Immunopathology or organ-specific autoimmunity as a consequence of virus infection

Immunological Reviews

Volumn , Issue 152, 1996, Pages 21-45

  Aichele, Peter ^a   Bachmann, Martin F ^a   Hengartner, Hans ^a   Zinkernagel, Rolf M ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CYCLOSPORIN; IMMUNOGLOBULIN M; RECOMBINANT PROTEIN; VIRUS ANTIGEN;

ANTIBODY RESPONSE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; AUTOIMMUNITY; CELL CONTACT; CROSS REACTION; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; ETIOLOGY; EVOLUTION; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; IMMUNOREGULATION; MOLECULAR MIMICRY; NONHUMAN; PREVENTION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; VACCINATION; VIRUS INFECTION; ANIMAL; AUTOIMMUNE DISEASE; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; ORGANIZATION; PATHOLOGY; VIRUS;

ANIMALS; ANTIGENS, VIRAL; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; HUMANS; IMMUNOSUPPRESSION; ORGANIZATIONS; SELF TOLERANCE; T-LYMPHOCYTES; VACCINATION; VIRUS DISEASES; VIRUSES;

EID: 0029658198     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065x.1996.tb00909.x     Document Type: Review

References (149)

1. Ada, G. (1990) The immunological principles of vaccination. Lancet 335, 523.
2. Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M. & Oldstone, M. B. A. (1984) Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice: role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 60, 521.
3. Aichele, P., Brduscha-Riem, K., Zinkernagel, R. M., Hengartner, H. & Pircher, H. (1995) T cell priming versus T cell tolerance induced by synthetic peptides. J. Exp. Med. 182, 261.
4. Aichele, P., Kyburz, D., Ohashi, P. S., Zinkernagel, R. M., Hengartner, H. & Pircher, H. (1994) Peptide induced T cell tolerance to prevent autoimmune diabetes in a transgenic mouse model. Proc. Natl. Acad. Sci. USA 91, 444.
5. Alley, R. A., Hawley, T. S., McKall-Faienza, K. J., Kündig, T. M., Oehen, S. U., Pircher, H., Hawley, R. G. & Ohashi, P. S. (1995) Prevention of autoimmune diabetes by retroviral-mediated gene therapy. J. Immunol. 155, 5404.
6. Anonymous (1988) Guillian-Barré syndrome. Lancet ii, 659.
7. Arnold, B., Schonrich, G. & Hammerling, G. J. (1993) Multiple levels of peripheral tolerance. Immunol. Today 14, 12.
8. Atkinson, M. A. & Maclaren, N. K. (1994) The pathogenesis of insulin dependent diabetes mellitus. N. Engl. J. Med. 331, 1428.
9. Baboonian, C., Venables, P. J. W. & Maini, R. N. (1990) Antibodies to human herpesvirus-6 in Sjogren's syndrome. Arthritis Rheum. 33, 1749.
10. Bachmann, M. F., Hoffmann Rohrer, U., Kündig, T. M., Bürki, K., Hengartner H. & Zinkernagel, R. M. (1993) The influence of antigen organisation on B cell responsiveness. Science 262, 1448.
11. Bachmann, M. F., Hoffmann Rohrer, U., Steinhoff, U., Bürki, K., Skuntz, S., Arnheiter, H., Hengartner, H. & Zinkernagel, R. M. (1994) T helper cell unresponsiveness: rapid induction in antigen-transgenic and reversion in non-transgenic mice. Eur. J. Immunol. 24, 2966.
12. Baer, G. M. & Cleary, W. F. (1972) A model in mice for the pathogenesis and treatment of rabies. J. Infect Dis. 125, 520.
13. Baker, F. D. & Hotchin, J. (1967) Slow virus kidney disease of mice. Science 158, 502.
14. Barker, C. F. & Billingham, R. E. (1972) Immunologically privileged sites. Adv. Immunol. 25, 1.
15. Beisel, K. W., Srinivasappa, J. & Prabhakar, B. S. (1991) Identification of a putative shared epitope between Coxsackie virus B4 and alpha cardiac myosin heavy chain. Clin. Exp. Immunol. 86, 49.
