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Volumn 1847, Issue 11, 2015, Pages 1354-1361

Mitochondrial DNA: Radically free of free-radical driven mutations

Author keywords

Ageing; Mitochondrial DNA; mtDNA; Somatic mutations

Indexed keywords

FREE RADICAL; MITOCHONDRIAL DNA;

EID: 84941746564     PISSN: 00052728     EISSN: 18792650     Source Type: Journal    
DOI: 10.1016/j.bbabio.2015.06.001     Document Type: Review
Times cited : (48)

References (136)
  • 1
    • 46349103594 scopus 로고    scopus 로고
    • A mitochondrial protein compendium elucidates complex i disease biology
    • D.J. Pagliarini, and et al. A mitochondrial protein compendium elucidates complex I disease biology Cell 134 2008 112 123
    • (2008) Cell , vol.134 , pp. 112-123
    • Pagliarini, D.J.1
  • 2
    • 0027724036 scopus 로고
    • Control of gene expression by redox potential and the requirement for chloroplast and mitochondrial genomes
    • J.F. Allen Control of gene expression by redox potential and the requirement for chloroplast and mitochondrial genomes J. Theor. Biol. 165 1993 609 631
    • (1993) J. Theor. Biol. , vol.165 , pp. 609-631
    • Allen, J.F.1
  • 3
    • 0022532186 scopus 로고
    • Why mitochondria need a genome
    • G. Von Heijne Why mitochondria need a genome FEBS Lett. 198 1986 1 4
    • (1986) FEBS Lett. , vol.198 , pp. 1-4
    • Von Heijne, G.1
  • 4
    • 0025944612 scopus 로고
    • Structural similarities between a mitochondrially encoded polypeptide and a family of prokaryotic respiratory toxins involved in plasmid maintenance suggest a novel mechanism for the evolutionary maintenance of mitochondrial DNA
    • H.T. Jacobs Structural similarities between a mitochondrially encoded polypeptide and a family of prokaryotic respiratory toxins involved in plasmid maintenance suggest a novel mechanism for the evolutionary maintenance of mitochondrial DNA J. Mol. Evol. 32 1991 333 339
    • (1991) J. Mol. Evol. , vol.32 , pp. 333-339
    • Jacobs, H.T.1
  • 5
    • 0344861878 scopus 로고    scopus 로고
    • Mitochondrial genomes: Anything goes
    • G. Burger, M.W. Gray, and B.F. Lang Mitochondrial genomes: anything goes Trends Genet. 19 2003 709 716
    • (2003) Trends Genet. , vol.19 , pp. 709-716
    • Burger, G.1    Gray, M.W.2    Lang, B.F.3
  • 6
    • 3242702091 scopus 로고    scopus 로고
    • The mitochondrial genome of Paraspadella gotoi is highly reduced and reveals that chaetognaths are a sister group to protostomes
    • K.G. Helfenbein, H.M. Fourcade, R.G. Vanjani, and J.L. Boore The mitochondrial genome of Paraspadella gotoi is highly reduced and reveals that chaetognaths are a sister group to protostomes Proc. Natl. Acad. Sci. U. S. A. 101 2004 10639 10643
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10639-10643
    • Helfenbein, K.G.1    Fourcade, H.M.2    Vanjani, R.G.3    Boore, J.L.4
  • 7
    • 33846820322 scopus 로고    scopus 로고
    • Mitochondrial genome of the homoscleromorph Oscarella carmela (Porifera, Demospongiae) reveals unexpected complexity in the common ancestor of sponges and other animals
    • X. Wang, and D.V. Lavrov Mitochondrial genome of the homoscleromorph Oscarella carmela (Porifera, Demospongiae) reveals unexpected complexity in the common ancestor of sponges and other animals Mol. Biol. Evol. 24 2007 363 373
    • (2007) Mol. Biol. Evol. , vol.24 , pp. 363-373
    • Wang, X.1    Lavrov, D.V.2
  • 10
    • 77953627194 scopus 로고    scopus 로고
    • Somatic mitochondrial DNA mutations in mammalian aging
    • N.G. Larsson Somatic mitochondrial DNA mutations in mammalian aging Annu. Rev. Biochem. 79 2010 683 706
    • (2010) Annu. Rev. Biochem. , vol.79 , pp. 683-706
    • Larsson, N.G.1
  • 11
    • 79959450877 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in disease and aging
    • C.B. Park, and N.G. Larsson Mitochondrial DNA mutations in disease and aging J. Cell Biol. 193 2011 809 818
    • (2011) J. Cell Biol. , vol.193 , pp. 809-818
    • Park, C.B.1    Larsson, N.G.2
  • 12
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • A. Trifunovic, and et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase Nature 429 2004 417 423
    • (2004) Nature , vol.429 , pp. 417-423
    • Trifunovic, A.1
  • 13
    • 22344456832 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
    • G.C. Kujoth, and et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging Science 309 2005 481 484
    • (2005) Science , vol.309 , pp. 481-484
    • Kujoth, G.C.1
  • 14
    • 84873930785 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development
    • T. Mito, and et al. Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development PLoS One 8 2013 e55789
    • (2013) PLoS One , vol.8 , pp. e55789
    • Mito, T.1
  • 15
    • 84855417557 scopus 로고    scopus 로고
    • Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice
    • Kati J. Ahlqvist, and et al. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice Cell Metab. 15 2012 100 109
    • (2012) Cell Metab. , vol.15 , pp. 100-109
    • Ahlqvist, K.J.1
  • 16
    • 19944383101 scopus 로고    scopus 로고
    • Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number
    • H. Tyynismaa, and et al. Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number Hum. Mol. Genet. 13 2004 3219 3227
