메뉴 건너뛰기




Volumn 50, Issue , 2015, Pages S39-S56

Inflammation and its genesis in cystic fibrosis

Author keywords

anti inflammatory; cystic fibrosis; elastase; inflammation; neutrophil

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTIINFLAMMATORY AGENT; BICARBONATE; CERAMIDE; CHLORIDE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOCOSAHEXAENOIC ACID; INTERLEUKIN 8; MATRIX METALLOPROTEINASE; MUCIN; THIOCYANATE; TRANSCRIPTION FACTOR NRF2; CFTR PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID;

EID: 84941102510     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.23242     Document Type: Review
Times cited : (146)

References (210)
  • 2
    • 0017198208 scopus 로고
    • The lung in cystic fibrosis. A quantitative study including prevalence of pathologic findings among different age groups
    • Bedrossian CW, Greenberg SD, Singer DB, Jansen JJ, Rosenberg HS,. The lung in cystic fibrosis. A quantitative study including prevalence of pathologic findings among different age groups. Hum Pathol 1976; 7: 195-204.
    • (1976) Hum Pathol , vol.7 , pp. 195-204
    • Bedrossian, C.W.1    Greenberg, S.D.2    Singer, D.B.3    Jansen, J.J.4    Rosenberg, H.S.5
  • 4
    • 0035991525 scopus 로고    scopus 로고
    • The role of inflammation in the pathophysiology of CF lung disease
    • Chmiel JF, Konstan MW, Berger M,. The role of inflammation in the pathophysiology of CF lung disease. Clin Rev Allergy Immunol 2002; 23: 5-27.
    • (2002) Clin Rev Allergy Immunol , vol.23 , pp. 5-27
    • Chmiel, J.F.1    Konstan, M.W.2    Berger, M.3
  • 5
    • 1542267080 scopus 로고    scopus 로고
    • State of the art: Why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection?
    • Chmiel JF, Davis PB,. State of the art: why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection? Respir Res 2003; 4: 8-21.
    • (2003) Respir Res , vol.4 , pp. 8-21
    • Chmiel, J.F.1    Davis, P.B.2
  • 7
    • 84936847453 scopus 로고    scopus 로고
    • Inflammation in the cystic fibrosis lung
    • Allen J.L. Panitch H.B. Rubenstein R.C. editors. New York: Informa Healthcare USA, Inc.;
    • Chmiel JF, Konstan MW,. Inflammation in the cystic fibrosis lung. In:, Allen JL, Panitch HB, Rubenstein RC, editors. Cystic Fibrosis. New York: Informa Healthcare USA, Inc.; 2010. pp 57-77.
    • (2010) Cystic Fibrosis , pp. 57-77
    • Chmiel, J.F.1    Konstan, M.W.2
  • 10
    • 0030893651 scopus 로고    scopus 로고
    • Cytokine concentrations in sputum from patients with cystic fibrosis and their relation to eosinophil activity
    • Koller DY, Nething I, Otto J, Urbanek R, Eichler I,. Cytokine concentrations in sputum from patients with cystic fibrosis and their relation to eosinophil activity. Am J Respir Crit Care Med 1997; 155: 1050-1054.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 1050-1054
    • Koller, D.Y.1    Nething, I.2    Otto, J.3    Urbanek, R.4    Eichler, I.5
  • 12
    • 84875227872 scopus 로고    scopus 로고
    • IL-33 is expressed in epithelia from patients with cystic fibrosis and potentiates neutrophil recruitment
    • Roussel L, Farias R, Rousseau S,. IL-33 is expressed in epithelia from patients with cystic fibrosis and potentiates neutrophil recruitment. J Allergy Clin Immunol 2013; 131: 913-916.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 913-916
    • Roussel, L.1    Farias, R.2    Rousseau, S.3
  • 13
    • 0028229533 scopus 로고
    • Enhancement by tumor necrosis factor-alpha of Fc alpha receptor expression and IgA-mediated superoxide generation and killing of Pseudomonas aeruginosa by polymorphonuclear leukocytes
    • Hostoffer RW, Krukovets I, Berger M,. Enhancement by tumor necrosis factor-alpha of Fc alpha receptor expression and IgA-mediated superoxide generation and killing of Pseudomonas aeruginosa by polymorphonuclear leukocytes. J Infect Dis 1994; 170: 82-87.
    • (1994) J Infect Dis , vol.170 , pp. 82-87
    • Hostoffer, R.W.1    Krukovets, I.2    Berger, M.3
  • 15
    • 0023671596 scopus 로고
    • The role of cachectin/TNF in endotoxic shock and cachexia
    • Cerami A, Beutler B,. The role of cachectin/TNF in endotoxic shock and cachexia. Immunol Today 1988; 9: 28-31.
    • (1988) Immunol Today , vol.9 , pp. 28-31
    • Cerami, A.1    Beutler, B.2
  • 16
    • 0036846144 scopus 로고    scopus 로고
    • Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways
    • Saba S, Soong G, Greenberg S, Prince A,. Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. Am J Respir Cell Mol Biol 2002; 27: 561-567.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 561-567
    • Saba, S.1    Soong, G.2    Greenberg, S.3    Prince, A.4
  • 17
    • 0032817772 scopus 로고    scopus 로고
    • Altered respiratory epithelial cell cytokine production in cystic fibrosis
    • Bonfield TL, Konstan MW, Berger M,. Altered respiratory epithelial cell cytokine production in cystic fibrosis. J Allergy Clin Immunol 1999; 104: 72-78.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 72-78
    • Bonfield, T.L.1    Konstan, M.W.2    Berger, M.3
  • 18
    • 0030961127 scopus 로고    scopus 로고
    • Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis
    • Grasemann H, Michler E, Wallot M, Ratjen F,. Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis. Pediatr Pulmonol 1997; 24: 173-177.
    • (1997) Pediatr Pulmonol , vol.24 , pp. 173-177
    • Grasemann, H.1    Michler, E.2    Wallot, M.3    Ratjen, F.4
  • 19
  • 21
    • 0029849044 scopus 로고    scopus 로고
    • Reduced IL-10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR)
    • Moss RB, Bocian RC, Hsu YP, Dong YJ, Kemna M, Wei T, Gardner P,. Reduced IL-10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR). Clin Exp Immunol 1996; 106: 374-388.
    • (1996) Clin Exp Immunol , vol.106 , pp. 374-388
    • Moss, R.B.1    Bocian, R.C.2    Hsu, Y.P.3    Dong, Y.J.4    Kemna, M.5    Wei, T.6    Gardner, P.7
  • 22
    • 0032925551 scopus 로고    scopus 로고
    • Nitric oxide-mediated regulation of transepithelial sodium and chloride transport in murine nasal epithelium
    • Elmer HL, Brady KG, Drumm ML, Kelley TJ,. Nitric oxide-mediated regulation of transepithelial sodium and chloride transport in murine nasal epithelium. Am J Physiol 1999; 276: L466-L473.
