Chemodiversity in the genus Aspergillus

Applied Microbiology and Biotechnology

Volumn 99, Issue 19, 2015, Pages 7859-7877

  Frisvad, Jens C ^a   Larsen, Thomas O ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Aspergillus; Chemodiversity; Extrolites; Heteroisoextrolites; Secondary metabolites

Indexed keywords

ASPERGILLUS; BIOMOLECULES; BIOSYNTHESIS; DNA SEQUENCES; MOLECULES;

CHEMODIVERSITY; EXTROLITES; GENOME SEQUENCING PROJECTS; HETEROISOEXTROLITES; SECONDARY METABOLITE PRODUCTION; SECONDARY METABOLITES; SMALL MOLECULES; SPECIES SPECIFICS;

METABOLITES;

BIOACTIVITY; BIOTECHNOLOGY; CHEMOTAXONOMY; CLADISTICS; DRUG; FUNGUS; GENOME; HERITABILITY; PHYLOGENETICS; SECONDARY METABOLITE; SPECIES DIVERSITY;

ASPERGILLUS; BIODIVERSITY; CHEMOTAXONOMY; FUNGAL GENE; FUNGUS ISOLATION; GENE SEQUENCE; METABOLITE; NONHUMAN; PHYLOGENY; REVIEW; CHEMISTRY; CLASSIFICATION; GENETICS; ISOLATION AND PURIFICATION; MOLECULAR GENETICS;

ASPERGILLUS; DICHOTOMOMYCES; FUNGI;

ASPERGILLUS; BIODIVERSITY; MOLECULAR SEQUENCE DATA; PHYLOGENY;

EID: 84941187997     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-6839-z     Document Type: Review

References (226)

1. Abad A, Fernandez-Molina V, Bikandi J, Ramirez A, Margareto J, Sendino J, Hernando FL, Ponton J, Garaizor J, Rementeria A (2010) What makes Aspergillus fumigatus such a successful pathogen? Rev Iberoam Micol 27:155–182
2. Abarca ML, Accensi F, Cano J, Cabañes FJ (2004) Taxonomy and significance of black Aspergilli. Antonie Van Leeuwenhoek 86:33–49
3. Amatov T, Jahn U (2014) Gliotoxin: nature’s way of making epidithio bridge. Angew Chem Int Ed 53:3312–3314
4. Andersen MR, Salazar MP, Schaap PJ, van de Vondervoort PJI, Culley D, Thykaer J, Frisvad JC, Nielsen KF, Albang R, Albermann K, Berka RM, Braus GH, Braus-Stromeyer SA, Corrochano LM, Dai Z, van Dijck PWM, Hofmann G, Lasure LL, Magnusson JK, Meijer SL, Nielsen JB, Nielsen ML, van Ooyen AJJ, Panther KS, Pel HJ, Poulsen L, Samson RA, Stam H, Tsang A, van den Brink JM, Atkins A, Aerts A, Shapiro H, Pangilinan J, Salamov A, Lou Y, Lindquist E, Lucas S, Grimwood J, Grigoriev IV, Kubicek CP, Martinez D, van NNME P, Roubos JA, Nielsen J, Baker S (2011) Comparative genomics of citric-acid producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88. Genome Res 21:885–897
5. Andersen R, Büchi G, Kobbe B, Demain AL (1977) Secalonic acids D and F are toxic metabolites of Aspergillus aculeatus. J Org Chem 42:352–353
6. Arabatis M, Velegraki A (2013) Sexual reproduction in the opportunistic human pathogen Aspergillus terreus. Mycologia 105:71–79
7. Arnstein HRV, Cook AH (1947) The penicillin produced by Aspergillus parasiticus. Br J Exp Pathol 28:94–98
8. Assante G, Camarda L, Merlini L, Nasini G (1979) Secondary mould metabolites. VII. Long-chain derivatives of citraconic anhydride: new metabolites of Aspergillus wentii Wehmer. Gazz Chim Ital 109:151–153
9. Assante G, Camarda L, Nasini G (1980) Secondary mould metabolites. IX. Structure of a new bianthrone and three secoanthraquinones from Aspergillus wentii Wehmer. Gazz Chim Ital 110:629–631
10. Baker S (2006) Aspergillus niger genomics: past, present and into the future. Med Mycol 44(Suppl 1):S17–S21
11. Balajee SA, Baddley JW, Peterson SW, Nickle D, Varga J, Boey A, Lass-Flörl C, Frisvad JC, Samson RA, the ISHAM Working group on A. terreus (2009) Aspergillus alabamensis, a new clinically relevant species in the section Terrei. Euk Cell 8:713–722
12. Barrow CJ, Cai P, Snyder JK, Sedlock DM, Sun HH, Cooper R (1993) WIN 64821, a new competitive antagonist to substance P, isolated from an Aspergillus species: structure determination and solution conformation. J Org Chem 58:6016–6021
13. Barrs VR, van Doorn TM, Houbraken J, Kidd SE, Martin P, Pinheiro MD, Richardson M, Varga J, Samson RA (2013) Aspergillus felis sp. nov., an emerging agent of invasive aspergillosis in humans, cats, and dogs. PLoS One 8: e64871
14. Berg DH, Massing RP, Hoehn MM, Boeck LD, Hamill RL (1976) A30461, a new epidithiodiketopiperazine with antifungal activity. J Antibiot 24:394–397
15. Brakhage AA (2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11:21–32
16. Brown DW, Salvo JJ (1994) Isolation and characterization of sexual spore pigments from Aspergillus nidulans. Appl Environ Microbiol 60:979–983
17. Bugni TS, Abbanat D, Berman VS, Maiese NM, Greenstein M, van Wagoner RM, Ireland CM (2014) Yanuthones: novel metabolites from a marine isolate of Aspergillus niger. J Org Chem 65:7195–7200
18. Burns MK, Coffin JM, Kurobane I, Vining LC (1979) Biosynthesis of chlorflavonin in Aspergillus candidus: a novel fungal route to flavonoids. J Chem Soc Chem Commun 1979:426–427
19. Busi S, Peddikotla P, Upadyayula SM, Yenamandav V (2009) Isolation and biological evaluation of two bioactive metabolites from Aspergillus gorakhpurensis. Rep Nat Prod 3:161–164
20. Buzina W (2013) Aspergillus—classification and antifungal susceptibilities. Curr Pharm Des 19:3615–3628