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 3219-3227
    • Tyynismaa, H.1
  • 17
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • D. Harman Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 18
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • D. Harman The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20 1972 145 147
    • (1972) J. Am. Geriatr. Soc. , vol.20 , pp. 145-147
    • Harman, D.1
  • 19
    • 33645999557 scopus 로고
    • Oxygen poisoning and x-irradiation: A mechanism in common
    • R. Gerschman, D.L. Gilbert, S.W. Nye, P. Dwyer, and W.O. Fenn Oxygen poisoning and x-irradiation: a mechanism in common Science 119 1954 623 626
    • (1954) Science , vol.119 , pp. 623-626
    • Gerschman, R.1    Gilbert, D.L.2    Nye, S.W.3    Dwyer, P.4    Fenn, W.O.5
  • 20
    • 0025309791 scopus 로고
    • Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
    • B. Bandy, and A.J. Davison Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radic. Biol. Med. 8 1990 523 539
    • (1990) Free Radic. Biol. Med. , vol.8 , pp. 523-539
    • Bandy, B.1    Davison, A.J.2
  • 21
    • 80555128721 scopus 로고    scopus 로고
    • The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA
    • H.B. Ngo, J.T. Kaiser, and D.C. Chan The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA Nat. Struct. Mol. Biol. 18 2011 1290 1296
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 1290-1296
    • Ngo, H.B.1    Kaiser, J.T.2    Chan, D.C.3
  • 22
    • 0022374832 scopus 로고
    • Characterization of DNA-protein complexes from the mitochondria of Xenopus laevis oocytes
    • M. Barat, D. Rickwood, C. Dufresne, and J.C. Mounolou Characterization of DNA-protein complexes from the mitochondria of Xenopus laevis oocytes Exp. Cell Res. 157 1985 207 217
    • (1985) Exp. Cell Res. , vol.157 , pp. 207-217
    • Barat, M.1    Rickwood, D.2    Dufresne, C.3    Mounolou, J.C.4
  • 23
    • 0026054963 scopus 로고
    • Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell
    • M. Satoh, and T. Kuroiwa Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell Exp. Cell Res. 196 1991 137 140
    • (1991) Exp. Cell Res. , vol.196 , pp. 137-140
    • Satoh, M.1    Kuroiwa, T.2
  • 24
    • 80051972817 scopus 로고    scopus 로고
    • Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA
    • C. Kukat, and et al. Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA Proc. Natl. Acad. Sci. U. S. A. 108 2011 13534 13539
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 13534-13539
    • Kukat, C.1
  • 25
    • 83255188980 scopus 로고    scopus 로고
    • Superresolution fluorescence imaging of mitochondrial nucleoids reveals their spatial range, limits, and membrane interaction
    • T.A. Brown, and et al. Superresolution fluorescence imaging of mitochondrial nucleoids reveals their spatial range, limits, and membrane interaction Mol. Cell. Biol. 31 2011 4994 5010
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 4994-5010
    • Brown, T.A.1
  • 26
    • 84864357812 scopus 로고    scopus 로고
    • Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis
    • J. He, and et al. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis Nucleic Acids Res. 40 2012 6109 6121
    • (2012) Nucleic Acids Res. , vol.40 , pp. 6109-6121
    • He, J.1
  • 27
    • 84897075686 scopus 로고    scopus 로고
    • To be or not to be a nucleoid protein: A comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins
    • F. Hensen, S. Cansiz, J.M. Gerhold, and J.N. Spelbrink To be or not to be a nucleoid protein: a comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins Biochimie 100 2014 219 226
    • (2014) Biochimie , vol.100 , pp. 219-226
    • Hensen, F.1    Cansiz, S.2    Gerhold, J.M.3    Spelbrink, J.N.4
  • 28
    • 84882835838 scopus 로고    scopus 로고
    • MtDNA makes a U-turn for the mitochondrial nucleoid
    • C. Kukat, and N.G. Larsson mtDNA makes a U-turn for the mitochondrial nucleoid Trends Cell Biol. 23 2013 457 463
    • (2013) Trends Cell Biol. , vol.23 , pp. 457-463
    • Kukat, C.1    Larsson, N.G.2
  • 29
    • 84856967391 scopus 로고    scopus 로고
    • Nanoscale organization of mitochondrial microcompartments revealed by combining tracking and localization microscopy
    • T. Appelhans, and et al. Nanoscale organization of mitochondrial microcompartments revealed by combining tracking and localization microscopy Nano Lett. 12 2012 610 616
    • (2012) Nano Lett. , vol.12 , pp. 610-616
    • Appelhans, T.1
  • 30
    • 0016625683 scopus 로고
    • Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells
    • D.A. Clayton, J.N. Doda, and E.C. Friedberg Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells Basic Life Sci. 5B 1975 589 591
    • (1975) Basic Life Sci. , vol.5 B , pp. 589-591
    • Clayton, D.A.1    Doda, J.N.2    Friedberg, E.C.3
  • 31
    • 0026493929 scopus 로고
    • Repair of mitochondrial-DNA after various types of DNA damage in Chinese-hamster ovary cells
    • S.P. Ledoux, and et al. Repair of mitochondrial-DNA after various types of DNA damage in Chinese-hamster ovary cells Carcinogenesis 13 1992 1967 1973
    • (1992) Carcinogenesis , vol.13 , pp. 1967-1973