    • (1999) Am J Physiol , vol.276 , pp. L466-L473
    • Elmer, H.L.1    Brady, K.G.2    Drumm, M.L.3    Kelley, T.J.4
  • 24
    • 0032779267 scopus 로고    scopus 로고
    • Nitric oxide-induced potentiation of the killing of Burkholderia cepacia by reactive oxygen species: Implications for cystic fibrosis
    • Smith AW, Green J, Eden CE, Watson ML,. Nitric oxide-induced potentiation of the killing of Burkholderia cepacia by reactive oxygen species: implications for cystic fibrosis. J Med Microbiol 1999; 48: 419-423.
    • (1999) J Med Microbiol , vol.48 , pp. 419-423
    • Smith, A.W.1    Green, J.2    Eden, C.E.3    Watson, M.L.4
  • 25
    • 0032964751 scopus 로고    scopus 로고
    • Nitric oxide reduces the sequestration of polymorphonuclear leukocytes in lung by changing deformability and CD18 expression
    • Sato Y, Walley KR, Klut ME, English D, D'yachkova Y, Hogg JC, van Eeden SF,. Nitric oxide reduces the sequestration of polymorphonuclear leukocytes in lung by changing deformability and CD18 expression. Am J Respir Crit Care Med 1999; 159: 1469-1476.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1469-1476
    • Sato, Y.1    Walley, K.R.2    Klut, M.E.3    English, D.4    D'yachkova, Y.5    Hogg, J.C.6    Van Eeden, S.F.7
  • 26
    • 0034997191 scopus 로고    scopus 로고
    • Proinflammatory cytokine responses to P. Aeruginosa infection in human airway epithelial cell lines
    • Kube D, Sontich U, Fletcher D, Davis PB,. Proinflammatory cytokine responses to P. Aeruginosa infection in human airway epithelial cell lines. Am J Physiol Lung Cell Mol Physiol 2001; 280: L493.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280 , pp. L493
    • Kube, D.1    Sontich, U.2    Fletcher, D.3    Davis, P.B.4
  • 29
    • 13444312010 scopus 로고    scopus 로고
    • Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice
    • Saadane A, Soltys J, Berger M,. Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice. J Allergy Clin Immunol 2005; 115: 405-411.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 405-411
    • Saadane, A.1    Soltys, J.2    Berger, M.3
  • 30
    • 0032081281 scopus 로고    scopus 로고
    • Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells
    • DiMango E, Ratner AJ, Bryan R, Tabibi S, Prince A,. Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells. J Clin Invest 1998; 101: 2598-2605.
    • (1998) J Clin Invest , vol.101 , pp. 2598-2605
    • DiMango, E.1    Ratner, A.J.2    Bryan, R.3    Tabibi, S.4    Prince, A.5
  • 32
    • 84855394399 scopus 로고    scopus 로고
    • Induction of type i interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells
    • Parker D, Cohen TS, Alhede M, Harfenist BS, Martin FJ, Prince A,. Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells. Am J Respir Cell Mol Biol 2012; 46: 6-13.
    • (2012) Am J Respir Cell Mol Biol , vol.46 , pp. 6-13
    • Parker, D.1    Cohen, T.S.2    Alhede, M.3    Harfenist, B.S.4    Martin, F.J.5    Prince, A.6
  • 33
    • 0033846368 scopus 로고    scopus 로고
    • In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium
    • Kelley TJ, Elmer HL,. In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium. J Clin Invest 2000; 106: 403-410.
    • (2000) J Clin Invest , vol.106 , pp. 403-410
    • Kelley, T.J.1    Elmer, H.L.2
  • 37
    • 78650177234 scopus 로고    scopus 로고
    • Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death
    • Becker KA, Tümmler B, Gulbins E, Grassmé H,. Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death. Biochem Biophys Res Commun 2010; 403: 368-374.
    • (2010) Biochem Biophys Res Commun , vol.403 , pp. 368-374
    • Becker, K.A.1    Tümmler, B.2    Gulbins, E.3    Grassmé, H.4
  • 40
    • 61949089083 scopus 로고    scopus 로고
    • Lipid metabolism in cystic fibrosis
    • Worgall TS., Lipid metabolism in cystic fibrosis. Curr Opin Clin Nutr Metab Care 2009; 12: 105-109.
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 105-109
    • Worgall, T.S.1
  • 41
    • 77953461364 scopus 로고    scopus 로고
    • The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis
    • Becker KA, Riethmüller J, Zhang Y, Gulbins E,. The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis. Open Respir Med J 2010; 4: 39-47.
    • (2010) Open Respir Med J , vol.4 , pp. 39-47
    • Becker, K.A.1    Riethmüller, J.2    Zhang, Y.3    Gulbins, E.4
  • 44
    • 77954627816 scopus 로고    scopus 로고
    • Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis
    • Fang D, West RH, Manson ME, Ruddy J, Jiang D, Previs SF, Sonawane ND, Burgess JD, Kelley TJ,. Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis. Respir Res 2010; 11: 61.
    • (2010) Respir Res , vol.11 , pp. 61
    • Fang, D.1    West, R.H.2    Manson, M.E.3    Ruddy, J.4    Jiang, D.5    Previs, S.F.6    Sonawane, N.D.7    Burgess, J.D.8    Kelley, T.J.9
  • 45
    • 84862333034 scopus 로고    scopus 로고
    • Regulatory role of β-arrestin-2 in cholesterol processing in cystic fibrosis epithelial cells
    • Manson ME, Corey DA, Bederman I, Burgess JD, Kelley TJ,. Regulatory role of β-arrestin-2 in cholesterol processing in cystic fibrosis epithelial cells. J Lipid Res 2012; 53: 1268-1276.
    • (2012) J Lipid Res , vol.53 , pp. 1268-1276
    • Manson, M.E.1    Corey, D.A.2    Bederman, I.3    Burgess, J.D.4    Kelley, T.J.5
  • 48
    • 0035411667 scopus 로고    scopus 로고
    • CAMP stimulation of HCO3-secretion across airway epithelia
    • Welsh MJ, Smith JJ,. CAMP stimulation of HCO3-secretion across airway epithelia. JOP 2001; 2: 291-293.
    • (2001) JOP , vol.2 , pp. 291-293
    • Welsh, M.J.1    Smith, J.J.2
  • 51
    • 33645451580 scopus 로고    scopus 로고
    • Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis
    • Song Y, Salinas D, Nielson DW, Verkman AS,. Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. Am J Physiol Cell Physiol 2006; 290: C741-C749.
    • (2006) Am J Physiol Cell Physiol , vol.290 , pp. C741-C749
    • Song, Y.1    Salinas, D.2    Nielson, D.W.3    Verkman, A.S.4
  • 53
    • 79959287741 scopus 로고    scopus 로고
    • Airway remodelling and its relationship to inflammation in cystic fibrosis
    • Regamey N, Jeffery PK, Alton EW, Bush A, Davies JC,. Airway remodelling and its relationship to inflammation in cystic fibrosis. Thorax 2011; 66: 624-649.
