-
1
-
-
77049308856
-
Ageing: A theory based on free radical and radiation chemistry
-
HARMAN, D. 1956. Ageing: a theory based on free radical and radiation chemistry. J. Gerontol. 11: 298-300.
-
(1956)
J. Gerontol
, vol.11
, pp. 298-300
-
-
HARMAN, D.1
-
2
-
-
0015319592
-
The biologic clock: The mitochondria?
-
HARMAN, D. 1972. The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20: 145-147.
-
(1972)
J. Am. Geriatr. Soc
, vol.20
, pp. 145-147
-
-
HARMAN, D.1
-
3
-
-
0024541837
-
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
-
LINNANE, A.W. et al. 1989. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1: 642-645.
-
(1989)
Lancet
, vol.1
, pp. 642-645
-
-
LINNANE, A.W.1
-
4
-
-
0028223609
-
Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion
-
LARSSON, N.G. et al. 1994. Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion. Biochem. Biophys. Res. Commun. 200: 1374-1381.
-
(1994)
Biochem. Biophys. Res. Commun
, vol.200
, pp. 1374-1381
-
-
LARSSON, N.G.1
-
5
-
-
0035313402
-
What regulates mitochondrial DNA copy number in animal cells?
-
MORAES, C.T. 2001. What regulates mitochondrial DNA copy number in animal cells? Trends Genet. 17: 199-205.
-
(2001)
Trends Genet
, vol.17
, pp. 199-205
-
-
MORAES, C.T.1
-
6
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
WU, Z. et al. 1999. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98: 115-124.
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
WU, Z.1
-
7
-
-
33644778845
-
Parkin enhances mitochondrial biogenesis in proliferating cells
-
KURODA, Y. et al. 2006. Parkin enhances mitochondrial biogenesis in proliferating cells. Hum. Mol. Genet. 15: 883-895.
-
(2006)
Hum. Mol. Genet
, vol.15
, pp. 883-895
-
-
KURODA, Y.1
-
8
-
-
26444432919
-
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
-
HANCE, N., M.I. EKSTRAND & A. TRIFUNOVIC. 2005. Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hum. Mol. Genet. 14: 1775-1783.
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 1775-1783
-
-
HANCE, N.1
EKSTRAND, M.I.2
TRIFUNOVIC, A.3
-
9
-
-
0034598918
-
Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA
-
HOLT, I.J., H.E. LORIMER & H.T. JACOBS. 2000. Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA. Cell 100: 515-524.
-
(2000)
Cell
, vol.100
, pp. 515-524
-
-
HOLT, I.J.1
LORIMER, H.E.2
JACOBS, H.T.3
-
10
-
-
0037112343
-
Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication
-
YANG, M.Y. et al. 2002. Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell 111: 495-505.
-
(2002)
Cell
, vol.111
, pp. 495-505
-
-
YANG, M.Y.1
-
11
-
-
0037158599
-
Paternal inheritance of mitochondrial DNA
-
SCHWARTZ, M. & J. VISSING. 2002. Paternal inheritance of mitochondrial DNA. N. Engl. J. Med. 347: 576-580.
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 576-580
-
-
SCHWARTZ, M.1
VISSING, J.2
-
12
-
-
0035112849
-
Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age
-
COTTRELL, D.A. et al. 2001. Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age. Neurobiol. Aging 22: 265-272.
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 265-272
-
-
COTTRELL, D.A.1
-
13
-
-
0029014248
-
Focal cytochrome c oxidase deficiency in the brain and dorsal root ganglia in a case with mitochondrial encephalomyopathy (tRNA(Ile) 4269 mutation): Histochemical, immunohistochemical, and ultrastructural study
-
KAIDO, M. et al. 1995. Focal cytochrome c oxidase deficiency in the brain and dorsal root ganglia in a case with mitochondrial encephalomyopathy (tRNA(Ile) 4269 mutation): histochemical, immunohistochemical, and ultrastructural study. J. Neurol. Sci. 131: 170-176.
-
(1995)
J. Neurol. Sci
, vol.131
, pp. 170-176
-
-
KAIDO, M.1
-
14
-
-
0028140454
-
Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy
-
SCIACCO, M. et al. 1994. Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy. Hum. Mol. Genet. 3: 13-19.
-
(1994)
Hum. Mol. Genet
, vol.3
, pp. 13-19
-
-
SCIACCO, M.1
-
15
-
-
0025113789
-
Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence
-
IKEBE, S. et al. 1990. Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. Biochem. Biophys. Res. Commun. 170: 1044-1048.
