-
1
-
-
78649988289
-
Emerging therapies in relapsing-remitting multiple sclerosis
-
Marriott JJ, O'Connor PW. Emerging therapies in relapsing-remitting multiple sclerosis. Rev Recent Clin Trials. 2010;5:179-188.
-
(2010)
Rev Recent Clin Trials
, vol.5
, pp. 179-188
-
-
Marriott, J.J.1
O'Connor, P.W.2
-
4
-
-
7644223637
-
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide-mechanisms independent of pyrimidine depletion
-
Korn T, Magnus T, Toyka K, Jung S. Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide-mechanisms independent of pyrimidine depletion. J Leukoc Biol. 2004;76:950-960.
-
(2004)
J Leukoc Biol
, vol.76
, pp. 950-960
-
-
Korn, T.1
Magnus, T.2
Toyka, K.3
Jung, S.4
-
6
-
-
0032374063
-
Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
-
Bruneau JM, Yea CM, Spinella-Jaegle S, et al. Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide. Biochem J. 1998;336:299-303.
-
(1998)
Biochem J
, vol.336
, pp. 299-303
-
-
Bruneau, J.M.1
Yea, C.M.2
Spinella-Jaegle, S.3
-
7
-
-
0029591467
-
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
-
Cherwinski HM, Cohn RG, Cheung P, et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther. 1995;275:1043-1049.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1043-1049
-
-
Cherwinski, H.M.1
Cohn, R.G.2
Cheung, P.3
-
8
-
-
0032804664
-
Mechanism of action for leflunomide in rheumatoid arthritis
-
Fox RI, Herrmann ML, Frangou CG, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999;93: 198-208.
-
(1999)
Clin Immunol
, vol.93
, pp. 198-208
-
-
Fox, R.I.1
Herrmann, M.L.2
Frangou, C.G.3
-
9
-
-
0032555586
-
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans
-
Ruckemann K, Fairbanks LD, Carrey EA, et al. Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans. J Biol Chem. 1998;273:21682-21691.
-
(1998)
J Biol Chem
, vol.273
, pp. 21682-21691
-
-
Ruckemann, K.1
Fairbanks, L.D.2
Carrey, E.A.3
-
10
-
-
0034122123
-
Leflunomide: An immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
-
Herrmann ML, Schleyerbach R, Kirschbaum BJ. Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology. 2000;47:273-289.
-
(2000)
Immunopharmacology
, vol.47
, pp. 273-289
-
-
Herrmann, M.L.1
Schleyerbach, R.2
Kirschbaum, B.J.3
-
11
-
-
0029585361
-
Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans.Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors
-
Fairbanks LD, Bofill M, Ruckemann K, Simmonds HA. Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors. J Biol Chem. 1995;270:29682-29689.
-
(1995)
J Biol Chem
, vol.270
, pp. 29682-29689
-
-
Fairbanks, L.D.1
Bofill, M.2
Ruckemann, K.3
Simmonds, H.A.4
-
12
-
-
0031179645
-
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
-
Elder RT, Xu X, Williams JW, Gong H, Finnegan A, Chong AS. The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. J Immunol. 1997;159:22-27.
-
(1997)
J Immunol
, vol.159
, pp. 22-27
-
-
Elder, R.T.1
Xu, X.2
Williams, J.W.3
Gong, H.4
Finnegan, A.5
Chong, A.S.6
-
13
-
-
0034840913
-
Suppression of experimental autoimmune neuritis by leflunomide
-
Korn T, Toyka K, Hartung HP, Jung S. Suppression of experimental autoimmune neuritis by leflunomide. Brain. 2001;124:1791-1802.
-
(2001)
Brain
, vol.124
, pp. 1791-1802
-
-
Korn, T.1
Toyka, K.2
Hartung, H.P.3
Jung, S.4
-
14
-
-
0032519992
-
Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production
-
Siemasko K, Chong AS, Jack HM, Gong H, Williams JW, Finnegan A. Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. J Immunol. 1998;160:1581-1588.