21. Cai S, Kong DX, Wang W, Zhou H, Zhu T, Li DH, Gu Q-Q (2012) Aspergilazine a, a diketopiperazine dimer with a rare N-1 to C-6 linkage, from a marine-derived fungus Aspergillus taichungensis. Tetrahedron Lett 53:2615–2617
22. Cai S, Luan Y, Kong X, Zhu T, Gu Q-Q, Li DH (2013) Isolation and photoinduced conversion of 6-epi-stephacidins from Aspergillus taichungensis. Org Lett 15:2168–2171
23. Campbell MA, Rokas A, Slot JC (2012) Horizontal transfer and death of a fungal secondary metabolite gene cluster. Genome Biol Evol 4:289–293
24. Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C (2014) Biosynthesis of the halogenated mycotoxin aspirochlorin in koji mold involves a cryptic amino acid conversion. Angew Chem Int Ed 53:13909–13913
25. Chiang Y-M, Oakley BR, Keller NP, Wang CCC (2010) Unraveling polyketide synthesis in members of the genus Aspergillus. Appl Microbiol Biotechnol 86:1719–1736
26. Clark AM, Hufford CD, Robertson LW (1977) 2 metabolites from Aspergillus flavipes. Lloydia –. J Nat Prod 40:146–151
27. Cole RJ, Dorner JW, Springer JP, Cox RH (1981) Indole metabolites from a strain of Aspergillus flavus. J Agric Food Chem 29:293–295
28. Cole RJ, Schweikert MA (2003) Handbook of secondary fungal metabolites vol. I & II. Academic Press, Amsterdam
29. Cole RJ, Jarvis BB, Schweikert MA (2003) Handbook of secondary fungal metabolites vol. I. Academic Press, Amsterdam
30. Cosulich DB, Nelseon NR, van den Hende JH (1968) Crystal and molecular structure of LL-S88a an antiviral epidithiapiperazinedione derivative from Aspergillus terreus. J Amer Chem Soc 90:6519–6521
31. Cruickshank RH, Pitt JI (1990) Isozyme patterns in Aspergillus flavus and closely related species. In: RA Samson and JI Pii (eds): Modern concepts in Penicillium and Aspergillus and classification. Plenum Press, New York, pp. 259-264
32. Cutler HG, Crumley FG, Cox RH, Hernandez O, Cole RJ, Dorner JW (1979) Orlandin: a nontoxic fungal metabolite with plant growth inhibiting properties. J Agric Food Chem 27:592–595
33. De Vries RP, Frisvad JC, van de Vondervoort PJI, Burgers K, Kuijpers AFA, Samson RA (2005) Aspergillus vadensis, a new species of the group of black Aspergilli. Antonie Van Leeuwenhoek 87:195–203
34. Dorner JW, Cole RJ, Springer JP, Cox RH, Cutler H, Wicklow DT (1980) Isolation and identification of two new biologically active norditerpene dilactones from Aspergillus wentii. Phytochem 19:1157–1161
35. Dulaney EL (1947a) Some aspects of penicillin production by Aspergillus nidulans. Mycologia 39:570–581
36. Dulaney EL (1947b) Penicillin production by Aspergillus nidulans group. Mycologia 39:582–586
37. Fedorova ND, Khaldi N, Joardar VS, Maiti R, Amedeo P, Anderson MJ, Crabtree J, Silva JC, Badger JH, Albarraq A, Angiuoli S, Bussey H, Rowyer P, Cotty PJ, Dyer PS, Egan A, Galens K, Fraser-Liggett CM, Haas BJ, Inman JM, Kent R, Lemieux S, Malazavi I, Orvis J, Roemer T, Ronning CM, Sundaram JP, Sutton G, Turner G, Venter JC, White OR, Whitty BR, Youngman P, Wolfe KH, Goldman GH, Wortman JR, Jiang B, Denning JW, Nierman WC (2008) Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. PLoS Genet 4: e1000046
38. Findlay JA, Radics L (1972) Flavipucine [3′-isovaleryl-6-methylpyridine-3-spiro-2′-oxiran-2(1H),-4(3H)-dione], an antibiotic from Aspergillus flavipes. J Chem Soc C 1972:2071–2074
39. Finefield JM, Frisvad JC, Sherman DH, Williams RM (2012) Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indol alkaloids. J Nat Prod 75:812–833
40. Frisvad JC (1985) Secondary metabolites as aid to Emericella classification. In: Samson RA, Pitt JI (eds) Advances in Penicillium and Aspergillus systematics. Plenum Press, New York, pp. 437–443
41. Frisvad JC (2015) Taxonomy, chemodiversity, and chemoconsistency of Aspergillus, Penicillium, and Talaromyces species. Front Microbiol 5: Article 773
42. Frisvad JC, Samson RA (1990) Chemotaxonomy and morphology of Aspergillus fumigatus and related taxa. In: RA Samson and JI Pii (eds): Modern concepts in Penicillium and Aspergillus and classification. Plenum Press, New York, pp. 201-208
43. Frisvad JC, Samson RA (2000) Neopetromyces gen. nov. and an overview of teleomorphs of Aspergillus subg. Circumdati. Stud Mycol 45:201–207
44. Frisvad JC, Frank JM, Houbraken JAMP, Kuijpers AFA, Samson RA (2004a) New ochratoxin producing species of Aspergillus section Circumdati. Stud Mycol 50:23–43
45. Frisvad JC, Smedsgaard J, Larsen TO, Samson RA (2004b) Mycotoxins, drugs and other extrolites produced by species in Penicillium subgenus Penicillium. Stud Mycol 49:201–241
46. 1, sterigmatocystin and 3-O-methylsterigmatocystin, Aspergillus rambellii sp. nov. Syst Appl Microbiol 28:442–453
47. Frisvad JC, Larsen TO, de Vries R, Meijer M, Houbraken J, Cabañes FJ, Ehrlich K, Samson RA (2007a) Secondary metabolite profiling, growth profiles and other tools for species recognition and important Aspergillus mycotoxins. Stud Mycol 59:31–37
48. 2 production by Aspergillus niger. J Agric Food Chem 55:9727–9732
49. Frisvad JC, Andersen B, Thrane U (2008) The use of secondary metabolite profiling in fungal taxonomy. Mycol Res 112:231–240