    • (2011) Thorax , vol.66 , pp. 624-649
    • Regamey, N.1    Jeffery, P.K.2    Alton, E.W.3    Bush, A.4    Davies, J.C.5
  • 55
    • 84861911235 scopus 로고    scopus 로고
    • Interaction with CREB binding protein modulates the activities of Nrf2 and NF-kappaB in cystic fibrosis airway epithelial cells
    • Ziady AG, Sokolow A, Shank S, Corey D, Myers R, Plafker S, Kelley TJ,. Interaction with CREB binding protein modulates the activities of Nrf2 and NF-kappaB in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2012; 302: L1221-L1231.
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302 , pp. L1221-L1231
    • Ziady, A.G.1    Sokolow, A.2    Shank, S.3    Corey, D.4    Myers, R.5    Plafker, S.6    Kelley, T.J.7
  • 57
    • 77954603744 scopus 로고    scopus 로고
    • Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa
    • Berube J, Roussel L, Nattagh L, Rousseau S,. Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa. J Biol Chem 2010; 285: 22299-22307.
    • (2010) J Biol Chem , vol.285 , pp. 22299-22307
    • Berube, J.1    Roussel, L.2    Nattagh, L.3    Rousseau, S.4
  • 58
    • 77951497702 scopus 로고    scopus 로고
    • In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: Evidence for an innate neutrophil disturbance
    • Moriceau S, Lenoir G, Witko-Sarsat V,. In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance. Journal Innate Immun 2010; 2: 260-266.
    • (2010) Journal Innate Immun , vol.2 , pp. 260-266
    • Moriceau, S.1    Lenoir, G.2    Witko-Sarsat, V.3
  • 60
    • 0032933252 scopus 로고    scopus 로고
    • Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis
    • Marguet C, Jouen-Boedes F, Dean TP, Warner JO,. Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis. Am J Respir Crit Care Med 1999; 159: 1533-1540.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1533-1540
    • Marguet, C.1    Jouen-Boedes, F.2    Dean, T.P.3    Warner, J.O.4
  • 61
    • 0029010510 scopus 로고
    • Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis
    • Armstrong DS, Grimwood K, Carzino R, Carlin JB, Olinsky A, Phelan PD,. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. BMJ 1995; 310: 1571-1572.
    • (1995) BMJ , vol.310 , pp. 1571-1572
    • Armstrong, D.S.1    Grimwood, K.2    Carzino, R.3    Carlin, J.B.4    Olinsky, A.5    Phelan, P.D.6
  • 64
    • 77953010658 scopus 로고    scopus 로고
    • The development of lung disease in cystic fibrosis pigs
    • Wine JJ., The development of lung disease in cystic fibrosis pigs. Sci Transl Med 2010; 2: 29ps20.
    • (2010) Sci Transl Med , vol.2 , pp. 29ps20
    • Wine, J.J.1
  • 69
    • 0031452350 scopus 로고    scopus 로고
    • Excessive inflammatory response on cystic fibrosis mice to bronchopulmonary infection with P. Aeruginosa
    • van Heeckeren A, Walenga R, Konstan MW, Bonfield T, Davis PB, Ferkol T,. Excessive inflammatory response on cystic fibrosis mice to bronchopulmonary infection with P. Aeruginosa. J Clin Invest 1997; 100: 2810-2815.
    • (1997) J Clin Invest , vol.100 , pp. 2810-2815
    • Van Heeckeren, A.1    Walenga, R.2    Konstan, M.W.3    Bonfield, T.4    Davis, P.B.5    Ferkol, T.6
  • 72
    • 72949095117 scopus 로고    scopus 로고
    • IL-17 primes airway epithelial cells lacking functional CFTR in increase NOD1 responses
    • Roussel L, Rousseau S,. IL-17 primes airway epithelial cells lacking functional CFTR in increase NOD1 responses. Biochem Biophys Res Commun 2010; 391: 505-509.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 505-509
    • Roussel, L.1    Rousseau, S.2
  • 74
    • 80051554943 scopus 로고    scopus 로고
    • Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses
    • Mueller C, Braag SA, Keeler A, Hodges C, Drumm M, Flotte TR,. Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses. Am J Respir Cell Mol Biol 2011; 44: 922-929.
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 922-929
    • Mueller, C.1    Braag, S.A.2    Keeler, A.3    Hodges, C.4    Drumm, M.5    Flotte, T.R.6
  • 75
    • 84865726240 scopus 로고    scopus 로고
    • Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: Interaction between intestinal and respiratory tracts and impact of nutritional exposures
    • Madan JC, Koestler DC, Stanton BA, Davidson L, Moulton LA, Housman ML, Moore JH, Guill MF, Morrison HG, Sogin ML, et al., Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: interaction between intestinal and respiratory tracts and impact of nutritional exposures. MBio 2012: 3.
    • (2012) MBio , vol.3
    • Madan, J.C.1    Koestler, D.C.2    Stanton, B.A.3    Davidson, L.4    Moulton, L.A.5    Housman, M.L.6    Moore, J.H.7    Guill, M.F.8    Morrison, H.G.9    Sogin, M.L.10
  • 77
  • 79
    • 79551607386 scopus 로고    scopus 로고
    • Hypertonic saline increases lung epithelial lining fluid glutathione and thiocyanate: Two protective CFTR-dependent thiols against oxidative injury
    • Gould NS, Gauthier S, Kariya CT, Min E, Huang J, Brian DJ,. Hypertonic saline increases lung epithelial lining fluid glutathione and thiocyanate: two protective CFTR-dependent thiols against oxidative injury. Respir Res 2010; 27: 119.
    • (2010) Respir Res , vol.27 , pp. 119
    • Gould, N.S.1    Gauthier, S.2    Kariya, C.T.3    Min, E.4    Huang, J.5    Brian, D.J.6
  • 82
    • 67149133088 scopus 로고    scopus 로고
    • Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia
    • Ribeiro CM, Hurd H, Wu Y, Martino ME, Jones L, Brighton B, Boucher RC, O'Neal WK,. Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia. PLoS ONE 2009; 4: e5806.
    • (2009) PLoS ONE , vol.4 , pp. e5806
    • Ribeiro, C.M.1    Hurd, H.2    Wu, Y.3    Martino, M.E.4    Jones, L.5    Brighton, B.6    Boucher, R.C.7    O'Neal, W.K.8
  • 84
    • 84934979662 scopus 로고    scopus 로고
    • Immunomodulatory effects of a Low-dose clarithromycin-based macrolide solution pressurised metered dose inhaler
    • Haghi M, Saadat A, Zhu B, Colombo G, King G, Young PM, Traini D,. Immunomodulatory effects of a Low-dose clarithromycin-based macrolide solution pressurised metered dose inhaler. Pharm Res 2015; 32: 2144-2153.