-
(1998)
J Immunol
, vol.160
, pp. 1581-1588
-
-
Siemasko, K.1
Chong, A.S.2
Jack, H.M.3
Gong, H.4
Williams, J.W.5
Finnegan, A.6
-
15
-
-
0029052321
-
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
-
Xu X, Williams JW, Bremer EG, Finnegan A, Chong AS. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995;270:12398-12403.
-
(1995)
J Biol Chem
, vol.270
, pp. 12398-12403
-
-
Xu, X.1
Williams, J.W.2
Bremer, E.G.3
Finnegan, A.4
Chong, A.S.5
-
16
-
-
0031721092
-
Dose-dependent enhancing and inhibitory effects of A77 1726 (leflunomide) on cytotoxic T lymphocyte induction
-
Hoskin DW, Taylor RM, Makrigiannis AP, James H, Lee TD. Dose-dependent enhancing and inhibitory effects of A77 1726 (leflunomide) on cytotoxic T lymphocyte induction. Int J Immunopharmacol. 1998;20:505-513.
-
(1998)
Int J Immunopharmacol
, vol.20
, pp. 505-513
-
-
Hoskin, D.W.1
Taylor, R.M.2
Makrigiannis, A.P.3
James, H.4
Lee, T.D.5
-
17
-
-
0033557695
-
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression
-
Manna SK, Aggarwal BB. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. J Immunol. 1999;162:2095-2102.
-
(1999)
J Immunol
, vol.162
, pp. 2095-2102
-
-
Manna, S.K.1
Aggarwal, B.B.2
-
18
-
-
70349384718
-
Inhibition of tumour necrosis factor and IL-17 production by leflunomide involves the JAK/STAT pathway
-
González-Alvaro I, Ortiz AM, Domínguez-Jiménez C, Aragón-Bodi A, Díaz Sánchez B, Sánchez-Madrid F. Inhibition of tumour necrosis factor and IL-17 production by leflunomide involves the JAK/STAT pathway. Ann Rheum Dis. 2009;68:1644-1650.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 1644-1650
-
-
González-Alvaro, I.1
Ortiz, A.M.2
Domínguez-Jiménez, C.3
Aragón-Bodi, A.4
Díaz Sánchez, B.5
Sánchez-Madrid, F.6
-
19
-
-
0027501428
-
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide
-
Mattar T, Kochhar K, Bartlett R, Bremer EG, Finnegan A. Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. FEBS Lett. 1993;334:161-164.
-
(1993)
FEBS Lett
, vol.334
, pp. 161-164
-
-
Mattar, T.1
Kochhar, K.2
Bartlett, R.3
Bremer, E.G.4
Finnegan, A.5
-
20
-
-
0034670031
-
Leflunomide suppresses TNF-induced cellular responses: Effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis
-
Manna SK, Mukhopadhyay A, Aggarwal BB. Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol. 2000;165:5962-5969.
-
(2000)
J Immunol
, vol.165
, pp. 5962-5969
-
-
Manna, S.K.1
Mukhopadhyay, A.2
Aggarwal, B.B.3
-
21
-
-
0032773737
-
A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner
-
Hamilton LC, Vojnovic I, Warner TD. A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner. Br J Pharmacol. 1999;127:1589-1596.
-
(1999)
Br J Pharmacol
, vol.127
, pp. 1589-1596
-
-
Hamilton, L.C.1
Vojnovic, I.2
Warner, T.D.3
-
22
-
-
0034143656
-
Cell-specific inhibition of inducible nitric oxide synthase activation by leflunomide
-
Jankovic V, Samardzic T, Stosic-Grujicic S, Popadic D, Trajkovic V. Cell-specific inhibition of inducible nitric oxide synthase activation by leflunomide. Cell Immunol. 2000;199:73-80.
