메뉴 건너뛰기




Volumn 20, Issue 16, 2014, Pages 2606-2620

Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; BIOLOGICAL MARKER; CARBONYL DERIVATIVE; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTATHIONE; ISOCITRATE DEHYDROGENASE 2; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN; SIRTUIN 1; SIRTUIN 3; UBIDECARENONE; AMP-ACTIVATED PROTEIN KINASE KINASE; MEMBRANE PROTEIN; NUCLEAR PROTEIN; PPARGC1A PROTEIN, HUMAN; PROTEIN KINASE; SAMP1 PROTEIN, MOUSE; SIRT1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; UBIQUINOL-10; UBIQUINONE;

EID: 84900384850     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5406     Document Type: Article
Times cited : (92)

References (74)
  • 1
    • 0026636509 scopus 로고
    • Distribution and redox state of ubiquinones in rat and human tissues
    • Aberg F, Appelkvist EL, Dallner G, and Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys 295: 230-234, 1992.
    • (1992) Arch Biochem Biophys , vol.295 , pp. 230-234
    • Aberg, F.1    Appelkvist, E.L.2    Dallner, G.3    Ernster, L.4
  • 3
    • 84885217983 scopus 로고    scopus 로고
    • Updating the mitochondrial free radical theory of aging: An integrated view, key aspects, and confounding concepts
    • Barja G. Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxid Redox Signal 19: 1420-1445, 2013.
    • (2013) Antioxid Redox Signal , vol.19 , pp. 1420-1445
    • Barja, G.1
  • 4
    • 24644463306 scopus 로고    scopus 로고
    • Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet
    • Bello RI, Gomez-Diaz C, Buron MI, Alcain FJ, Navas P, and Villalba JM. Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp Gerontol 40: 694-706, 2005.
    • (2005) Exp Gerontol , vol.40 , pp. 694-706
    • Bello, R.I.1    Gomez-Diaz, C.2    Buron, M.I.3    Alcain, F.J.4    Navas, P.5    Villalba, J.M.6
  • 6
    • 50949112045 scopus 로고    scopus 로고
    • The oxidative stress theory of aging: Embattled or invincible? Insights from non-traditional model organisms
    • Buffenstein R, Edrey YH, Yang T, and Mele J. The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms. Age (Dordr) 30: 99-109, 2008.
    • (2008) Age (Dordr) , vol.30 , pp. 99-109
    • Buffenstein, R.1    Edrey, Y.H.2    Yang, T.3    Mele, J.4
  • 7
    • 84866839740 scopus 로고    scopus 로고
    • Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1
    • Cai W, Ramdas M, Zhu L, Chen X, Striker GE, and Vlassara H. Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1. Proc Natl Acad Sci USA 109: 15888-15893, 2012.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 15888-15893
    • Cai, W.1    Ramdas, M.2    Zhu, L.3    Chen, X.4    Striker, G.E.5    Vlassara, H.6
  • 9
    • 0023642627 scopus 로고
    • A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
    • Carling D, Zammit VA, and Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 223: 217-222, 1987.
    • (1987) FEBS Lett , vol.223 , pp. 217-222
    • Carling, D.1    Zammit, V.A.2    Hardie, D.G.3
  • 12
    • 0036528005 scopus 로고    scopus 로고
    • Obesity therapy: Altering the energy intake-and-expenditure balance sheet
    • Crowley VE, Yeo GS, and O'Rahilly S. Obesity therapy: altering the energy intake-and-expenditure balance sheet. Nat Rev Drug Discov 1: 276-286, 2002.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 276-286
    • Crowley, V.E.1    Yeo, G.S.2    O'Rahilly, S.3
  • 13
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
    • Donmez G, Wang D, Cohen DE, and Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142: 320-332, 2010.
    • (2010) Cell , vol.142 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 14
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T, Deng CX, and Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 460: 587-591, 2009.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 15
    • 4444297565 scopus 로고    scopus 로고
    • Mitochondria: Are they the seat of senescence?
    • Fridovich I. Mitochondria: are they the seat of senescence? Aging Cell 3: 13-16, 2004.
    • (2004) Aging Cell , vol.3 , pp. 13-16
    • Fridovich, I.1
  • 16
    • 79955768567 scopus 로고    scopus 로고
    • Peroxisome pro-liferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype
    • Giralt A, Hondares E, Villena JA, Ribas F, Diaz-Delfin J, Giralt M, Iglesias R, and Villarroya F. Peroxisome pro-liferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype. J Biol Chem 286: 16958-16966, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 16958-16966
    • Giralt, A.1    Hondares, E.2    Villena, J.A.3    Ribas, F.4    Diaz-Delfin, J.5    Giralt, M.6    Iglesias, R.7    Villarroya, F.8
  • 17
    • 78649350746 scopus 로고    scopus 로고
    • The aging stress response
    • Haigis MC and Yankner BA. The aging stress response. Mol Cell 40: 333-344, 2010.
