Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

Neuroscience Letters

Volumn 584, Issue , 2015, Pages 191-196

  Park, Junghyung ^a   Min, Ju Sik ^a   Kim, Bokyung ^a   Chae, Un Bin ^a   Yun, Jong Won ^b   Choi, Myung Sook ^a   Kong, Il Keun ^c   Chang, Kyu Tae ^d   Lee, Dong Seok ^a  

^a Kyungpook National University   (South Korea)

^b Daegu University   (South Korea)

^c Gyeongsang National University   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Lipopolysaccharide; MAPKs; Microglia; Mito TEMPO; Mitochondrial ROS; NF B

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHONIUM DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; [2 (2,2,6,6 TETRAMETHYLPIPERIDIN 1 OXYL 4 YLAMINO) 2 OXOETHYL]TRIPHENYLPHOSPHONIUM CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOTEMPO; ORGANOPHOSPHORUS COMPOUND; PIPERIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG MECHANISM; IMMUNE RESPONSE; INFLAMMATION; MICROGLIA; MITOCHONDRION; NONHUMAN; ANIMAL; CELL LINE; DRUG EFFECTS; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INFLAMMATION; LIPOPOLYSACCHARIDES; MAP KINASE KINASE 4; MICE; MICROGLIA; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; ORGANOPHOSPHORUS COMPOUNDS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PIPERIDINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84910046575     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.10.016     Document Type: Article

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