-
(2000)
Cell Immunol
, vol.199
, pp. 73-80
-
-
Jankovic, V.1
Samardzic, T.2
Stosic-Grujicic, S.3
Popadic, D.4
Trajkovic, V.5
-
23
-
-
25444448197
-
Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: Involvement of impaired integrin activation and immunologic synapse formation
-
Zeyda M, Poglitsch M, Geyeregger R, et al. Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation. Arthritis Rheum. 2005;52:2730-2739.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 2730-2739
-
-
Zeyda, M.1
Poglitsch, M.2
Geyeregger, R.3
-
24
-
-
0347416897
-
T cell aggregation induced through CD43: Intracellular signals and inhibition by the immunomodulatory drug leflunomide
-
Layseca-Espinosa E, Pedraza-Alva G, Montiel JL, et al. T cell aggregation induced through CD43: intracellular signals and inhibition by the immunomodulatory drug leflunomide. J Leukoc Biol. 2003;74:1083-1093.
-
(2003)
J Leukoc Biol
, vol.74
, pp. 1083-1093
-
-
Layseca-Espinosa, E.1
Pedraza-Alva, G.2
Montiel, J.L.3
-
25
-
-
0037105395
-
Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation
-
Dimitrova P, Skapenko A, Herrmann ML, Schleyerbach R, Kalden JR, Schulze-Koops H. Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation. J Immunol. 2002;169:3392-3399.
-
(2002)
J Immunol
, vol.169
, pp. 3392-3399
-
-
Dimitrova, P.1
Skapenko, A.2
Herrmann, M.L.3
Schleyerbach, R.4
Kalden, J.R.5
Schulze-Koops, H.6
-
26
-
-
0345491507
-
Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissueinhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases
-
Deage V, Burger D, Dayer JM. Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissueinhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases. Eur Cytokine Netw. 1998;9:663-668.
-
(1998)
Eur Cytokine Netw
, vol.9
, pp. 663-668
-
-
Deage, V.1
Burger, D.2
Dayer, J.M.3
-
27
-
-
0037378668
-
Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis
-
Cutolo M, Sulli A, Ghiorzo P, Pizzorni C, Craviotto C, Villaggio B. Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis. Ann Rheumatic Dis. 2003;62:297-302.
-
(2003)
Ann Rheumatic Dis
, vol.62
, pp. 297-302
-
-
Cutolo, M.1
Sulli, A.2
Ghiorzo, P.3
Pizzorni, C.4
Craviotto, C.5
Villaggio, B.6
-
28
-
-
0033947789
-
Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis:Findings in a prospective, randomized, double-blind clinical trial in fifteen patients
-
Kraan MC, de Koster BM, Elferink JG, Post WJ, Breedveld FC, Tak PP. Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients. Arthritis Rheum. 2000;43:1488-1495.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 1488-1495
-
-
Kraan, M.C.1
De Koster, B.M.2
Elferink, J.G.3
Post, W.J.4
Breedveld F.C.Tak, P.P.5
-
29
-
-
0033884087
-
Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis
-
Kraan MC, Reece RJ, Barg EC, et al. Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers. Arthritis Rheum. 2000;43:1820-1830.
-
(2000)
Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers Arthritis Rheum
, vol.43
, pp. 1820-1830
-
-
Kraan, M.C.1
Reece, R.J.2
Barg, E.C.3
-
30
-
-
84856103060
-
An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors
-
Fuentealba RA, Marasa J, Diamond MI, Piwnica-Worms D, Weihl CC. An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. Hum Mol Genet. 2012;21:664-680.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 664-680
-
-
Fuentealba, R.A.1
Marasa, J.2
Diamond, M.I.3
Piwnica-Worms, D.4
Weihl, C.C.5
-
31
-
-
84877902352
-
-
Sanofi. Teriflunomide data on file, France, Sanofi
-
Sanofi. Teriflunomide data on file. Paris, France: Sanofi; 2012.