    • Ledoux, S.P.1
  • 32
    • 0030730327 scopus 로고    scopus 로고
    • DNA repair of UV photoproducts and mutagenesis in human mitochondrial DNA
    • B. Pascucci, and et al. DNA repair of UV photoproducts and mutagenesis in human mitochondrial DNA J. Mol. Biol. 273 1997 417 427
    • (1997) J. Mol. Biol. , vol.273 , pp. 417-427
    • Pascucci, B.1
  • 33
    • 0030841051 scopus 로고    scopus 로고
    • Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene
    • H. Nilsen, and et al. Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene Nucleic Acids Res. 25 1997 750 755
    • (1997) Nucleic Acids Res. , vol.25 , pp. 750-755
    • Nilsen, H.1
  • 34
    • 0028933306 scopus 로고
    • Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase
    • G. Slupphaug, and et al. Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase Biochemistry 34 1995 128 138
    • (1995) Biochemistry , vol.34 , pp. 128-138
    • Slupphaug, G.1
  • 35
    • 0033568099 scopus 로고    scopus 로고
    • Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase
    • M. Takao, Q.M. Zhang, S. Yonei, and A. Yasui Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase Nucleic Acids Res. 27 1999 3638 3644
    • (1999) Nucleic Acids Res. , vol.27 , pp. 3638-3644
    • Takao, M.1    Zhang, Q.M.2    Yonei, S.3    Yasui, A.4
  • 36
    • 0032840464 scopus 로고    scopus 로고
    • Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein
    • M.M. Slupska, W.M. Luther, J.H. Chiang, H. Yang, and J.H. Miller Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein J. Bacteriol. 181 1999 6210 6213
    • (1999) J. Bacteriol. , vol.181 , pp. 6210-6213
    • Slupska, M.M.1    Luther, W.M.2    Chiang, J.H.3    Yang, H.4    Miller, J.H.5
  • 38
    • 28844478775 scopus 로고    scopus 로고
    • Repair of formamidopyrimidines in DNA involves different glycosylases: Role of the OGG1, NTH1, and NEIL1 enzymes
    • J. Hu, and et al. Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes J. Biol. Chem. 280 2005 40544 40551
    • (2005) J. Biol. Chem. , vol.280 , pp. 40544-40551
    • Hu, J.1
  • 39
    • 0141594940 scopus 로고    scopus 로고
    • Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases
    • B. Karahalil, N.C. De Souza-Pinto, J.L. Parsons, R.H. Elder, and V.A. Bohr Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases J. Biol. Chem. 278 2003 33701 33707
    • (2003) J. Biol. Chem. , vol.278 , pp. 33701-33707
    • Karahalil, B.1    De Souza-Pinto, N.C.2    Parsons, J.L.3    Elder, R.H.4    Bohr, V.A.5
  • 40
    • 18444385675 scopus 로고    scopus 로고
    • Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols
    • M. Takao, and et al. Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols EMBO J. 21 2002 3486 3493
    • (2002) EMBO J. , vol.21 , pp. 3486-3493
    • Takao, M.1
  • 41
    • 0032555571 scopus 로고    scopus 로고
    • Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III - Direct identification of Lys-212 as the active nucleophilic residue
    • S. Ikeda, and et al. Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III - direct identification of Lys-212 as the active nucleophilic residue J. Biol. Chem. 273 1998 21585 21593
    • (1998) J. Biol. Chem. , vol.273 , pp. 21585-21593
    • Ikeda, S.1
  • 42
    • 0037125133 scopus 로고    scopus 로고
    • A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII
    • V. Bandaru, S. Sunkara, S.S. Wallace, and J.P. Bond A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII DNA Repair 1 2002 517 529
    • (2002) DNA Repair , vol.1 , pp. 517-529
    • Bandaru, V.1    Sunkara, S.2    Wallace, S.S.3    Bond, J.P.4
  • 43
    • 0037133684 scopus 로고    scopus 로고
    • Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA
    • T.K. Hazra, and et al. Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA Proc. Natl. Acad. Sci. U. S. A. 99 2002 3523 3528
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 3523-3528
    • Hazra, T.K.1
  • 44
    • 84856070741 scopus 로고    scopus 로고
    • Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′phosphatase in maintenance of mitochondrial genome
    • S.M. Mandal, and et al. Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′phosphatase in maintenance of mitochondrial genome J. Biol. Chem. 287 2012 2819 2829
    • (2012) J. Biol. Chem. , vol.287 , pp. 2819-2829
    • Mandal, S.M.1
  • 45
    • 0037162995 scopus 로고    scopus 로고
    • Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions
    • T.K. Hazra, and et al. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions J. Biol. Chem. 277 2002 30417 30420
    • (2002) J. Biol. Chem. , vol.277 , pp. 30417-30420
    • Hazra, T.K.1
  • 46
    • 0347379928 scopus 로고    scopus 로고
    • Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2
    • H. Dou, S. Mitra, and T.K. Hazra Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2 J. Biol. Chem. 278 2003 49679 49684
    • (2003) J. Biol. Chem. , vol.278 , pp. 49679-49684
    • Dou, H.1    Mitra, S.2    Hazra, T.K.3
  • 47
    • 33645928711 scopus 로고    scopus 로고
    • Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells
    • R. Chattopadhyay, and et al. Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells Nucleic Acids Res. 34 2006 2067 2076
    • (2006) Nucleic Acids Res. , vol.34 , pp. 2067-2076
