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Volumn 124, Issue 2, 2011, Pages 75-84

Pathophysiology of multiple sclerosis and the place of teriflunomide

Author keywords

Disease modifying therapies; Immunology; Immunomodulator; Multiple sclerosis; Relapsing remitting; Teriflunomide

Indexed keywords

ALANINE AMINOTRANSFERASE; BETA INTERFERON; BETA1A INTERFERON; CREATINE KINASE; GLATIRAMER; MAJOR HISTOCOMPATIBILITY ANTIGEN; MIDAZOLAM; PLACEBO; TERIFLUNOMIDE; WARFARIN;

EID: 79953016820     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2010.01444.x     Document Type: Review
Times cited : (99)

References (48)
  • 1
    • 20444489863 scopus 로고    scopus 로고
    • The spectrum of multiple sclerosis: new lessons from pathology
    • Bruck W, Stadelmann C. The spectrum of multiple sclerosis: new lessons from pathology. Curr Opin Neurol 2005;18:221-4.
    • (2005) Curr Opin Neurol , vol.18 , pp. 221-224
    • Bruck, W.1    Stadelmann, C.2
  • 2
    • 0034686907 scopus 로고    scopus 로고
    • Drug treatment of multiple sclerosis
    • Polman CH, Uitdehaag BM. Drug treatment of multiple sclerosis. BMJ 2000;321:490-4.
    • (2000) BMJ , vol.321 , pp. 490-494
    • Polman, C.H.1    Uitdehaag, B.M.2
  • 4
    • 0029979038 scopus 로고    scopus 로고
    • Epidemiology of multiple sclerosis
    • Weinshenker BG. Epidemiology of multiple sclerosis. Neurol Clin 1996;14:291-308.
    • (1996) Neurol Clin , vol.14 , pp. 291-308
    • Weinshenker, B.G.1
  • 5
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46:907-11.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 6
    • 0024504359 scopus 로고
    • The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability
    • Weinshenker BG, Bass B, Rice GP et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989;112(Pt 1):133-46.
    • (1989) Brain , vol.112 , Issue.PART 1 , pp. 133-146
    • Weinshenker, B.G.1    Bass, B.2    Rice, G.P.3
  • 7
    • 20444481545 scopus 로고    scopus 로고
    • Primary progressive multiple sclerosis
    • Montalban X. Primary progressive multiple sclerosis. Curr Opin Neurol 2005;18:261-6.
    • (2005) Curr Opin Neurol , vol.18 , pp. 261-266
    • Montalban, X.1
  • 8
    • 28544436950 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria"
    • Polman CH, Reingold SC, Edan G et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 2005;58:840-6.
    • (2005) Ann Neurol , vol.58 , pp. 840-846
    • Polman, C.H.1    Reingold, S.C.2    Edan, G.3
  • 9
    • 33750579981 scopus 로고    scopus 로고
    • Multiple sclerosis: new insights and trends
    • Inglese M. Multiple sclerosis: new insights and trends. AJNR Am J Neuroradiol 2006;27:954-7.
    • (2006) AJNR Am J Neuroradiol , vol.27 , pp. 954-957
    • Inglese, M.1
  • 10
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis-the plaque and its pathogenesis
    • Frohman EM, Racke MK, Raine CS. Multiple sclerosis-the plaque and its pathogenesis. N Engl J Med 2006;354:942-55.
    • (2006) N Engl J Med , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 11
    • 2142662186 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Hafler DA. Multiple sclerosis. J Clin Invest 2004;113:788-94.
    • (2004) J Clin Invest , vol.113 , pp. 788-794
    • Hafler, D.A.1
  • 12
    • 0036546066 scopus 로고    scopus 로고
    • New concepts in the immunopathogenesis of multiple sclerosis
    • Hemmer B, Archelos JJ, Hartung HP. New concepts in the immunopathogenesis of multiple sclerosis. Nat Rev Neurosci 2002;3:291-301.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 291-301
    • Hemmer, B.1    Archelos, J.J.2    Hartung, H.P.3
  • 13
    • 33749059726 scopus 로고    scopus 로고
    • The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration
    • Hauser SL, Oksenberg JR. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 2006;52:61-76.
