NZ suppresses TLR4/NF-κB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages

Inflammation Research

Volumn 64, Issue 10, 2015, Pages 799-808

  Xiang, Pengjun ^a   Chen, Tong ^a   Mou, Yi ^a   Wu, Hui ^a   Xie, Peng ^a   Lu, Guo ^a   Gong, Xiaojian ^a   Hu, Qinghua ^a   Zhang, Yihua ^a   Ji, Hui ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

LPS; NF B; NLRP3; NO; NZ; RAW264.7

Indexed keywords

ANTIINFLAMMATORY AGENT; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING CARD; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; OLEAN 28,13BETA OLIDE; PROTEIN; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TRITERPENOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CYTOKINE; INFLAMMASOME; MYD88 PROTEIN, MOUSE; NONSTEROID ANTIINFLAMMATORY AGENT; OLEAN-28-13BETA-OLIDE-2; OLEANOLIC ACID; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; RAW 264.7 CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRIER PROTEINS; CASPASE 1; CELL SURVIVAL; CYTOKINES; INFLAMMASOMES; LIPOPOLYSACCHARIDES; MICE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; NITRIC OXIDE; OLEANOLIC ACID; RAW 264.7 CELLS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84941417769     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-015-0863-4     Document Type: Article

References (34)

1. Su ZQ, Mo ZZ, Liao JB, Feng XX, Liang YZ, Zhang X, et al. Usnic acid protects LPS-induced acute lung injury in mice through attenuating inflammatory responses and oxidative stress. Int Immunopharmacol. 2014;22:371–8.
2. De Jesus NM, Wang L, Herren AW, Wang J, Shenasa F, Bers DM, et al. Atherosclerosis exacerbates arrhythmia following myocardial infarction: role of myocardial inflammation. Heart Rhythm Off J Heart Rhythm Soc. 2015;12:169–78.
3. Reddy SA, Shelar SB, Dang TM, Lee BN, Yang H, Ong SM, et al. Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-kappaB- and MAPK-dependent manner. Int Immunopharmacol. 2015;24:440–50.
4. Kim EA, Han AR, Choi J, Ahn JY, Choi SY, Cho SW. Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells. Int Immunopharmacol. 2014;22:73–83.
5. Li Y, Wu Q, Deng Y, Lv H, Qiu J, Chi G, et al. D(-)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models. Int Immunopharmacol. 2015;26:286–94.
6. Piazza M, Calabrese V, Baruffa C, Gioannini T, Weiss J, Peri F. The cationic amphiphile 3,4-bis(tetradecyloxy)benzylamine inhibits LPS signaling by competing with endotoxin for CD14 binding. Biochem Pharmacol. 2010;80:2050–6.
7. Byun EB, Sung NY, Park JN, Yang MS, Park SH, Byun EH. Gamma-irradiated resveratrol negatively regulates LPS-induced MAPK and NF-kappaB signaling through TLR4 in macrophages. Int Immunopharmacol. 2015;25:249–59.
8. Ahmad SF, Ansari MA, Zoheir KM, Bakheet SA, Korashy HM, Nadeem A, et al. Regulation of TNF-alpha and NF-kappaB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation. Immunobiology. 2015;220:889–98.
9. Ma J, Shi H, Mi C, Li HL, Lee JJ, Jin X. Malloapelta B suppresses LPS-induced NF-kappaB activation and NF-kappaB-regulated target gene products. Int Immunopharmacol. 2015;24:147–52.
10. Beninson LA, Fleshner M. Exosomes in fetal bovine serum dampen primary macrophage IL-1beta response to lipopolysaccharide (LPS) challenge. Immunol Lett. 2015;163:187–92.
11. Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, et al. NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol. 2015;4:296–307.
12. Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, et al. Oligomerized CARD16 promotes caspase-1 assembly and IL-1beta processing. FEBS Open Biol. 2015;5:348–56.
13. Huang Z, Fu J, Liu L, Sun Y, Lai Y, Ji H, et al. Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents. Org Biomol Chem. 2012;10:3882–91.
14. To C, Ringelberg CS, Royce DB, Williams CR, Risingsong R, Sporn MB, et al. Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis. Carcinogenesis. 2015;36:769–81.