-
(1990)
Biochem. Biophys. Res. Commun
, vol.170
, pp. 1044-1048
-
-
IKEBE, S.1
-
16
-
-
0026624980
-
Diseases of the mitochondrial DNA
-
WALLACE, D.C. 1992. Diseases of the mitochondrial DNA. Annu. Rev. Biochem. 61: 1175-1212.
-
(1992)
Annu. Rev. Biochem
, vol.61
, pp. 1175-1212
-
-
WALLACE, D.C.1
-
17
-
-
2942672611
-
Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA
-
WANROOIJ, S. et al. 2004. Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA. Nucleic Acids Res. 32: 3053-3064.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 3053-3064
-
-
WANROOIJ, S.1
-
18
-
-
17744393686
-
Mitochondrial DNA mutations in human disease
-
TAYLOR, R.W. & D.M. TURNBULL. 2005. Mitochondrial DNA mutations in human disease. Nat. Rev. Genet. 6: 389-402.
-
(2005)
Nat. Rev. Genet
, vol.6
, pp. 389-402
-
-
TAYLOR, R.W.1
TURNBULL, D.M.2
-
19
-
-
0027527023
-
Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain
-
MECOCCI, P. et al. 1993. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 34: 609-616.
-
(1993)
Ann. Neurol
, vol.34
, pp. 609-616
-
-
MECOCCI, P.1
-
20
-
-
0029116061
-
Oxidative damage to mitochondrial DNA and its relationship to ageing
-
RICHTER, C. 1995. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int. J. Biochem. Cell Biol. 27: 647-653.
-
(1995)
Int. J. Biochem. Cell Biol
, vol.27
, pp. 647-653
-
-
RICHTER, C.1
-
21
-
-
0033972463
-
Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
-
BARJA, G. & A. HERRERO. 2000. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J. 14: 312-318.
-
(2000)
FASEB J
, vol.14
, pp. 312-318
-
-
BARJA, G.1
HERRERO, A.2
-
22
-
-
0030807666
-
Mitochondrial damage in human ageing
-
BRIERLEY, E.J. 1997. Mitochondrial damage in human ageing. Rev. Clin. Gerontol. 7: 95-105.
-
(1997)
Rev. Clin. Gerontol
, vol.7
, pp. 95-105
-
-
BRIERLEY, E.J.1
-
23
-
-
0031885843
-
Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
-
BRIERLEY, E.J. et al. 1998. Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann. Neurol. 43: 217-223.
-
(1998)
Ann. Neurol
, vol.43
, pp. 217-223
-
-
BRIERLEY, E.J.1
-
24
-
-
0034915760
-
Accelerated ageing changes in the choroid plexus of a case with multiple mitochondrial DNA deletions
-
COTTRELL, D.A. et al. 2001. Accelerated ageing changes in the choroid plexus of a case with multiple mitochondrial DNA deletions. Neuropathol. Appl. Neurobiol. 27: 206-214.
-
(2001)
Neuropathol. Appl. Neurobiol
, vol.27
, pp. 206-214
-
-
COTTRELL, D.A.1
-
25
-
-
0024366601
-
Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - an age-related phenomenon. A histochemical ultracytochemical study
-
MULLER-HOCKER, J. 1989. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - an age-related phenomenon. A histochemical ultracytochemical study. Am. J. Pathol. 134: 1167-1173.
-
(1989)
Am. J. Pathol
, vol.134
, pp. 1167-1173
-
-
MULLER-HOCKER, J.1
-
26
-
-
0025673968
-
Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration
-
MULLER-HOCKER, J. 1990. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J. Neurol. Sci. 100: 14-21.
-
(1990)
J. Neurol. Sci
, vol.100
, pp. 14-21
-
-
MULLER-HOCKER, J.1
-
27
-
-
0026840464
-
Mitochondria and ageing
-
MULLER-HOCKER, J. 1992. Mitochondria and ageing. Brain Pathol. 2: 149-158.
-
(1992)
Brain Pathol
, vol.2
, pp. 149-158
-
-
MULLER-HOCKER, J.1
-
28
-
-
0347600946
-
Mitochondrial DNA mutations in human colonic crypt stem cells
-
TAYLOR, R.W. et al. 2003. Mitochondrial DNA mutations in human colonic crypt stem cells. J. Clin. Invest. 112: 1351-1360.
-
(2003)
J. Clin. Invest
, vol.112
, pp. 1351-1360
-
-
TAYLOR, R.W.1
-
29
-
-
3042631024
-
Gene regulation and DNA damage in the ageing human brain
-
LU, T. et al. 2004. Gene regulation and DNA damage in the ageing human brain. Nature. 429: 883-891.