16. Bevan, M. J. (1976) Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 cytotoxic cells which do not cross-react in the cytotoxic assay. J. Exp. Med. 143, 1283.
17. Blüthmann, H., Kisielow, P., Uematsu, Y., Malissen, M., Krimpenfort, P., Berns, A., von Boehmer, H. & Steinmetz, M. (1988) T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous a- and b-genes. Nature 334, 156.
18. Bodansky, H. J., Dean, B. M., Bottazzo, G. F., Grant, P. J., McNally, J., Hambling, M. H. & Wales, J.K. (1986) Islet cell antibodies and insulin autoantibodies in association with common viral infections. Lancet 1351, 1351.
19. Bodansky, H. J., Littlewood, J. M., Bottazzo, G. F., Dean, B. M. & Hambling, M. H. (1984) Which virus causes the initial islet lesion in type 1 diabetes? Lancet i, 401.
20. Bretscher, P. & Conn, M. (1970) A theory of self-nonself discrimination. Science 169, 1042.
21. Buchmeier, M. J., Welsh, R. M., Dutko, F. J. & Oldstone, M. B. A. (1980) The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv. Immunol. 30, 275.
22. Cohn, M. & Langman, R. E. (1990) The protecton: the unit of humoral immunity selected by evolution. Immunol. Rev. 115, 7.
23. Cole, G. A., Nathanson, N. & Prendergast, R. A. (1972) Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. Nature 238, 335.
24. Contran, R. S., Kumar, V., Robbins, S. L. & Robbins, S. L. (1989) Pathologic basis of disease. 4th edn. W.B. Saunders.
25. Czaja, A. J., Carpenter, H. A. & Santrach, P. J. (1993) Evidence against hepatitis viruses as important causes of severe autoimmune hepatitis in the United States. J. Hepatol. 18, 342.
26. Dintzis, R. Z., Middleton, M. H. & Dintzis, H. M. (1983) Studies on the immunogenicity and tolerogenicity of T-independent antigens. J. Immunol. 131, 2196.
27. Fairchild, P. J., Thorpe, C.J., Travers, P. J. & Wraith, D. C. (1994) Modulation of the immune response with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease. Immunology 81, 487.
28. Fambrough, D. M., Drachman, D. B. & Satyamurti, S. (1973) Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors. Science 182, 293.
29. Ferber, I., Schönrich, G., Schenkel, J., Mellor, A. L., Hammerling, G. J. & Arnold, B. (1994) Levels of peripheral T cell tolerance induced by different doses of tolerogen. Science 263, 674.
30. Ferrari, C., Penna, A., Giuberti T. Tong, M. J., Ribera, E., Fiaccadori F. & Chisari, F. V. (1987) Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B. J. Immunol. 139, 2050.
31. Ferraro, A. S. & Newkirk, M. M. (1993) Correlative studies of rheumatoid factors and antiviral antibodies in patients with rheumatoid arthritis. Clin. Exp. Immunol. 92, 425.
32. Ferri, C., Greco, F. & Longombardo, G. (1991) Association between hepatitis C and mixed cryoglobulinemia. Clin. Exp. Rheumatol. 9, 621.
33. Fox, R. I. (1994) Epidemiology, pathogenesis, animal models, and treatment of Sjogren's syndrome. Curr. Opin. Rheumatol. 6, 501.
34. Freund, J., Stern, E. R. & Pisani, T. M. (1947) Isoallergic encephalomyelitis and radiculitis in guinea pigs after one injection of brain and mycobacteria in water-in-oil emulsion. J. Immunol. 57, 179.
35. Fujii, Y. & Lindstrom, J. (1988) Specificity of the T cell immune response to acetylcholine receptor in experimental autoimmune myasthenia gravis. Response to subunits and synthetic peptides. J. Immunol. 140, 1830.
36. Fujinami, R. S., Nelson, J. A., Walker, L. & Oldstone, M. B. A. (1988) Sequence homology and immunologic cross-reactivity of human cytomegalovirus with HLA-DR β chain: a means for graft rejection and immunosuppression. J. Virol. 62, 100.