15. Chen T, Mou Y, Tan J, Wei L, Qiao Y, Wei T, et al. The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol. 2015;25:55–64.
16. Ding Y, Huang Z, Yin J, Lai Y, Zhang S, Zhang Z, et al. DDQ-promoted dehydrogenation from natural rigid polycyclic acids or flexible alkyl acids to generate lactones by a radical ion mechanism. Chem Commun. 2011;47:9495–7.
17. Chen T, Xiao L, Zhu L, Ma S, Yan T, Ji H. Anti-asthmatic effects of ginsenoside Rb1 in a mouse model of allergic asthma through relegating Th1/Th2. Inflammation. 2015. doi:10.1007/s10753-015-0159-4.
18. Tianzhu Z, Shihai Y, Juan D. The effects of morin on lipopolysaccharide-induced acute lung injury by suppressing the lung NLRP3 inflammasome. Inflammation. 2014;37:1976–83.
19. Wang Y, Cui Y, Cao F, Qin Y, Li W, Zhang J. Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-kappaB signaling pathways through TLR4. Int Immunopharmacol. 2015;28:136–45.
20. Tian Y, Zhang Y, Zhang R, Qiao S, Fan J. Resolvin D2 recovers neural injury by suppressing inflammatory mediators expression in lipopolysaccharide-induced Parkinson’s disease rat model. Biochem Biophys Res Commun. 2015;460:799–805.
21. Jing W, Chunhua M, Shumin W. Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-kappaB pathway in vivo and in vitro. Toxicol Appl Pharmacol. 2015;285:128–35.
22. Wu XF, Ouyang ZJ, Feng LL, Chen G, Guo WJ, Shen Y, et al. Suppression of NF-kappaB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone. Toxicol Appl Pharmacol. 2014;281:146–56.
23. Jo YH, Park HC, Choi S, Kim S, Bao C, Kim HW, et al. Metabolomic Analysis Reveals Cyanidins in Black Raspberry as Candidates for Suppression of Lipopolysaccharide-Induced Inflammation in Murine Macrophages. J Agric Food Chem. 2015;63:5449–58.
24. Wu XL, Liou CJ, Li ZY, Lai XY, Fang LW, Huang WC. Sesamol suppresses the inflammatory response by inhibiting NF-kappaB/MAPK activation and upregulating AMP kinase signaling in RAW264.7 macrophages. Inflamm Res. 2015;64:577–88.
25. Cui L, Feng L, Zhang ZH, Jia XB. The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-kappaB pathway activation. Int Immunopharmacol. 2014;23:294–303.
26. Pan H, Xu LH, Ouyang DY, Wang Y, Zha QB, Hou XF, et al. The second-generation mTOR kinase inhibitor INK128 exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 cells. Inflammation. 2014;37:756–65.
27. Ni W, Zhang Q, Liu G, Wang F, Yuan H, Guo Y, et al. Escherichia coli maltose-binding protein activates mouse peritoneal macrophages and induces M1 polarization via TLR2/4 in vivo and in vitro. Int Immunopharmacol. 2014;21:171–80.
28. Jang SE, Jeong JJ, Hyam SR, Han MJ, Kim DH. Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to Toll-like receptor 4 on macrophages. J Agric Food Chem. 2014;62:9711–21.
29. Luo YP, Jiang L, Kang K, Fei DS, Meng XL, Nan CC, et al. Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1. Int Immunopharmacol. 2014;20:24–32.
30. Chao LK, Lin CH, Chiu HW, Wong WT, Chiu HW, Tasi YL, et al. peroxyauraptenol inhibits inflammation and nlrp3 inflammasome activation by inhibiting reactive oxygen species generation and preserving mitochondrial integrity. J Agric and Food Chem 2015.
31. Li X, Zhong F. Nickel induces interleukin-1beta secretion via the NLRP3-ASC-caspase-1 pathway. Inflammation. 2014;37:457–66.
32. Wang S, Zhao J, Wang H, Liang Y, Yang N, Huang Y. Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome. Int Immunopharmacol. 2015;27:38–45.
33. Park J, Min JS, Kim B, Chae UB, Yun JW, Choi MS, et al. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-kappaB pathways. Neurosci Lett. 2015;584:191–6.
34. Li Y, Li J, Li S, Li Y, Wang X, Liu B, et al. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol Appl Pharmacol. 2015;286:53–63.