-
(2012)
Paris
-
-
-
32
-
-
84856211605
-
Pharmacokinetics of Oral Teriflunomide, a Novel Oral Disease-modifying Agent Under Investigation For the Treatment of Multiple Sclerosis
-
Toronto, ON, Canada
-
Limsakun T, Menguy-Vacheron F, Mazarin C. Pharmacokinetics of oral teriflunomide, a novel oral disease-modifying agent under investigation for the treatment of multiple sclerosis. Programs and abstracts of the 62nd American Academy of Neurology Annual Meeting; April 10-17, 2010; Toronto, ON, Canada.
-
(2010)
Programs and Abstracts of the 62nd American Academy of Neurology Annual Meeting; April 10-17
-
-
Limsakun, T.1
Menguy-Vacheron, F.2
Mazarin, C.3
-
34
-
-
0031688565
-
Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology
-
Storch MK, Stefferl A, Brehm U, et al. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol. 1998;8:681-694.
-
(1998)
Brain Pathol
, vol.8
, pp. 681-694
-
-
Storch, M.K.1
Stefferl, A.2
Brehm, U.3
-
35
-
-
0032531157
-
MHC haplotype-dependent regulation of MOG-induced EAE in rats
-
Weissert R, Wallström E, Storch MK, et al. MHC haplotype-dependent regulation of MOG-induced EAE in rats. J Clin Invest. 1998;102: 1265-1273.
-
(1998)
J Clin Invest
, vol.102
, pp. 1265-1273
-
-
Weissert, R.1
Wallström, E.2
Storch, M.K.3
-
36
-
-
77956898047
-
Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis
-
Korn T, Mitsdoerffer M, Kuchroo VK. Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis. Results Probl Cell Differ. 2010;51: 43-74.
-
(2010)
Results Probl Cell Differ
, vol.51
, pp. 43-74
-
-
Korn, T.1
Mitsdoerffer, M.2
Kuchroo, V.K.3
-
37
-
-
62149096116
-
Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis
-
Merrill JE, Hanak S, Pu SF, et al. Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. J Neurol. 2009;256:89-103.
-
(2009)
J Neurol
, vol.256
, pp. 89-103
-
-
Merrill, J.E.1
Hanak, S.2
Pu, S.F.3
-
38
-
-
84877892420
-
-
Styren S, San Diego, CA, USA
-
Styren S, Barbier A, Selk D, Wettstein JG. Beneficial effects of teriflunomide in experimental allergic encephalomyelitis. Paper presented at Society for Neuroscience Annual Meeting; October 23-27, 2004; San Diego, CA, USA.
-
(2004)
Beneficial Effects of Teriflunomide In Experimental Allergic Encephalomyelitis. Paper Presented At Society For Neuroscience Annual Meeting
-
-
Barbier, A.1
Selk, D.2
Wettstein, J.G.3
-
39
-
-
33645799680
-
A phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
-
O'Connor PW, Li D, Freedman MS, et al. A phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology. 2006;66:894-900.
-
(2006)
Neurology
, vol.66
, pp. 894-900
-
-
O'Connor, P.W.1
Li, D.2
Freedman, M.S.3
-
40
-
-
84860199056
-
Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: Safety and efficacy results up to 8.5 years
-
Confavreux C, Li DK, Freedman MS, et al. Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: safety and efficacy results up to 8.5 years. Mult Scler. 2012;18:1278-1289.
-
(2012)
Mult Scler
, vol.18
, pp. 1278-1289
-
-
Confavreux, C.1
Li, D.K.2
Freedman, M.S.3
-
41
-
-
84863567558
-
Teriflunomide added to interferon-beta in relapsing multiple sclerosis: A randomized phase II trial
-
Freedman MS, Wolinsky JS, Wamil B, et al. Teriflunomide added to interferon-beta in relapsing multiple sclerosis: a randomized phase II trial. Neurology. 2012;78:1877-1885.
