-
2
-
-
0024796845
-
The natural history of multiple sclerosis: A geographically based study. 2. Predictive value of the early clinical course
-
Weinshenker BG, Bass B, Rice GP, et al. The natural history of multiple sclerosis: a geographically based study. 2. Predictive value of the early clinical course. Brain 1989;112:1419-28. (Pubitemid 20024212)
-
(1989)
Brain
, vol.112
, Issue.6
, pp. 1419-1428
-
-
Weinshenker, B.G.1
Bass, B.2
Rice, G.P.A.3
Noseworthy, J.4
Carriere, W.5
Baskerville, J.6
Ebers, G.C.7
-
3
-
-
43549113832
-
Natural history of secondary-progressive multiple sclerosis
-
DOI 10.1177/1352458507084264
-
Tremlett H, Yinshan Z, Devonshire V. Natural history of secondary-progressive multiple sclerosis. Mult Scler 2008;14:314-24. (Pubitemid 351676426)
-
(2008)
Multiple Sclerosis
, vol.14
, Issue.3
, pp. 314-324
-
-
Tremlett, H.1
Zhao, Y.2
Devonshire, V.3
-
4
-
-
0026780512
-
Life expectancy in patients attending multiple sclerosis clinics
-
Sadovnick AD, Ebers GC, Wilson RW, Paty DW. Life expectancy in patients attending multiple sclerosis clinics. Neurology 1992;42:991-4.
-
(1992)
Neurology
, vol.42
, pp. 991-994
-
-
Sadovnick, A.D.1
Ebers, G.C.2
Wilson, R.W.3
Paty, D.W.4
-
5
-
-
1842734164
-
Trends in survival and cause of death in Danish patients with multiple sclerosis
-
DOI 10.1093/brain/awh104
-
Brønnum-Hansen H, Koch-Henriksen N, Stenager E. Trends in survival and cause of death in Danish patients with multiple sclerosis. Brain 2004;127:844-50. (Pubitemid 38478529)
-
(2004)
Brain
, vol.127
, Issue.4
, pp. 844-850
-
-
Bronnum-Hansen, H.1
Koch-Henriksen, N.2
Stenager, E.3
-
6
-
-
33745675511
-
Costs and quality of life in multiple sclerosis: A cross-sectional study in the United States
-
DOI 10.1212/01.wnl.0000218309.01322.5c, PII 0000611420060613000019
-
Kobelt G, Berg J, Atherly D, Hadjimichael O. Costs and quality of life in multiple sclerosis: a cross-sectional study in the United States. Neurology 2006;66: 1696-702. (Pubitemid 43964625)
-
(2006)
Neurology
, vol.66
, Issue.11
, pp. 1696-1702
-
-
Kobelt, G.1
Berg, J.2
Atherly, D.3
Hadjimichael, O.4
-
7
-
-
16244405888
-
Multiple sclerosis
-
DOI 10.1111/j.0105-2896.2005.00240.x
-
Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. Multiple sclerosis. Immunol Rev 2005; 204:208-31. (Pubitemid 40460504)
-
(2005)
Immunological Reviews
, vol.204
, pp. 208-231
-
-
Hafler, D.A.1
Slavik, J.M.2
Anderson, D.E.3
O'Connor, K.C.4
De Jager, P.5
Baecher-Allan, C.6
-
8
-
-
0035076949
-
FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression
-
DOI 10.1016/S0041-1345(00)02126-6, PII S0041134500021266
-
Brinkmann V, Chen S, Feng L, Pinschewer D, Nikolova Z, Hof R. FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression. Transplant Proc 2001; 33:530-1. (Pubitemid 32237498)
-
(2001)
Transplantation Proceedings
, vol.33
, Issue.1-2
, pp. 530-531
-
-
Brinkmann, V.1
-
9
-
-
36248956701
-
Finding a way out: Lymphocyte egress from lymphoid organs
-
DOI 10.1038/ni1545, PII NI1545
-
Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol 2007;8:1295-301. (Pubitemid 350131168)
-
(2007)
Nature Immunology
, vol.8
, Issue.12
, pp. 1295-1301
-
-
Schwab, S.R.1
Cyster, J.G.2
-
10
-
-
37849033437
-
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress
-
Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity 2008;28:122-33.
