Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase

Journal of the American Chemical Society

Volumn 128, Issue 9, 2006, Pages 3067-3074

  Chen, Alice Y ^a   Schnarr, Nathan A ^b   Kim, Chu Young ^a,b,d   Cane, David E ^c   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONDENSATION REACTIONS; PROTEINS; SUBSTRATES;

6-DEOXYERYTHRONOLIDE B SYNTHASE (DEBS); ACP DOMAIN; KETOREDUCTASE (KR) DOMAIN; METHYLMALONYL;

ORGANIC COMPOUNDS;

6 DEOXYERYTHRONOLIDE B SYNTHASE; ACYL CARRIER PROTEIN; MALONIC ACID; METHYLMALONIC ACID; NATURAL PRODUCT; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL ENGINEERING; COVALENT BOND; DECARBOXYLATION; ENZYME KINETICS; ENZYME SPECIFICITY; MOLECULAR RECOGNITION; POLYMERIZATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; REDUCTION;

ACYL CARRIER PROTEIN; ACYLATION; CATALYTIC DOMAIN; ESCHERICHIA COLI; KINETICS; POLYKETIDE SYNTHASES; RECOMBINANT PROTEINS; SACCHAROPOLYSPORA; SUBSTRATE SPECIFICITY;

EID: 33644950516     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja058093d     Document Type: Article

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