37. Fujinami, R. S. & Oldstone, M. B. A. (1985) Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230, 1043.
38. Fujinami, R. S., Oldstone, M. B. A., Wroblewska, Z., Frankel, M. E. & Koprowski, H. (1983) Molecular mimicry in virus infection: cross-reaction of measles phosphoprotein or of herpes simplex virus protein with human intermediate filaments. Proc. Natl. Acad. Sci. USA 80, 2346.
39. Gaur, A., Wiers, B., Liu, A., Rothbard, J. & Fathman, C. G. (1992) Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide induced anergy. Science 258, 1491.
40. Gautam, A. M., Lock, C. B., Smilek, D. E., Pearson, C., Steinman, L. & McDevitt, H. O. (1994) Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules: implications in induction of autoimmunity. Proc. Natl. Acad. Sci. USA 91, 767.
41. Gonzalo, J. A., de Alborán, I. M., Alés-Martinez, J. E., Martinez-A., C. & Kroemer, G. (1992) Expansion and clonal deletion of peripheral T cells induced by bacterial super-antigen is independent of the interleukin-2 pathway. Eur. J. Immunol. 22, 1007.
42. Guerder, S., Picarella, D., Linsley, P. S. & Flavell, R. A. (1994) Costimulation B71 confers antigen-presenting cell function to parenchymal tissue and in conjugation with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. Proc. Natl. Acad. Sci. USA 91, 5138.
43. Halstead, S. B. (1988) Pathogenesis of dengue: challenges to molecular biology. Science 239, 476.
44. Hämmerling, G. J., Schönrich, G., Momburg, F., Auphan, N., Malissen, M., Malissen, B., Schmitt-Verhulst, A. M. & Arnold, B. (1991) Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue specific expression of a foreign MHC class I antigen. Immunol. Rev. 122, 47.
45. Harlan, D. M., Hengartner, H., Huang, M. L., Kang, Y.-H., Abe, R., Moreadith, R. W., Pircher H., Gray, G. S., Ohashi, P. S., Freeman, G. J., Nadler, L. M., June, C. H. & Aichele, P. (1994) Mice expressing both B7 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T lymphocyte unresponsiveness. Proc. Natl. Acad. Sci. USA 91, 3137.
46. Hart, I. K. & Kennedy, P. G. E. (1988) Guillain-Barre syndrome associated with cytomegalovirus infection. Quart. J. Med. 253, 425.
47. Hartley, S. B., Crosbie, J., Brink, R., Kantor, A. B., Basten, A. & Goodnow, C. C. (1991) Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353, 765.
48. Haspel, M. V., Onodera, T., Prabhakar, B. S., Horita, M., Suzuki, H. & Notkins, A. L. (1983) Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues. Science 220, 304.
49. Heath, W. R., Allison, J., Hoffmann, M. W., Schonrich, G., Hammerling, G., Arnold, B. & Miller, J. F. (1992) Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature 359, 547.
50. von Herrath, M. G., Docker, J. & Oldstone, M. B. (1994) How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1, 231.
51. von Herrath, M. G., Guerder, S., Lewicki, H., Flavell, R. A. & Oldstone, M. B. A. (1995) Coexpression of B7-1 and viral ('self') transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. Immunity 3, 727.
52. Higuchi, Y., Herrera, P., Muniesa, P., Huarte, J., Belin, D., Ohashi, P. S., Aichele, P., Orci, L., Vassalli J.-D. & Vassalli, P. (1992) Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes. J. Exp Med. 176, 1719.
53. Hotchin, J. (1962) The biology of lymphocytic choriomeningitis infection: virus induced immune disease. Cold Spring Harbor Symp. Quant. Biol. 27, 479.
54. Hotchin, J. (1971) Persistent and slow virus infections. Monogr. Virol. 3, 1.
55. Huber, S. A. & Lodge, P. A. (1984) Coxsackie B-3 myocarditis in Balb/c mice. Am. J. Pathol. 116, 21.
56. Inman, R. D., Chiu, B. & Hamilton, N. C. (1987) Analysis of immune complexes in rheumatoid arthritis for Epstein-Barr virus antigens reveals cross-reactivity of viral capsid antigen and humans IgG. J. Immunol. 138, 407.
