Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-κB- and MAPK-dependent manner

International Immunopharmacology

Volumn 24, Issue 2, 2015, Pages 440-450

  Reddy, Shridhivya A ^a   Shelar, Sandeep B ^a   Dang, Truong Minh ^b   Lee, Baxter Neng Cun ^a   Yang, Hong ^a,c   Ong, Siew Min ^b   Ng, Hui Li ^a   Chui, Wai Keung ^a   Wong, Siew Cheng ^b   Chew, Eng Hui ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c SCHOOL OF APPLIED SCIENCE   (Singapore)

Author keywords

Human monocytes; Inflammation; Isothiocyanates; MAPK; NF ?B

Indexed keywords

1 ISOTHIOCYANATO 3 (METHYLCARBONYL)PROPANE; CARBONYL DERIVATIVE; CYCLOOXYGENASE 2; GELATINASE B; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; SULFORAPHANE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CYTOKINE; I KAPPA B KINASE; ISOTHIOCYANIC ACID DERIVATIVE; MMP9 PROTEIN, HUMAN; MMP9 PROTEIN, MOUSE; NITRITE; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; SULFORAFAN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ISOLATION; CELL MIGRATION; CELL STIMULATION; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL LINE; CELL MOTION; CELL SURVIVAL; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; CYTOKINES; DINOPROSTONE; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; ISOTHIOCYANATES; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 9; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PHAGOCYTOSIS;

EID: 84921416531     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.12.037     Document Type: Article

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