    • (2006) Neuron , vol.52 , pp. 61-76
    • Hauser, S.L.1    Oksenberg, J.R.2
  • 14
    • 79960131907 scopus 로고    scopus 로고
    • Multiple sclerosis. In: Emedicine Neurology. (accessed 24 August 2009).
    • Dangond F. Multiple sclerosis. In: Emedicine Neurology. (accessed 24 August 2009).
    • Dangond, F.1
  • 15
    • 66549129834 scopus 로고    scopus 로고
    • Immunomodulatory effects of Vitamin D in multiple sclerosis
    • Correale J, Ysrraelit MC, Gaitan MI. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 2009;132:1146-60.
    • (2009) Brain , vol.132 , pp. 1146-1160
    • Correale, J.1    Ysrraelit, M.C.2    Gaitan, M.I.3
  • 17
    • 12344288034 scopus 로고    scopus 로고
    • Genetics of multiple sclerosis
    • Oksenberg JR, Hauser SL. Genetics of multiple sclerosis. Neurol Clin 2005;23:61-75.
    • (2005) Neurol Clin , vol.23 , pp. 61-75
    • Oksenberg, J.R.1    Hauser, S.L.2
  • 18
    • 39449090773 scopus 로고    scopus 로고
    • Genetics and natural history of multiple sclerosis
    • Kantarci OH. Genetics and natural history of multiple sclerosis. Semin Neurol 2008;28:7-16.
    • (2008) Semin Neurol , vol.28 , pp. 7-16
    • Kantarci, O.H.1
  • 19
    • 0037371325 scopus 로고    scopus 로고
    • HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course
    • Barcellos LF, Oksenberg JR, Begovich AB et al. HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet 2003;72:710-6.
    • (2003) Am J Hum Genet , vol.72 , pp. 710-716
    • Barcellos, L.F.1    Oksenberg, J.R.2    Begovich, A.B.3
  • 20
    • 18544365397 scopus 로고    scopus 로고
    • Multiple susceptibility loci for multiple sclerosis
    • Haines JL, Bradford Y, Garcia ME et al. Multiple susceptibility loci for multiple sclerosis. Hum Mol Genet 2002;11:2251-6.
    • (2002) Hum Mol Genet , vol.11 , pp. 2251-2256
    • Haines, J.L.1    Bradford, Y.2    Garcia, M.E.3
  • 21
    • 58149122959 scopus 로고    scopus 로고
    • The complex genetics of multiple sclerosis: pitfalls and prospects
    • Sawcer S. The complex genetics of multiple sclerosis: pitfalls and prospects. Brain 2008;131:3118-31.
    • (2008) Brain , vol.131 , pp. 3118-3131
    • Sawcer, S.1
  • 23
    • 0035096330 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy
    • Lassmann H, Bruck W, Lucchinetti C. Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med 2001;7:115-21.
    • (2001) Trends Mol Med , vol.7 , pp. 115-121
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.3
  • 24
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold R, Linington C, Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006;129:1953-71.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 25
    • 34248639557 scopus 로고    scopus 로고
    • The role of CD4 T cells in the pathogenesis of multiple sclerosis
    • Chitnis T. The role of CD4 T cells in the pathogenesis of multiple sclerosis. Int Rev Neurobiol 2007;79:43-72.
    • (2007) Int Rev Neurobiol , vol.79 , pp. 43-72
    • Chitnis, T.1
  • 26
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • Ben-Nun A, Wekerle H, Cohen IR. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 1981;11:195-9.
    • (1981) Eur J Immunol , vol.11 , pp. 195-199
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 27
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos JS, Friese MA, Craner MJ et al. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008;172:146-55.
    • (2008) Am J Pathol , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3
  • 28
    • 35848951169 scopus 로고    scopus 로고
    • Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy
    • Flugel A, Odoardi F, Nosov M, Kawakami N. Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy. J Neuroimmunol 2007;191:86-97.
