Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 7, 2015, Pages 1257-1267

  Alcocer Gómez, Elísabet ^a,b   Garrido Maraver, Juan ^b   Bullón, Pedro ^a   Marín Aguilar, Fabiola ^a   Cotán, David ^b   Carrión, Angel M ^c   Alvarez Suarez, José Miguel ^d,e,f   Giampieri, Francesca ^d   Sánchez Alcazar, José Antonio ^b   Battino, Maurizio ^d,g   Cordero, Mario D ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSIDAD PABLO DE OLAVIDE   (Spain)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^e Universidad Internacional Iberoamericana (UNINI)   (Mexico)

^f UNIVERSIDAD NACIONAL DE CHIMBORAZO   (Ecuador)

^g Parque Científico y Tecnológico de Cantabria   (Spain)

Author keywords

AMPK; Caloric restriction; Fibromyalgia; Metformin; Mitochondria; Oxidative stress

Indexed keywords

CITRATE SYNTHASE; CYTOCHROME C OXIDASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; UBIQUINOL CYTOCHROME C REDUCTASE; AMP-ACTIVATED PROTEIN KINASES; DNA, MITOCHONDRIAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOGENESIS; CALORIC RESTRICTION; CELL ACTIVATION; CELL GROWTH; CELL METABOLISM; CELL STRUCTURE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; FIBROMYALGIA; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY CHAIN; SKIN FIBROBLAST; ADULT; ANIMALS; CASE-CONTROL STUDIES; CELLS, CULTURED; DRUG EFFECTS; FIBROBLASTS; GENETICS; HUMANS; METABOLISM; MICE; MICE, INBRED C57BL; MITOCHONDRIA;

MUS;

ADULT; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALORIC RESTRICTION; CASE-CONTROL STUDIES; CELLS, CULTURED; DNA, MITOCHONDRIAL; FEMALE; FIBROBLASTS; FIBROMYALGIA; HUMANS; MALE; METFORMIN; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OXIDATIVE STRESS;

EID: 84925763796     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2015.03.005     Document Type: Article

References (27)

1. Haas R.H., Parikh S., Falk M.J., Saneto R., Wolf N.I., Darin N., Wong L.J., Cohen B.H., Naviaux R.K. The in-depth evaluation of suspected mitochondrial disease. Mol. Genet. Metab. 2008, 94:16-37.
2. Turrens J.F. Mitochondrial formation of reactive oxygen species. J. Physiol. 2003, 552:335-441.
3. Steinberg G.R., Kemp B.E. AMPK in health and disease. Physiol. Rev. 2009, 89:1025-1078.
4. Colombo S.L., Moncada S. AMPKalpha1 regulates the antioxidant status of vascular endothelial cells. Biochem. J. 2009, 421:163-169.
5. Altindag O., Celik H. Total antioxidant capacity and the severity of the pain in patients with fibromyalgia. Redox Rep. 2006, 11:131-135.
6. Bagis S., Tamer L., Sahin G., Bilgin R., Guler H., Ercan B., Erdogan C. Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder?. Rheumatol. Int. 2005, 25:188-190.
7. Ozgocmen S., Ozyurt H., Sogut S., Akyol O. Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide. Rheumatol. Int. 2006, 26:585-597.
8. Cordero M.D., Díaz-Parrado E., Carrión A.M., Alfonsi S., Sánchez-Alcazar J.A., Bullón P., Battino M., de Miguel M. Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?. Antioxid. Redox Signal. 2013, 18:800-807.
9. Cordero M.D., Alcocer-Gómez E., de Miguel M., Culic O., Carrión A.M., Alvarez-Suarez J.M., Bullón P., Battino M., Fernández-Rodríguez A., Sánchez-Alcazar J.A. Can coenzyme Q10 improve clinical and molecular parameter in fibromyalgia?. Antioxid. Redox Signal. 2013, 19:1356-1361.
10. Bazzichi L., Giannaccini G., Betti L., Fabbrini L., Schmid L., Palego L., Giacomelli C., Rossi A., Giusti L., De Feo F., Giuliano T., Mascia G., Bombardieri S., Lucacchini A. ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia. Clin. Biochem. 2008, 41:1084-1090.
11. Neyal M., Yimenicioglu F., Aydeniz A., Taskin A., Saglam S., Cekmen M., Neyal A., Gursoy S., Erel O., Balat A. Plasma nitrite levels, total antioxidant status, total oxidant status, and oxidative stress index in patients with tension-type headache and fibromyalgia. Clin. Neurol. Neurosurg. 2013, 115:736-740.
12. Aebi H. Catalase in vitro. Methods Enzymol. 1984, 105:121-126.
13. Kakkar P., Das B., Viswanathan P.N. A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys. 1984, 21:130-132.
14. Hardie D.G., Ross F.A., Hawley S.A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 2012, 13:251-262.
15. Wu S.B., Wei Y.H. AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases. Biochim. Biophys. Acta 2012, 1822:233-247.
16. Melemedjian O.K., Asiedu M.N., Tillu D.V., Sanoja R., Yan J., Lark A., Khoutorsky A., Johnson J., Peebles K.A., Lepow T., Sonenberg N., Dussor G., Price T.J. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol. Pain 2011, 7:70.
17. Cao K., Zheng A., Xu J., Li H., Liu J., Peng Y., Long J., Zou X., Li Y., Chen C., Liu J., Feng Z. AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic. Biol. Med. 2014, 75:156-166.
18. Wu S.B., Wu Y.T., Wu T.P., Wei Y.H. Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress. Biochim. Biophys. Acta 2014, 1840:1331-1344.
19. Takeuchi K., Morizane Y., Kamami-Levy C., Suzuki J., Kayama M., Cai W., Miller J.W., Vavvas D.G. AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells. J. Biol. Chem. 2013, 288:20581-20591.
20. Lu Z., Xu X., Hu X., Fassett J., Zhu G., Tao Y., Li J., Huang Y., Zhang P., Zhao B., Chen Y. PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxid. Redox Signal. 2010, 13:1011-1022.
21. Marmolino D., Manto M., Acquaviva F., Vergara P., Ravella A., Monticelli A., Pandolfo M. PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia. PLoS One 2010, 5:e10025.
22. Clauw D.J. Fibromyalgia: a clinical review. JAMA 2014, 311:1547-1555.
23. Bote M.E., García J.J., Hinchado M.D., Ortega E. Inflammatory/stress feedback dysregulation in women with fibromyalgia. Neuroimmunomodulation 2012, 19:343-351.
24. Alok R., Das S.K., Agarwal G.G., Salwahan L., Srivastava R. Relationship of severity of depression, anxiety and stress with severity of fibromyalgia. Clin. Exp. Rheumatol. 2011, 29:S70-S72.
25. Arranz L., Canela M.A., Rafecas M. Relationship between body mass index, fat mass and lean mass with SF-36 quality of life scores in a group of fibromyalgia patients. Rheumatol. Int. 2012, 32:3605-3611.
26. Loevinger B.L., Muller D., Alonso C., Coe C.L. Metabolic syndrome in women with chronic pain. Metabolism 2007, 56:87-93.
27. de Cabo R., Fürer-Galbán S., Anson R.M., Gilman C., Gorospe M., Lane M.A. An in vitro model of caloric restriction. Exp. Gerontol. 2003, 38:631-639.