50. Frisvad JC, Rank C, Nielsen KF, Larsen TO (2009) Metabolomics of Aspergillus fumigatus. Med Mycol 47:S53–S71
51. Frisvad JC, Larsen TO, Thrane U, Meijer M, Varga J, Samson RA, Nielsen KF (2011) Fumonisin and ochratoxin production in industrial Aspergillus niger strains. PLoS One 6: e23496
52. Frisvad JC, Petersen LM, Lyhne EK, Larsen TO (2014) Formation of sclerotia and production of indoloterpenes by Aspergillus niger and other species in section Nigri. PLoS One 9: e94857
53. Gallagher RT, McCabe T, Hirotsu K, Clardy J, Nicholson J (1980) Aflavinine, a novel indole-mevalonate metabolite from tremorgen-producing Aspergillus flavus species. Tetrahedron Lett 21:243–246
54. Gao H, Guo W, Wang Q, Zhang L, Zhu M, Zhu TJ, Gu Q-Q, Wang W, Li DH (2013) Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity. Bioorg Med Chem Lett 23:1776–1778
55. Geiser D, Frisvad JC, Taylor JW (1998) Evolutionary relationships in Aspergillus section Fumigati inferred from partial beta-tubulin and hydrophobin DNA sequences. Mycologia 90:832–846
56. Geiser DM, Klich MA, Frisvad JC, Peterson SW, Varga J, Samson RA (2007) Current status of species recognition and identification in Aspergillus. Stud Mycol 59:1–10
57. Gibbons JG, Rokas A (2013) The function and evolution of the Aspergillus genome. Trends Microbiol 21:14–22
58. Goldberg I, Rokem JS, Pines O (2006) Organic acids: old metabolites new themes. J Chem Technol Biotechnol 81:1601–1611
59. Gomes NM, Dethoup T, Singburaudom N, Gales L, Silva AMS, Kijjoa A (2012) Eurocristatine, a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum. Phytochem Lett 5:717–720
60. Greiner K, Persoh D, Weig A, Rambold G (2014) Phialosimplex salinarum, a new species of Eurotiomycetes from a hypersaline habitat. IMA Fungus 5:161–172
61. Guo, C-J., Sun, W-W, Bruno KS, Wang CC. 2014. Molecular genetic characterization of terreic acid pathway in Aspergillus terreus. Org Lett 16: 5250-5253
62. Guo C-J, Yeh H-H, Chiang Y-M, Sanchez JF, Chang S-L, Bruno KS, Wang CCC (2013) Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis. J Amer Chem Soc 135:7205–7213
63. Guo C-J, Wang CCC (2014) Recent advances in genome mining of secondary metabolites in Aspergillus terreus. Front Microbiol 5: Art 717
64. Hamazaki T, Kimura Y (1983) Isolation and structures of four new metabolites from Aspergillus wentii. Agric Biol Chem 47:163–165
65. Harms H, Rempel V, Kehraus S, Kaiser M, Hufendiek P, Muller CE, Konig GM (2014) Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity ast GPR18 and cinnabinoid receptors. J Nat Prod 77:673–677
66. Hawksworth DL (2011) Naming Aspergillus species: progress towards one name for each species. Med Mycol 49:570–576
67. Hawksworth DL, Crous PW, Redhead SA, Reynolds DR, Samson RA, Seifert KA, Taylor JW, Wingfield MJ, Abasi Ö, Aime C, Asan A, Bai F-Y, de Beer ZW, Gegerow D, Berikten D, Boekhout T, Buchanan PK, Burgess T, Buzina W, Cai L, Cannon PF, Crane JL, Damm U, Daniel H-M, van Diepeningen AD, Druzhinina I, Dyer PS, Eberhardt U, Fell JW, Frisvad JC, Geiser DM, Geml J, Glienke C, Gräfenhan T, Greonewald JZ, Groenewald M, de Gruyter J, Guého-Kellerman E, Guo L-D, Hibbett DS, Hong S-B, de Hoog GS, Houbraken J, Huhndorf SM, Hyde KD, Ismail A, Johnston PR, Kadaifciler DG, Kirk PM, Kõljalg U, Kurtzman CP, Lagneau P-E, Lévesque CA, Liu X, Lombard L, Meyer W, Miller A, Minter DW, Najafzadeh MJ, Norvell L, Ozeweskaya SM, Öziç R, Pennycock SR, Peterson SW, Pettersson OV, Quaedvlieg W, Robert VA, Riubal C, Schnürer J, Schroers H-J, Shivas R, Slippers B, Spierenburg H, Takashima M, Taşkin E, Thines M, Thrane U, Uztan AH, van Raak M, Varga J, Vasco A, Verkley G, Videira SIR, de Vries RP, Weir BS, Yilmaz N, Yurkov A, Zhang N (2011) The Amsterdam declaration on fungal nomenclature. IMA Fungus 2:105–112
68. Hiort J, Maksimenka K, Reichert M, Perovic-Ottstadt S, Lin WH, Wray V, Steube K, Schaumann K, Weber H, Proksch P, Ebel R, Muller WEG, Bringman G (2004) New natural products from the sponge-derived fungus Aspergillus niger. J. Nat Prod 67:1532–1543
69. Holm DK, Petersen LM, Klitgaard A, Knudsen PB, Jarzynska ZD, Nielsen KF, Gotfredsen CH, Larsen TO, Mortensen UH (2014) Molecular and chemical characterization of the biosynthesis of the 6-MSA-derived meroterpenoid yanuthone D in Aspergillus niger. Chem Biol 21:519–529
70. Hong SB, Go SJ, Shin HD, Frisvad JC, Samson RA (2005) Polyphasic taxonomy of Aspergillus fumigatus and related species. Mycologia 97:1316–1329
71. Hong SB, Cho HS, Shin HD, Frisvad JC, Samson RA (2006) New Neosartorya species isolated from soil in Korea. Int J Syst Evol Microbiol 56:439–442
72. Hong SB, Shin HD, Hong J, Frisvad JC, Nielsen PV, Varga J, Samson RA (2008) New taxa of Neosartorya and Aspergillus in Aspergillus section Fumigati. Antonie Van Leeuwenhoek 93:87–98
73. Hong S-B, Lee M, Kim D-H, Varga J, Frisvad JC, Perrone G, Gomi K, Yamada O, Machida M, Houbraken J, Samson RA (2013) Aspergillus luchuensis, an industrially important black Aspergillus in East Asia. PLoS One 8: e63769.
