The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation

International Immunopharmacology

Volumn 23, Issue 1, 2014, Pages 294-303

  Cui, Li ^a   Feng, Liang ^a   Zhang, Zhen Hai ^a   Jia, Xiao Bin ^a  

^a KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

Author keywords

Baicalin; NF B; Pathway; TLR4; Ulcerative colitis

Indexed keywords

BAICALIN; CYCLOOXYGENASE 2; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESALAZINE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; CCL2 PROTEIN, MOUSE; CYTOKINE; FLAVONOID; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; COLON MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIARRHEA; DISEASE ACTIVITY; DISEASE SEVERITY; DOWN REGULATION; DRUG MEGADOSE; ENZYME ACTIVITY; EXPERIMENTAL COLITIS; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LOOSE FECES; LOW DRUG DOSE; MALE; MELENA; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STOMACH LAVAGE; TREATMENT DURATION; WEIGHT REDUCTION; WESTERN BLOTTING; ANIMAL; CELL LINE; COLITIS, ULCERATIVE; COLON; DISEASE MODEL; DRUG EFFECTS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CHEMOKINE CCL2; COLITIS, ULCERATIVE; COLON; CYTOKINES; DISEASE MODELS, ANIMAL; FLAVONOIDS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MICE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84907504042     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.09.005     Document Type: Article

References (41)