    • (2007) J Neuroimmunol , vol.191 , pp. 86-97
    • Flugel, A.1    Odoardi, F.2    Nosov, M.3    Kawakami, N.4
  • 29
    • 77956898047 scopus 로고    scopus 로고
    • Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple Sclerosis
    • Korn T, Mitsdoerffer M, Kuchroo VK. Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple Sclerosis. Results Probl Cell Differ 2010;51:43-74.
    • (2010) Results Probl Cell Differ , vol.51 , pp. 43-74
    • Korn, T.1    Mitsdoerffer, M.2    Kuchroo, V.K.3
  • 30
    • 79960132739 scopus 로고    scopus 로고
    • An overview of multiple sclerosis: diagnosis and management strategies. In: Topics in Advance Practice Nursing [online]. (accessed 24 August 2009).
    • Costello K. An overview of multiple sclerosis: diagnosis and management strategies. In: Topics in Advance Practice Nursing [online]. (accessed 24 August 2009).
    • Costello, K.1
  • 31
    • 34249818493 scopus 로고    scopus 로고
    • Oral disease-modifying treatments for multiple sclerosis: the story so far
    • Kieseier BC, Wiendl H. Oral disease-modifying treatments for multiple sclerosis: the story so far. CNS Drugs 2007;21:483-502.
    • (2007) CNS Drugs , vol.21 , pp. 483-502
    • Kieseier, B.C.1    Wiendl, H.2
  • 32
  • 34
    • 0032374063 scopus 로고    scopus 로고
    • Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
    • Bruneau JM, Yea CM, Spinella-Jaegle S et al. Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide. Biochem J 1998;336:299-303.
    • (1998) Biochem J , vol.336 , pp. 299-303
    • Bruneau, J.M.1    Yea, C.M.2    Spinella-Jaegle, S.3
  • 35
    • 0029591467 scopus 로고
    • The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
    • Cherwinski HM, Cohn RG, Cheung P et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 1995;275:1043-9.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 1043-1049
    • Cherwinski, H.M.1    Cohn, R.G.2    Cheung, P.3
  • 36
    • 0032555586 scopus 로고    scopus 로고
    • Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans
    • Ruckemann K, Fairbanks LD, Carrey EA et al. Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans. J Biol Chem 1998;273:21682-91.
    • (1998) J Biol Chem , vol.273 , pp. 21682-21691
    • Ruckemann, K.1    Fairbanks, L.D.2    Carrey, E.A.3
  • 38
    • 0032804664 scopus 로고    scopus 로고
    • Mechanism of action for leflunomide in rheumatoid arthritis
    • Fox RI, Herrmann ML, Frangou CG et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol 1999;93:198-208.
    • (1999) Clin Immunol , vol.93 , pp. 198-208
    • Fox, R.I.1    Herrmann, M.L.2    Frangou, C.G.3
  • 39
    • 62149096116 scopus 로고    scopus 로고
    • Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis
    • Merrill JE, Hanak S, Pu SF et al. Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. J Neurol 2009;256:89-103.
    • (2009) J Neurol , vol.256 , pp. 89-103
    • Merrill, J.E.1    Hanak, S.2    Pu, S.F.3
  • 40
    • 79960135948 scopus 로고    scopus 로고
    • Teriflunomide reduces neurological behaviour and pathology in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. Presented at 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 11, 2009; Dusseldorf.
    • Mcmonagle-Strucko K, Hanak S, Pu SF et al. Teriflunomide reduces neurological behaviour and pathology in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. Presented at 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 11, 2009; Dusseldorf.
    • Mcmonagle-Strucko, K.1    Hanak, S.2    Pu, S.F.3
  • 41
    • 79960113267 scopus 로고    scopus 로고
    • Teriflunomide treatment reduces infiltration of macrophages, T cells and B cells, and increases survival of oligodendrocytes in the spinal cord of the Dark Agouti rat model of Experimental Allergic Encephalomyelitis. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 15, 2010; Toronto, Canada.