74. Horie Y (1980) Ascospore ornamentation and its application to the taxonomic re-evaluation of Emericella. Trans Mycol Soc Japan 21:483–493
75. Horn BW, Moore GG, Carbone I (2009a) Sexual reproduction in Aspergillus flavus. Mycologia 101:423–429
76. Horn BW, Moore GG, Carbone I (2009b) Sexual reproduction in aflatoxin-producing Aspergillus nomius. Mycologia 103:174–183
77. Horn BW, Ramirez-Prado JH, Carbone I (2009c) The sexual state of Aspergillus parasiticus. Mycologia 101:275–280
78. Horn BW, Olarte RA, Peterson SW, Carbone I (2013) Sexual reproduction in Aspergillus tubingensis from section Nigri. Mycologia 105:1153–1163
79. Houbraken J, Samson RA (2011) Phylogeny of Penicillium and the segregation of Trichocomaceae into three families. Stud Mycol 70:1–51
80. Houbraken J, de Vries RP, Samson RA (2012) Modern taxonomy of biotechnological important Aspergillus and Penicillium species. Adv Appl Microbiol 66:199–249
81. Houbraken J, Due M, Varga J, Meijer M, Frisvad JC, Samson RA (2007) Polyphasic taxonomy of Aspergillus section Usti. Stud Mycol 59:107–128
82. Hubka V, Kolarik M, Kubátová A, Peterson SW (2013) Taxonomic revision of Eurotium and transfer to Aspergillus. Mycologia 105:912–937
83. Hubka V, Nováková A, Kolarik M, Jurjevic Z, Peterson SW (2015) Revision of Aspergillus section Flavipedes: seven new species and proposal of section Jani sect. nov. Mycologia 107:169–208
84. Ishida M, Hamasaki T, Hatsuda Y (1975) The structure of two new metabolites, emerin and emericellin, from Aspergillus nidulans. Agric Biol Chem 39:2181–2184
85. Ishikawa N, Tanaka H, Koyama F, Noguchi H, Wang CCC, Hotta K, Watanabe K (2014) Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids. Angew Chem Int Ed 53:12880–12884
86. Itabashi T, Matsuishi N, Hosoe T, Toyazaki N, Udagawa S, Imai T, Adachi M, Kawai K (2006) Two new dioxopiperazine derivatives, arestrictins A and B, isolated from Aspergillus restrictus and Aspergillus penicillioides. Chem Pharm Bull 54:1639–1641
87. Izhaki I (2002) Emodin—a secondary metabolite with multiple ecological functions in higher plants. New Phytol 155:205–217
88. Jurjevic Z, Peterson SW, Horn BW (2012a) Aspergillus section Versicolores: nine new species and multilocus sequence based phylogeny. IMA Fungus 3:59–79
89. 1H NMR. RCS Adv 4:7710–7715
90. Jurjevic Z, Peterson SW, Stea G, Solfrizzo M, Varga J, Hubka V, Perrone G (2012b) Two novel species of Aspergillus section Nigri from indoor air. IMA Fungus 3:159–173
91. Kato H, Sugimoto K, Nakahara T, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S (2015) Isolation of notoamide S and enantiomeric 6-epistephacidin A from the terrestrial fungus Aspergillus amoenus: biogenetic implications. Org Lett 17:700–703
92. Kawahara N, Selkita S, Satake M, Usagawa S, Kawai K (1994) Structures of a new dihydroxanthone derivative, nidulalin A, and a new benzophenone derivative, nidulalin B, from Emericella nidulans. Chem Pharm Bull 42:1720–1723
93. Khaldi N, Wolfe KH (2011) Evolutionary origins of the fumonisin secondary metabolite gene cluster in Fusarium verticillioides and Aspergillus niger. Int J Evol Biol 2011:423821
94. Khaldi N, Collemare J, Lebrun MH, Wolfe KH (2008) Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi. Genome Biol 9:R18
95. Kinoshita K (1931) Über ein neue Aspergillus Art Aspergillus itaconicus nov. Spec. Bot Mag 45: 45-61
96. Klich MA (1993) Morphological studies of Aspergillus section Versicolores and related species. Mycologia 85:100–107
97. Klich MA (2002) Identification of common Aspergillus species. Centraalbureau voor Schimmelcultures, Utrecht
98. Knuf C, Nookaew I, Remmers I, Khoomrung S, Brown S, Berry A, Nielsen J (2014) Physiological characterization of high malic acid producing Aspergillus oryzae strain 2103a-68. Appl Microbiol Biotechnol 98:3517–3527
99. Kontani M, Fukushima Y, Sakagami Y, Marumo S (1990) Inhibitors of β-glucan biosynthesis in fungal metabolites. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 32:103–110
100. Kornsakulkarn J, Saepua S, Srichomthong K, Supothina S, Thongpanchang C (2012) New mycotoxins from the scale insect fungus Aschersonia coffeae Henn. BBC 28712. Tetrahedron 68:8480–8486
101. Kornsakulkarn J, Saepua S, Laksanacharoen P, Rachtawee P, Thongpanchang C (2013) Xanthone and anthraquinone-type mycotoxins from the scale insect fungus Aschersonia marginata BCC 28721. Tetrahedron Lett 54:3813–3815
102. Kozakiewicz Z (1989) Aspergillus species on stored products. Mycol Pap 161:1–188
103. Kupfahl C, Michalka A, Lass-Flörl C, Fischer G, Haase G, Ruppert T, Geginat G, Hof H (2008) Gliotoxin production by clinical and environmental Aspergillus fumigatus strains. Int J Med Microbiol 298:319–327
104. Laakso JA, Gloer JB, Wicklow DT, Dowd PF (1992) Radarin A, radarin B, radarin C, and radarin D—new antiinsectan and cytotoxic indole diterpenoids from the sclerotia of Aspergillus sulphureus. J Org Chem 57:138–141
105. Laakso JA, Narske ED, Gloer JB, Wicklow DT, Down PF (1994) Isokotanins A-C: new bicoumarins from the sclerotia of Aspergillus alliaceus. J Nat Prod 57:128–133
106. Larsen TO, Smedsgaard J, Nielsen KF, Hansen ME, Frisvad JC (2005) Phenotypic taxonomy and metabolite profiling in microbial drug discovery. Nat Prod Rep 22:672–695
107. Larsen TO, Smedsgaard J, Nielsen KF, Hansen ME, Samson RA, Frisvad JC (2007) Production of mycotoxins by Aspergillus lentulus and other medically important and closely related species in section Fumigati. Med Mycol 45:225–232
108. Leong SL, Lantz H, Petterson OV, Frisvad JC, Thrane U, Heipieper HJ, Dijksterhuis J, Grabherr M, Tellgren-Roth C, Schnürer J (2015) Genome and physiology of the ascomycete filamentous fungus Xeromyces bisporus, the most xerophilic organism isolated to date. Environ Microbiol 17:496–513