    • (2015) Pharm Res , vol.32 , pp. 2144-2153
    • Haghi, M.1    Saadat, A.2    Zhu, B.3    Colombo, G.4    King, G.5    Young, P.M.6    Traini, D.7
  • 85
    • 84865975368 scopus 로고    scopus 로고
    • Doxycycline exhibits anti-inflammatory activity in CF bronchial epithelial cells
    • Bensman TJ, Nguyen AN, Rao AP, Beringer PM,. Doxycycline exhibits anti-inflammatory activity in CF bronchial epithelial cells. Pulm Pharmacol Ther 2012; 25: 377-382.
    • (2012) Pulm Pharmacol Ther , vol.25 , pp. 377-382
    • Bensman, T.J.1    Nguyen, A.N.2    Rao, A.P.3    Beringer, P.M.4
  • 86
    • 84924087708 scopus 로고    scopus 로고
    • Antimicrobial activity of ibuprofen: New perspectives on an "old" non-antibiotic drug
    • Obad J, Suskovic J, Kos B,. Antimicrobial activity of ibuprofen: new perspectives on an "old" non-antibiotic drug. Eur J Pharm Sci 2015; 71: 93-98.
    • (2015) Eur J Pharm Sci , vol.71 , pp. 93-98
    • Obad, J.1    Suskovic, J.2    Kos, B.3
  • 87
    • 0028934779 scopus 로고
    • Antibacterial activity of the anti-inflammatory compound ibuprofen
    • Elvers KT, Wright SJ,. Antibacterial activity of the anti-inflammatory compound ibuprofen. Lett Appl Microbiol 1995; 20: 82-84.
    • (1995) Lett Appl Microbiol , vol.20 , pp. 82-84
    • Elvers, K.T.1    Wright, S.J.2
  • 89
    • 84905992903 scopus 로고    scopus 로고
    • A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy
    • Pohl K, Hayes E, Keenan J, Henry M, Meleady P, Molloy K, Jundi B, Bergin DA, McCarthy C, McElvaney OJ, et al., A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy. Blood 2014; 124: 999-1009.
    • (2014) Blood , vol.124 , pp. 999-1009
    • Pohl, K.1    Hayes, E.2    Keenan, J.3    Henry, M.4    Meleady, P.5    Molloy, K.6    Jundi, B.7    Bergin, D.A.8    McCarthy, C.9    McElvaney, O.J.10
  • 95
    • 0027682586 scopus 로고
    • Leukotriene B4 markedly elevated in the epithelial lining fluid of patients with cystic fibrosis
    • Konstan MW, Walenga RW, Hilliard KA, Hilliard JB,. Leukotriene B4 markedly elevated in the epithelial lining fluid of patients with cystic fibrosis. Am Rev Respir Dis 1993; 148: 896-901.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 896-901
    • Konstan, M.W.1    Walenga, R.W.2    Hilliard, K.A.3    Hilliard, J.B.4
  • 96
    • 0028015883 scopus 로고
    • Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation
    • Konstan MW, Hilliard KA, Norvell TM, Berger M,. Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med 1994; 150: 448-454.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 448-454
    • Konstan, M.W.1    Hilliard, K.A.2    Norvell, T.M.3    Berger, M.4
  • 97
    • 0027203886 scopus 로고
    • Eicosapentaenoic acid in cystic fibrosis: Evidence of a pathogenetic role for leukotriene B4
    • Lawrence R, Sorrell T,. Eicosapentaenoic acid in cystic fibrosis: evidence of a pathogenetic role for leukotriene B4. Lancet 1993; 342: 465-469.
    • (1993) Lancet , vol.342 , pp. 465-469
    • Lawrence, R.1    Sorrell, T.2
  • 98
    • 0031035884 scopus 로고    scopus 로고
    • Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis
    • Noah TL, Black HR, Cheng PW, Wood RE, Leigh MW,. Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. J Infect Dis 1997; 175: 638-647.
    • (1997) J Infect Dis , vol.175 , pp. 638-647
    • Noah, T.L.1    Black, H.R.2    Cheng, P.W.3    Wood, R.E.4    Leigh, M.W.5
  • 99
    • 0032770489 scopus 로고    scopus 로고
    • Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients
    • Muhlebach MS, Stewart PW, Leigh MW, Noah TL,. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Am J Respir Crit Care Med 1999; 160: 186-191.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 186-191
    • Muhlebach, M.S.1    Stewart, P.W.2    Leigh, M.W.3    Noah, T.L.4
  • 100
    • 0029346937 scopus 로고
    • The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis
    • Balough K, McCubbin M, Weinberger M, Smits W, Ahrens R, Fick R,. The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis. Pediatr Pulmonol 1995; 20: 63-70.
    • (1995) Pediatr Pulmonol , vol.20 , pp. 63-70
    • Balough, K.1    McCubbin, M.2    Weinberger, M.3    Smits, W.4    Ahrens, R.5    Fick, R.6
  • 102
    • 58149359833 scopus 로고    scopus 로고
    • Oxidative stress causes IL8 promoter hyperacetylation in cystic fibrosis airway cell models
    • Bartling TR, Drumm ML,. Oxidative stress causes IL8 promoter hyperacetylation in cystic fibrosis airway cell models. Am J Respir Cell Mol Biol 2009; 40: 58-65.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 58-65
    • Bartling, T.R.1    Drumm, M.L.2
  • 103
    • 67650073195 scopus 로고    scopus 로고
    • Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells
    • Bartling TR, Drumm ML,. Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009; 297: L35-L43.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. L35-L43
    • Bartling, T.R.1    Drumm, M.L.2
  • 106
    • 0027174515 scopus 로고
    • Neutrophil mediators, pseudomonas, and pulmonary dysfunction in cystic fibrosis
    • Meyer KC, Zimmerman J,. Neutrophil mediators, pseudomonas, and pulmonary dysfunction in cystic fibrosis. J Lab Clin Med 1993; 121: 654-661.
    • (1993) J Lab Clin Med , vol.121 , pp. 654-661
    • Meyer, K.C.1    Zimmerman, J.2
  • 108
    • 0036907325 scopus 로고    scopus 로고
    • Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis
    • Sagel SD, Sontag MK, Wagener JS, Kapsner RK, Osberg I, Accurso FJ,. Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis. J Pediatr 2002; 141: 811-817.
    • (2002) J Pediatr , vol.141 , pp. 811-817
    • Sagel, S.D.1    Sontag, M.K.2    Wagener, J.S.3    Kapsner, R.K.4    Osberg, I.5    Accurso, F.J.6
  • 110
    • 0026599949 scopus 로고
    • Neutrophil elastase stimulates tracheal submucosa gland secretion that is inhibited by ICI 200,355
    • Schuster A, Ueki I, Nadel JA,. Neutrophil elastase stimulates tracheal submucosa gland secretion that is inhibited by ICI 200,355. Am J Physiol 1992; 262: L86.
    • (1992) Am J Physiol , vol.262 , pp. L86
    • Schuster, A.1    Ueki, I.2    Nadel, J.A.3
  • 111
    • 0025228983 scopus 로고
    • Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells
    • Sommerhoff CP, Nadel JA, Basbaum CB, Caughey GH,. Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J Clin Invest 1990; 85: 682-689.