    • Chattopadhyay, R.1
  • 48
    • 84860379069 scopus 로고    scopus 로고
    • Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair
    • N. Tahbaz, S. Subedi, and M. Weinfeld Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair Nucleic Acids Res. 40 8 2011 3484 3495
    • (2011) Nucleic Acids Res. , vol.40 , Issue.8 , pp. 3484-3495
    • Tahbaz, N.1    Subedi, S.2    Weinfeld, M.3
  • 49
    • 49449102611 scopus 로고    scopus 로고
    • Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria
    • P. Liu, and et al. Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria Mol. Cell. Biol. 28 2008 4975 4987
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 4975-4987
    • Liu, P.1
  • 50
  • 51
    • 40649109989 scopus 로고    scopus 로고
    • Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis
    • M. Akbari, T. Visnes, H.E. Krokan, and M. Otterlei Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis DNA Repair 7 2008 605 616
    • (2008) DNA Repair , vol.7 , pp. 605-616
    • Akbari, M.1    Visnes, T.2    Krokan, H.E.3    Otterlei, M.4
  • 52
    • 84896270394 scopus 로고    scopus 로고
    • Identification of the C4′-oxidized abasic site as the most abundant 2-deoxyribose lesion in radiation-damaged DNA using a novel HPLC-based approach
    • M. Roginskaya, R. Mohseni, T.J. Moore, W.A. Bernhard, and Y. Razskazovskiy Identification of the C4′-oxidized abasic site as the most abundant 2-deoxyribose lesion in radiation-damaged DNA using a novel HPLC-based approach Radiat. Res. 181 2014 131 137
    • (2014) Radiat. Res. , vol.181 , pp. 131-137
    • Roginskaya, M.1    Mohseni, R.2    Moore, T.J.3    Bernhard, W.A.4    Razskazovskiy, Y.5
  • 55
    • 67349125744 scopus 로고    scopus 로고
    • Novel DNA mismatch-repair activity involving YB-1 in human mitochondria
    • N.C. De Souza-Pinto, and et al. Novel DNA mismatch-repair activity involving YB-1 in human mitochondria DNA Repair 8 2009 704 719
    • (2009) DNA Repair , vol.8 , pp. 704-719
    • De Souza-Pinto, N.C.1
  • 56
    • 34547105083 scopus 로고    scopus 로고
    • MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis
    • K. Sakamoto, and et al. MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis Cancer Res. 67 2007 6599 6604
    • (2007) Cancer Res. , vol.67 , pp. 6599-6604
    • Sakamoto, K.1
  • 57
    • 33645288241 scopus 로고    scopus 로고
    • The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA
    • T. Arai, V.P. Kelly, O. Minowa, T. Noda, and S. Nishimura The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA Toxicology 221 2006 179 186
    • (2006) Toxicology , vol.221 , pp. 179-186
    • Arai, T.1    Kelly, V.P.2    Minowa, O.3    Noda, T.4    Nishimura, S.5
  • 58
    • 84871270797 scopus 로고    scopus 로고
    • 8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction
    • H. Sampath, and et al. 8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction PLoS One 7 2012 e51697
    • (2012) PLoS One , vol.7 , pp. e51697
    • Sampath, H.1
  • 59
    • 32444434993 scopus 로고    scopus 로고
    • The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase
    • V. Vartanian, and et al. The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase Proc. Natl. Acad. Sci. U. S. A. 103 2006 1864 1869
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 1864-1869
    • Vartanian, V.1
  • 60
    • 84901735727 scopus 로고    scopus 로고
    • Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations
    • L.S. Itsara, and et al. Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations PLoS Genet. 10 2014 e1003974
    • (2014) PLoS Genet. , vol.10 , pp. e1003974
    • Itsara, L.S.1
  • 61
    • 84856577031 scopus 로고    scopus 로고
    • Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis
    • R. Halsne, and et al. Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis DNA Repair 11 2012 278 285
    • (2012) DNA Repair , vol.11 , pp. 278-285
    • Halsne, R.1
  • 62
    • 0025972738 scopus 로고
    • DNA damage by oxygen-derived species Its mechanism and measurement in mammalian systems
    • B. Halliwell, and O.I. Aruoma DNA damage by oxygen-derived species Its mechanism and measurement in mammalian systems FEBS Lett. 281 1991 9 19
    • (1991) FEBS Lett. , vol.281 , pp. 9-19
    • Halliwell, B.1    Aruoma, O.I.2
  • 63
    • 0026774104 scopus 로고
    • Electron spin resonance study on the permeability of superoxide radicals in lipid bilayers and biological membranes
    • G.D. Mao, and M.J. Poznansky Electron spin resonance study on the permeability of superoxide radicals in lipid bilayers and biological membranes FEBS Lett. 305 1992 233 236
    • (1992) FEBS Lett. , vol.305 , pp. 233-236
    • Mao, G.D.1    Poznansky, M.J.2
  • 64
    • 0021105282 scopus 로고
    • Superoxide anion permeability of phospholipid-membranes and chloroplast thylakoids
    • M.A. Takahashi, and K. Asada Superoxide anion permeability of phospholipid-membranes and chloroplast thylakoids Arch. Biochem. Biophys. 226 1983 558 566
    • (1983) Arch. Biochem. Biophys. , vol.226 , pp. 558-566
    • Takahashi, M.A.1    Asada, K.2
  • 65
    • 70349515574 scopus 로고    scopus 로고
    • Is there more to aging than mitochondrial DNA and reactive oxygen species?