109. Lewis RE, Wiederhold NP, Lionakis MS, Prince RA, Kontoyiannis DP (2005) Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center. J Clin Microbiol 43:6120–6122
110. Li X-B, Li Y-L, Zhou J-C, Yuan H-Q, Wang X-N, Lou HX (2015) A new diketopiperazine heterodimer from an endophytic fungus Aspergillus niger. J Asian Nat Prod Res 17:182–187
111. Ma LJ, van der Does HC, Borkovich KA, Coleman JJ, Daboussi MJ, Dipieko A, Dufresne M, Freitag M, Grabherr M, Henrissat B, Hauterman PM, Kang S, Shim WB, Woloshuk C, Xie XH, Xu JR, Antoniw J, Baker SE, Bluhm BH, Breakspear A, Brown DW, RAE B, Chapman S, Coulson R, Coutinho PM, EGJ D, Diener A, Gale LR, Gardiner DM, Goff S, Hammons-Kosach KE, Hilburn K, Hua-Van A, Jonkers W, Kazan K, Kodira CD, Kochrsen M, Kumar L, Lee YH, Li LD, Manners JM, Miranda-Saavedra D, Mukerjee M, Park G, Park J, Park SY, Proctor RH, Regev A, Ruiz-Roldan MC, Sain D, Sakthikumar S, Sykes S, Schwartz PC, Turgeon BG, Wapinski I, Yoder O, Young S, Zeng QD, Zhou SG, Galaghan J, Boumo CA, Kistler HC, Rep M (2010) Comparative genomics reveal mobile pathway chromosomes in Fusarium. Nature 464:367–373
112. Maebayashi Y, Sumita M, Fukushima K, Yamazaki M (1978) Isolation and structure of red pigment from Aspergillus ochraceus Wilh. Chem Pharm Bull 26:1320–1322
113. Martin WR, Foster JW (1955) Production of trans-L-epoxysuccinic acid by fungi and its microbiological conversion to meta-tartaric acid. J Bacteriol 70:405–414
114. Masi M, Andolfi A, Mathieu V, Boari A, Cimmino A, Banuis LMY, Vurro M, Komienko A, Kiss R, Evidente A (2013) Fischerindoline, a pyrroloindole sesquiterpenoid isolated from Neosartorya pseudofischeri, with in vitro growth inhibitory activity in human cancer cell lines. Tetrahedron 69:7466–7470
115. Matsuzawa T, Tanaka R, Horie Y, Hui Y, Abliz P, Yaguchi T (2012) The correlation among molecular phylogenetics, morphological data, and growth temperature of the genus Emericella, and a new species. Mycoscience 53:433–445
116. Meijer M, Houbraken JAMP, Dalhuijsen S, Samson RA, de Vries RP (2011) Growth and hydrolase profiles can be used as characteristics to distinguish Aspergillus niger and other black Aspergilli. Stud Mycol 69:19–30
117. Meyer V, Wu B, Ram AFJ (2010) Aspergillus as a multipurpose cell factory: current status and perspectives. Biotechnol Lett 33:469–447
118. Moyer AJ (1953a) Effect of alcohols on the mycological production of citric acid in surface and submerged culture. I. Nature of the alcohol effect. Appl Microbiol 1:1–7
119. Miller JD, McMullin DR (2014) Fungal secondary metabolites as harmful indoor air contaminants. Appl Microbiol Biotechnol 98:9953–9966
120. Miller PA, Trown PW, Fulmor W, Morton GO, Karliner J (1968) An epidithiapiperazinedione antiviral agent from Aspergillus terreus. Biochem Biophys Res Commun 33:219–221
121. Monti F, Ripamonti F, Hawser SP, Islam K (1999) Aspirochlorine: a highly selective and potent inhibitor of fungal protein analysis. J Antibiot 52:311–318
122. Moyer AJ (1953b) Effect of alcohols in the mycological production of citric acid in surface and submerged culture. 1. Nature of the alcohol effect. Appl Microbiol 1:1–7
123. Ng TB, Wang HX (2006) Fungal peptides with ribonucelase activity. In: Kastin AJ (ed) Handbook of biologically active peptides. Elsevier, San Diego, pp. 137–143
124. Nielsen KF, Mogensen JM, Johansen M, Larsen TO, Frisvad JC (2009) Review of secondary metabolites and mycotoxins from the Aspergillus niger group. Anal Bioanal Chem 395:1225–1246
125. Nielsen ML, Nielsen JB, Rank C, Klejnstrup ML, Holm DMK, Brogaard KH, Hansen BG, Frisvad JC, Larsen TO, Mortensen UH (2011) A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans. FEMS Microbiol Lett 321:157–166
126. Nielsen MT, Nielsen JB, Anyaogu DC, Holm DK, Nielsen KF, Larsen TO, Mortensen UH (2013) Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach. PLoS One 8: e72871
127. Noonim P, Mahakarnchanakul W, Varga J, Frisvad JC, Samson RA (2008) Two new species of Aspergillus section Nigri from Thai coffee beans. Int J Syst Evol Microbiol 58:1727–1734
128. Nováková A, Hubka V, Dudová Z, Matsuzawa T, Kubátová A, Yaguchi T, Kolarik M (2014) New species in Aspergillus section Fumigati from reclamation sites in Wyoming (U.S.A.) and revision of A. viridinutans complex. Fungal Div 64:253–274
129. Nozawa K, Seyea H, Nakajima S, Udagawa S, Kawai K (1987) Studies on fungal products. Part 10. Isolation and structures of novel bicoumarins, desertorin A, B, and C, from Emericella desertorum. J Chem Soc Perkin Trans I 1987:1735–1738
130. Nozawa K, Nakajima S, Kawai K, Udagawa (1988) Isolation and structures of indoloterpenes, possible biosynthetic intermediates to the tremorgenic mycotoxin, paxilline, from Emerciella striata. J Chrm Soc. Perkin Trans I, 1988: 2707-2610
131. Oeemig JS, Lynggaard C, Knudsen DH, Hansen FT, Nørgaard KD, Schneider T, Vad BS, Sandvang DH, Nielsen LA, Kristensen HH, Sahl HG, Otzen DE, Wimmer R (2012) Eurocin, a new fungal defensin. Structure, lipid binding, and its mode of action. J Biol Chem 287:42361–42372
132. Ooike M, Nozawa K, Kawai K (1997) An epitetrathiodioxopiperazine related to emestrin from Emericella foveolata. Phytochemistry 46:123–126
133. Parenicová L, Skouboe P, Frisvad JC, Samson RA, Rossen L, ten Hoor-Suykerbuyk M, Visser J (2001) Combined molecular and biochemical approach identifies Aspergillus japonicus and A. aculeatus as two species. Appl Environ Microbiol 67:521–527
134. Patron NJ, Waller RF, Cozijnsen AJ, Straney DC, Gardinert DM, Nierman WC, Howlett BJ (2007) Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes. BMC Evol Biol 7:174
135. Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap, PJ., Turner, G., de Vries R.P., Albang, R., Alberman, K., Andersen, M.R., Bendtsen, J.D., Benen, J.A., van den Berg, M., Breetstraat, S., Caddick, M.S., Contreras, R., Cornell, M., Coutinho, P.M., Dancnin, E.G., Debets, A.J., Dekker, P., van Dijck, P.W., van Dijk, A., Dijkhuizen, L., Driessen, A.J., d’Enfert, C., Geysens, S., Goosen, C., Groot, G.S., de Groot, P.W., Guillemette, T., Henrissat, B. Herweijer, M., van den Homberg, J.P., van den Hondel, C.A., van der Heijden, R.T., van der Kaaij, R.M., Klis, F.M., Kools, H.J., Kubicek, C.P., van Kuyk, P.A., Lauber, J., Lu, X., van der Marel, M.J., Meulenberg, R., Menke, H., Mortimer, M.A., Nielsen, J., Oliver, S.G., Olsthoorn, M, Pal, K., van Peij, N.N., Ram, A.F., Rinas, U.,. TRoubos, J.A., Sagt, C.M., Schmoll, M., Sun, J., Ussery, D., Varga, J., Vervecken, W, van de Vondervoort, P.J., Wedler, H., Wosten, H.A., Zeng, A.P., van Oorwen, A.J., Visser, J., Stam, H. (2007) Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat Biotechnol 25: 221-231
136. Peleg Y, Stieglitz B, Goldberg I (1988) Malic acid accumulation by Aspergillus flavus. I. Biochemical aspects and acid biosynthesis. Appl Microbiol Biotechnol 28:69–75
137. Perrone G, Susca A, Ehrlich K, Varga J, Frisvad JC, Meijer M, Noonim P, Mahakarnchanakul W, Samson RA (2007) Biodiversity of Aspergillus species in some important agricultural products. Stud Mycol 59:53–66
138. Perrone G, Varga J, Susca A, Frisvad JC, Stea G, Kocsube S, Tóth B, Kozakiewicz Z, Samson RA (2008) Aspergillus uvarum sp. nov., an uniseriate black Aspergillus species isolated from grapes in Europe. Int J Syst Evol Microbiol 58:1032–1039
139. Perrone G, Stea G, Epifani F, Varga J, Frisvad JC, Samson RA (2011) Aspergillus niger contains the cryptic phylogenetic species A. awamori. Fungal Biol 115:1138–1150
140. Peterson SW (1995) Phylogenetic analysis of Aspergillus section Cremei and Wentii, based on ribosomal DNA sequences. Mycol Res 99:1349–1355
141. Peterson SW (2000) Phylogenetic relationships in Aspergillus based on rDNA sequence analysis. In: Samson RA, Pitt JI (eds) Integration of modern taxonomic methods for Penicillium and Aspergillus classification. Harwood Academic Publishers, Amsterdam, pp. 323–355
142. Peterson SW, Jurjevic Z, Bills GF, Stchigl AM, Guarro J, Vega FE (2010) Genus Hamigera, six new species and multilocus DNA sequence based phylogeny. Mycologia 102:847–864
143. Pildain MB, Frisvad JC, Vaamonde G, Cabral D, Varga J, Samson RA (2008) Two new aflatoxin producing Aspergillus species from Argentinean peanuts. Int J Syst Evol Microbiol 58:725–735
144. Pitt JI, Hocking AD (1985) New species of fungi from Indonesian dried fish. Mycotaxon 22:197–208
145. Pitt JI, Hocking AD (2009) Fungi and food spoilage, 3rd edn. Springer, Dordrecht
146. Pitt JI, Taylor JW (2014) Aspergillus, its sexual states and the new International Code of Nomenclature. Mycologia 106:1051–1062
147. Rabie CJ, Steyn PS, van Heerden FR (1986) The isolation and identification of toxic constituents of Aspergillus wentii Wehmer. Mycotox Res 2:19–24
148. Rahbæk L, Frisvad JC, Christophersen C (2000) An amendation of Aspergillus section Candidi based on chemotaxonomical evidence. Phytochemistry 53:581–586
149. Rai JN, Chowdhery HJ (1975) Hemisartorya, a new genus of cleistothecial ascomycetes with Aspergillus state. Kavaka 3:73–76
150. Rank C, Larsen TO, Frisvad JC (2011) Distribution of sterigmatocystin in filamentous fungi. Fung Biol 115:406–420
151. Raper KB, Fennell DI (1965) The genus Aspergillus. Williams and Wilkins, Baltimore, MD
152. Sakata K, Kuwatsuka T, Sakurai A, Takahashi N, Tamura G (1983) Isolation of aspirochlorine (= antibiotic A30461) as a true antimicrobial constituent of the antibiotic, oryzachlorin, from Aspergillus oryzae. Agric Biol Chem 47:2673–2674
153. Sakata K, Masago H, Sakurai A, Takahashi N (1982) Isolation of aspirochlorine (= antibiotic A30461) possessing a novel dithiodiketopiperazine structure from Aspergillus flavus. Tetrahedron Lett 23:2095–2098
154. Samson RA, Nielsen PV, Frisvad JC (1990) The genus Neosartorya: differentiation by scanning electron microscopy and mycotoxin profiles. In: RA Samson and JI Pitt (eds): Modern concepts in Penicillium and Aspergillus and classification. Plenum Press, New York, pp. 455-467
155. Samson RA, Houbraken JAMP, Kuijpers AFA, Frank JM, Frisvad JC (2004) New ochratoxin or sclerotium producing species in Aspergillus section Nigri. Stud Mycol 50:45–61
156. Samson RA, Noonim P, Meijer M, Houbraken J, Frisvad JC, Varja J (2007a) Diagnostic tools to identify black Aspergilli. Stud Mycol 59:129–145
157. Samson RA, Hong S-B, Peterson SW, Frisvad JC, Varga J (2007b) Polyphasic taxonomy of Aspergillus section Fumigati and its teleomorph Neosartorya. Stud Mycol 59:147–203
158. Samson RA, Hong S-B, Frisvad JC (2006) Old and new concepts of species differentiation in Aspergillus. Med Mycol 44:S133–S144
159. Samson RA, Houbraken J, Thrane U, Frisvad JC, Andersen B (2010) Food and indoor fungi. CBS KNAW Fungal Biodiversity Center, Utrecht
160. Samson RA, Peterson SW, Frisvad JC, Varga J (2011a) New species in Aspergillus section Terrei. Stud Mycol 69:39–55
161. Samson RA, Varga J, Meijer M, Samson RA (2011b) New taxa in Aspergillus section Usti. Stud Mycol 69:81–97
162. Samson RA, Visagie CM, Houbraken J, Hong S-B, Hubka V, Klaassen CHW, Perrone G, Seifert KA, Susca A, Tanney JB, Varga J, Kocsubé S, Szigeti G, Yaguchi T, Frisvad JC (2014) Taxonomy, identification and nomenclature of the genus Aspergillus. Stud Mycol 78:141–173