-
(2004)
Nature
, vol.429
, pp. 883-891
-
-
LU, T.1
-
30
-
-
33646871787
-
Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle
-
DIRKS, A.J. et al. 2006. Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle. Ageing Res. Rev. 5: 179-195.
-
(2006)
Ageing Res. Rev
, vol.5
, pp. 179-195
-
-
DIRKS, A.J.1
-
31
-
-
0036089622
-
Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia
-
BUA, E.A. et al. 2002. Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia. J. Appl. Physiol. 92: 2617-2624.
-
(2002)
J. Appl. Physiol
, vol.92
, pp. 2617-2624
-
-
BUA, E.A.1
-
32
-
-
0035127889
-
Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia
-
WANAGAT, J. et al. 2001. Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J. 15: 322-332.
-
(2001)
FASEB J
, vol.15
, pp. 322-332
-
-
WANAGAT, J.1
-
33
-
-
0033595684
-
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
-
MICHIKAWA, Y. et al. 1999. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286: 774-779.
-
(1999)
Science
, vol.286
, pp. 774-779
-
-
MICHIKAWA, Y.1
-
34
-
-
0035957323
-
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
-
WANG, Y. et al. 2001. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc. Natl. Acad. Sci. USA 98: 4022-4027.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4022-4027
-
-
WANG, Y.1
-
35
-
-
0035125774
-
Point mutations of the mtDNA control region in normal and neurodegenerative human brains
-
CHINNERY, P.F. et al. 2001. Point mutations of the mtDNA control region in normal and neurodegenerative human brains. Am. J. Hum. Genet. 68: 529-532.
-
(2001)
Am. J. Hum. Genet
, vol.68
, pp. 529-532
-
-
CHINNERY, P.F.1
-
36
-
-
0034327572
-
The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method
-
MURDOCK, D.G., N.C. CHRISTACOS & D.C. WALLACE. 2000. The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method. Nucleic Acids Res. 28: 4350-4355.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 4350-4355
-
-
MURDOCK, D.G.1
CHRISTACOS, N.C.2
WALLACE, D.C.3
-
38
-
-
25144514232
-
Somatic mitochondrial DNA mutations in single neurons and glia
-
CANTUTI-CASTELVETRI, I. et al. 2005. Somatic mitochondrial DNA mutations in single neurons and glia. Neurobiol. Aging. 26: 1343-1355.
-
(2005)
Neurobiol. Aging
, vol.26
, pp. 1343-1355
-
-
CANTUTI-CASTELVETRI, I.1
-
39
-
-
10744231633
-
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease
-
SIMON, D.K. et al. 2004. Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiol. Aging 25: 71-81.
-
(2004)
Neurobiol. Aging
, vol.25
, pp. 71-81
-
-
SIMON, D.K.1
-
40
-
-
0037081814
-
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
-
LIN, M.T. et al. 2002. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum. Mol. Genet. 11: 133-145.
-
(2002)
Hum. Mol. Genet
, vol.11
, pp. 133-145
-
-
LIN, M.T.1
-
41
-
-
0035432034
-
The determination of complete human mitochondrial DNA sequences in single cells: Implications for the study of somatic mitochondrial DNA point mutations
-
TAYLOR, R.W. et al. 2001. The determination of complete human mitochondrial DNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutations. Nucleic Acids Res. 29: E74-E84.
-
(2001)
Nucleic Acids Res
, vol.29
-
-
TAYLOR, R.W.1
-
42
-
-
31444433936
-
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
-
GREAVES, L.C. et al. 2006. Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. Proc. Natl. Acad. Sci. USA 103: 714-719.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 714-719
-
-
GREAVES, L.C.1
-
43
-
-
0025674177
-
Detection of a specific mitochondrial DNA deletion in tissues of older humans
-
CORTOPASSI, G.A. & N. ARNHEIM. 1990. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 18: 6927-6933.
-
(1990)
Nucleic Acids Res
, vol.18
, pp. 6927-6933
-
-
CORTOPASSI, G.A.1
ARNHEIM, N.2
-
44
-
-
0027017232
-
Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age
-
CORRAL-DEBRINSKI, M. et al. 1992. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat. Genet. 2: 324-329.
-
(1992)
Nat. Genet
, vol.2
, pp. 324-329
-
-
CORRAL-DEBRINSKI, M.1
-
45
-
-
0026732706
-
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
-
CORTOPASSI, G.A. et al. 1992. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. USA 89: 7370-7374.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 7370-7374
-
-
CORTOPASSI, G.A.1
-
46
-
-
0027021442
-
Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
-
SOONG, N.W. et al. 1992. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat. Genet. 2: 318-323.
