-
1
-
-
0032475992
-
Harnessing the biosynthetic code: combinations, permutations, and mutations
-
Cane D.E., Walsh C.T., and Khosla C. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science 282 (1998) 63-68
-
(1998)
Science
, vol.282
, pp. 63-68
-
-
Cane, D.E.1
Walsh, C.T.2
Khosla, C.3
-
3
-
-
0034887171
-
Polyketide biosynthesis: a millennium review
-
Staunton J., and Weissman K.J. Polyketide biosynthesis: a millennium review. Nat. Prod. Rep. 18 (2001) 380-416
-
(2001)
Nat. Prod. Rep.
, vol.18
, pp. 380-416
-
-
Staunton, J.1
Weissman, K.J.2
-
4
-
-
0036523418
-
Combinatorial biosynthesis of antibiotics: challenges and opportunities
-
Walsh C.T. Combinatorial biosynthesis of antibiotics: challenges and opportunities. ChemBioChem 3 (2002) 125-134
-
(2002)
ChemBioChem
, vol.3
, pp. 125-134
-
-
Walsh, C.T.1
-
5
-
-
1642304143
-
Polyketide and nonribosomal peptide antibiotics: modularity and versatility
-
Walsh C.T. Polyketide and nonribosomal peptide antibiotics: modularity and versatility. Science 303 (2004) 1805-1810
-
(2004)
Science
, vol.303
, pp. 1805-1810
-
-
Walsh, C.T.1
-
6
-
-
0141736926
-
Strategies for combinatorial biosynthesis with modular polyketide synthases
-
Donadio S., and Sosio M. Strategies for combinatorial biosynthesis with modular polyketide synthases. Comb. Chem. High Throughput Screen. 6 (2003) 489-500
-
(2003)
Comb. Chem. High Throughput Screen.
, vol.6
, pp. 489-500
-
-
Donadio, S.1
Sosio, M.2
-
7
-
-
10844239054
-
Polyketide biosynthesis: understanding and exploiting modularity
-
Weissman K.J. Polyketide biosynthesis: understanding and exploiting modularity. Philos. Trans. R. Soc. Lond. B Biol. Sci. 362 (2004) 2671-2690
-
(2004)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.362
, pp. 2671-2690
-
-
Weissman, K.J.1
-
8
-
-
30544434619
-
Combinatorial biosynthesis of reduced polyketides
-
Weissman K.J., and Leadlay P.F. Combinatorial biosynthesis of reduced polyketides. Nat. Rev. Microbiol. 3 (2005) 925-936
-
(2005)
Nat. Rev. Microbiol.
, vol.3
, pp. 925-936
-
-
Weissman, K.J.1
Leadlay, P.F.2
-
9
-
-
14844353677
-
Genetic approaches to polyketide antibiotics. 1
-
McDaniel R., Welch M., and Hutchinson C.R. Genetic approaches to polyketide antibiotics. 1. Chem. Rev. 105 (2005) 543-558
-
(2005)
Chem. Rev.
, vol.105
, pp. 543-558
-
-
McDaniel, R.1
Welch, M.2
Hutchinson, C.R.3
-
10
-
-
33645451499
-
The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites
-
Hill A.M. The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites. Nat. Prod. Rep. 23 (2006) 256-320
-
(2006)
Nat. Prod. Rep.
, vol.23
, pp. 256-320
-
-
Hill, A.M.1
-
11
-
-
4043122568
-
Manipulation and analysis of polyketide synthases
-
Kumar P., Khosla C., and Tang Y. Manipulation and analysis of polyketide synthases. Methods Enzymol. 388 (2004) 269-293
-
(2004)
Methods Enzymol.
