Antiinflammatory and antimicrobial effects of thiocyanate in a cystic fibrosis mouse model

American Journal of Respiratory Cell and Molecular Biology

Volumn 53, Issue 2, 2015, Pages 193-205

  Chandler, Joshua D ^a,b   Min, Elysia ^b   Huang, Jie ^b   McElroy, Cameron S ^a,b   Dickerhof, Nina ^c   Mocatta, Tessa ^c   Fletcher, Ashley A ^d   Evans, Christopher M ^d   Liang, Liping ^a   Patel, Manisha ^a   Kettle, Anthony J ^c   Nichols, David P ^b   Day, Brian J ^a,b  

^a Department of Pharmaceutical Sciences ^*  (United States)

^b DEPARTMENT OF MEDICINE   (United States)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Antioxidant; Glutathione sulfonamide; Hypothiocyanous acid; Innate immunity; Nebulization

Indexed keywords

EPITHELIAL SODIUM CHANNEL; GAMMA INTERFERON; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MUCIN 5B; THIOCYANATE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; THIOCYANIC ACID DERIVATIVE; THIOREDOXIN REDUCTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL LOAD; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; HOST RESISTANCE; LUNG LAVAGE; LUNG PARENCHYMA; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PSEUDOMONAS INFECTION; RESPIRATORY EPITHELIUM; ANIMAL; C57BL MOUSE; CELL LINE; DRUG SCREENING; ENZYMOLOGY; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; LUNG; METABOLISM; MICROBIOLOGY; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

BACTERIA (MICROORGANISMS); MAMMALIA; MUS; PSEUDOMONAS AERUGINOSA;

ADMINISTRATION, INHALATION; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYSTIC FIBROSIS; DRUG EVALUATION, PRECLINICAL; FEMALE; LUNG; MALE; MICE, INBRED C57BL; OXIDATIVE STRESS; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; THIOCYANATES; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 84938928408     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2014-0208OC     Document Type: Article

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