    • M.F. Alexeyev Is there more to aging than mitochondrial DNA and reactive oxygen species? FEBS J. 276 2009 5768 5787
    • (2009) FEBS J. , vol.276 , pp. 5768-5787
    • Alexeyev, M.F.1
  • 66
    • 0026740508 scopus 로고
    • Biologically relevant metal ion-dependent hydroxyl radical generation - An update
    • B. Halliwell, and J. Gutteridge Biologically relevant metal ion-dependent hydroxyl radical generation - an update FEBS Lett. 307 1992 108 112
    • (1992) FEBS Lett. , vol.307 , pp. 108-112
    • Halliwell, B.1    Gutteridge, J.2
  • 68
  • 71
    • 0344172784 scopus 로고    scopus 로고
    • Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages
    • R.M. Anson, S. Senturker, M. Dizdaroglu, and V.A. Bohr Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages Free Radic. Biol. Med. 27 1999 456 462
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 456-462
    • Anson, R.M.1    Senturker, S.2    Dizdaroglu, M.3    Bohr, V.A.4
  • 73
    • 0038799736 scopus 로고    scopus 로고
    • Oxidative DNA damage: Mechanisms, mutation, and disease
    • M.S. Cooke, M.D. Evans, M. Dizdaroglu, and J. Lunec Oxidative DNA damage: mechanisms, mutation, and disease FASEB J. 17 2003 1195 1214
    • (2003) FASEB J. , vol.17 , pp. 1195-1214
    • Cooke, M.S.1    Evans, M.D.2    Dizdaroglu, M.3    Lunec, J.4
  • 74
    • 35548972018 scopus 로고    scopus 로고
    • The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2′-deoxyguanosine
    • M.A. Graziewicz, R.J. Bienstock, and W.C. Copeland The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2′-deoxyguanosine Hum. Mol. Genet. 16 2007 2729 2739
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 2729-2739
    • Graziewicz, M.A.1    Bienstock, R.J.2    Copeland, W.C.3
  • 75
    • 0028901020 scopus 로고
    • Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage
    • K.G. Pinz, S. Shibutani, and D.F. Bogenhagen Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage J. Biol. Chem. 270 1995 9202 9206
    • (1995) J. Biol. Chem. , vol.270 , pp. 9202-9206
    • Pinz, K.G.1    Shibutani, S.2    Bogenhagen, D.F.3
  • 76
    • 0033539610 scopus 로고    scopus 로고
    • Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
    • A. Klungland, and et al. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage Proc. Natl. Acad. Sci. U. S. A. 96 1999 13300 13305
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 13300-13305
    • Klungland, A.1
  • 77
    • 0031761127 scopus 로고    scopus 로고
    • The nature of antioxidant defense mechanisms: A lesson from transgenic studies
    • Y.S. Ho, J.L. Magnenat, M. Gargano, and J. Cao The nature of antioxidant defense mechanisms: a lesson from transgenic studies Environ. Health Perspect. 106 Suppl. 5 1998 1219 1228
    • (1998) Environ. Health Perspect. , vol.106 , pp. 1219-1228
    • Ho, Y.S.1    Magnenat, J.L.2    Gargano, M.3    Cao, J.4
  • 78
    • 67649204729 scopus 로고    scopus 로고
    • Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
    • D.F. Dai, and et al. Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging Circulation 119 2009 2789 2797
    • (2009) Circulation , vol.119 , pp. 2789-2797
    • Dai, D.F.1
  • 79
    • 78049434938 scopus 로고    scopus 로고
    • Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria
    • D.F. Dai, and et al. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria Aging Cell 9 2010 536 544
    • (2010) Aging Cell , vol.9 , pp. 536-544
    • Dai, D.F.1
  • 80
    • 21144434217 scopus 로고    scopus 로고
    • Extension of murine life span by overexpression of catalase targeted to mitochondria
    • S.E. Schriner, and et al. Extension of murine life span by overexpression of catalase targeted to mitochondria Science 308 2005 1909 1911
    • (2005) Science , vol.308 , pp. 1909-1911
    • Schriner, S.E.1
  • 81
    • 0027278557 scopus 로고
    • Instability and decay of the primary structure of DNA
    • T. Lindahl Instability and decay of the primary structure of DNA Nature 362 1993 709 715
    • (1993) Nature , vol.362 , pp. 709-715
    • Lindahl, T.1
  • 82
    • 37549060396 scopus 로고    scopus 로고
    • Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil
    • V. Thiviyanathan, and et al. Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil Biochem. Biophys. Res. Commun. 366 2008 752 757
    • (2008) Biochem. Biophys. Res. Commun. , vol.366 , pp. 752-757
    • Thiviyanathan, V.1
  • 83
    • 33745891786 scopus 로고    scopus 로고
    • Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors
    • W. Zheng, K. Khrapko, H.A. Coller, W.G. Thilly, and W.C. Copeland Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors Mutat. Res. 599 2006 11 20
    • (2006) Mutat. Res. , vol.599 , pp. 11-20
    • Zheng, W.1    Khrapko, K.2    Coller, H.A.3    Thilly, W.G.4    Copeland, W.C.5
  • 84
    • 84903517886 scopus 로고    scopus 로고
    • Specificity and catalytic mechanism in family 5 uracil DNA glycosylase
    • B. Xia, and et al. Specificity and catalytic mechanism in family 5 uracil DNA glycosylase J. Biol. Chem. 289 2014 18413 18426
    • (2014) J. Biol. Chem. , vol.289 , pp. 18413-18426
    • Xia, B.1
  • 85
    • 0026653104 scopus 로고
    • Phenol sensitization of DNA to subsequent oxidative damage in 8-hydroxyguanine assays
    • H.G. Claycamp Phenol sensitization of DNA to subsequent oxidative damage in 8-hydroxyguanine assays Carcinogenesis 13 1992 1289 1292
    • (1992) Carcinogenesis , vol.13 , pp. 1289-1292
    • Claycamp, H.G.1
  • 86
    • 84887983173 scopus 로고    scopus 로고
    • An estimation of the number of cells in the human body
