The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA

Toxicology

Volumn 221, Issue 2-3, 2006, Pages 179-186

  Arai, Tsuyoshi ^a   Kelly, Vincent P ^a,b,c,d   Minowa, Osamu ^b   Noda, Tetsuo ^b   Nishimura, Susumu ^a,c  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b CANCER INSTITUTE   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

8 hydroxydeoxyguanosine (8 OH dG); 8 Hydroxyguanine (8 OH G); Carcinogenesis; Chronic exposure; Ogg1 knockout mice; Potassium bromate (KBrO3)

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; DNA; DRINKING WATER; POTASSIUM BROMATE;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA ISOLATION; FLUID INTAKE; KIDNEY DYSFUNCTION; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; BROMATES; CARCINOGENICITY TESTS; DNA DAMAGE; DNA GLYCOSYLASES; GUANINE; KIDNEY; MICE; MICE, KNOCKOUT; NEOPLASMS;

ANIMALIA;

EID: 33645288241     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.01.004     Document Type: Article

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