-
(2008)
Immunity
, vol.28
, pp. 122-133
-
-
Pham, T.H.1
Okada, T.2
Matloubian, M.3
Lo, C.G.4
Cyster, J.G.5
-
11
-
-
2442679391
-
The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors
-
Gräler MH, Goetzl EJ. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J 2004;18:551-3.
-
(2004)
FASEB J
, vol.18
, pp. 551-553
-
-
Gräler, M.H.1
Goetzl, E.J.2
-
12
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
DOI 10.1126/science.1070238
-
Mandala S, Hajdu R, Bergstrom J, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002;296:346-9. (Pubitemid 34303689)
-
(2002)
Science
, vol.296
, Issue.5566
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
Thornton, R.7
Shei, G.-J.8
Card, D.9
Keohane, C.10
Rosenbach, M.11
Hale, J.12
Lynch, C.L.13
Rupprecht, K.14
Parsons, W.15
Rosen, H.16
-
13
-
-
54449099880
-
FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis
-
Mehling M, Brinkmann V, Antel J, et al. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology 2008;71:1261-7.
-
(2008)
Neurology
, vol.71
, pp. 1261-1267
-
-
Mehling, M.1
Brinkmann, V.2
Antel, J.3
-
14
-
-
77955358808
-
Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis
-
Mehling M, Lindberg R, Raulf F, et al. Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis. Neurology 2010;75:403-10.
-
(2010)
Neurology
, vol.75
, pp. 403-410
-
-
Mehling, M.1
Lindberg, R.2
Raulf, F.3
-
15
-
-
66849115613
-
Immunomodulatory drug FTY720 induces regulatory CD4(+)CD25(+) T cells in vitro
-
Zhou PJ, Wang H, Shi GH, Wang XH, Shen ZJ, Xu D. Immunomodulatory drug FTY720 induces regulatory CD4(+)CD25(+) T cells in vitro. Clin Exp Immunol 2009; 157:40-7.
-
(2009)
Clin Exp Immunol
, vol.157
, pp. 40-47
-
-
Zhou, P.J.1
Wang, H.2
Shi, G.H.3
Wang, X.H.4
Shen, Z.J.5
Xu, D.6
-
16
-
-
79960895505
-
Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo
-
Hu Y, Lee X, Ji B, et al. Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo. Mol Cell Neurosci 2011; 48:72-81.
-
(2011)
Mol Cell Neurosci
, vol.48
, pp. 72-81
-
-
Hu, Y.1
Lee, X.2
Ji, B.3
-
17
-
-
39049125218
-
FTY720 modulates human oligodendrocyte progenitor process extension and survival
-
DOI 10.1002/ana.21227
-
Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP. FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann Neurol 2008;63:61-71. (Pubitemid 351240552)
-
(2008)
Annals of Neurology
, vol.63
, Issue.1
, pp. 61-71
-
-
Miron, V.E.1
Jung, C.G.2
Kim, H.J.3
Kennedy, T.E.4
Soliven, B.5
Antel, J.P.6
-
18
-
-
77953225859
-
Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
-
Miron VE, Ludwin SK, Darlington PJ, et al. Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am J Pathol 2010;176:2682-94.
