Combinatorialization of fungal polyketide synthase-peptide synthetase hybrid proteins

Journal of the American Chemical Society

Volumn 136, Issue 51, 2014, Pages 17882-17890

  Kakule, Thomas B ^a   Lin, Zhenjian ^a   Schmidt, Eric W ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; FUNGI; GENE EXPRESSION; KETONES; PEPTIDES; REACTION INTERMEDIATES; SYNTHESIS (CHEMICAL);

ACYL CARRIER PROTEINS; BIOCHEMICAL REACTIONS; DOMAIN ARCHITECTURES; NATURAL PRODUCTS; NONRIBOSOMAL PEPTIDE SYNTHETASES; POLYKETIDE SYNTHASES; SHEDDING LIGHT; SINGLE MODULES;

C (PROGRAMMING LANGUAGE);

ACYL CARRIER PROTEIN; FUNGAL ENZYME; HYBRID PROTEIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; PEPTIDE SYNTHASE; POLYKETIDE SYNTHASE; BIOLOGICAL PRODUCT; DECALIN; MEVINOLIN; NAPHTHALENE DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYCLIZATION; DIELS ALDER REACTION; ENZYME PURIFICATION; FUSARIUM; GENE FUSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR RECOGNITION; NONHUMAN; PHYLOGENY; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN PROTEIN INTERACTION; RECOMBINANT GENE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; FUNGUS; GENETICS; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE;

ACYL CARRIER PROTEIN; BIOLOGICAL PRODUCTS; FUNGI; LOVASTATIN; MUTATION; NAPHTHALENES; PEPTIDE SYNTHASES; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84919933641     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja511087p     Document Type: Article

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