57. Jitsukawa, S., Faure, F., Lipinski, M., Triebet, F.& Hercend, T. (1987) A novel subset of human lymphocytes with a T cell receptor-gamma complex. J. Exp Med. 166, 1192.
58. June, C. H., Bluestone, J. A., Nadler, L. M. & Thompson, C. B. (1994) The B7 and CD28 receptor families. Immunol. Today 15, 321.
59. Kägi, D., Ledermann, B., Bürki, K., Zinkernagel, R. M. & Hengartner, H. (1995) Lymphocyte-mediated cytotoxicity in vitro and in vivo: mechanisms and significance. Immunol. Rev. 146, 95.
60. Kagnoff, M. F., Austin, R. K., Hubert, J. J., Bernardin, J. E. & Kasarda, D. D. (1984) Possible role for a human adenovirus in the pathogenesis of celiac disease. J. Exp. Med. 169, 1544.
61. Kalden, J. R. & Gay, S. (1994) Retroviruses and autoimmune rheumatic diseases. Clin. Exp. Immunol. 98, 1.
62. Kaplan, C., Morinet, F. & Cartron, J. (1992) Virus induced autoimmune thrombocytopenia and neutropenia. Sem. Hematol. 29, 34.
63. Kappler, J. W., Roehm, N. & Marrack, P. (1987) T cell tolerance by clonal elimination in the thymus. Cell 49, 273.
64. Kaufman, D. L., Clare-Salzler, M., Tian, J., Forsthuber, T., Ting, G. S. P., Robinson, P., Atkinson, M. A., Sercarz, E. E., Tobin, A. J. & Lehmann, P. V. (1993) Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69.
65. + thymocytes. Nature 333, 742.
66. Kündig, T., Bachmann, M., DiPaolo, C., Simard, J., Battegay, M., Lother, H., Gessner, A., Kühicke, K., Döhring, C., Ohashi, P., Hengartner, H. & Zinkernagel, R. M. (1995) Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 268, 1343.
67. Kurane, I. & Ennis, F. E. (1992) Immunity and immunopathology in dengue virus infections. Semin. Immunol. 4, 121.
68. Kyburz, D., Aichele, P., Speiser, D. E., Hengartner, H., Zinkernagel, R. & Pircher, H. (1993) T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides. Eur. J. Immunol. 23, 1956.
69. Lafferty, K. J. & Cunningham, A. J. (1975) A new analysis of allogeneic interactions. Aust. J. Exp. Biol. Med. Sci. 53, 27.
70. Lafferty, K. & Woolnough, J. (1977) The origin and mechanism of allograft reaction. Immunol. Rev. 35, 231.
71. Lau, L. L., Jamieson, B. D., Somasundaram, T. & Ahmed, R. (1994) Cytotoxic T-cell memory without antigen. Nature 369, 648.
72. Lehmann-Grube, F. (1971) Lymphocytic choriomeningitis virus. Virol. Monogr. 10, 1.
73. Lehmann-Grube, F., Moskophidis, D. & Lohler, J. (1988) Recovery from acute virus infection. Role of cytotoxic T lymphocytes in the elimination of lymphocytic choriomeningitis virus from spleens of mice. Ann. NY Acad. Sci. 532, 238.
74. Leist, T. P., Rüedi, E. & Zinkernagel, R. M. (1988) Virus-triggered immune suppression in mice caused by virus-specific cytotoxic T cells. J. Exp. Med. 167, 1749.
75. Lilly, F. (1972) Mouse leukemia: a model of a multiple-gene disease. J. Natl. Cancer Inst. 49, 927.
76. Lindstrom, J. (1985) Immunobiology of myasthenia gravis, experimental autoimmune myasthenia gravis, and Lambert-Eaton syndrome. Annu. Rev. Immunol. 3, 109.
77. Linsley, R S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K. & Ledbetter, J. A. (1991) Binding of the B cell activation antigen B7 to CD28 costimulutes T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173, 721.
78. Linsley, P. S. & Ledbetter, J. A. (1993) The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11, 191.
79. Lo, D., Freedman, J., Hesse, S., Brinster, R. L. & Sherman, L. (1991) Peripheral tolerance in transgenic mice: tolerance to class II MHC and non-MHC transgene antigens. Immunol. Rev. 122, 87.
