-
1
-
-
20444489863
-
The spectrum of multiple sclerosis: new lessons from pathology
-
Bruck W, Stadelmann C. The spectrum of multiple sclerosis: new lessons from pathology. Curr Opin Neurol 2005;18:221-4.
-
(2005)
Curr Opin Neurol
, vol.18
, pp. 221-224
-
-
Bruck, W.1
Stadelmann, C.2
-
2
-
-
0034686907
-
Drug treatment of multiple sclerosis
-
Polman CH, Uitdehaag BM. Drug treatment of multiple sclerosis. BMJ 2000;321:490-4.
-
(2000)
BMJ
, vol.321
, pp. 490-494
-
-
Polman, C.H.1
Uitdehaag, B.M.2
-
4
-
-
0029979038
-
Epidemiology of multiple sclerosis
-
Weinshenker BG. Epidemiology of multiple sclerosis. Neurol Clin 1996;14:291-308.
-
(1996)
Neurol Clin
, vol.14
, pp. 291-308
-
-
Weinshenker, B.G.1
-
5
-
-
0029913882
-
Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
-
Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46:907-11.
-
(1996)
Neurology
, vol.46
, pp. 907-911
-
-
Lublin, F.D.1
Reingold, S.C.2
-
6
-
-
0024504359
-
The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability
-
Weinshenker BG, Bass B, Rice GP et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989;112(Pt 1):133-46.
-
(1989)
Brain
, vol.112
, Issue.PART 1
, pp. 133-146
-
-
Weinshenker, B.G.1
Bass, B.2
Rice, G.P.3
-
7
-
-
20444481545
-
Primary progressive multiple sclerosis
-
Montalban X. Primary progressive multiple sclerosis. Curr Opin Neurol 2005;18:261-6.
-
(2005)
Curr Opin Neurol
, vol.18
, pp. 261-266
-
-
Montalban, X.1
-
8
-
-
28544436950
-
Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria"
-
Polman CH, Reingold SC, Edan G et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 2005;58:840-6.
-
(2005)
Ann Neurol
, vol.58
, pp. 840-846
-
-
Polman, C.H.1
Reingold, S.C.2
Edan, G.3
-
9
-
-
33750579981
-
Multiple sclerosis: new insights and trends
-
Inglese M. Multiple sclerosis: new insights and trends. AJNR Am J Neuroradiol 2006;27:954-7.
-
(2006)
AJNR Am J Neuroradiol
, vol.27
, pp. 954-957
-
-
Inglese, M.1
-
10
-
-
33644607018
-
Multiple sclerosis-the plaque and its pathogenesis
-
Frohman EM, Racke MK, Raine CS. Multiple sclerosis-the plaque and its pathogenesis. N Engl J Med 2006;354:942-55.
-
(2006)
N Engl J Med
, vol.354
, pp. 942-955
-
-
Frohman, E.M.1
Racke, M.K.2
Raine, C.S.3
-
11
-
-
2142662186
-
Multiple sclerosis
-
Hafler DA. Multiple sclerosis. J Clin Invest 2004;113:788-94.
-
(2004)
J Clin Invest
, vol.113
, pp. 788-794
-
-
Hafler, D.A.1
-
12
-
-
0036546066
-
New concepts in the immunopathogenesis of multiple sclerosis
-
Hemmer B, Archelos JJ, Hartung HP. New concepts in the immunopathogenesis of multiple sclerosis. Nat Rev Neurosci 2002;3:291-301.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 291-301
-
-
Hemmer, B.1
Archelos, J.J.2
Hartung, H.P.3
-
13
-
-
33749059726
-
The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration
-
Hauser SL, Oksenberg JR. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 2006;52:61-76.
-
(2006)
Neuron
, vol.52
, pp. 61-76
-
-
Hauser, S.L.1
Oksenberg, J.R.2
-
14
-
-
79960131907
-
-
Multiple sclerosis. In: Emedicine Neurology. (accessed 24 August 2009).
-
Dangond F. Multiple sclerosis. In: Emedicine Neurology. (accessed 24 August 2009).