    • E. Bianconi, and et al. An estimation of the number of cells in the human body Ann. Hum. Biol. 40 2013 463 471
    • (2013) Ann. Hum. Biol. , vol.40 , pp. 463-471
    • Bianconi, E.1
  • 87
    • 0030921648 scopus 로고    scopus 로고
    • Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence
    • P. Andre, A. Kim, K. Khrapko, and W.G. Thilly Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence Genome Res. 7 1997 843 852
    • (1997) Genome Res. , vol.7 , pp. 843-852
    • Andre, P.1    Kim, A.2    Khrapko, K.3    Thilly, W.G.4
  • 88
    • 0033358580 scopus 로고    scopus 로고
    • Relaxed replication of mtDNA: A model with implications for the expression of disease
    • P.F. Chinnery, and D.C. Samuels Relaxed replication of mtDNA: a model with implications for the expression of disease Am. J. Hum. Genet. 64 1999 1158 1165
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 1158-1165
    • Chinnery, P.F.1    Samuels, D.C.2
  • 89
    • 84884686924 scopus 로고    scopus 로고
    • Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage
    • S.R. Kennedy, J.J. Salk, M.W. Schmitt, and L.A. Loeb Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage PLoS Genet. 9 2013 e1003794
    • (2013) PLoS Genet. , vol.9 , pp. e1003794
    • Kennedy, S.R.1    Salk, J.J.2    Schmitt, M.W.3    Loeb, L.A.4
  • 90
    • 77950083955 scopus 로고    scopus 로고
    • Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
    • Y. He, and et al. Heteroplasmic mitochondrial DNA mutations in normal and tumour cells Nature 464 2010 610 614
    • (2010) Nature , vol.464 , pp. 610-614
    • He, Y.1
  • 91
    • 77955562856 scopus 로고    scopus 로고
    • Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes
    • M. Li, and et al. Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes Am. J. Hum. Genet. 87 2010 237 249
    • (2010) Am. J. Hum. Genet. , vol.87 , pp. 237-249
    • Li, M.1
  • 92
    • 84871565767 scopus 로고    scopus 로고
    • Universal heteroplasmy of human mitochondrial DNA
    • B.A. Payne, and et al. Universal heteroplasmy of human mitochondrial DNA Hum. Mol. Genet. 22 2013 384 390
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 384-390
    • Payne, B.A.1
  • 93
    • 84892698220 scopus 로고    scopus 로고
    • Somatic mtDNA mutation spectra in the aging human putamen
    • S.L. Williams, D.C. Mash, S. Züchner, and C.T. Moraes Somatic mtDNA mutation spectra in the aging human putamen PLoS Genet. 9 2013 e1003990
    • (2013) PLoS Genet. , vol.9 , pp. e1003990
    • Williams, S.L.1    Mash, D.C.2    Züchner, S.3    Moraes, C.T.4
  • 94
    • 79959467651 scopus 로고    scopus 로고
    • Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study
    • H. Goto, and et al. Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study Genome Biol. 12 2011 R59
    • (2011) Genome Biol. , vol.12 , pp. R59
    • Goto, H.1
  • 95
    • 84892497789 scopus 로고    scopus 로고
    • Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain
    • S.D. Taylor, and et al. Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain Aging Cell 13 2014 29 38
    • (2014) Aging Cell , vol.13 , pp. 29-38
    • Taylor, S.D.1
  • 96
    • 84861337035 scopus 로고    scopus 로고
    • A new approach for detecting low-level mutations in next-generation sequence data
    • M. Li, and M. Stoneking A new approach for detecting low-level mutations in next-generation sequence data Genome Biol. 13 2012 R34
    • (2012) Genome Biol. , vol.13 , pp. R34
    • Li, M.1    Stoneking, M.2
  • 97
    • 84907598441 scopus 로고    scopus 로고
    • High-throughput sequencing in mitochondrial DNA research
    • F. Ye, D.C. Samuels, T. Clark, and Y. Guo High-throughput sequencing in mitochondrial DNA research Mitochondrion 17 2014 157 163
    • (2014) Mitochondrion , vol.17 , pp. 157-163
    • Ye, F.1    Samuels, D.C.2    Clark, T.3    Guo, Y.4
  • 98
    • 77649210966 scopus 로고    scopus 로고
    • Molecular poltergeists: Mitochondrial DNA copies (numts) in sequenced nuclear genomes
    • E. Hazkani-Covo, R.M. Zeller, and W. Martin Molecular poltergeists: mitochondrial DNA copies (numts) in sequenced nuclear genomes PLoS Genet. 6 2010 e1000834
    • (2010) PLoS Genet. , vol.6 , pp. e1000834
    • Hazkani-Covo, E.1    Zeller, R.M.2    Martin, W.3
  • 99
    • 79953735503 scopus 로고    scopus 로고
    • Ultra-deep sequencing of mouse mitochondrial DNA: Mutational patterns and their origins
    • A. Ameur, and et al. Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins PLoS Genet. 7 2011 e1002028
    • (2011) PLoS Genet. , vol.7 , pp. e1002028
    • Ameur, A.1
  • 100
    • 84867487186 scopus 로고    scopus 로고
    • Fidelity of capture-enrichment for mtDNA genome sequencing: Influence of NUMTs
    • M. Li, R. Schroeder, A. Ko, and M. Stoneking Fidelity of capture-enrichment for mtDNA genome sequencing: influence of NUMTs Nucleic Acids Res. 40 2012 e137
    • (2012) Nucleic Acids Res. , vol.40 , pp. e137
    • Li, M.1    Schroeder, R.2    Ko, A.3    Stoneking, M.4
  • 101
    • 84923828628 scopus 로고    scopus 로고
    • The genomic landscape of polymorphic human nuclear mitochondrial insertions
    • G. Dayama, S.B. Emery, J.M. Kidd, and R.E. Mills The genomic landscape of polymorphic human nuclear mitochondrial insertions Nucleic Acids Res. 42 2014 12640 12649
    • (2014) Nucleic Acids Res. , vol.42 , pp. 12640-12649
    • Dayama, G.1    Emery, S.B.2    Kidd, J.M.3    Mills, R.E.4
  • 102
    • 84865979581 scopus 로고    scopus 로고
    • Detection of ultra-rare mutations by next-generation sequencing