80. MacDonald, H. R., Schneider, R., Lees, R. K., Howe, R. C., Acha-Orbea, H., Festenstein, H., Zinkernagel, R. M. & Hengartner, H. (1988) T cell receptor Vβ use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature 332, 40.
81. Matzinger, P. (1994a) Memories are made of this? Nature 369, 605.
82. Matzinger, P. (1994b) Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991.
83. Matzinger, P. & Guerder, S. (1989) Does T-cell tolerance require a dedicated antigen-presenting cell. Nature 338, 74.
84. Meruelo D., Rossomando, A., Offer, M., Buxbaum, J. & Pellicer, A. (1983) Association of endogeneous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens. Proc. Natl. Acad. Sci. USA 80, 5032.
85. Minis, C. A. (1985) Virus immunity and pathogenesis. Br. Med. Bull. 41, 1.
86. Mims C. A. (1987) The pathogenesis of infectious disease, 3rd edn. London: Academic Press.
87. Mims, C. A. & Wainwright, S. (1968) The immunodepressive action of lymphocytic choriomeningitis virus in mice. J. Immunol. 101, 717.
88. Mitchison, N. A. (1964) Induction of immunological paralysis in two zones of dosage. Roy. Soc. Proc. 161, 275.
89. Moskophidis, D., Lechner, F., Pircher, H. P. & Zinkernagel, R. M. (1993) Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362, 758.
90. Muller, D., Koller, B. H., Whitton, J. L., LaPan, K. E., Brigman, K. K. & Frelinger, J. A. (1992) LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice. Science 255, 1576.
91. Narayan, O., Zink, M. C. & Gorrell, M. (1992) Lentivirus induce arthritis in animals. J. Rheumatol. 19, 25.
92. Nemazee, D. A. & Bürki, K. (1989) Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337, 562.
93. Nossal, G. J. V. (1992) Cellular and molecular mechanisms of B lymphocyte tolerance. Adv. Immunol. 52, 283.
94. Notkins, A. L., Mahar, S., Scheele, C. & Goffman, J. (1966) Infectious virus-antibody complex in the blood of chronically infected mice. J. Exp. Med. 124, 81.
95. Notkins, A. L., Onodera, T., Prabhakar, B., Notkins, A. L. & Oldstone, M. B. A. (1984) Concepts in viral pathogenesis. New York: Springer Verlag.
96. Odermatt, B., Eppler, M., Leist, T. P., Hengartner, H. & Zinkernagel, R. M. (1991) Virus triggered acquired immunodeficiency by cytotoxic T-cell dependent destruction of antigen-presenting cells and lymph follicle structure. Proc. Natl. Acad. Sci. USA 88, 8252.
97. Oehen, S., Hengartner, H. & Zinkernagel, R. M. (1991) Vaccination for disease. Science 251, 195.
98. Oehen, S., Ohashi, P. S., Aichele, P., Hengartner, H. & Zinkernagel, R. M. (1992) Vaccination or tolerance to prevent diabetes. Eur. J. Immunol. 22, 3149.
99. Ohashi, P. S., Oehen, S., Aichele, P., Pircher, H., Odermatt, B., Herrera, P., Higuchi, Y., Buerki, K., Hengartner, H. & Zinkemagel, R. M. (1993) Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and TNF-α. J. Immunol. 150, 5185.
100. Ohashi, P. S., Oehen, S., Bürki, K., Pircher, H. P., Ohashi, C. T., Odermatt, B., Malissen, B., Zinkernagel, R. & Hengartner, H. (1991) Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65, 305.
101. Oldstone, M. B. A. (1987) Molecular mimicry and autoimmune disease. Cell 50, 819.
102. Oldstone, M. B. A. & Dixon, F .J. (1967) Lymphocytic choriomeningitis: production of antibody by 'tolerant' infected mice. Science 158, 1193.
103. Oldstone, M. B. A. & Dixon, F. J. (1971) Lactic dhydrogenase virus-induced immune complex type of glomerulonephritis. J. Immunol. 106, 1260.