-
(2012)
Neurology
, vol.78
, pp. 1877-1885
-
-
Freedman, M.S.1
Wolinsky, J.S.2
Wamil, B.3
-
42
-
-
84877900479
-
Oral Teriflunomide Or Placebo Added to Glatiramer Acetate For 6 Months In Patients With Relapsing Multiple Sclerosis: Safety and Efficacy Results
-
Toronto, ON, Canada, April 10-17
-
Freedman MS, WJ, Frangin GA, et al. Oral teriflunomide or placebo added to glatiramer acetate for 6 months in patients with relapsing multiple sclerosis: safety and efficacy results. Programs and abstracts of the 62nd American Academy of Neurology Annual Meeting; April 10-17, 2010; Toronto, ON, Canada.
-
(2010)
Programs and Abstracts of the 62nd American Academy of Neurology Annual Meeting
-
-
Freedman, M.S.W.J.1
Frangin, G.A.2
-
45
-
-
84993703372
-
Effect of teriflunomide on immune responses to seasonal influenza vaccination in patients with relapsing multiple sclerosis
-
October 10-13, Lyon, France
-
Bar-Or A, Freedman MS, Kremenchutzky F, et al. Effect of teriflunomide on immune responses to seasonal influenza vaccination in patients with relapsing multiple sclerosis: results from the TERIVA study. Paper presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); October 10-13, 2012; Lyon, France.
-
(2012)
Results From the TERIVA Study. Paper Presented At the 28th Congress of the European Committee For Treatment and Research In Multiple Sclerosis (ECTRIMS)
-
-
Bar-Or, A.1
Freedman, M.S.2
Kremenchutzky, F.3
-
46
-
-
80053533877
-
Randomized trial of oral teriflunomide for relapsing multiple sclerosis
-
O'Connor P, Wolinsky JS, Confavreux C, et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med. 2011;365: 1293-1303.
-
(2011)
N Engl J Med
, vol.365
, pp. 1293-1303
-
-
O'Connor, P.1
Wolinsky, J.S.2
Confavreux, C.3
-
48
-
-
84885848919
-
The efficacy and safety of teriflunomide in patients with relapsing MS: Results from TOWER, a phase III, placebo-controlled study
-
October 10-13, Lyon, France
-
Kappos L, Comi G, Confavreux C, et al. The efficacy and safety of teriflunomide in patients with relapsing MS: results from TOWER, a phase III, placebo-controlled study. Paper presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); October 10-13, 2012; Lyon, France.
-
(2012)
Paper Presented At the 28th Congress of the European Committee For Treatment and Research In Multiple Sclerosis (ECTRIMS)
-
-
Kappos, L.1
Comi, G.2
Confavreux, C.3
-
49
-
-
84885384570
-
A multicenter, randomized, parallel-group, rater-blinded study comparing the effectiveness and safety of teriflunomide and subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis
-
October 10-13, Lyon, France
-
Vermersch P, Czlonkowska A, Grimaldi LME, et al. A multicenter, randomized, parallel-group, rater-blinded study comparing the effectiveness and safety of teriflunomide and subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis. Paper presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); October 10-13, 2012; Lyon, France.
-
(2012)
Paper Presented At the 28th Congress of the European Committee For Treatment and Research In Multiple Sclerosis (ECTRIMS)
-
-
Vermersch, P.1
Czlonkowska, A.2
Grimaldi, L.M.E.3
-
51
-
-
0035116073
-
Teratogen update: Reproductive risks of leflunomide (Arava); a pyrimidine synthesis inhibitor: Counseling women taking leflunomide before or during pregnancy and men taking leflunomide who are contemplating fathering a child
-
Brent RL. Teratogen update: reproductive risks of leflunomide (Arava); a pyrimidine synthesis inhibitor: counseling women taking leflunomide before or during pregnancy and men taking leflunomide who are contemplating fathering a child. Teratology. 2001;63:106-112.