-
-
-
Dangond, F.1
-
15
-
-
66549129834
-
Immunomodulatory effects of Vitamin D in multiple sclerosis
-
Correale J, Ysrraelit MC, Gaitan MI. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 2009;132:1146-60.
-
(2009)
Brain
, vol.132
, pp. 1146-1160
-
-
Correale, J.1
Ysrraelit, M.C.2
Gaitan, M.I.3
-
18
-
-
39449090773
-
Genetics and natural history of multiple sclerosis
-
Kantarci OH. Genetics and natural history of multiple sclerosis. Semin Neurol 2008;28:7-16.
-
(2008)
Semin Neurol
, vol.28
, pp. 7-16
-
-
Kantarci, O.H.1
-
19
-
-
0037371325
-
HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course
-
Barcellos LF, Oksenberg JR, Begovich AB et al. HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet 2003;72:710-6.
-
(2003)
Am J Hum Genet
, vol.72
, pp. 710-716
-
-
Barcellos, L.F.1
Oksenberg, J.R.2
Begovich, A.B.3
-
20
-
-
18544365397
-
Multiple susceptibility loci for multiple sclerosis
-
Haines JL, Bradford Y, Garcia ME et al. Multiple susceptibility loci for multiple sclerosis. Hum Mol Genet 2002;11:2251-6.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2251-2256
-
-
Haines, J.L.1
Bradford, Y.2
Garcia, M.E.3
-
21
-
-
58149122959
-
The complex genetics of multiple sclerosis: pitfalls and prospects
-
Sawcer S. The complex genetics of multiple sclerosis: pitfalls and prospects. Brain 2008;131:3118-31.
-
(2008)
Brain
, vol.131
, pp. 3118-3131
-
-
Sawcer, S.1
-
22
-
-
0032576752
-
Axonal transection in the lesions of multiple sclerosis
-
Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338:278-85.
-
(1998)
N Engl J Med
, vol.338
, pp. 278-285
-
-
Trapp, B.D.1
Peterson, J.2
Ransohoff, R.M.3
Rudick, R.4
Mork, S.5
Bo, L.6
-
23
-
-
0035096330
-
Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy
-
Lassmann H, Bruck W, Lucchinetti C. Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med 2001;7:115-21.
-
(2001)
Trends Mol Med
, vol.7
, pp. 115-121
-
-
Lassmann, H.1
Bruck, W.2
Lucchinetti, C.3
-
24
-
-
33746729791
-
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70years of merits and culprits in experimental autoimmune encephalomyelitis research
-
Gold R, Linington C, Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006;129:1953-71.
-
(2006)
Brain
, vol.129
, pp. 1953-1971
-
-
Gold, R.1
Linington, C.2
Lassmann, H.3
-
25
-
-
34248639557
-
The role of CD4 T cells in the pathogenesis of multiple sclerosis
-
Chitnis T. The role of CD4 T cells in the pathogenesis of multiple sclerosis. Int Rev Neurobiol 2007;79:43-72.
-
(2007)
Int Rev Neurobiol
, vol.79
, pp. 43-72
-
-
Chitnis, T.1
-
26
-
-
0019465142
-
The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
-
Ben-Nun A, Wekerle H, Cohen IR. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 1981;11:195-9.
-
(1981)
Eur J Immunol
, vol.11
, pp. 195-199
-
-
Ben-Nun, A.1
Wekerle, H.2
Cohen, I.R.3
-
27
-
-
38749143286
-
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
-
Tzartos JS, Friese MA, Craner MJ et al. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008;172:146-55.
-
(2008)
Am J Pathol
, vol.172
, pp. 146-155
-
-
Tzartos, J.S.1
Friese, M.A.2
Craner, M.J.3
-
28
-
-
35848951169
-
Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy
-
Flugel A, Odoardi F, Nosov M, Kawakami N. Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy. J Neuroimmunol 2007;191:86-97.