    • (1990) J Clin Invest , vol.85 , pp. 682-689
    • Sommerhoff, C.P.1    Nadel, J.A.2    Basbaum, C.B.3    Caughey, G.H.4
  • 112
    • 0021135892 scopus 로고
    • Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: A serine protease effect
    • Smallman LA, Hill SL, Stockley RA,. Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: a serine protease effect. Thorax 1984; 39: 663-667.
    • (1984) Thorax , vol.39 , pp. 663-667
    • Smallman, L.A.1    Hill, S.L.2    Stockley, R.A.3
  • 113
    • 0018645925 scopus 로고
    • Effect of human leukocyte enzymes on tracheal mucosa and mucociliary activity
    • Tegner H, Ohlsson K, Toremalm NG, von Mecklenburg C,. Effect of human leukocyte enzymes on tracheal mucosa and mucociliary activity. Rhinology 1979; 17: 199-206.
    • (1979) Rhinology , vol.17 , pp. 199-206
    • Tegner, H.1    Ohlsson, K.2    Toremalm, N.G.3    Von Mecklenburg, C.4
  • 114
    • 24044456312 scopus 로고    scopus 로고
    • Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism
    • Park JA, He F, Martin LD, Li Y, Chorley BN, Adler KB,. Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism. Am J Pathol 2005; 167: 651-661.
    • (2005) Am J Pathol , vol.167 , pp. 651-661
    • Park, J.A.1    He, F.2    Martin, L.D.3    Li, Y.4    Chorley, B.N.5    Adler, K.B.6
  • 115
    • 0033045546 scopus 로고    scopus 로고
    • Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells
    • Voynow JA, Young LR, Wang Y, Horger T, Rose MC, Fischer BM,. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 1999; 276: L835-L843.
    • (1999) Am J Physiol , vol.276 , pp. L835-L843
    • Voynow, J.A.1    Young, L.R.2    Wang, Y.3    Horger, T.4    Rose, M.C.5    Fischer, B.M.6
  • 116
    • 0026474443 scopus 로고
    • Modulation of airway inflammation in cystic fibrosis. in vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor
    • McElvaney NG, Nakamura H, Birrer P, Hebert CA, Wong WL, Alphonso M, Baker JB, Catalano MA, Crystal RG,. Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J Clin Invest 1992; 90: 1296-1301.
    • (1992) J Clin Invest , vol.90 , pp. 1296-1301
    • McElvaney, N.G.1    Nakamura, H.2    Birrer, P.3    Hebert, C.A.4    Wong, W.L.5    Alphonso, M.6    Baker, J.B.7    Catalano, M.A.8    Crystal, R.G.9
  • 117
    • 0026681802 scopus 로고
    • Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in human bronchial epithelial cell line
    • Nakamura H, Yoshimura K, McElvaney NG, Crystal RG,. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in human bronchial epithelial cell line. J Clin Invest 1992; 89: 1478-1484.
    • (1992) J Clin Invest , vol.89 , pp. 1478-1484
    • Nakamura, H.1    Yoshimura, K.2    McElvaney, N.G.3    Crystal, R.G.4
  • 118
    • 17444418987 scopus 로고    scopus 로고
    • Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport
    • Caldwell RA, Boucher RC, Stutts MJ,. Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport. Am J Physiol Lung Cell Mol Physiol 2005; 288: L813-L819.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288 , pp. L813-L819
    • Caldwell, R.A.1    Boucher, R.C.2    Stutts, M.J.3
  • 122
    • 0024459145 scopus 로고
    • Complement receptor expression on neutrophils at an inflammatory site, the pseudomonas-infected lung in cystic fibrosis
    • Berger M, Sorensen RU, Tosi MF, Dearborn DG, Doring G,. Complement receptor expression on neutrophils at an inflammatory site, the pseudomonas-infected lung in cystic fibrosis. J Clin Invest 1989; 84: L302-L313.
    • (1989) J Clin Invest , vol.84 , pp. L302-L313
    • Berger, M.1    Sorensen, R.U.2    Tosi, M.F.3    Dearborn, D.G.4    Doring, G.5
  • 123
    • 0023766047 scopus 로고
    • Functional differences between the 40 kDa and 50 to 70 kDa IgG Fc receptors on human neutrophils revealed by elastase treatment and antireceptor antibodies
    • Tosi MF, Berger M,. Functional differences between the 40 kDa and 50 to 70 kDa IgG Fc receptors on human neutrophils revealed by elastase treatment and antireceptor antibodies. J Immunol 1988; 141: 2097-2103.
    • (1988) J Immunol , vol.141 , pp. 2097-2103
    • Tosi, M.F.1    Berger, M.2
  • 124
    • 0025374923 scopus 로고
    • Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch
    • Tosi MF, Zakem H, Berger M,. Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J Clin Invest 1990; 86: 300-308.
    • (1990) J Clin Invest , vol.86 , pp. 300-308
    • Tosi, M.F.1    Zakem, H.2    Berger, M.3
  • 125
    • 0026737931 scopus 로고
    • Surface expression of Fc gamma receptor III (CD 16) on chemoattractant-stimulated neutrophils is determined by both surface shedding and translocation from intracellular storage compartments
    • Tosi MF, Zakem H,. Surface expression of Fc gamma receptor III (CD 16) on chemoattractant-stimulated neutrophils is determined by both surface shedding and translocation from intracellular storage compartments. J Clin Invest 1992; 90: 462-470.
    • (1992) J Clin Invest , vol.90 , pp. 462-470
    • Tosi, M.F.1    Zakem, H.2
  • 127
    • 61549139061 scopus 로고    scopus 로고
    • Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice
    • Bruscia EM, Zhang PX, Ferreira E, Caputo C, Emerson JW, Tuck D, Kraus DS, Egan ME,. Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. Am J Respir Cell Mol Biol 2009; 40: 295-304.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 295-304
    • Bruscia, E.M.1    Zhang, P.X.2    Ferreira, E.3    Caputo, C.4    Emerson, J.W.5    Tuck, D.6    Kraus, D.S.7    Egan, M.E.8
  • 128
    • 79959572825 scopus 로고    scopus 로고
    • Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis
    • Bruscia EM, Zhang PX, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Kraus DS,. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol 2011; 186: 6990-6998.
    • (2011) J Immunol , vol.186 , pp. 6990-6998
    • Bruscia, E.M.1    Zhang, P.X.2    Satoh, A.3    Caputo, C.4    Medzhitov, R.5    Shenoy, A.6    Egan, M.E.7    Kraus, D.S.8
  • 130
    • 72149093771 scopus 로고    scopus 로고
    • Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages
    • Deriy LV, Gomez EA, Zhang G, Beacham DW, Hopson JA, Gallan AJ, Shevchenko PD, Bindokas VP, Nelson DJ,. Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages. J Biol Chem 2009; 284: 35926-35938.