, vol.388
, pp. 269-293
-
-
Kumar, P.1
Khosla, C.2
Tang, Y.3
-
12
-
-
0025081416
-
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
-
Cortes J., Haydock S.F., Roberts G.A., Bevitt D.J., and Leadlay P.F. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature 348 (1990) 176-178
-
(1990)
Nature
, vol.348
, pp. 176-178
-
-
Cortes, J.1
Haydock, S.F.2
Roberts, G.A.3
Bevitt, D.J.4
Leadlay, P.F.5
-
13
-
-
0026415106
-
Modular organization of genes required for complex polyketide biosynthesis
-
Donadio S., Staver M.J., McAlpine J.B., Swanson S.J., and Katz L. Modular organization of genes required for complex polyketide biosynthesis. Science 252 (1991) 675-679
-
(1991)
Science
, vol.252
, pp. 675-679
-
-
Donadio, S.1
Staver, M.J.2
McAlpine, J.B.3
Swanson, S.J.4
Katz, L.5
-
14
-
-
8344270313
-
Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase
-
Kim C.Y., Alekseyev V.Y., Chen A.Y., Tang Y., Cane D.E., and Khosla C. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry 43 (2004) 13892-13898
-
(2004)
Biochemistry
, vol.43
, pp. 13892-13898
-
-
Kim, C.Y.1
Alekseyev, V.Y.2
Chen, A.Y.3
Tang, Y.4
Cane, D.E.5
Khosla, C.6
-
15
-
-
33644950516
-
Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase
-
Chen A.Y., Schnarr N.A., Kim C.Y., Cane D.E., and Khosla C. Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. J. Am. Chem. Soc. 128 (2006) 3067-3074
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 3067-3074
-
-
Chen, A.Y.1
Schnarr, N.A.2
Kim, C.Y.3
Cane, D.E.4
Khosla, C.5
-
16
-
-
33746776204
-
The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase
-
Tang Y., Kim C.Y., Mathews I.I., Cane D.E., and Khosla C. The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proc. Natl. Acad. Sci. USA 103 (2006) 11124-11129
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 11124-11129
-
-
Tang, Y.1
Kim, C.Y.2
Mathews, I.I.3
Cane, D.E.4
Khosla, C.5
-
17
-
-
34447516335
-
Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase
-
in press
-
Tang Y., Kim C.Y., Chen A.Y., Cane D.E., and Khosla C. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chem. Biol. (2007) in press
-
(2007)
Chem. Biol.
-
-
Tang, Y.1
Kim, C.Y.2
Chen, A.Y.3
Cane, D.E.4
Khosla, C.5
-
18
-
-
24344469124
-
Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry
-
Schnarr N.A., Chen A.Y., Cane D.E., and Khosla C. Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. Biochemistry 44 (2005) 11836-11842
-
(2005)
Biochemistry
, vol.44
, pp. 11836-11842
-
-
Schnarr, N.A.1
Chen, A.Y.2
Cane, D.E.3
Khosla, C.4
-
19
-
-
0037435553
-
Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases
-
Liou G.F., Lau J., Cane D.E., and Khosla C. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. Biochemistry 42 (2003) 200-207
-
(2003)
Biochemistry
, vol.42
, pp. 200-207
-
-
Liou, G.F.1
Lau, J.2
Cane, D.E.3
Khosla, C.4
-
20
-
-
26944480788
-
Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases
-
Siskos A.P., Baerga-Ortiz A., Bali S., Stein V., Mamdani H., Spiteller D., Popovic B., Spencer J.B., Staunton J., Weissman K.J., and Leadlay P.F. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chem. Biol. 12 (2005) 1145-1153
-
(2005)
Chem. Biol.
, vol.12
, pp. 1145-1153
-
-
Siskos, A.P.1
Baerga-Ortiz, A.2
Bali, S.3
Stein, V.4
Mamdani, H.5
Spiteller, D.6
Popovic, B.7
Spencer, J.B.8
Staunton, J.9
Weissman, K.J.10
Leadlay, P.F.11
-
21
-
-
0030722980
-
Biosynthesis of 2-nor-6-deoxyerythronolide B by rationally designed domain substitution
-
Liu L., Thamchaipenet A., Fu H., Betlach M., and Ashley G. Biosynthesis of 2-nor-6-deoxyerythronolide B by rationally designed domain substitution. J. Am. Chem. Soc. 119 (1997) 10553-10554
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 10553-10554
-
-
Liu, L.1
Thamchaipenet, A.2
Fu, H.3
Betlach, M.4
Ashley, G.5
-
22
-
-
13144249211
-
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering
-
Stassi D.L., Kakavas S.J., Reynolds K.A., Gunawardana G., Swanson S., Zeidner D., Jackson M., Liu H., Buko A., and Katz L. Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering. Proc. Natl. Acad. Sci. USA 95 (1998) 7305-7309
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7305-7309
-
-
Stassi, D.L.1
Kakavas, S.J.2
Reynolds, K.A.3
Gunawardana, G.4
Swanson, S.5
Zeidner, D.6
Jackson, M.7
Liu, H.8
Buko, A.9
Katz, L.10
-
23
-
-
0033515090
-
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
-
McDaniel R., Thamchaipenet A., Gustafsson C., Fu H., Betlach M., and Ashley G. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. Proc. Natl. Acad. Sci. USA 96 (1999) 1846-1851
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1846-1851
-
-
McDaniel, R.1
Thamchaipenet, A.2
Gustafsson, C.3
Fu, H.4
Betlach, M.5
Ashley, G.6
-
24
-
-
0037094002
-
Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B
-
Kato Y., Bai L., Xue Q., Revill W.P., Yu T.-W., and Floss H.G. Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. J. Am. Chem. Soc. 124 (2002) 5268-5269
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 5268-5269
-
-
Kato, Y.1
Bai, L.2
Xue, Q.3
Revill, W.P.4
Yu, T.-W.5
Floss, H.G.6
-
25
-
-
0037617464
-
Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules
-
Hans M., Hornung A., Dziarnowski A., Cane D.E., and Khosla C. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. J. Am. Chem. Soc. 125 (2003) 5366-5374
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 5366-5374
-
-
Hans, M.1
Hornung, A.2
Dziarnowski, A.3
Cane, D.E.4
Khosla, C.5
-
26
-
-
0030266007
-
A hybrid modular polyketide synthase obtained by domain swapping
-
Oliynyk M., Brown M.J., Cortes J., Staunton J., and Leadlay P.F. A hybrid modular polyketide synthase obtained by domain swapping. Chem. Biol. 3 (1996) 833-839
-
(1996)
Chem. Biol.