1. B. Khor, A. Gardet, and R. Xavier Genetics and pathogenesis of inflammatory bowel disease Nature 118 2011 307 317
2. Q. Ouyang, R. Tandon, K.L. Goh, C.J. Ooi, H. Ogata, and C. Fiocchi The emergence of inflammatory bowel disease in the Asian Pacific region Curr Opin Gastroenterol 21 2005 408 413
3. F. Gutierrez-Orozco, J.M. Thomas-Ahner, L.D. Berman-Booty, J.D. Galley, C. Chitchumroonchokchai, and T. Mace Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice Mol Nutr Food Res 58 2014 1226 1238
4. M.M. Heimesaat, A. Fischer, H.K. Jahn, J. Niebergall, M. Freudenberg, and M. Blaut Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli Gut 56 2007 941 948
5. S. Lin, Q. Yin, Q. Zhong, F.L. Lv, Y. Zhou, and J.Q. Li Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage J Neuroinflammation 9 2012 46
6. R. Fiorotto, R. Scirpo, M. Trauner, L. Fabris, R. Hoque, and C. Spirli Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice Gastroenterology 141 2011 1498 1508
7. J.K. Ko, and K.K. Auyeung Inflammatory bowel disease: etiology, pathogenesis and current therapy Curr Pharm Des 20 2014 1082 1096
8. G.X. Liu, Y.X. Yang, J. Yan, T. Zhang, Y.P. Zou, and X.L. Huang Glial-derived neurotrophic factor reduces inflammation and improves delayed colonic transit in rat models of dextran sulfate sodium-induced colitis Int Immunopharmacol 19 2014 145 152
9. G. Lanzoni, G. Roda, A. Belluzzi, E. Roda, and G.P. Bagnara Inflammatory bowel disease: moving toward a stem cell-based therapy World J Gastroenterol 14 2008 4616 4626
10. M. Li-Weber New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin Cancer Treat Rev 35 2009 57 68
11. M. Guo, N. Zhang, D. Li, D. Liang, Z. Liu, and F. Li Baicalin plays an anti-inflammatory role through reducing nuclear factor-κB and p38 phosphorylation in S. aureus-induced mastitis Int Immunopharmacol 16 2013 125 130
12. L. Taiming, and J. Xuehua Investigation of the absorption mechanisms of baicalin and baicalein in rats J Pharm Sci 95 2006 1326 1333
13. T. Lu, J. Song, F. Huang, Y. Deng, L. Xie, and G. Wang Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats J Ethnopharmacol 110 2007 412 418
14. C. Zhang, Y.L. Chi, P.Y. Wang, Y.Q. Wang, Y.X. Zhang, and J. Deng MiR-511 and miR-1297 inhibit human lung adenocarcinoma cell proliferation by targeting oncogene TRIB2 PLoS One 7 2012 e46090
15. G.P. Morris, P.L. Beck, M.S. Herridge, W.T. Depew, M.R. Szewczuk, and J.L. Wallace Hapten-induced model of chronic inflammation and ulceration in the rat colon Gastroenterology 96 1989 795 803
16. X. Deng, G. Tolstanova, T. Khomenko, L. Chen, A. Tarnawski, and S. Szabo Mesalamine restores angiogenic balance in experimental ulcerative colitis by reducing expression of endostatin and angiostatin: novel molecular mechanism for therapeutic action of mesalamine J Pharmacol Exp Ther 331 2009 1071 1078
17. H.S. Cooper, S.N. Murthy, R.S. Shah, and D.J. Sedergran Clinicopathologic study of dextran sulfate sodium experimental murine colitis Lab Invest 69 1993 238 249
18. A.F. Bento, D.F. Leite, R.F. Claudino, D.B. Hara, P.C. Leal, and J.B. Calixto The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice J Leukoc Biol 84 2008 1213 1221
19. C. Schierwagen, A.C. Bylund-Fellenius, and C. Lundberg Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity J Pharmacol Methods 23 1990 179 186
20. H. Fan, X.X. Liu, L.J. Zhang, H. Hu, Q. Tang, and X.Y. Duan Intervention effects of QRZSLXF, a Chinese medicinal herb recipe, on the DOR-β-arrestin1-Bcl2 signal transduction pathway in a rat model of ulcerative colitis J Ethnopharmacol 154 2014 88 97
21. L. Liu, Y.H. Li, Y.B. Niu, Y. Sun, Z.J. Guo, and Q. Li An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer Carcinogenesis 31 2010 1822 1832
22. X. Teng, L.F. Xu, P. Zhou, H.W. Sun, and M. Sun Effects of trefoil peptide 3 on expression of TNF-alpha, TLR4, and NF-kappaB in trinitrobenzene sulphonic acid induced colitis mice Inflammation 32 2009 120 129
23. D.K. Zhang, L.N. Cheng, X.L. Huang, W. Shi, J.Y. Xiang, and H.T. Gan Tetrandrine ameliorates dextran sulfate sodium-induced colitis in mice through inhibition of nuclear factor-kappa B activation Int J Colorectal Dis 24 2009 5 12
24. L.A. Menchén, A.L. Colón, M.A. Moro, J.C. Leza, I. Lizasoain, and P. Menchén N-(3-(aminomethyl)benzyl) acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats Life Sci 69 2001 479 491
25. J.H. Lee, B. Lee, H.S. Lee, E.A. Bae, H. Lee, and Y.T. Ahn Lactobacillus suntoryeus inhibits pro-inflammatory cytokine expression and TLR-4-linked NF-kappaB activation in experimental colitis Int J Colorectal Dis 24 2009 231 237
26. Z. Li, K. Zhang de, W.Q. Yi, Q. Ouyang, Y.Q. Chen, and H.T. Gan NF-kappaB p65 antisense oligonucleotides may serve as a novel molecular approach for the treatment of patients with ulcerative colitis Arch Med Res 39 2008 729 734
27. G. Diamant, and R. Dikstein Transcriptional control by NF-κB: elongation in focus Biochim Biophys Acta 2013 1829 937 945
28. J. Cheng, Y.M. Shah, X. Ma, X. Pang, T. Tanaka, and T. Kodama Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation J Pharmacol Exp Ther 335 2010 32 41
29. A.A. Mohamed, L. Rashed, H. Amin, M. Abu-Farha, S.A. El Fadl, and S. Pakhoum K469E polymorphism of the intercellular adhesion molecule-1 gene in Egyptians with coronary heart disease Ann Saudi Med 30 2010 432 436
30. B. Vainer, and O.H. Nielsen Changed colonic profile of P-selectin, platelet-endothelial cell adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), ICAM-2, and ICAM-3 in inflammatory bowel disease Clin Exp Immunol 121 2000 242 247
31. M. Uguccioni, P. Gionchetti, D.F. Robbiani, F. Rizzello, S. Peruzzo, and M. Campieri Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis Am J Pathol 155 1999 331 336
32. W.I. Khan, Y. Motomura, H. Wang, R.T. El-Sharkawy, E.F. Verdu, and M. Verma-Gandhu Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells Am J Physiol Gastrointest Liver Physiol 291 2006 G803 G811
33. A. Tabernero, J.M. Reimund, S. Chasserot, C.D. Muller, and R. Andriantsitohaina Cyclooxygenase-2 expression and role of vasoconstrictor prostanoids in small mesenteric arteries from patients with Crohn's disease Circulation 107 2003 1407 1410
34. K.M. Sakthivel, and C. Guruvayoorappan Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis Int Immunopharmacol 17 2013 907 916
35. I.I. Singer, D.W. Kawka, S. Schloemann, T. Tessner, T. Riehl, and W.F. Stenson Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease Gastroenterology 115 1998 297 306
36. Y. Ishiguro Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis J Gastroenterol 34 1999 66 74
37. G. Rogler, and T. Andus Cytokines in inflammatory bowel disease World J Surg 22 1998 382 389
38. I.J. Fuss, T. Marth, M.F. Neurath, G.R. Pearlstein, A. Jain, and W. Strober Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice Gastroenterology 117 1999 1078 1088
39. M. Suzuki, T. Hisamatsu, and D.K. Podolsky Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex Infect Immun 71 2003 3503 3511
40. M.E. Blam, R.B. Stein, and G.R. Lichtenstein Integrating anti-tumor necrosis factor therapy in inflammatory bowel disease: current and future perspectives Am J Gastroenterol 96 2001 1977 1997
41. R.B. Sartor Cytokines in intestinal inflammation: pathophysiological and clinical considerations Gastroenterology 106 1994 533 539