    • (2009) J Biol Chem , vol.284 , pp. 35926-35938
    • Deriy, L.V.1    Gomez, E.A.2    Zhang, G.3    Beacham, D.W.4    Hopson, J.A.5    Gallan, A.J.6    Shevchenko, P.D.7    Bindokas, V.P.8    Nelson, D.J.9
  • 131
  • 135
    • 35748973573 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages
    • Haggie PM, Verkman AS,. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J Biol Chem 2007; 282: 31422-31428.
    • (2007) J Biol Chem , vol.282 , pp. 31422-31428
    • Haggie, P.M.1    Verkman, A.S.2
  • 136
    • 56049106702 scopus 로고    scopus 로고
    • High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine
    • Liu G, Wang J, Park YJ, Tsuruta Y, Lorne EF, Zhao X, Abraham E,. High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J Immunol 2008; 181: 4240-4246.
    • (2008) J Immunol , vol.181 , pp. 4240-4246
    • Liu, G.1    Wang, J.2    Park, Y.J.3    Tsuruta, Y.4    Lorne, E.F.5    Zhao, X.6    Abraham, E.7
  • 137
    • 0037083448 scopus 로고    scopus 로고
    • Functional IL-10 deficiency in the lung of cystic fibrosis (CFTR -/-) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar Macrophages
    • Soltys J, Bonfield T, Chmiel J, Berger M,. Functional IL-10 deficiency in the lung of cystic fibrosis (cftr -/-) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar Macrophages. J Immunol 2002; 168: 1903-1910.
    • (2002) J Immunol , vol.168 , pp. 1903-1910
    • Soltys, J.1    Bonfield, T.2    Chmiel, J.3    Berger, M.4
  • 138
    • 25444479344 scopus 로고    scopus 로고
    • Gammadelta T lymphocytes from cystic fibrosis patients and healthy donors are high TNF-alpha and IFN-gamma-producers in response to Pseudomonas aeruginosa
    • Raga S, Julià MR, Crespí C, Figuerola J, Martínez N, Milà J, Matamoros N,. Gammadelta T lymphocytes from cystic fibrosis patients and healthy donors are high TNF-alpha and IFN-gamma-producers in response to Pseudomonas aeruginosa. Respir Res 2003; 4: 9.
    • (2003) Respir Res , vol.4 , pp. 9
    • Raga, S.1    Julià, M.R.2    Crespí, C.3    Figuerola, J.4    Martínez, N.5    Milà, J.6    Matamoros, N.7
  • 140
    • 84896374061 scopus 로고    scopus 로고
    • T helper cell subsets specific for Pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis
    • Bayes HK, Bicknell S, MacGregor G, Evans TJ,. T helper cell subsets specific for Pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis. PLoS ONE 2014; 9: e90263.
    • (2014) PLoS ONE , vol.9 , pp. e90263
    • Bayes, H.K.1    Bicknell, S.2    MacGregor, G.3    Evans, T.J.4
  • 142
    • 33847043963 scopus 로고    scopus 로고
    • IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice
    • Dubin PJ, Kolls JK,. IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice. Am J Physiol Lung Cell Mol Physiol 2007; 292: L519-L528.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L519-L528
    • Dubin, P.J.1    Kolls, J.K.2
  • 143
    • 21244455537 scopus 로고    scopus 로고
    • Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: Implications for airway inflammation in cystic fibrosis
    • McAllister F, Henry A, Kreindler JL, Dubin PJ, Ulrich L, Steele C, Finder JD, Pilewski JM, Carreno BM, Goldman SJ, et al., Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol 2005; 175: 404-412.
    • (2005) J Immunol , vol.175 , pp. 404-412
    • McAllister, F.1    Henry, A.2    Kreindler, J.L.3    Dubin, P.J.4    Ulrich, L.5    Steele, C.6    Finder, J.D.7    Pilewski, J.M.8    Carreno, B.M.9    Goldman, S.J.10
  • 144
    • 84879939404 scopus 로고    scopus 로고
    • IL-17 in lung disease: Friend or foe?
    • Tan HL, Rosenthal M,. IL-17 in lung disease: friend or foe? Thorax 2013; 68: 788-790.
    • (2013) Thorax , vol.68 , pp. 788-790
    • Tan, H.L.1    Rosenthal, M.2
  • 145
    • 0037442137 scopus 로고    scopus 로고
    • IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger
    • Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A,. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol 2003; 170: 2106-2112.
    • (2003) J Immunol , vol.170 , pp. 2106-2112
    • Ferretti, S.1    Bonneau, O.2    Dubois, G.R.3    Jones, C.E.4    Trifilieff, A.5
  • 146
    • 49349089472 scopus 로고    scopus 로고
    • IL-17 targeted antibody treatment increases the excessive pulmonary inflammation in CF mice
    • Hsu DP, van Heeckeren A, Schlucter M, Xue W, Davis PB,. IL-17 targeted antibody treatment increases the excessive pulmonary inflammation in CF mice. Pediatr Pulmonol 2006; S29: 256.
    • (2006) Pediatr Pulmonol , vol.29 S , pp. 256
    • Hsu, D.P.1    Van Heeckeren, A.2    Schlucter, M.3    Xue, W.4    Davis, P.B.5
  • 147
    • 0019443593 scopus 로고
    • Bronchial reactivity in cystic fibrosis with normal pulmonary function
    • Van Asperen P, Mellis CM, South RT, Simpson SJ,. Bronchial reactivity in cystic fibrosis with normal pulmonary function. Am J Dis Child 1981; 135: 815-819.
    • (1981) Am J Dis Child , vol.135 , pp. 815-819
    • Van Asperen, P.1    Mellis, C.M.2    South, R.T.3    Simpson, S.J.4
  • 148
    • 0027480179 scopus 로고
    • Wheezing and airflow obstruction during methacholine challenge in children with cystic fibrosis and in normal children
    • Sanchez I, Powell RE, Pasterkamp H,. Wheezing and airflow obstruction during methacholine challenge in children with cystic fibrosis and in normal children. Am Rev Respir Dis 1993; 147: 705-709.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 705-709
    • Sanchez, I.1    Powell, R.E.2    Pasterkamp, H.3
  • 149
    • 33748488451 scopus 로고    scopus 로고
    • Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation
    • Vandebrouck C, Melin P, Norez C, Robert R, Guibert C, Mettey Y, Becq F,. Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation. Respir Res 2006; 7: 113.
    • (2006) Respir Res , vol.7 , pp. 113
    • Vandebrouck, C.1    Melin, P.2    Norez, C.3    Robert, R.4    Guibert, C.5    Mettey, Y.6    Becq, F.7
  • 155
    • 79953232042 scopus 로고    scopus 로고
    • Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway
    • Cosgrove S, Chotirmall SH, Greene CM, McElvaney NG,. Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway. J Biol Chem 2011; 286: 7692-7704.