-
(2007)
J Neuroimmunol
, vol.191
, pp. 86-97
-
-
Flugel, A.1
Odoardi, F.2
Nosov, M.3
Kawakami, N.4
-
29
-
-
77956898047
-
Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple Sclerosis
-
Korn T, Mitsdoerffer M, Kuchroo VK. Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple Sclerosis. Results Probl Cell Differ 2010;51:43-74.
-
(2010)
Results Probl Cell Differ
, vol.51
, pp. 43-74
-
-
Korn, T.1
Mitsdoerffer, M.2
Kuchroo, V.K.3
-
30
-
-
79960132739
-
-
An overview of multiple sclerosis: diagnosis and management strategies. In: Topics in Advance Practice Nursing [online]. (accessed 24 August 2009).
-
Costello K. An overview of multiple sclerosis: diagnosis and management strategies. In: Topics in Advance Practice Nursing [online]. (accessed 24 August 2009).
-
-
-
Costello, K.1
-
31
-
-
34249818493
-
Oral disease-modifying treatments for multiple sclerosis: the story so far
-
Kieseier BC, Wiendl H. Oral disease-modifying treatments for multiple sclerosis: the story so far. CNS Drugs 2007;21:483-502.
-
(2007)
CNS Drugs
, vol.21
, pp. 483-502
-
-
Kieseier, B.C.1
Wiendl, H.2
-
33
-
-
53549086138
-
Emerging oral drugs for multiple sclerosis
-
Gasperini C, Cefaro LA, Borriello G, Tosto G, Prosperini L, Pozzilli C. Emerging oral drugs for multiple sclerosis. Expert Opin Emerg Drugs 2008;13:465-77.
-
(2008)
Expert Opin Emerg Drugs
, vol.13
, pp. 465-477
-
-
Gasperini, C.1
Cefaro, L.A.2
Borriello, G.3
Tosto, G.4
Prosperini, L.5
Pozzilli, C.6
-
34
-
-
0032374063
-
Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
-
Bruneau JM, Yea CM, Spinella-Jaegle S et al. Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide. Biochem J 1998;336:299-303.
-
(1998)
Biochem J
, vol.336
, pp. 299-303
-
-
Bruneau, J.M.1
Yea, C.M.2
Spinella-Jaegle, S.3
-
35
-
-
0029591467
-
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
-
Cherwinski HM, Cohn RG, Cheung P et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 1995;275:1043-9.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1043-1049
-
-
Cherwinski, H.M.1
Cohn, R.G.2
Cheung, P.3
-
36
-
-
0032555586
-
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans
-
Ruckemann K, Fairbanks LD, Carrey EA et al. Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans. J Biol Chem 1998;273:21682-91.
-
(1998)
J Biol Chem
, vol.273
, pp. 21682-21691
-
-
Ruckemann, K.1
Fairbanks, L.D.2
Carrey, E.A.3
-
37
-
-
0029913383
-
Regulation of B cell function by the immunosuppressive agent leflunomide
-
Siemasko KF, Chong AS, Williams JW, Bremer EG, Finnegan A. Regulation of B cell function by the immunosuppressive agent leflunomide. Transplantation 1996;61:635-42.
-
(1996)
Transplantation
, vol.61
, pp. 635-642
-
-
Siemasko, K.F.1
Chong, A.S.2
Williams, J.W.3
Bremer, E.G.4
Finnegan, A.5
-
38
-
-
0032804664
-
Mechanism of action for leflunomide in rheumatoid arthritis
-
Fox RI, Herrmann ML, Frangou CG et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol 1999;93:198-208.
-
(1999)
Clin Immunol
, vol.93
, pp. 198-208
-
-
Fox, R.I.1
Herrmann, M.L.2
Frangou, C.G.3
-
39
-
-
62149096116
-
Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis
-
Merrill JE, Hanak S, Pu SF et al. Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. J Neurol 2009;256:89-103.
-
(2009)
J Neurol
, vol.256
, pp. 89-103
-
-
Merrill, J.E.1
Hanak, S.2
Pu, S.F.3
-
40
-
-
79960135948
-
-
Teriflunomide reduces neurological behaviour and pathology in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. Presented at 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 11, 2009; Dusseldorf.
