The Effects of Morin on Lipopolysaccharide-Induced Acute Lung Injury by Suppressing the Lung NLRP3 Inflammasome

Inflammation

Volumn 37, Issue 6, 2014, Pages 1976-1983

  Tianzhu, Zhang ^a   Shihai, Yang ^b   Juan, Du ^c  

^a CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

LPS induced acute lung injury; morin; NLRP3 inflammasome

Indexed keywords

ANTIOXIDANT; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; FLAVONOID; LIPOPOLYSACCHARIDE; MORIN;

ACUTE LUNG INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICALLY INDUCED; DRUG EFFECTS; FEMALE; LUNG; METABOLISM; MOUSE; TREATMENT OUTCOME;

ACUTE LUNG INJURY; ANIMALS; ANTIOXIDANTS; CARRIER PROTEINS; FEMALE; FLAVONOIDS; LIPOPOLYSACCHARIDES; LUNG; MICE; MICE, INBRED BALB C; TREATMENT OUTCOME;

EID: 84928609835     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-9930-1     Document Type: Article

References (20)

1. Rubenfeld, G.D. 2003. Epidemiology of acute lung injury. Critical Care Medicine 31: S276–S284.
2. Zhang, X.M., K.J. Song, H.Z. Xiong, H.Y. Li, X. Chu, and X.M. Deng. 2009. Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice. International Immunopharmacology 9: 1525–1529.
3. Matthay, M.A., G.A. Zimmerman, C. Esmon, J. Bhattacharya, B. Coller, C.M. Doerschuk, et al. 2003. Future research directions in acute lung injury summary of a National Heart Lung and Blood Institute Working Group. American Journal of Respiratory and Critical Care Medicine 167: 1027–1035.
4. Chen, Z., X. Zhang, X. Chu, X. Zhang, K. Song, Y. Jiang, L. Yu, and X. Deng. 2010. Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice. Inflammation 33: 306–314.
5. Itoh, T., H. Obata, S. Murakami, K. Hamada, K. Kangawa, H. Kimura, and N. Nagaya. 2007. Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats. American Journal of Physiology 293: L446–L452.
6. Riedemann, M.E., H.S. Murphy Murphy, and P.A. Ward. 2003. Regulatory effects of iNOS on acute lung inflammatory responses in mice. American Journal of Pathology 163: 2319–2328.
7. Strowig, T., J. Henao-Mejia, E. Elinav, and R. Flavell. 2012. Inflammasomes in health and disease. Nature 481: 278–286.
8. Dinarello, C.A., and G. Fantuzzi. 2003. Interleukin-18 and host defense against infection. Journal of Infectious Diseases 187(Suppl 2): S370–S384.
9. Dinarello, C.A. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annual Review of Immunology 27: 519–550.
10. Wang, L., Y.C. Tu, T.W. Lian, J.T. Hung, J.H. Yen, and M.J. Wu. 2006. Distinctive antioxidant and antiinflammatory effects of flavonols. Journal of Agricultural and Food Chemistry 54: 9798–9804.
11. Kumazawa, Y., K. Kawaguchi, and H. Takimoto. 2006. Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha. Current Pharmaceutical Design 12: 4271–4279.
12. Yunhe, Fu., Liu Bo, Feng Xiaosheng, et al. 2012. The effect of magnolol on the toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice. European Journal of Pharmacology 689: 255–261.
13. Nanashima, N., M. Akita, T. Yamada, T. Shimizu, H. Nakano, Y. Fan, et al. 2008. The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes. Journal of Biological Chemistry 283: 16868–16875.
14. Parsey, M.V., R. Tuder, and E. Abraham. 1998. Neutrophils are major contributors to intraparenchymal lung IL-1β expression after hemorrhage and endotoxemia. Journal of Immunology 160: 1007–1101.
15. Shenkar, R., and E. Abraham. 1999. Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-κB, and cyclic AMP response element binding protein. Journal of Immunology 163: 954–962.
16. Bradley, P.P., D.A. Priebat, R.D. Christensen, and G. Rothstein. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. The Journal of Investigative Dermatology 78: 206–209.
17. Bhatia, M., and S. Moochhala. 2004. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. Journal of Pathology 202: 145–156.
18. Cribbs, S.K., M.A. Matthay, and G.S. Martin. 2010. Stem cells in sepsis and acute lung injury. Critical Care Medicine 38: 2379–2385.
19. Goodman, R.B., J. Pugin, J.S. Lee, and M.A. Matthay. 2003. Cytokine-mediated inflammation in acute lung injury. Cytokine and Growth Factor Reviews 14: 523–535.
20. Giebelen, I.A., D.J. van Westerloo, G.J. LaRosa, A.F. de Vos, and T. van der Poll. 2007. Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung. Shock 28: 700–703.