-
(1992)
Nat. Genet
, vol.2
, pp. 318-323
-
-
SOONG, N.W.1
-
47
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
BENDER, A. et al. 2006. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat. Genet. 38: 515-517.
-
(2006)
Nat. Genet
, vol.38
, pp. 515-517
-
-
BENDER, A.1
-
48
-
-
33646351299
-
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
-
KRAYTSBERG, Y. et al. 2006. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat. Genet. 38: 518-520.
-
(2006)
Nat. Genet
, vol.38
, pp. 518-520
-
-
KRAYTSBERG, Y.1
-
49
-
-
0025954066
-
Ageing and Parkinson's disease: Substantia nigra regional selectivity
-
FEARNLEY, J.M. & A.J. LEES. 1991. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114(Pt 5): 2283-2301.
-
(1991)
Brain
, vol.114
, Issue.PART 5
, pp. 2283-2301
-
-
FEARNLEY, J.M.1
LEES, A.J.2
-
50
-
-
33748643416
-
Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers
-
BUA, E. et al. 2006. Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am. J. Hum. Genet. 79: 469-480.
-
(2006)
Am. J. Hum. Genet
, vol.79
, pp. 469-480
-
-
BUA, E.1
-
51
-
-
0027055332
-
Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts
-
HAYAKAWA, M. et al. 1992. Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem. Biophys. Res. Commun. 189: 979-985.
-
(1992)
Biochem. Biophys. Res. Commun
, vol.189
, pp. 979-985
-
-
HAYAKAWA, M.1
-
52
-
-
0036242399
-
Frequent intracellular clonal expansions of somatic mtDNA mutations: Significance and mechanisms
-
COLLER, H.A., N.D. BODYAK & K. KHRAPKO. 2002. Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms. Ann. N. Y. Acad. Sci. 959: 434-447.
-
(2002)
Ann. N. Y. Acad. Sci
, vol.959
, pp. 434-447
-
-
COLLER, H.A.1
BODYAK, N.D.2
KHRAPKO, K.3
-
53
-
-
0035097502
-
-
ELSON, J.L. et al. 2001. Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Am. J. Hum. Genet. 68: 802-806. Epub 2001 Feb 6.
-
ELSON, J.L. et al. 2001. Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Am. J. Hum. Genet. 68: 802-806. Epub 2001 Feb 6.
-
-
-
-
54
-
-
0028879644
-
Multiple deletions are detectable in mitochondrial DNA of aging mice
-
TANHAUSER, S.M. & P.J. LAIPIS. 1995. Multiple deletions are detectable in mitochondrial DNA of aging mice. J. Biol. Chem. 270: 24769-24775.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 24769-24775
-
-
TANHAUSER, S.M.1
LAIPIS, P.J.2
-
55
-
-
0027971105
-
Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA
-
EDRIS, W. et al. 1994. Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA. Mutat. Res. 316: 69-78.
-
(1994)
Mutat. Res
, vol.316
, pp. 69-78
-
-
EDRIS, W.1
-
56
-
-
0026712284
-
Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats
-
GADALETA, M.N. et al. 1992. Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats. Mutat. Res. 275: 181-193.
-
(1992)
Mutat. Res
, vol.275
, pp. 181-193
-
-
GADALETA, M.N.1
-
57
-
-
0030067344
-
Multiple, large deletions in rat mitochondrial DNA: Evidence for a major hot spot
-
VAN TUYLE, G.C. et al. 1996. Multiple, large deletions in rat mitochondrial DNA: evidence for a major hot spot. Mutat. Res. 349: 95-107.
-
(1996)
Mutat. Res
, vol.349
, pp. 95-107
-
-
VAN TUYLE, G.C.1
-
58
-
-
0027366179
-
Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys
-
LEE, C.M. et al. 1993. Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J. Gerontol. 48: B201-B205.
-
(1993)
J. Gerontol
, vol.48
-
-
LEE, C.M.1
-
59
-
-
0029019546
-
Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans
-
MELOV, S. et al. 1995. Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. Nucleic Acids Res. 23: 1419-1425.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 1419-1425
-
-
MELOV, S.1
-
60
-
-
0028285538
-
Detection of deletions in the mitochondrial genome of Caenorhabditis elegans
-
MELOV, S. et al. 1994. Detection of deletions in the mitochondrial genome of Caenorhabditis elegans. Nucleic Acids Res. 22: 1075-1078.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 1075-1078
-
-
MELOV, S.1
-
61
-
-
0030747292
-
The rate of mitochondrial mutagenesis is faster in mice than humans
-
WANG, E., A. WONG & G. CORTOPASSI. 1997. The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat. Res. 377: 157-166.
