Dysfunction of Nrf-2 in CF epithelia leads to excess intracellular H2O2 and inflammatory cytokine production

PLoS ONE

Volumn 3, Issue 10, 2008, Pages

  Chen, Junnan ^a   Kinter, Michael ^b   Shank, Samuel ^a   Cotton, Calvin ^a   Kelley, Thomas J ^a   Ziady, Assem G ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CYTOKINE; HYDROGEN PEROXIDE; INTERLEUKIN 6; INTERLEUKIN 8; SELENIUM; TRANSCRIPTION FACTOR NRF2; TRANSMEMBRANE CONDUCTANCE REGULATOR; INTERLEUKIN 1BETA; NFE2L2 PROTEIN, HUMAN; OXIDIZING AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CELL IMMORTALIZATION; CELL LEVEL; CELL STIMULATION; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEOMICS; REGULATORY MECHANISM; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; STEADY STATE; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; OXIDANTS; OXIDATION-REDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 54449093079     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003367     Document Type: Article

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