163. Sanchez JF, Entwistle R, Hung J-H, Yaegashi J, Jain S, Chiang YM, Wang CCC, Oakley BR (2011) Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans. J Amer Chem Soc 133:4010–4017
164. Schmitt I, Lumsch HT (2009) Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. PLoS One 4: e4437
165. Selva A, Traldi P, Camarda L, Nasini G (1980) New secondary metabolites of Aspergillus wentii Wehmer. The positive and negative ion mass spectra produced by electron impact. Biol Mass Spectrom 7:148–152
166. Serra R, Cabañes AF, Perrone G, Kozakiewicz Z, Castellá G, Venancio A, Mule G, Kozakiewicz Z (2006) Aspergillus ibericus: a new species of the section Nigri isolated from grapes. Mycologia 98:295–306
167. Seya H, Nakajima S, Kawai K, Udagawa S (1985) Structure and absolute configuration of emestrin, a new macrocyclic epidithiodioxopiperazine from Emericella striata. J Chem Soc Chem Commun 1985:657–658
168. Simpson TJ (2012) Genetic and biosynthetic studies of the fungal prenylated xanthone shamixanthone and related metabolites in Aspergillus spp. Revisited. Chembiochem 13:1680–1688
169. Singh RS, Kaur HP, Singh J (2014a) New lectins from aspergilli and their carbohydrate specificity. Biologia 69:15–23
170. Singh RS, Kaur HP, Singh J (2014b) Purification and characterization of a mucin specific mycelial lectin from Aspergillus gorakhpurensis: application for mitogenic and antimicrobial activity. PLoS One 9: e109265
171. Slack G, Puniani E, Frisvad JC, Samson RA, Miller JD (2009) Secondary metabolites from Eurotium species, A. calidoustus and A. insuetus common in Canadian homes with a review of their chemistry and biological activities. Mycol Res 113:480–490
172. Slot JC, Rokas A (2011) Horizontal transfer of a large and highly toxic secondary metabolite gene cluster between fungi. Curr Biol 21:134–139
173. Son BW, Choi JK, Kim JC, Nam KW, Kim D-S, Chung HY, Kang JS, Choi HD (2002) Parasitenone, a new epoxycyclohexanone related to gabosine from the marine-derived fungus Aspergillus parasiticus. J Nat Prod 65:794–795
174. Springer JP, Büchi G, Kobbe B, Demain AL, Clardy J (1977) The structure of ditryptophenaline—a new metabolite of Aspergillus flavus. Tetrahedron Lett 18:2403–2406
175. Srivastava RS, Kamal (1980) Citric acid production by aspergilli II. Strain selection. Indian J Mycol Plant Pathol 10:23–29
176. Sugui JA, Kwon-Chung KJ, Juvvadi PR, Latgé JP, Steinbach WJ (2014a) Aspergillus fumigatus and related species. Cold Spring Harbor Persp Med 5:a019786
177. Sugui JA, Peterson SW, Figat A, Hansen B, Samson RA, Mellado E, Cuenca-Estrella M, Kwon-Chung KJ (2014b) Genetic relatedness versus biological compatibility between Aspergillus fumigatus and related species. J Clin Microbiol 52:3703–3721
178. Sun H-F, Li X-M, Meng L, Cui C-M, Gao S-S, Li CS, Huang CG, Wong BG (2012) Asperolides A-C, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus Aspergillus wentii EN-48. J Nat Prod 75:148–152
179. Szewczyk E, Chiang Y-M, Oakley CE, Davidson AD, Wang CCC, Oakley BR (2008) Identification and characetrization of the asperthecin gene cluster of Aspergillus nidulans. Appl Environ Microbiol 74:7607–7612
180. Takahashi H, Nozawa K, Kawai K (1996) Isolation and structures of dicyanide derivatives, epurpurins A to C, from Emericella purpurea. Chem Pharm Bull 44:2276–2230
181. Takahashi C, Sekita S, Yoshihira K, Natori S (1976) The structures of toxic metabolites of Aspergillus candidus. II. The compound B (xanthoascin), a hepato- and cardio-toxic xanthocillin analogue. Chem Pharm Bull 24:2317–2321
182. Takeda I, Umemura M, Koike H, Asai K, Machida M (2014) Motif-independent prediction of a secondary metabolite gene cluster using comparative genomics: application to sequenced genomes of Aspergillus and ten other filamentous fungal species. DNA Res 21:447–457
183. Tatsuda D, Momose I, Someno T, Sawa R, Kubota Y, Iijima M, Kunisada T, Watanabe T, Shibazaki M, Nomoto A (2015) Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF 1444, show p53-dependent growth suppression. J Nat Prod 78:188–195
184. Tepaske MR, Gloer JB, Wicklow DT, Down PF (1989) 3 new aflavinines from the sclerotia of Aspergillus tubingensis. Tetrahedron 45:4961–4968
185. TePaske MR, Gloer JB, Wicklow DT, Dowd PF (1992) Aflavarin and β-aflatrem: new anti-insectan metabolites from the sclerotia of Aspergillus flavus. J Nat Prod 55:1080–1086
186. Terao K, Ito E, Kawai K, Nozawa K, Udagaea S (1990) Experimental acute poisoning in mice induced by emestrin, a new mycotoxin isolated from Emericella species. Mycopahtologia 112:71–79
187. Terebayashi Y, Sano M, Yamana N, Marui J, Tamano K, Sagara J, Dohmoto M, Oda K, Oshima E, Tachibana K, Higa Y, Ohashi S, Koike H, Machida M (2010) Identification and characterization of genes responsible for biosynthesis of kojic acid, an industrially important compound from Aspergillus oryzae. Fung Genet Biol 47:953–961
188. Turner WB (1971) Fungal metabolites. Academic Press, London
189. Turner WB, Aldridge DC (1983) Fungal metabolites II. Academic Press, London
190. Van der Straat L, Vernooij M, Lammus M, van den Berg W, Schonewille T, Cordawene J, van der Meer I, Koops A, de Graff LH (2014) Expression of the Aspergillus terreus terreic acid gene cluster in Aspergillus niger. Microb Cell Factories 13:11
191. Varga J, Tóth B, Kocsubé S, Farkas B, Szakács G, Teren J, Kozakiwwicz Z (1995) Evolutionary relationships among Aspergilllus terreus and their relatives. Antonie Van Leeuwenhoek 88:141–150
192. Varga J, Frisvad JC, Samson RA (2009) A reappraisal of fungi producing aflatoxin. World Mycotox J 2:263–277
193. Varga J, Kevei É, Tóth B, Kozakiewicz Z, Hoekstra RF (2000a) Molecular analysis of variability within the toxigenic Aspergillus ochraceus species. Can J Microbiol 46:593–599