    • M.W. Schmitt, and et al. Detection of ultra-rare mutations by next-generation sequencing Proc. Natl. Acad. Sci. U. S. A. 109 2012 14508 14513
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 14508-14513
    • Schmitt, M.W.1
  • 103
    • 0001878831 scopus 로고    scopus 로고
    • Chapter 39: Mitochondrial DNA replication
    • M.A. Depamphillis, Cold Spring Harbour Press Plainview, New York
    • D.A. Clayton Chapter 39: mitochondrial DNA replication M.A. Depamphillis, DNA Replication in Eukaryotic Cells 1996 Cold Spring Harbour Press Plainview, New York
    • (1996) DNA Replication in Eukaryotic Cells
    • Clayton, D.A.1
  • 104
    • 50949100985 scopus 로고    scopus 로고
    • Inverted replication of vertebrate mitochondria
    • M.M. Fonseca, D. Posada, and D.J. Harris Inverted replication of vertebrate mitochondria Mol. Biol. Evol. 25 2008 805 808
    • (2008) Mol. Biol. Evol. , vol.25 , pp. 805-808
    • Fonseca, M.M.1    Posada, D.2    Harris, D.J.3
  • 105
    • 84907480658 scopus 로고    scopus 로고
    • The inversion of the Control Region in three mitogenomes provides further evidence for an asymmetric model of vertebrate mtDNA replication
    • M.M. Fonseca, D.J. Harris, and D. Posada The inversion of the Control Region in three mitogenomes provides further evidence for an asymmetric model of vertebrate mtDNA replication PLoS One 9 2014 e106654
    • (2014) PLoS One , vol.9 , pp. e106654
    • Fonseca, M.M.1    Harris, D.J.2    Posada, D.3
  • 106
    • 0347600946 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human colonic crypt stem cells
    • R.W. Taylor, and et al. Mitochondrial DNA mutations in human colonic crypt stem cells J. Clin. Invest. 112 2003 1351 1360
    • (2003) J. Clin. Invest. , vol.112 , pp. 1351-1360
    • Taylor, R.W.1
  • 107
    • 84870721304 scopus 로고    scopus 로고
    • Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: Absence of evidence for purifying selection in somatic mitochondrial DNA point mutations
    • L.C. Greaves, and et al. Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations PLoS Genet. 8 2012 e1003082
    • (2012) PLoS Genet. , vol.8 , pp. e1003082
    • Greaves, L.C.1
  • 108
    • 0035097502 scopus 로고    scopus 로고
    • Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age
    • J.L. Elson, D.C. Samuels, D.M. Turnbull, and P.F. Chinnery Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age Am. J. Hum. Genet. 68 2001 802 806
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 802-806
    • Elson, J.L.1    Samuels, D.C.2    Turnbull, D.M.3    Chinnery, P.F.4
  • 109
    • 84907587254 scopus 로고    scopus 로고
    • Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing
    • L.C. Greaves, and et al. Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing PLoS Genet. 10 2014 e1004620
    • (2014) PLoS Genet. , vol.10 , pp. e1004620
    • Greaves, L.C.1
  • 111
    • 84905060455 scopus 로고    scopus 로고
    • Response to: 'When man got his mtDNA deletions?'
    • S.D. Taylor, J.J. Salk, and J.H. Bielas Response to: 'when man got his mtDNA deletions?' Aging Cell 13 2014 583
    • (2014) Aging Cell , vol.13 , pp. 583
    • Taylor, S.D.1    Salk, J.J.2    Bielas, J.H.3
  • 112
    • 0023944266 scopus 로고
    • Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging
    • L. Piko, A.J. Hougham, and K.J. Bulpitt Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging Mech. Ageing Dev. 43 1988 279 293
    • (1988) Mech. Ageing Dev. , vol.43 , pp. 279-293
    • Piko, L.1    Hougham, A.J.2    Bulpitt, K.J.3
  • 113
    • 84880507874 scopus 로고    scopus 로고
    • Mitochondrial mutations and aging: Random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals
    • A. Kowald, and T.B.L. Kirkwood Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals Aging Cell 12 2013 728 731
    • (2013) Aging Cell , vol.12 , pp. 728-731
    • Kowald, A.1    Kirkwood, T.B.L.2
  • 114
  • 115
    • 84884416043 scopus 로고    scopus 로고
    • Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
    • J.M. Ross, and et al. Germline mitochondrial DNA mutations aggravate ageing and can impair brain development Nature 501 2013 412 415
    • (2013) Nature , vol.501 , pp. 412-415
    • Ross, J.M.1
  • 116
    • 84902989327 scopus 로고    scopus 로고
    • Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans
    • H.L. Baines, and et al. Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans Mech. Ageing Dev. 139 2014 22 30
    • (2014) Mech. Ageing Dev. , vol.139 , pp. 22-30
    • Baines, H.L.1
  • 117
    • 17744393686 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human disease
    • R.W. Taylor, and D.M. Turnbull Mitochondrial DNA mutations in human disease Nat. Rev. Genet. 6 2005 389 402
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 389-402
    • Taylor, R.W.1    Turnbull, D.M.2
  • 118
    • 84931346628 scopus 로고    scopus 로고
    • Maternally transmitted mitochondrial DNA mutations can reduce lifespan
    • J.M. Ross, G. Coppotelli, B.J. Hoffer, and L. Olson Maternally transmitted mitochondrial DNA mutations can reduce lifespan Sci. Rep. 4 2014
    • (2014) Sci. Rep. , vol.4
    • Ross, J.M.1    Coppotelli, G.2    Hoffer, B.J.3    Olson, L.4
  • 119
    • 38949091096 scopus 로고    scopus 로고
    • Strong purifying selection in transmission of mammalian mitochondrial DNA
    • J.B. Stewart, and et al. Strong purifying selection in transmission of mammalian mitochondrial DNA PLoS Biol. 6 2008 e10
    • (2008) PLoS Biol. , vol.6 , pp. e10
    • Stewart, J.B.1
  • 120
    • 39349105943 scopus 로고    scopus 로고