    • (2011) J Biol Chem , vol.286 , pp. 7692-7704
    • Cosgrove, S.1    Chotirmall, S.H.2    Greene, C.M.3    McElvaney, N.G.4
  • 156
    • 77951951482 scopus 로고    scopus 로고
    • Human neutrophil elastase-mediated cleavage sites on MMP-9 and TIMP-1: Implications to cystic fibrosis proteolytic dysfunction
    • Jackson PL, Xu X, Wilson L, Weathington NM, Clancy JP, Blalock JE, Gaggar A,. Human neutrophil elastase-mediated cleavage sites on MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction. Mol Med 2010; 16: 159-166.
    • (2010) Mol Med , vol.16 , pp. 159-166
    • Jackson, P.L.1    Xu, X.2    Wilson, L.3    Weathington, N.M.4    Clancy, J.P.5    Blalock, J.E.6    Gaggar, A.7
  • 157
    • 76249114693 scopus 로고    scopus 로고
    • Decreased levels of secretory leucoprotease inhibitor in the pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degredation
    • Weldon S, McNally P, McElvaney NG, Elborn JS, McAuley DF, Wartelle J, Belaaouaj A, Levine RL, Taggart CC, et al., Decreased levels of secretory leucoprotease inhibitor in the pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degredation. J Immunol 2009; 183: 8146-8156.
    • (2009) J Immunol , vol.183 , pp. 8146-8156
    • Weldon, S.1    McNally, P.2    McElvaney, N.G.3    Elborn, J.S.4    McAuley, D.F.5    Wartelle, J.6    Belaaouaj, A.7    Levine, R.L.8    Taggart, C.C.9
  • 159
    • 33748556522 scopus 로고    scopus 로고
    • Prolastin aerosol therapy and sputum taurine in cystic fibrosis
    • Cantin AM, Berthiaume Y, Cloutier D, Martel M,. Prolastin aerosol therapy and sputum taurine in cystic fibrosis. Clin Invest Med 2006; 29: 201-207.
    • (2006) Clin Invest Med , vol.29 , pp. 201-207
    • Cantin, A.M.1    Berthiaume, Y.2    Cloutier, D.3    Martel, M.4
  • 161
    • 84941043379 scopus 로고    scopus 로고
    • A 3 week dose escalation, randomized, double-blind, placebo-controlled trial to assess the safety, tolerability, and possible efficacy of 100 mg or 200 mg of once daily inhaled alpha-1 HC in cystic fibrosis (CF)
    • Nichols D, Donalson SH, Dorkin H, Flume PA, Gaggar A, Chmiel J, Griffin R,. A 3 week dose escalation, randomized, double-blind, placebo-controlled trial to assess the safety, tolerability, and possible efficacy of 100 mg or 200 mg of once daily inhaled alpha-1 HC in cystic fibrosis (CF). Pediatr Pulmonol 2014; S38: 316.
    • (2014) Pediatr Pulmonol , vol.38 S , pp. 316
    • Nichols, D.1    Donalson, S.H.2    Dorkin, H.3    Flume, P.A.4    Gaggar, A.5    Chmiel, J.6    Griffin, R.7
  • 163
    • 33845687299 scopus 로고    scopus 로고
    • Oxidative stress and lipid-derived inflammatory mediators during acute exacerbations of cystic fibrosis
    • Reid DW, Misso N, Aggarwal S, Thompson PJ, Walter EH,. Oxidative stress and lipid-derived inflammatory mediators during acute exacerbations of cystic fibrosis. Respirology 2007; 12: 63-69.
    • (2007) Respirology , vol.12 , pp. 63-69
    • Reid, D.W.1    Misso, N.2    Aggarwal, S.3    Thompson, P.J.4    Walter, E.H.5
  • 167
    • 84901601510 scopus 로고    scopus 로고
    • A pilot study evaluating the effect of sulforaphane in broccoli sprouts on Nrf2 activation, glutathione, markers of oxidative stress, and neutrophil migration in healthy volunteers and subjects with CF
    • Chmiel JF, Ziady AG, Cantin A, Comhair S, Hazen SL, Schluchter MD, Margevicius S, Bucur C, Campbell PW, Konstan MW,. A pilot study evaluating the effect of sulforaphane in broccoli sprouts on Nrf2 activation, glutathione, markers of oxidative stress, and neutrophil migration in healthy volunteers and subjects with CF. Pediatr Pulmonol 2012; S35: 250.
    • (2012) Pediatr Pulmonol , vol.35 S , pp. 250
    • Chmiel, J.F.1    Ziady, A.G.2    Cantin, A.3    Comhair, S.4    Hazen, S.L.5    Schluchter, M.D.6    Margevicius, S.7    Bucur, C.8    Campbell, P.W.9    Konstan, M.W.10
  • 168
  • 171
    • 33846211109 scopus 로고    scopus 로고
    • The lactoperoxidase system links anion transport to host defense in cystic fibrosis
    • Conner GE, Wijkstrom-Frei C, Randell SH, Fernandez VE, Salathe M,. The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett 2007; 581: 271-278.
    • (2007) FEBS Lett , vol.581 , pp. 271-278
    • Conner, G.E.1    Wijkstrom-Frei, C.2    Randell, S.H.3    Fernandez, V.E.4    Salathe, M.5
  • 172
    • 84880052989 scopus 로고    scopus 로고
    • Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense
    • Chandler JD, Nichols DP, Nick JA, Hondal RJ, Day BJ,. Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense. J Biol Chem 2013; 288: 18421-18428.
    • (2013) J Biol Chem , vol.288 , pp. 18421-18428
    • Chandler, J.D.1    Nichols, D.P.2    Nick, J.A.3    Hondal, R.J.4    Day, B.J.5
  • 173
    • 73949105483 scopus 로고    scopus 로고
    • The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases
    • Xu Y, Szep S, Lu Z,. The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases. Proc Natl Acad Sci USA 2009; 106: 20515-20519.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20515-20519
    • Xu, Y.1    Szep, S.2    Lu, Z.3
  • 174
    • 84928315351 scopus 로고    scopus 로고
    • Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate Pseudomonas aeruginosa biofilms growing on cystic fibrosis airway epithelial cells
    • Moreau-Marquis S, Coutermarsh B, Stanton BA,. Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate Pseudomonas aeruginosa biofilms growing on cystic fibrosis airway epithelial cells. J Antimicrob Chemother 2015; 70: 160-166.
    • (2015) J Antimicrob Chemother , vol.70 , pp. 160-166
    • Moreau-Marquis, S.1    Coutermarsh, B.2    Stanton, B.A.3
  • 175
    • 0021367065 scopus 로고
    • Clinical pharmacokinetics of nitroprusside, cyanide, thiosulphate and thiocyanate
    • Schulz V,. Clinical pharmacokinetics of nitroprusside, cyanide, thiosulphate and thiocyanate. Clin Pharmacokinet 1984; 9: 239-251.
    • (1984) Clin Pharmacokinet , vol.9 , pp. 239-251
    • Schulz, V.1
  • 176
    • 84868456659 scopus 로고    scopus 로고
    • Thiocyanate: A potentially useful therapeutic agent with host defense and antioxidant properties
    • Chandler JD, Day BJ,. Thiocyanate: a potentially useful therapeutic agent with host defense and antioxidant properties. Biochem Pharmacol 2012; 84: 1381-1387.
