The cationic amphiphile 3,4-bis(tetradecyloxy)benzylamine inhibits LPS signaling by competing with endotoxin for CD14 binding

Biochemical Pharmacology

Volumn 80, Issue 12, 2010, Pages 2050-2056

  Piazza, Matteo ^a   Calabrese, Valentina ^a   Baruffa, Chiara ^a   Gioannini, Theresa ^b,c   Weiss, Jerrold ^b   Peri, Francesco ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF IOWA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

CD14; Endotoxin; Inflammation; LPS; Septic shock; TRL4

Indexed keywords

3,4 BIS(TETRADECYLOXY)BENZYLAMINE; CD14 ANTIGEN; ENDOTOXIN; LIPOOLIGOSACCHARIDE; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN; PROTEIN INHIBITOR; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; ANTIGENS, CD14; BENZYLAMINES; BINDING, COMPETITIVE; CELL LINE; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; NF-KAPPA B; SURFACE-ACTIVE AGENTS; TOLL-LIKE RECEPTOR 4;

EID: 78049435260     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.06.019     Document Type: Article

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