    • Petty M, Lee L, Ying X et al. Teriflunomide treatment reduces infiltration of macrophages, T cells and B cells, and increases survival of oligodendrocytes in the spinal cord of the Dark Agouti rat model of Experimental Allergic Encephalomyelitis. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 15, 2010; Toronto, Canada.
    • Petty, M.1    Lee, L.2    Ying, X.3
  • 42
    • 57649116340 scopus 로고    scopus 로고
    • In vitro and in vivo pharmacological models to assess demyelination and remyelination
    • Merrill JE. In vitro and in vivo pharmacological models to assess demyelination and remyelination. Neuropsychopharmacology 2009;34:55-73.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 55-73
    • Merrill, J.E.1
  • 43
    • 79960138930 scopus 로고    scopus 로고
    • Pharmacokinetics of oral teriflunomide, a novel oral disease-modifying agent under investigation for the treatment of MS. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 15, 2010; Toronto.
    • Limsakun T, Menguy-Vacheron F. Pharmacokinetics of oral teriflunomide, a novel oral disease-modifying agent under investigation for the treatment of MS. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 15, 2010; Toronto.
    • Limsakun, T.1    Menguy-Vacheron, F.2
  • 44
    • 79960125289 scopus 로고    scopus 로고
    • Sanofi-Aventis. Data on file.
    • Sanofi-Aventis. Data on file.
  • 45
    • 33645799680 scopus 로고    scopus 로고
    • A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
    • O'connor PW, Li D, Freedman MS et al. A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology 2006;66:894-900.
    • (2006) Neurology , vol.66 , pp. 894-900
    • O'connor, P.W.1    Li, D.2    Freedman, M.S.3
  • 46
    • 79960115545 scopus 로고    scopus 로고
    • Oral teriflunomide is effective and well tolerated in multiple sclerosis with relapses: results of an open-label 144-week extension study. Presented at 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 28, 2006; Madrid.
    • O'connor PW, Freedman MS, Bar-Or A, Rice GP, Confavreux C, Traboulsee A. Oral teriflunomide is effective and well tolerated in multiple sclerosis with relapses: results of an open-label 144-week extension study. Presented at 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 28, 2006; Madrid.
    • O'connor, P.W.1    Freedman, M.S.2    Bar-Or, A.3    Rice, G.P.4    Confavreux, C.5    Traboulsee, A.6
  • 47
    • 79960134003 scopus 로고    scopus 로고
    • Oral teriflunomide or placebo to added to interferon beta for 6months in patients with relapsing multiple sclerosis: safety and efficacy results. Presented at 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 11, 2009; Dusseldorf.
    • Freedman MS, Wolinsky JS, Byrnes WJ et al. Oral teriflunomide or placebo to added to interferon beta for 6months in patients with relapsing multiple sclerosis: safety and efficacy results. Presented at 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); September 11, 2009; Dusseldorf.
    • Freedman, M.S.1    Wolinsky, J.S.2    Byrnes, W.J.3
  • 48
    • 79960113998 scopus 로고    scopus 로고
    • Oral teriflunomide or placebo added to glatiramer acetate for 6months in patients with relapsing multiple sclerosis: safety and efficacy results. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 14, 2010; Toronto.
    • Freedman MS, Wolinsky JS, Frangin GA et al. Oral teriflunomide or placebo added to glatiramer acetate for 6months in patients with relapsing multiple sclerosis: safety and efficacy results. Presented at the Annual Meeting of the American Academy of Neurology (AAN); April 14, 2010; Toronto.
    • Freedman, M.S.1    Wolinsky, J.S.2    Frangin, G.A.3


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