    • (2012) Biochem Pharmacol , vol.84 , pp. 1381-1387
    • Chandler, J.D.1    Day, B.J.2
  • 179
    • 0038013967 scopus 로고    scopus 로고
    • Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation
    • Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN,. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 2003; 278: 14677-14687.
    • (2003) J Biol Chem , vol.278 , pp. 14677-14687
    • Hong, S.1    Gronert, K.2    Devchand, P.R.3    Moussignac, R.L.4    Serhan, C.N.5
  • 180
    • 84878640144 scopus 로고    scopus 로고
    • Contribution of CFTR to alveolar fluid clearance by lipoxin A4 via PI3K/Akt pathway in LPS-induced acute lung injury
    • Yang Y, Cheng Y, Lian QQ, Yang L, Qi W, Wu DR, Zheng X, Liu YJ, Li WJ, Jin SW, et al., Contribution of CFTR to alveolar fluid clearance by lipoxin A4 via PI3K/Akt pathway in LPS-induced acute lung injury. Mediators Inflamm 2013; 2013: 862628.
    • (2013) Mediators Inflamm , vol.2013 , pp. 862628
    • Yang, Y.1    Cheng, Y.2    Lian, Q.Q.3    Yang, L.4    Qi, W.5    Wu, D.R.6    Zheng, X.7    Liu, Y.J.8    Li, W.J.9    Jin, S.W.10
  • 184
    • 78049477852 scopus 로고    scopus 로고
    • Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis
    • Bravo E, Napolitano M, Valentini SB, Quattrucci S,. Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis. Lipids Health Dis 2010; 9: 129.
    • (2010) Lipids Health Dis , vol.9 , pp. 129
    • Bravo, E.1    Napolitano, M.2    Valentini, S.B.3    Quattrucci, S.4
  • 185
    • 55349092036 scopus 로고    scopus 로고
    • Lipoxin A(4) and interleukin-8 levels in cystic fibrosis sputum after antibiotherapy
    • Chiron R, Grumbach YY, Quynh NV, Verriere V, Urbach V,. Lipoxin A(4) and interleukin-8 levels in cystic fibrosis sputum after antibiotherapy. J Cyst Fibros 2008; 7: 463-468.
    • (2008) J Cyst Fibros , vol.7 , pp. 463-468
    • Chiron, R.1    Grumbach, Y.Y.2    Quynh, N.V.3    Verriere, V.4    Urbach, V.5
  • 189
    • 34147174942 scopus 로고    scopus 로고
    • Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia
    • Button B, Picher M, Boucher RC,. Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia. J Physiol 2007; 580: 577-592.
    • (2007) J Physiol , vol.580 , pp. 577-592
    • Button, B.1    Picher, M.2    Boucher, R.C.3
  • 190
    • 80052078622 scopus 로고    scopus 로고
    • The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease
    • Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA,. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 2011; 11: 607-615.
    • (2011) Nat Rev Immunol , vol.11 , pp. 607-615
    • Gleeson, M.1    Bishop, N.C.2    Stensel, D.J.3    Lindley, M.R.4    Mastana, S.S.5    Nimmo, M.A.6
  • 196
    • 84856324330 scopus 로고    scopus 로고
    • British Association of Sport and Exercise Sciences. The BASES expert statement on exercise, immunity, and infection
    • Gleeson M, Walsh NP,. British Association of Sport and Exercise Sciences. The BASES expert statement on exercise, immunity, and infection. J Sports Sci 2012; 30: 321-324.
    • (2012) J Sports Sci , vol.30 , pp. 321-324
    • Gleeson, M.1    Walsh, N.P.2
  • 197
  • 199
    • 74049136105 scopus 로고    scopus 로고
    • The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: A systematic review
    • Ploeger HE, Takken T, de Greef MH, Timmons BW,. The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review. Exerc Immunol Rev 2009; 15: 6-41.
    • (2009) Exerc Immunol Rev , vol.15 , pp. 6-41
    • Ploeger, H.E.1    Takken, T.2    De Greef, M.H.3    Timmons, B.W.4
  • 201
    • 0034027956 scopus 로고    scopus 로고
    • Effect of 3 weeks' rehabilitation on neutrophil surface antigens and lung function in cystic fibrosis
    • Nikolaizik WH, Simon HU, Iseli P, Blaser K, Schoni MH,. Effect of 3 weeks' rehabilitation on neutrophil surface antigens and lung function in cystic fibrosis. Eur Respir J 2000; 15: 942-948.
    • (2000) Eur Respir J , vol.15 , pp. 942-948
    • Nikolaizik, W.H.1    Simon, H.U.2    Iseli, P.3    Blaser, K.4    Schoni, M.H.5
  • 202
    • 55049142454 scopus 로고    scopus 로고
    • Health-related fitness and trainability in children with cystic fibrosis
    • Gruber W, Orenstein DM, Braumann KM, Huls G,. Health-related fitness and trainability in children with cystic fibrosis. Pediatr Pulmonol 2008; 43: 953-964.
    • (2008) Pediatr Pulmonol , vol.43 , pp. 953-964
    • Gruber, W.1    Orenstein, D.M.2    Braumann, K.M.3    Huls, G.4
  • 204
    • 9644270365 scopus 로고    scopus 로고
    • Individualised unsupervised exercise training in adults with cystic fibrosis: A 1 year randomised controlled trial
    • Moorcroft AJ, Dodd ME, Morris J, Webb AK,. Individualised unsupervised exercise training in adults with cystic fibrosis: a 1 year randomised controlled trial. Thorax 2004; 59: 1074-1080.
    • (2004) Thorax , vol.59 , pp. 1074-1080
    • Moorcroft, A.J.1    Dodd, M.E.2    Morris, J.3    Webb, A.K.4
  • 206
    • 16344370090 scopus 로고    scopus 로고
    • Effects of anaerobic training in children with cystic fibrosis: A randomized controlled study
    • Klijn PH, Oudshoorn A, van der Ent CK, van der Net J, Kimpen JL, Helders PJ,. Effects of anaerobic training in children with cystic fibrosis: a randomized controlled study. Chest 2004; 125: 1299-1305.
    • (2004) Chest , vol.125 , pp. 1299-1305
    • Klijn, P.H.1    Oudshoorn, A.2    Van Der Ent, C.K.3    Van Der Net, J.4    Kimpen, J.L.5    Helders, P.J.6
  • 209
    • 0026454890 scopus 로고
    • The prognostic value of exercise testing in patients with cystic fibrosis
    • Nixon PA, Orenstein DM, Kelsey SF, Doershuk CF,. The prognostic value of exercise testing in patients with cystic fibrosis. N Engl J Med 1992; 327: 1785-1788.
    • (1992) N Engl J Med , vol.327 , pp. 1785-1788
    • Nixon, P.A.1    Orenstein, D.M.2    Kelsey, S.F.3    Doershuk, C.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.