194. Varga J, Samson RA (2008) Ribotoxin genes in isolates of Aspergillus section Clavati. Antonie Van Leeuwenhoek 94:4871–4485
195. Varga J, Tóth B, Kevei É, Palágyi A, Kozakiewicz Z (2000b) Analysis of genetic variability within the genus Petromyces. Antonie Van Leeuwenhoek 77:83–89
196. Varga J, Tóth B, Rigó K, Téren J, Hoekstra RF, Kozakiewicz Z (2000c) Phylogenetic analysis of Aspergillus section Circumdati based on sequences of the internally transcribed spacer regions of the 5.8S rRNA gene. Fung Genet Biol 30:71–80
197. Varga J, Rigó K, Molnár J, Tóth B, Szencz S, Teren J, Kozakiewicz Z (2003a) Mycotoxin production and evolutionary relationships among species of Aspergillus section Clavati. Antonie Van Leeuwenhoek 83:191–200
198. Varga J, Rigó K, Kocsubé S, Farkas B, Pál K (2003b) Diversity of polyketide synthase gene sequences in Aspergillus species. Res Microbiol 154:593–600
199. Varga J, Kocsubé S, Tóth B, Frisvad JC, Perrone G, Susca A, Meijer M, Samson RA (2007a) Aspergillus brasiliensis sp. nov., a biseriate black Aspergillus species with world-wide distribution. Int J Syst Evol Microbiol 57:1925–1932
200. Varga J, Frisvad JC, Samson RA (2007b) Polyphasic taxonomy of Aspergillus section Candidi based on molecular, morphological and physiological data. Stud Mycol 59:75–88
201. Varga J, Due M, Frisvad JC, Samson RA (2007c) Taxonomic revision of Aspergillus section Clavati based on molecular, morphological and physiological data. Stud Mycol 59:89–106
202. Varga J, Frisvad JC, Samson RA (2010a) Aspergillus sect. Aenei sect. nov., a new section of the genus for A. karnatakaensis sp. nov. and some allied fungi. IMA Fungus 1:197–205
203. Varga J, Frisvad JC, Samson RA (2010b) Polyphasic taxonomy of Aspergillus section Sparsi. IMA Fungus 1:187–195
204. Varga J, Frisvad JC, Kocsubé S, Brankovics B, Tóth B, Szigeti G, Samson RA (2011a) New and revisited species in Aspergillus section Nigri. Stud Mycol 69:1–17
205. Varga J, Frisvad JC, Samson RA (2011b) Two new aflatoxin producing species, and an overview of Aspergillus section Flavi. Stud Mycol 69:57–80
206. Varoglou M, Corbett TH, Valeriote FA, Crews P (1997) Asperazine, a selective cytotoxic alkaloid from a sponge-derived culture of Aspergillus niger. J Org Chem 62:7078–7079
207. Verchère J-F, Fleury MB, Souchay P (1969) Étude d’une réaction de biocondensation de l’acide leuconique en solution acids. CR Acad Sci Paris Sect C267:1221–1224
208. Visagie CM, Varga J, Houbraken J, Meijer M, Kocsubé S, Yilmaz N, Fotedar R, Seifert KA, Frisvad JC, Samson RA (2014a) Ochratoxin production and taxonomy of the yellow Aspergilli (Aspergillus section Circumdati). Stud Mycol 78:1–61
209. Visagie CM, Hirooka Y, Tanney JB, Whitfield E, Mwange K, Meijer M, Amend AS, Seifert K, Samson RA (2014b) Aspergillus, Penicillium and Talaromyces isolated from house dust samples collected around the world. Stud Mycol 78:63–139
210. Visagie CM, Houbraken J, Frisvad JC, Hong S-B, Klaassen CHW Perrone, G, Seifert KA, Varga J, Yaguchi T, Samson RA (2014c). Identification and nomenclature of the genus Penicillium. Stud Mycol 78: 343-371
211. Wells JM, Cole RJ, Kirksey JW (1975) Emodin, a toxic metabolite of Aspergillus wentii isolated from weevil-damaged chestnuts. Appl Microbiol 30:26–28
212. Wenke J, Anke H, Sterner O (1993) Pseurotin A and 8-O-demethylpseurotin A from Aspergillus fumigatus and their inhibitory activities on chitin synthase. Biosci Biotech Biochem 57:961–964
213. West TP (2011) Malic acid production from thin stillage by Aspergillus species. Biotechnol Lett 33:2463–2467
214. White EC, Hill JH (1943) Studies on antibacterial products formed by moulds. I. Aspergillic acid, a product of a strain of Aspergillus flavus. J Bacteriol 45:433–443
215. Wisecaver JH, Rokas A (2015) Fungal metabolic gene clusters—caravans travelling across genomes and environments. Front Microbiol 6: Article 161
216. Wisecaver JH, Slot JC, Rokas A (2014) The evolution of fungal metabolic pathways. PLoS Genet 10: e1004816
217. Yaguchi T, Someya A, Udagawa S (1994) Fennelllia flavipes and Neosartorya stramenia, two new records from Japan. Mycoscience 35:175–178
218. Yamamoto Y, Nitta K, Tango K, Saito T (1965) Studies on the metabolic products of a strain of Aspergillus fumigatus (DH 413). I. Isolation Chemical Struct Metab Chem Pharm Bull 13:935–841
219. Yamamoto Y, Kiriyama N, Arahata S (1968) Studies on the metabolic products of Aspergillus fumigatus (J-4). Chem Struct Metab Prod Chem Pharm Bull 16:304–310
220. Yamazaki M, Maebayashi Y, Miyaka K (1971) The isolation of secalonic acid A from Aspergillus ochraceus cultured on rice. Chem Pharm Bull 19:199–201
221. Yang L, Lübeck M, Lübeck PS (2014) Deletion of glucose oxidase changes the pattern of organic acids produced in Aspergillus carbonarius. AMB Express 4:54
222. Yen G-C, Chang Y-C, Sheu F, Chiang H-C (2001) Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J Agric Food Chem 49:1426–1431
223. Yilmaz N, Visagie CM, Houbraken J, Frisvad JC, Samson RA (2014) Polyphasic taxonomy of the genus Talaromyces. Stud Mycol 78:175–341
224. Yin W-B, Baccile JA, Bok JW, Chen Y, Keller NP, Schroeder FC (2013) A nonribosomal peptide synthase-derived iron (III) complex from the pathogenic fungus Aspergillus fumigatus. J Amer Chem Soc 135:2064–2067
225. Zalar P, Frisvad JC, Gunde-Cimerman N, Varga J, Samson RA (2008) Four new species of Emericella from the Mediterranean region of Europe. Mycologia 100:779–795
226. Zuck KM, Shipley S, Newman DJ (2011) Induced production of N-formyl alkaloids from Aspergillus fumigatus by co-culture with Streptomyces peuceticus. J Nat Prod 74:1653–1657