104. Oldstone, M. B. A., Nerenberg, M., Southern, P., Price, J. & Lewicki, H. (1991) Virus infection triggers insulin-dependent diabtes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65, 319.
105. Oldstone, M. B. A., Schwimmbeck, P., Dyrberg, T. & Fujinami, R. (1986) Mimicry by virus of host molecules: implications for autoimmune disease. Prog. Immunol. 6, 787.
106. Onodera, T., Ray, U. R., Melez, K. A., Suzuki, H., Toniolo, A. & Notkins, A. L. (1982) Virus induced diabetes mellitus: autoimmunity and polyendocrine disease prevented by immunosupression. Nature 297, 66.
107. Paul, W. E. (1993) Fundamental immunology, 3rd edn. New York: Raven Press.
108. Peters, M., Vierling, J., Gershwin, M. E., Milich, D., Chisari, F. V. & Hoofnagle, J. H. (1991) Immunology and the liver. Hepatology 13, 977.
109. Pfau, C. J., Valenti, J. K., Jacobson, S. & Pevear, D. C. (1982) Cytotoxic T cells are induced in mice infected with lymphocytic choriomeningitis virus strains of markedly different pathogenicities. Infect. Immun. 36, 598.
110. Picarella, D. E., Kretz, A., Li C.-B., Rudoltes, N. H. & Flavell, R. A. (1993) Transgenic TNF-alpha production in islets leads to insulitis, not diabetes: distinct pattern of inflammation in TNF-alpha and TNF-beta transgenic mice. J. Immunol. 149, 4136.
111. Pircher, H. P., Mak, T. W., Lang, R., Ballhausen, W., Rüedi, E., Hengartner, H., Zinkernagel, R. M. & Bürki, K. (1989) T cell tolerance to Mlsa encoded antigens in T cell receptor β-chain transgenic mice. EMBO J. 8, 719.
112. Plagemann, P. G. W. & Moennig, V. (1992) Lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus: a new group of positive-strand RNA viruses. Adv. Virus Res. 41, 99.
113. Rajewsky, K. (1989) Evolutionary and somatic immunological memory. Progr. Imm. 7, 397.
114. Rammensee H.-G., Falk, K. & Rötzschke, O. (1993) MHC molecules as peptide receptors. Curr. Biol. 5, 35.
115. Russell, D. M., Dembic, Z., Morahan, G., Miller, J. F. A. P., Bürki, K. & Nemazee, D. (1991) Peripheral deletion of self-reactive B cells. Nature 354, 308.
116. Saito, I., Servenius, B., Compton, T. & Fox, R. I. (1989) Detection of Epstein-Barr virus DNA by polmerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome. J. Exp Med. 169, 2191.
117. Schild, H. J., Rötzschke, O., Kalbacher, H. & Rammensee, H.-G. (1990) Limit of T cell tolerance to self proteins by peptide presentation. Science 247, 1587.
118. Schwartz, R. H. (1990) A cell culture model for T lymphocyte clonal energy. Science 248, 1349.
119. Selin, L. K., Nahill, S. R. & Welsh, R. M. (1994) Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179, 1933.
120. Shulman, N. R. & Barker, L. F. (1969) Virus-like antigen, antibody, and antigenantibody complexes in hepatitis measured by complement fixation. Science 165, 304.
121. Speiser, D. E., Kyburz, D., Stübi, U., Hengartner, H. & Zinkernagel, R. M. (1992) Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. J. Immunol. 149, 972.
122. Sprent, J., Hurd, M., Schaefer, M. & Heath, W. (1995) Split tolerance in spleen chimeras. J. Immunol. 154, 1198.
123. Sprent, J., Lo, D., Gao, K. E. & Ron, Y. (1988) T cell selection in the thymus. Immunol. Rev. 101, 173.
124. Springer, T. A. (1990) Adhesion receptors of the immune system. Nature 346, 425.
125. Strellrecht-Broomhall, K. A. (1991) Evidence for immune mediated destruction as mechanism for LCMV-induced anemia in persistently infected mice. Viral Immunol. 4, 269.
126. Sykulev, Y., Brunmark, A., Jackson, M., Cohen, R. J., Peterson, P. A. & Eisen, H. N. (1994a) Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. Immunity 1, 15.
