Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation

Immunobiology

Volumn 220, Issue 7, 2015, Pages 889-898

  Ahmad, Sheikh Fayaz ^a   Ansari, Mushtaq Ahmad ^a   Zoheir, Khairy M A ^a,b   Bakheet, Saleh A ^a   Korashy, Hesham M ^a   Nadeem, Ahmed ^a   Ashour, Abdelkader E ^a   Attia, Sabry M ^a,c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c Al Azhar University   (Egypt)

Author keywords

4 Methylhistamine dihydrochloride; Histamine 4 receptor; Inflamed rat knee; JAK STAT signaling pathway; JNJ77777120; Lipopolysaccharide; Tumor necrosis factor alpha

Indexed keywords

HISTAMINE H4 RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; JANUS KINASE; JANUS KINASE 1; LIPOPOLYSACCHARIDE; MESSENGER RNA; STAT PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; 4-METHYLHISTAMINE; ANTIHISTAMINIC AGENT; ANTIINFLAMMATORY AGENT; G PROTEIN COUPLED RECEPTOR; HISTAMINE AGONIST; HISTAMINE DERIVATIVE; HISTAMINE RECEPTOR; HRH4 PROTEIN, RAT; I KAPPA B; IL1B PROTEIN, RAT; INDOLE DERIVATIVE; JAK1 PROTEIN, RAT; NF-KAPPAB INHIBITOR ALPHA; PIPERAZINE DERIVATIVE; STAT3 PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BLOOD; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INFLAMMATION; KNEE; METABOLISM; PATHOLOGY; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; I-KAPPA B PROTEINS; INDOLES; INFLAMMATION; INTERLEUKIN-1BETA; JANUS KINASE 1; KNEE JOINT; LIPOPOLYSACCHARIDES; METHYLHISTAMINES; NF-KAPPA B; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84988241370     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2015.01.008     Document Type: Article

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