    • (2010) Mol Cell , vol.40 , pp. 333-344
    • Haigis, M.C.1    Yankner, B.A.2
  • 18
    • 80053124673 scopus 로고    scopus 로고
    • Takinga ''good'' look at free radicals in the aging process
    • Hekimi S, Lapointe J, and Wen Y. Takinga ''good'' look at free radicals in the aging process. Trends Cell Biol 21: 569-576, 2011.
    • (2011) Trends Cell Biol , vol.21 , pp. 569-576
    • Hekimi, S.1    Lapointe, J.2    Wen, Y.3
  • 21
    • 19344374925 scopus 로고    scopus 로고
    • Sir2-independent life span extension by calorie restriction in yeast
    • Kaeberlein M, Kirkland KT, Fields S, and Kennedy BK. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2: E296, 2004.
    • (2004) PLoS Biol , vol.2
    • Kaeberlein, M.1    Kirkland, K.T.2    Fields, S.3    Kennedy, B.K.4
  • 24
    • 0032490102 scopus 로고    scopus 로고
    • Quinone specificity of complex i
    • Lenaz G. Quinone specificity of complex I. Biochim Biophys Acta 1364: 207-221, 1998.
    • (1998) Biochim Biophys Acta , vol.1364 , pp. 207-221
    • Lenaz, G.1
  • 27
    • 83055170861 scopus 로고    scopus 로고
    • SOD2 contributes to anti-oxidative capacity in rabbit corneal endothelial cells
    • Liu C, Ogando D, and Bonanno JA. SOD2 contributes to anti-oxidative capacity in rabbit corneal endothelial cells. Mol Vis 17: 2473-2481, 2011.
    • (2011) Mol Vis , vol.17 , pp. 2473-2481
    • Liu, C.1    Ogando, D.2    Bonanno, J.A.3
  • 29
    • 0034033586 scopus 로고    scopus 로고
    • Caloric restriction and aging: An update
    • Masoro EJ. Caloric restriction and aging: an update. Exp Gerontol 35: 299-305, 2000.
    • (2000) Exp Gerontol , vol.35 , pp. 299-305
    • Masoro, E.J.1
  • 30
    • 0035430282 scopus 로고    scopus 로고
    • Transcriptional regulation by the phosphorylation-dependent factor CREB
    • Mayr B and Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2: 599-609, 2001.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 599-609
    • Mayr, B.1    Montminy, M.2
  • 33
    • 0026734786 scopus 로고
    • Dietary supplementation with coenzyme Q10 results in increased levels of ubi-quinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation
    • Mohr D, Bowry VW, and Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubi-quinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1126: 247-254, 1992.
    • (1992) Biochim Biophys Acta , vol.1126 , pp. 247-254
    • Mohr, D.1    Bowry, V.W.2    Stocker, R.3
  • 35
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 417: 1-13, 2009.
    • (2009) Biochem J , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 36
    • 33847059997 scopus 로고    scopus 로고
    • The mitochondrial energy trans-duction system and the aging process
    • Navarro A and Boveris A. The mitochondrial energy trans-duction system and the aging process. Am J Physiol Cell Physiol 292: C670-C686, 2007.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Navarro, A.1    Boveris, A.2
  • 37
    • 34248195909 scopus 로고    scopus 로고
    • The importance of plasma membrane coenzyme Q in aging and stress responses
    • Navas P, Villalba JM, and de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 7 Suppl: S34-S40, 2007.
    • (2007) Mitochondrion , vol.7 , Issue.SUPPL.
    • Navas, P.1    Villalba, J.M.2    De Cabo, R.3
  • 38
    • 18144411313 scopus 로고    scopus 로고
    • SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
    • Nemoto S, Fergusson MM, and Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 280: 16456-16460, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 16456-16460
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 41
    • 60549083066 scopus 로고    scopus 로고
    • Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phospho-diesterases, protein kinase B, protein kinase A, Epac and lipolysis
    • Omar B, Zmuda-Trzebiatowska E, Manganiello V, Gor-ansson O, and Degerman E. Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phospho-diesterases, protein kinase B, protein kinase A, Epac and lipolysis. Cell Signal 21: 760-766, 2009.
    • (2009) Cell Signal , vol.21 , pp. 760-766
    • Omar, B.1    Zmuda-Trzebiatowska, E.2    Manganiello, V.3    Gor-Ansson, O.4    Degerman, E.5
  • 42
    • 0037108799 scopus 로고    scopus 로고
    • SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
    • Onyango P, Celic I, McCaffery JM, Boeke JD, and Feinberg AP. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci USA 99: 13653-13658, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13653-13658
    • Onyango, P.1    Celic, I.2    McCaffery, J.M.3    Boeke, J.D.4    Feinberg, A.P.5
  • 44
    • 78649521247 scopus 로고    scopus 로고
    • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    • Qiu X, Brown K, Hirschey MD, Verdin E, and Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 12: 662-667, 2010.