-
Mcmonagle-Strucko K, Hanak S, Pu SF et al. Teriflunomide reduces neurological behaviour and pathology in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. Presented at 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 11, 2009; Dusseldorf.
-
-
-
Mcmonagle-Strucko, K.1
Hanak, S.2
Pu, S.F.3
-
41
-
-
79960113267
-
-
Teriflunomide treatment reduces infiltration of macrophages, T cells and B cells, and increases survival of oligodendrocytes in the spinal cord of the Dark Agouti rat model of Experimental Allergic Encephalomyelitis. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 15, 2010; Toronto, Canada.
-
Petty M, Lee L, Ying X et al. Teriflunomide treatment reduces infiltration of macrophages, T cells and B cells, and increases survival of oligodendrocytes in the spinal cord of the Dark Agouti rat model of Experimental Allergic Encephalomyelitis. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 15, 2010; Toronto, Canada.
-
-
-
Petty, M.1
Lee, L.2
Ying, X.3
-
42
-
-
57649116340
-
In vitro and in vivo pharmacological models to assess demyelination and remyelination
-
Merrill JE. In vitro and in vivo pharmacological models to assess demyelination and remyelination. Neuropsychopharmacology 2009;34:55-73.
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 55-73
-
-
Merrill, J.E.1
-
43
-
-
79960138930
-
-
Pharmacokinetics of oral teriflunomide, a novel oral disease-modifying agent under investigation for the treatment of MS. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 15, 2010; Toronto.
-
Limsakun T, Menguy-Vacheron F. Pharmacokinetics of oral teriflunomide, a novel oral disease-modifying agent under investigation for the treatment of MS. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 15, 2010; Toronto.
-
-
-
Limsakun, T.1
Menguy-Vacheron, F.2
-
44
-
-
79960125289
-
-
Sanofi-Aventis. Data on file.
-
Sanofi-Aventis. Data on file.
-
-
-
-
45
-
-
33645799680
-
A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
-
O'connor PW, Li D, Freedman MS et al. A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology 2006;66:894-900.
-
(2006)
Neurology
, vol.66
, pp. 894-900
-
-
O'connor, P.W.1
Li, D.2
Freedman, M.S.3
-
46
-
-
79960115545
-
-
Oral teriflunomide is effective and well tolerated in multiple sclerosis with relapses: results of an open-label 144-week extension study. Presented at 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 28, 2006; Madrid.
-
O'connor PW, Freedman MS, Bar-Or A, Rice GP, Confavreux C, Traboulsee A. Oral teriflunomide is effective and well tolerated in multiple sclerosis with relapses: results of an open-label 144-week extension study. Presented at 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 28, 2006; Madrid.
-
-
-
O'connor, P.W.1
Freedman, M.S.2
Bar-Or, A.3
Rice, G.P.4
Confavreux, C.5
Traboulsee, A.6
-
47
-
-
79960134003
-
-
Oral teriflunomide or placebo to added to interferon beta for 6months in patients with relapsing multiple sclerosis: safety and efficacy results. Presented at 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 11, 2009; Dusseldorf.
-
Freedman MS, Wolinsky JS, Byrnes WJ et al. Oral teriflunomide or placebo to added to interferon beta for 6months in patients with relapsing multiple sclerosis: safety and efficacy results. Presented at 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 11, 2009; Dusseldorf.
-
-
-
Freedman, M.S.1
Wolinsky, J.S.2
Byrnes, W.J.3
-
48
-
-
79960113998
-
-
Oral teriflunomide or placebo added to glatiramer acetate for 6months in patients with relapsing multiple sclerosis: safety and efficacy results. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 14, 2010; Toronto.
-
Freedman MS, Wolinsky JS, Frangin GA et al. Oral teriflunomide or placebo added to glatiramer acetate for 6months in patients with relapsing multiple sclerosis: safety and efficacy results. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 14, 2010; Toronto.
-
-
-
Freedman, M.S.1
Wolinsky, J.S.2
Frangin, G.A.3
|