, vol.3
, pp. 833-839
-
-
Oliynyk, M.1
Brown, M.J.2
Cortes, J.3
Staunton, J.4
Leadlay, P.F.5
-
27
-
-
29244477223
-
A recombinant ketoreductase tool-box. Assessing the substrate selectivity and stereoselectivity toward the reduction of β-ketoesters
-
Zhu D.M., Mukherjee C., Rozzell J.D., Kambourakis S., and Hua L. A recombinant ketoreductase tool-box. Assessing the substrate selectivity and stereoselectivity toward the reduction of β-ketoesters. Tetrahedron 62 (2006) 901-905
-
(2006)
Tetrahedron
, vol.62
, pp. 901-905
-
-
Zhu, D.M.1
Mukherjee, C.2
Rozzell, J.D.3
Kambourakis, S.4
Hua, L.5
-
28
-
-
33646118964
-
Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase
-
Baerga-Ortiz A., Popovic B., Siskos A.P., O'Hare H.M., Spiteller D., Williams M.G., Campillo N., Spencer J.B., and Leadlay P.F. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase. Chem. Biol. 13 (2006) 277-285
-
(2006)
Chem. Biol.
, vol.13
, pp. 277-285
-
-
Baerga-Ortiz, A.1
Popovic, B.2
Siskos, A.P.3
O'Hare, H.M.4
Spiteller, D.5
Williams, M.G.6
Campillo, N.7
Spencer, J.B.8
Leadlay, P.F.9
-
29
-
-
33646115667
-
High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase
-
O'Hare H.M., Baerga-Ortiz A., Popovic B., Spencer J.B., and Leadlay P.F. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chem. Biol. 13 (2006) 287-296
-
(2006)
Chem. Biol.
, vol.13
, pp. 287-296
-
-
O'Hare, H.M.1
Baerga-Ortiz, A.2
Popovic, B.3
Spencer, J.B.4
Leadlay, P.F.5
-
30
-
-
33645962845
-
The structure of a ketoreductase determines the organization of the β-carbon processing enzymes of modular polyketide synthases
-
Keatinge-Clay A.T., and Stroud R.M. The structure of a ketoreductase determines the organization of the β-carbon processing enzymes of modular polyketide synthases. Structure 14 (2006) 737-748
-
(2006)
Structure
, vol.14
, pp. 737-748
-
-
Keatinge-Clay, A.T.1
Stroud, R.M.2
-
31
-
-
33644905256
-
Broad substrate specificity of ketoreductases derived from modular polyketide synthases
-
Bali S., O'Hare H.M., and Weissman K.J. Broad substrate specificity of ketoreductases derived from modular polyketide synthases. ChemBioChem 7 (2006) 478-484
-
(2006)
ChemBioChem
, vol.7
, pp. 478-484
-
-
Bali, S.1
O'Hare, H.M.2
Weissman, K.J.3
-
32
-
-
0036008126
-
Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides
-
Cane D.E., Kudo F., Kinoshita K., and Khosla C. Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides. Chem. Biol. 9 (2002) 131-142
-
(2002)
Chem. Biol.
, vol.9
, pp. 131-142
-
-
Cane, D.E.1
Kudo, F.2
Kinoshita, K.3
Khosla, C.4
-
33
-
-
0030875774
-
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase
-
Jacobsen J.R., Hutchinson C.R., Cane D.E., and Khosla C. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science 277 (1997) 367-369
-
(1997)
Science
, vol.277
, pp. 367-369
-
-
Jacobsen, J.R.1
Hutchinson, C.R.2
Cane, D.E.3
Khosla, C.4
-
34
-
-
2542457801
-
Enantiospecific synthesis of analogues of the diketide intermediate of the erythromycin polyketide synthase (PKS)
-
Harris R.C., Cutter A.L., Weissman K.J., Hanefeld U., Timoney M.C., and Staunton J. Enantiospecific synthesis of analogues of the diketide intermediate of the erythromycin polyketide synthase (PKS). J. Chem. Res. 283 (1998) 1230-1247
-
(1998)
J. Chem. Res.
, vol.283
, pp. 1230-1247
-
-
Harris, R.C.1
Cutter, A.L.2
Weissman, K.J.3
Hanefeld, U.4
Timoney, M.C.5
Staunton, J.6
|