-
(2010)
Am J Pathol
, vol.176
, pp. 2682-2694
-
-
Miron, V.E.1
Ludwin, S.K.2
Darlington, P.J.3
-
19
-
-
0037440379
-
Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes
-
DOI 10.1002/glia.10180
-
Yamagata K, Tagami M, Torii Y, et al. Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. Glia 2003;41:199-206. (Pubitemid 36262197)
-
(2003)
GLIA
, vol.41
, Issue.2
, pp. 199-206
-
-
Yamagata, K.1
Tagami, M.2
Torii, Y.3
Takenaga, F.4
Tsumagari, S.5
Itoh, S.6
Yamori, Y.7
Nara, Y.8
-
20
-
-
0030780015
-
Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation
-
Edsall LC, Pirianov GG, Spiegel S. Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. J Neurosci 1997;17:6952-60. (Pubitemid 27427874)
-
(1997)
Journal of Neuroscience
, vol.17
, Issue.18
, pp. 6952-6960
-
-
Edsall, L.C.1
Pirianov, G.G.2
Spiegel, S.3
-
21
-
-
1042278008
-
Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells
-
Harada J, Foley M, Moskowitz MA, Waeber C. Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. J Neurochem 2004;88:1026-39. (Pubitemid 38199325)
-
(2004)
Journal of Neurochemistry
, vol.88
, Issue.4
, pp. 1026-1039
-
-
Harada, J.1
Foley, M.2
Moskowitz, M.A.3
Waeber, C.4
-
22
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401.
-
(2010)
N Engl J Med
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
-
23
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402-15.
-
(2010)
N Engl J Med
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
24
-
-
79952501096
-
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
-
Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292-302.
-
(2011)
Ann Neurol
, vol.69
, pp. 292-302
-
-
Polman, C.H.1
Reingold, S.C.2
Banwell, B.3
-
25
-
-
0034727059
-
Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis
-
Jacobs LD, Beck RW, Simon JH, et al. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. N Engl J Med 2000;343:898-904.
-
(2000)
N Engl J Med
, vol.343
, pp. 898-904
-
-
Jacobs, L.D.1
Beck, R.W.2
Simon, J.H.3
-
26
-
-
0035912520
-
Effect of early interferon treatment on conversion to definite multiple sclerosis: A randomised study
-
DOI 10.1016/S0140-6736(00)04725-5
-
Comi G, Filippi M, Barkhof F, et al. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet 2001;357:1576-82. (Pubitemid 32488815)
-
(2001)
Lancet
, vol.357
, Issue.9268
, pp. 1576-1582
-
-
Comi, G.1
Filippi, M.2
Barkhof, F.3
Durelli, L.4
Edan, G.5
Fernandez, O.6
Hartung, H.-P.7
Seeldrayers, P.8
Sorensen, P.S.9
Rovaris, M.10
Martinelli, V.11
Hommes, O.R.12
-
27
-
-
33749661011
-
Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes
-
DOI 10.1212/01.wnl.0000237641.33768.8d, PII 0000611420061010000027
-
Kappos L, Polman CH, Freedman MS, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology 2006; 67:1242-9. (Pubitemid 44563835)
-
(2006)
Neurology
, vol.67
, Issue.7
, pp. 1242-1249
-
-
Kappos, L.1
Polman, C.H.2
Freedman, M.S.3
Edan, G.4
Hartung, H.P.5
Miller, D.H.6
Montalban, X.7
Barkhof, F.8
Bauer, L.9
Jakobs, P.10
Pohl, C.11
Sandbrink, R.12
-
28
-
-
70350786389
-
Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): A randomised, double-blind, placebo-controlled trial
-
Erratum, Lancet 2010;375:1436
-
Comi G, Martinelli V, Rodegher M, et al. Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. Lancet 2009;374:1503-11. [Erratum, Lancet 2010;375:1436.]
-
(2009)
Lancet
, vol.374
, pp. 1503-1511
-
-
Comi, G.1
Martinelli, V.2
Rodegher, M.3
-
29
-
-
22844445230
-
Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
-
DOI 10.1056/NEJMoa051847
-
Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 2005;353:375-81. (Pubitemid 41132342)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.4
, pp. 375-381
-
-
Langer-Gould, A.1
Atlas, S.W.2
Green, A.J.3
Bollen, A.W.4
Pelletier, D.5
-
30
-
-
22844439662
-
Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
-
DOI 10.1056/NEJMoa051782
-
Kleinschmidt-DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 2005;353:369-74. (Pubitemid 41132341)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.4
, pp. 369-374
-
-
Kleinschmidt-DeMasters, B.K.1
Tyler, K.L.2
-
31
-
-
77956387401
-
Anti-JC virus antibodies: Implications for PML risk stratification
-
Gorelik L, Lerner M, Bixler S, et al. Anti-JC virus antibodies: implications for PML risk stratification. Ann Neurol 2010; 68:295-303.