    • (2010) Cell Metab , vol.12 , pp. 662-667
    • Qiu, X.1    Brown, K.2    Hirschey, M.D.3    Verdin, E.4    Chen, D.5
  • 47
    • 0026723743 scopus 로고
    • Coenzyme Q-pool function in glycerol-3-phosphate oxidation in hamster brown adipose tissue mitochondria
    • Rauchova H, Battino M, Fato R, Lenaz G, and Drahota Z. Coenzyme Q-pool function in glycerol-3-phosphate oxidation in hamster brown adipose tissue mitochondria. J Bioe-nerg Biomembr 24: 235-241, 1992.
    • (1992) J Bioe-nerg Biomembr , vol.24 , pp. 235-241
    • Rauchova, H.1    Battino, M.2    Fato, R.3    Lenaz, G.4    Drahota, Z.5
  • 48
    • 37349110355 scopus 로고    scopus 로고
    • Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways
    • Rodgers JT, Lerin C, Gerhart-Hines Z, and Puigserver P. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett 582: 46-53, 2008.
    • (2008) FEBS Lett , vol.582 , pp. 46-53
    • Rodgers, J.T.1    Lerin, C.2    Gerhart-Hines, Z.3    Puigserver, P.4
  • 49
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • Rossi DJ, Jamieson CH, and Weissman IL. Stems cells and the pathways to aging and cancer. Cell 132: 681-696, 2008.
    • (2008) Cell , vol.132 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.2    Weissman, I.L.3
  • 50
    • 84863728173 scopus 로고    scopus 로고
    • Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: A double-blind, placebo controlled, randomized study
    • Safarinejad MR, Safarinejad S, and Shafiei N. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. J Urol 188: 526-531, 2012.
    • (2012) J Urol , vol.188 , pp. 526-531
    • Safarinejad, M.R.1    Safarinejad, S.2    Shafiei, N.3
  • 53
    • 84860552236 scopus 로고    scopus 로고
    • Micronutrient special issue: Coenzyme Q(10) requirements for DNA damage prevention
    • Schmelzer C and Doring F. Micronutrient special issue: Coenzyme Q(10) requirements for DNA damage prevention. Mutat Res 733: 61-68, 2012.
    • (2012) Mutat Res , vol.733 , pp. 61-68
    • Schmelzer, C.1    Doring, F.2
  • 54
    • 77954171665 scopus 로고    scopus 로고
    • Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice
    • Schmelzer C, Kubo H, Mori M, Sawashita J, Kitano M, Hosoe K, Boomgaarden I, Doring F, and Higuchi K. Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice. Mol Nutr Food Res 54: 805-815, 2010.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 805-815
    • Schmelzer, C.1    Kubo, H.2    Mori, M.3    Sawashita, J.4    Kitano, M.5    Hosoe, K.6    Boomgaarden, I.7    Doring, F.8    Higuchi, K.9
  • 55
    • 0037135972 scopus 로고    scopus 로고
    • The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleo-tide-dependent deacetylase
    • Schwer B, North BJ, Frye RA, Ott M, and Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleo-tide-dependent deacetylase. J Cell Biol 158: 647-657, 2002.
    • (2002) J Cell Biol , vol.158 , pp. 647-657
    • Schwer, B.1    North, B.J.2    Frye, R.A.3    Ott, M.4    Verdin, E.5
  • 57
    • 0032483007 scopus 로고    scopus 로고
    • Molecular remedy of complex i defects: Rotenone-insensitive internal NADH-quinone oxidoreduc-tase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells
    • Seo BB, Kitajima-Ihara T, Chan EK, Scheffler IE, Matsuno-Yagi A, and Yagi T. Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreduc-tase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. Proc Natl Acad Sci USA 95: 9167-9171, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9167-9171
    • Seo, B.B.1    Kitajima-Ihara, T.2    Chan, E.K.3    Scheffler, I.E.4    Matsuno-Yagi, A.5    Yagi, T.6
  • 58
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford DB and Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 9: 563-575, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 59
    • 79959873784 scopus 로고    scopus 로고
    • Reversible acetylation of metabolic enzymes celebration: SIRT2 and p300 join the party
    • Shin J, Zhang D, and Chen D. Reversible acetylation of metabolic enzymes celebration: SIRT2 and p300 join the party. Mol Cell 43: 3-5, 2011.