-
(1997)
Mutat. Res
, vol.377
, pp. 157-166
-
-
WANG, E.1
WONG, A.2
CORTOPASSI, G.3
-
62
-
-
0011555560
-
Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species
-
HART, R.W. & R.B. SETLOW. 1974. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc. Natl. Acad. Sci. USA 71: 2169-2173.
-
(1974)
Proc. Natl. Acad. Sci. USA
, vol.71
, pp. 2169-2173
-
-
HART, R.W.1
SETLOW, R.B.2
-
63
-
-
0042471736
-
Accumulation of deleted mitochondrial DNA in aging Drosophila melanogaster
-
YUI, R., Y. OHNO & E.T. MATSUURA. 2003. Accumulation of deleted mitochondrial DNA in aging Drosophila melanogaster. Genes Genet. Syst. 78: 245-251.
-
(2003)
Genes Genet. Syst
, vol.78
, pp. 245-251
-
-
YUI, R.1
OHNO, Y.2
MATSUURA, E.T.3
-
64
-
-
31644446957
-
Detection of deletions flanked by short direct repeats in mitochondrial DNA of aging Drosophila
-
YUI, R. & E.T. MATSUURA. 2006. Detection of deletions flanked by short direct repeats in mitochondrial DNA of aging Drosophila. Mutat. Res. 594: 155-161.
-
(2006)
Mutat. Res
, vol.594
, pp. 155-161
-
-
YUI, R.1
MATSUURA, E.T.2
-
65
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
TRIFUNOVIC, A. et al. 2004. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417-423.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
TRIFUNOVIC, A.1
-
66
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
KUJOTH, G.C. et al. 2005. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309: 481-484.
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
KUJOTH, G.C.1
-
67
-
-
29144486726
-
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice
-
TYYNISMAA, H. et al. 2005. Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc. Natl. Acad. Sci. USA 102: 17687-17692.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 17687-17692
-
-
TYYNISMAA, H.1
-
68
-
-
29144458899
-
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
-
TRIFUNOVIC, A. et al. 2005. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc. Natl. Acad. Sci.USA 102: 17993-17998.
-
(2005)
Proc. Natl. Acad. Sci.USA
, vol.102
, pp. 17993-17998
-
-
TRIFUNOVIC, A.1
-
69
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 308: 1909-1911
-
May 5
-
SCHRINER, S.E. et al. 2005. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 308: 1909-1911. Epub 2005 May 5.
-
(2005)
Epub
, pp. 2005
-
-
SCHRINER, S.E.1
-
70
-
-
0017816161
-
Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy
-
PFEIFER, U. 1978. Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J. Cell Biol. 78: 152-167.
-
(1978)
J. Cell Biol
, vol.78
, pp. 152-167
-
-
PFEIFER, U.1
-
71
-
-
33746704943
-
Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: A safe and easy way to meet goals in the SENS agenda
-
DONATI, A. et al. 2006. Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: a safe and easy way to meet goals in the SENS agenda. Rejuv. Res. 9: 408-412.
-
(2006)
Rejuv. Res
, vol.9
, pp. 408-412
-
-
DONATI, A.1
-
72
-
-
8844239959
-
Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis
-
GU, Y., C. WANG & A. COHEN. 2004. Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis. FEBS Lett. 577: 357-360.
-
(2004)
FEBS Lett
, vol.577
, pp. 357-360
-
-
GU, Y.1
WANG, C.2
COHEN, A.3
-
73
-
-
0036236006
-
The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
-
BRUNK, U.T. & A. TERMAN. 2002. The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur. J. Biochem. 269: 1996-2002.
-
(2002)
Eur. J. Biochem
, vol.269
, pp. 1996-2002
-
-
BRUNK, U.T.1
TERMAN, A.2
-
74
-
-
0032031920
-
Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c
-
YANG, J.C. & G.A. CORTOPASSI. 1998. Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c. Free Radic. Biol. Med. 24: 624-631.
-
(1998)
Free Radic. Biol. Med
, vol.24
, pp. 624-631
-
-
YANG, J.C.1
CORTOPASSI, G.A.2
-
75
-
-
0037214525
-
Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy
-
ZHANG, D. et al. 2003. Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy. Cardiovasc. Res. 57: 147-157.
-
(2003)
Cardiovasc. Res
, vol.57
, pp. 147-157
-
-
ZHANG, D.1
|