-
(2010)
Ann Neurol
, vol.68
, pp. 295-303
-
-
Gorelik, L.1
Lerner, M.2
Bixler, S.3
-
32
-
-
79959520067
-
Longterm safety profile of mitoxantrone in a French cohort of 802 multiple sclerosis patients: A 5-year prospective study
-
Le Page E, Leray E, Edan G. Longterm safety profile of mitoxantrone in a French cohort of 802 multiple sclerosis patients: a 5-year prospective study. Mult Scler 2011;17:867-75.
-
(2011)
Mult Scler
, vol.17
, pp. 867-875
-
-
Le Page, E.1
Leray, E.2
Edan, G.3
-
33
-
-
80655128161
-
Delayed fingolimod- associated asystole
-
Espinosa PS, Berger JR. Delayed fingolimod- associated asystole. Mult Scler 2011;17:1387-9.
-
(2011)
Mult Scler
, vol.17
, pp. 1387-1389
-
-
Espinosa, P.S.1
Berger, J.R.2
-
34
-
-
85031199182
-
-
home page
-
Medi-Span home page (http://www.medi-span.com).
-
-
-
-
35
-
-
77955799815
-
Oral fingolimod (FTY720) for relapsing multiple sclerosis
-
DOI 10.1056/NEJMoa052643
-
Kappos L, Antel J, Comi G, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006;355:1124-40. (Pubitemid 44394919)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.11
, pp. 1124-1140
-
-
Kappos, L.1
Antel, J.2
Comi, G.3
Montalban, X.4
O'Connor, P.5
Polman, C.H.6
Haas, T.7
Korn, A.A.8
Karlsson, G.9
Radue, E.W.10
-
36
-
-
76449120437
-
Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
-
Comi G, O'Connor P, Montalban X, et al. Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results. Mult Scler 2010;16:197-207.
-
(2010)
Mult Scler
, vol.16
, pp. 197-207
-
-
Comi, G.1
O'Connor, P.2
Montalban, X.3
-
38
-
-
14644408845
-
KACh
-
DOI 10.1111/j.1600-6143.2005.00754.x
-
Koyrakh L, Roman MI, Brinkmann V, Wickman K. The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I. Am J Transplant 2005;5:529-36. (Pubitemid 40313344)
-
(2005)
American Journal of Transplantation
, vol.5
, Issue.3
, pp. 529-536
-
-
Koyrakh, L.1
Roman, M.I.2
Brinkmann, V.3
Wickman, K.4
-
39
-
-
80051688285
-
Melanoma occurring during treatment with fingolimod for multiple sclerosis: A case report
-
Conzett KB, Kolm I, Jelcic I, et al. Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report. Arch Dermatol 2011;147:991-2.
-
(2011)
Arch Dermatol
, vol.147
, pp. 991-992
-
-
Conzett, K.B.1
Kolm, I.2
Jelcic, I.3
-
40
-
-
33747419124
-
Pulmonary and vascular pharmacology of sphingosine 1-phosphate
-
DOI 10.1016/j.coph.2005.12.004, PII S1471489206000518, Respiratory/Musculoskeletal
-
Brinkmann V, Baumruker T. Pulmonary and vascular pharmacology of sphingosine 1-phosphate. Curr Opin Pharmacol 2006;6:244-50. (Pubitemid 44274746)
-
(2006)
Current Opinion in Pharmacology
, vol.6
, Issue.3
, pp. 244-250
-
-
Brinkmann, V.1
Baumruker, T.2
-
43
-
-
70449368864
-
Bleak prospects for primary progressive multiple sclerosis therapy: Downs and downs, but a glimmer of hope
-
Hartung HP, Aktas O. Bleak prospects for primary progressive multiple sclerosis therapy: downs and downs, but a glimmer of hope. Ann Neurol 2009;66:429-32.
-
(2009)
Ann Neurol
, vol.66
, pp. 429-432
-
-
Hartung, H.P.1
Aktas, O.2
|