    • (2011) Mol Cell , vol.43 , pp. 3-5
    • Shin, J.1    Zhang, D.2    Chen, D.3
  • 60
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal RS and Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273: 59-63, 1996.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 62
    • 78651468722 scopus 로고    scopus 로고
    • Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    • Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeu-wenburgh C, Tanokura M, Denu JM, and Prolla TA. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143: 802-812, 2010.
    • (2010) Cell , vol.143 , pp. 802-812
    • Someya, S.1    Yu, W.2    Hallows, W.C.3    Xu, J.4    Vann, J.M.5    Leeu-Wenburgh, C.6    Tanokura, M.7    Denu, J.M.8    Prolla, T.A.9
  • 63
    • 0027218182 scopus 로고
    • Extracellular reduction of ubiqui-none-1 and-10 by human Hep G2 and blood cells
    • Stocker R and Suarna C. Extracellular reduction of ubiqui-none-1 and-10 by human Hep G2 and blood cells. Biochim Biophys Acta 1158: 15-22, 1993.
    • (1993) Biochim Biophys Acta , vol.1158 , pp. 15-22
    • Stocker, R.1    Suarna, C.2
  • 64
    • 0029785919 scopus 로고    scopus 로고
    • Senescence-accelerated mouse (SAM): With special reference to age-associated pathologies and their modulation]
    • Takeda T. [Senescence-accelerated mouse (SAM): with special reference to age-associated pathologies and their modulation]. Nihon Eiseigaku Zasshi 51: 569-578, 1996.
    • (1996) Nihon Eiseigaku Zasshi , vol.51 , pp. 569-578
    • Takeda, T.1
  • 65
    • 0030896787 scopus 로고    scopus 로고
    • Senescence-accelerated mouse (SAM): A novel murine model of senescence
    • Takeda T, Hosokawa M, and Higuchi K. Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp Gerontol 32: 105-109, 1997.
    • (1997) Exp Gerontol , vol.32 , pp. 105-109
    • Takeda, T.1    Hosokawa, M.2    Higuchi, K.3
  • 67
    • 0033216635 scopus 로고    scopus 로고
    • Coen-zyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes
    • Tomasetti M, Littarru GP, Stocker R, and Alleva R. Coen-zyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes. Free Radic Biol Med 27: 1027-1032, 1999.
    • (1999) Free Radic Biol Med , vol.27 , pp. 1027-1032
    • Tomasetti, M.1    Littarru, G.P.2    Stocker, R.3    Alleva, R.4
  • 68
    • 79957607586 scopus 로고    scopus 로고
    • Rosuvastatin combined with regular exercise preserves co-enzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease
    • Toyama K, Sugiyama S, Oka H, Iwasaki Y, Sumida H, Tanaka T, Tayama S, Jinnouchi H, Matsui K, and Ogawa H. Rosuvastatin combined with regular exercise preserves co-enzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease. Atherosclerosis 217: 158-164, 2011.
    • (2011) Atherosclerosis , vol.217 , pp. 158-164
    • Toyama, K.1    Sugiyama, S.2    Oka, H.3    Iwasaki, Y.4    Sumida, H.5    Tanaka, T.6    Tayama, S.7    Jinnouchi, H.8    Matsui, K.9    Ogawa, H.10
  • 69
    • 33750721631 scopus 로고    scopus 로고
    • Clinical oxidation parameters of aging
    • Voss P and Siems W. Clinical oxidation parameters of aging. Free Radic Res 40: 1339-1349, 2006.
    • (2006) Free Radic Res , vol.40 , pp. 1339-1349
    • Voss, P.1    Siems, W.2
  • 70
    • 34347372635 scopus 로고    scopus 로고
    • Redox status of coenzyme Q10 is associated with chronological age
    • Wada H, Goto H, Hagiwara S, and Yamamoto Y. Redox status of coenzyme Q10 is associated with chronological age. J Am Geriatr Soc 55: 1141-1142, 2007.
    • (2007) J Am Geriatr Soc , vol.55 , pp. 1141-1142
    • Wada, H.1    Goto, H.2    Hagiwara, S.3    Yamamoto, Y.4
  • 71
    • 0022517746 scopus 로고
    • The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake
    • Weindruch R, Walford RL, Fligiel S, and Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr 116: 641-654, 1986.
    • (1986) J Nutr , vol.116 , pp. 641-654
    • Weindruch, R.1    Walford, R.L.2    Fligiel, S.3    Guthrie, D.4
  • 72
    • 84865822755 scopus 로고    scopus 로고
    • Skeletal muscle SIRT1 and the genetics of metabolic health: Therapeutic activation by pharmaceuticals and exercise
    • Williams CB and Gurd BJ. Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise. Appl Clin Genet 5: 81-91, 2012.
    • (2012) Appl Clin Genet , vol.5 , pp. 81-91
    • Williams, C.B.1    Gurd, B.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.