127. Sykulev, Y., Brunmark, A., Tsomides, T. J., Kageyama, S., Jackson, M., Peterson, P. A. & Eisen, H. N. (1994b) High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA 91, 11487.
128. Theofilopoulos, A. N. & Dixon, F. J. (1979) The biology and detection of immune complexes. Adv. Immunol. 28, 89.
129. Tindle, R. W. & Frazer, I. H. (1994) Immune response to human papillomaviruses and the prospects for human papillomavirus-specific immunisation. Curr. Top. Microbiol. Immunol. 186, 217.
130. Tisch, R. & McDevitt, H. O. (1994) Antigen-specific immunotherapy: is it a real possibility to combat T-cell-mediated autoimmunity? Proc. Natl. Acad. Sci. USA 91, 437.
131. Tisch, R., Yang, X.-D., Singer, S. M., Liblau, R. S., Fugger, L. & McDevitt, H. O. (1993) Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72.
132. Townsend, A. R. M., Rothbard, J., Gotch, F. M., Bahadur, G., Wraith, D. & McMichael, A. J. (1986) The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44, 959.
133. Uhr, J. W. & Moeller, G. (1968) Regulatory effect of antibody on the immune response. Adv. Immunol. 8, 81.
134. Valitutti, S., Müller, S., Cella, M., Padovan, E. & Lanzavecchia, A. (1995) Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148.
135. Vaughan, J. H., Nguyen, M. D., Valbracht, J. R., Patrick, K. & Rhodes, G. H. (1995) Epstein-barr virus-induced autoimmune responses. II. immunoglobulin γ autoantibodies to mimicking and nonmimicking epitopes. Presence in autimmune disease. J. Clin. Invest 95, 1316.
136. Vento, S., McFarlane, B. M., McSorley, C. G., Ranieri, S., Giuliani-Piccari, G., Dal-Monte, P. R., Verucchi, G., Williams, R., Chiodo, F. & McFarlane, I. G. (1988) Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis. J. Clin. Lab. Immunol. 25, 1.
137. Webb, S., Morris, C. & Sprent, J. (1990) Extrathymic tolerance of mature T cells: elimination as a consequence of immunity. Cell 63, 1249.
138. Weber, S., Traunecker, A., Oliveri, F., Gerhard, W. & Karjalainen, K. (1992) Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor. Nature 356, 793.
139. Weigle, W. O. (1973) Immunological unresponsiveness. Adv. Immunol. 16, 61.
140. Weigle, W. O. (1980) Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv. Immunol. 30, 159.
141. Wekerle, H., Pette, M., Fujita, K., Nomura, K. & Meyermann, R. (1989) Autoimmunity in the nervous system: functional properties of an encephalitogenic protein. Prog. Immunol. 7, 813.
142. Whittingham, S. M., McNeilage, J. & Mackay, I. R. (1985) Primary Sjogren's syndrome after infectious mononucleosis. Ann. Intern. Med. 102, 490.
143. Wolfgram, L. J., Beisel, K. W. & Rose, N. R. (1985) Heart-specific autoantibodies following murine coxackievirus B3 myocarditis. J. Exp Med. 161, 1112.
144. Wraith, D. C., Smilek, D. E., Mitchell, D. J., Steinman, L. & McDevitt, H. O. (1989) Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 59, 247.
145. Wucherpfennig, K. W. & Strominger, J. L. (1995) Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80, 695.
146. Yoon, J. W. & Notkins, A. L. (1976) Virus-induced diabetes mellitus. VI. Genetically determined host differences in the replication of encephalomyocarditis virus in pancreatic beta cells. J. Exp. Med. 1170, 1185.
147. Zinkernagel, R. M. (1996) Immunology taught by viruses. Science 271, 173.
148. Zinkernagel, R. M., Cooper, S., Chambers, J., Lazzarini, R. A., Hengartner, H. & Arnheiter, H. (1990) Virus induced autoantibody response to a transgenic viral antigen. Nature 344, 68.
149. Zinkernagel, R. M., Haenseler, E., Leist, T. P., Cerny, A., Hengartner, H. & Althage, A. (1986) T cell mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. J. Exp. Med. 164, 1075.