    • A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations
    • W. Fan, and et al. A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations Science 319 2008 958 962
    • (2008) Science , vol.319 , pp. 958-962
    • Fan, W.1
  • 121
    • 84898058673 scopus 로고    scopus 로고
    • Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster
    • H. Ma, H. Xu, and P.H. O'Farrell Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster Nat. Genet. 46 2014 393 397
    • (2014) Nat. Genet. , vol.46 , pp. 393-397
    • Ma, H.1    Xu, H.2    O'Farrell, P.H.3
  • 122
    • 84898058958 scopus 로고    scopus 로고
    • Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant
    • J.H. Hill, Z. Chen, and H. Xu Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant Nat. Genet. 46 2014 389 392
    • (2014) Nat. Genet. , vol.46 , pp. 389-392
    • Hill, J.H.1    Chen, Z.2    Xu, H.3
  • 123
    • 0033772263 scopus 로고    scopus 로고
    • Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes
    • K. Inoue, and et al. Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes Nat. Genet. 26 2000 176 181
    • (2000) Nat. Genet. , vol.26 , pp. 176-181
    • Inoue, K.1
  • 124
    • 84868211657 scopus 로고    scopus 로고
    • Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission
    • C. Freyer, and et al. Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission Nat. Genet. 44 2012 1282 1285
    • (2012) Nat. Genet. , vol.44 , pp. 1282-1285
    • Freyer, C.1
  • 125
    • 84896848552 scopus 로고    scopus 로고
    • Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene
    • A. Shimizu, and et al. Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene Proc. Natl. Acad. Sci. U. S. A. 111 2014 3104 3109
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 3104-3109
    • Shimizu, A.1
  • 126
    • 84908313144 scopus 로고    scopus 로고
    • Keeping mtDNA in shape between generations
    • J.B. Stewart, and N.-G. Larsson Keeping mtDNA in shape between generations PLoS Genet. 10 2014 e1004670
    • (2014) PLoS Genet. , vol.10 , pp. e1004670
    • Stewart, J.B.1    Larsson, N.-G.2
  • 127
    • 0034746790 scopus 로고    scopus 로고
    • Decrease of 3243 A → G mtDNA mutation from blood in MELAS syndrome: A longitudinal study
    • S. Rahman, J. Poulton, D. Marchington, and A. Suomalainen Decrease of 3243 A → G mtDNA mutation from blood in MELAS syndrome: a longitudinal study Am. J. Hum. Genet. 68 2001 238 240
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 238-240
    • Rahman, S.1    Poulton, J.2    Marchington, D.3    Suomalainen, A.4
  • 128
    • 29144458899 scopus 로고    scopus 로고
    • Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
    • A. Trifunovic, and et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production Proc. Natl. Acad. Sci. U. S. A. 102 2005 17993 17998
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 17993-17998
    • Trifunovic, A.1
  • 129
    • 84870579042 scopus 로고    scopus 로고
    • In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication
    • S. Wanrooij, and et al. In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication EMBO Rep. 13 2012 1130 1137
    • (2012) EMBO Rep. , vol.13 , pp. 1130-1137
    • Wanrooij, S.1
  • 130
    • 84888250062 scopus 로고    scopus 로고
    • Recurrent tissue-specific mtDNA mutations are common in humans
    • D.C. Samuels, and et al. Recurrent tissue-specific mtDNA mutations are common in humans PLoS Genet. 9 2013 e1003929
    • (2013) PLoS Genet. , vol.9 , pp. e1003929
    • Samuels, D.C.1
  • 131
    • 84923675351 scopus 로고    scopus 로고
    • Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations
    • M. Li, R. Schroder, S. Ni, B. Madea, and M. Stoneking Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations Proc. Natl. Acad. Sci. U. S. A. 112 2015 2491 2496
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 2491-2496
    • Li, M.1    Schroder, R.2    Ni, S.3    Madea, B.4    Stoneking, M.5
  • 132
    • 79961034773 scopus 로고    scopus 로고
    • A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity
    • T. Andrew, and et al. A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity PLoS One 6 2011 e22332
    • (2011) PLoS One , vol.6 , pp. e22332
    • Andrew, T.1
  • 133
    • 84864039117 scopus 로고    scopus 로고
    • Decreased mitochondrial DNA mutagenesis in human colorectal cancer
    • N.G. Ericson, and et al. Decreased mitochondrial DNA mutagenesis in human colorectal cancer PLoS Genet. 8 2012 e1002689
    • (2012) PLoS Genet. , vol.8 , pp. e1002689
    • Ericson, N.G.1
  • 134
    • 84994324806 scopus 로고    scopus 로고
    • Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
    • Y.S. Ju, and et al. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer Elife 3 2014
    • (2014) Elife , vol.3
    • Ju, Y.S.1
  • 135
    • 84865560511 scopus 로고    scopus 로고
    • Spectrum of somatic mitochondrial mutations in five cancers
    • T.C. Larman, and et al. Spectrum of somatic mitochondrial mutations in five cancers Proc. Natl. Acad. Sci. U. S. A. 109 2012 14087 14091
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 14087-14091
    • Larman, T.C.1
  • 136
    • 33846011884 scopus 로고    scopus 로고
    • Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase
    • J.W. Hanes, D.M. Thal, and K.A. Johnson Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase J. Biol. Chem. 281 2006 36241 36248
    • (2006) J. Biol. Chem. , vol.281 , pp. 36241-36248
    • Hanes, J.W.1    Thal, D.M.2    Johnson, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.