-
(2001)
Teratology
, vol.63
, pp. 106-112
-
-
Brent, R.L.1
-
52
-
-
35548953841
-
Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice
-
Fukushima R, Kanamori S, Hirashiba M, et al. Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice. Reprod Toxicol. 2007;24:310-316.
-
(2007)
Reprod Toxicol
, vol.24
, pp. 310-316
-
-
Fukushima, R.1
Kanamori, S.2
Hirashiba, M.3
-
53
-
-
77951756564
-
Birth outcomes in women who have taken leflunomide during pregnancy
-
Chambers CD, Johnson DL, Robinson LK, et al. Birth outcomes in women who have taken leflunomide during pregnancy. Arthritis Rheum. 2010;62:1494-1503.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 1494-1503
-
-
Chambers, C.D.1
Johnson, D.L.2
Robinson, L.K.3
-
54
-
-
84863228217
-
Pregnancy outcome in women exposed to leflunomide before or during pregnancy
-
Cassina M, Johnson DL, Robinson LK, et al. Pregnancy outcome in women exposed to leflunomide before or during pregnancy. Arthritis Rheum. 2012;64:2085-2094.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2085-2094
-
-
Cassina, M.1
Johnson, D.L.2
Robinson, L.K.3
-
55
-
-
84874598779
-
Pregnancy outcomes from the teriflunomide clinical development programme: Retrospective analysis of the teriflunomide clinical trial database
-
October 10-13, Lyon, France
-
Kieseier B, Benamor M, Benzerdjeb H, Stüve O. Pregnancy outcomes from the teriflunomide clinical development programme: retrospective analysis of the teriflunomide clinical trial database. Paper presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); October 10-13, 2012; Lyon, France.
-
(2012)
Paper Presented At the 28th Congress of the European Committee For Treatment and Research In Multiple Sclerosis (ECTRIMS)
-
-
Kieseier, B.1
Benamor, M.2
Benzerdjeb, H.3
Stüve, O.4
-
56
-
-
63849254103
-
Leflunomide use in New Zealand.A national prospective post-marketing study
-
White DH, Lynskey NV, Jones PB. Leflunomide use in New Zealand. A national prospective post-marketing study. Intern Medicine J. 2009;39: 95-102.
-
(2009)
Intern Medicine J
, vol.39
, pp. 95-102
-
-
White, D.H.1
Lynskey, N.V.2
Jones, P.B.3
-
57
-
-
0037214085
-
Infectious CNS disease as a differential diagnosis in systemic rheumatic diseases: Three case reports and a review of the literature
-
Warnatz K, Peter HH, Schumacher M, et al. Infectious CNS disease as a differential diagnosis in systemic rheumatic diseases: three case reports and a review of the literature. Ann Rheumatic Dis. 2003;62:50-57.
-
(2003)
Ann Rheumatic Dis
, vol.62
, pp. 50-57
-
-
Warnatz, K.1
Peter, H.H.2
Schumacher, M.3
-
58
-
-
55949099918
-
Leflunomide-associated progressive multifocal leukoencephalopathy
-
Rahmlow M, Shuster EA, Dominik J, et al. Leflunomide-associated progressive multifocal leukoencephalopathy. Arch Neurol. 2008;65: 1538-1539.
-
(2008)
Arch Neurol
, vol.65
, pp. 1538-1539
-
-
Rahmlow, M.1
Shuster, E.A.2
Dominik, J.3
-
59
-
-
79953016820
-
Pathophysiology of multiple sclerosis and the place of teriflunomide
-
Gold R, Wolinsky JS. Pathophysiology of multiple sclerosis and the place of teriflunomide. Acta Neurol Scand. 2011;124:75-84.
-
(2011)
Acta Neurol Scand
, vol.124
, pp. 75-84
-
-
Gold, R.1
Wolinsky, J.S.2
|