathogenesis of multiple sclerosis
    • Yong, V. W. 2004. Immunopathogenesis of multiple sclerosis. Contin. Lifelong Learn. Neurol. 10:11-27.
    • (2004) Contin. Lifelong Learn. Neurol. , vol.10 , pp. 11-27
    • Yong, V.W.1
  • 113
    • 0008376732 scopus 로고    scopus 로고
    • Interferon beta in the treatment of multiple sclerosis: mechanisms of action
    • Yong, V. W., S. Chabot, O. Stuve, and G. Williams 1998. Interferon beta in the treatment of multiple sclerosis: mechanisms of action. Neurology 51:682-689.
    • (1998) Neurology , vol.51 , pp. 682-689
    • Yong, V.W.1    Chabot, S.2    Stuve, O.3    Williams, G.4
  • 114
    • 33644605483 scopus 로고    scopus 로고
    • Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
    • Yousry, T. A., E. O. Major, C. Ryschkewitsch, G. Fahle, S. Fischer, J. Hou, et al. 2006. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N. Engl. J. Med. 354:924-933.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 924-933
    • Yousry, T.A.1    Major, E.O.2    Ryschkewitsch, C.3    Fahle, G.4    Fischer, S.5    Hou, J.6
  • 115
    • 84855967278 scopus 로고    scopus 로고
    • Immune-mediated CNS diseases: a review on nosological classification and clinical features
    • Zettl, U. K., O. Stuve, and R. Patejdl 2012. Immune-mediated CNS diseases: a review on nosological classification and clinical features. Autoimmun. Rev. 11:167-173.
    • (2012) Autoimmun. Rev. , vol.11 , pp. 167-173
    • Zettl, U.K.1    Stuve, O.2    Patejdl, R.3


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