Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape

PLoS Genetics

Volumn 11, Issue 5, 2015, Pages

  Hancks, Dustin C ^a   Hartley, Melissa K ^a   Hagan, Celia ^b   Clark, Nathan L ^c   Elde, Nels C ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' 5' OLIGOADENYLATE SYNTHASE 1; 2' 5' OLIGOADENYLATE SYNTHASE 2; 2' 5' OLIGOADENYLATE SYNTHASE 3; CYCLIC GMP ADENOSINE MONOPHOSPHATE SYNTHASE; DOUBLE STRANDED RNA; PATTERN RECOGNITION RECEPTOR; UNCLASSIFIED DRUG; 2',5' OLIGOADENYLATE SYNTHETASE; CYCLIC GUANOSINE MONOPHOSPHATE-ADENOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE; NUCLEIC ACID;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENE DUPLICATION; GENE FUSION; HOST RESISTANCE; IMMUNE EVASION; INNATE IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMATE; PROTEIN DNA BINDING; SEQUENCE ANALYSIS; ALTERNATIVE RNA SPLICING; ANIMAL; BIOLOGICAL MODEL; DNA SEQUENCE; GENETICS; IMMUNITY; IMMUNOLOGY; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PROTEIN CONFORMATION;

PRIMATES;

2',5'-OLIGOADENYLATE SYNTHETASE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; EVOLUTION, MOLECULAR; IMMUNITY; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NUCLEIC ACIDS; NUCLEOTIDES, CYCLIC; PRIMATES; PROTEIN CONFORMATION; RNA, DOUBLE-STRANDED; SEQUENCE ANALYSIS, DNA;

EID: 84930792220     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005203     Document Type: Article

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